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Volumn 326, Issue 2-3, 1997, Pages 257-263

Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels

Author keywords

Antihistaminic agent; Carebastine; Ebastine; hKv1.5 channel; K+ current; Terfenadine

Indexed keywords

CAREBASTINE; DRUG METABOLITE; EBASTINE; HISTAMINE H1 RECEPTOR ANTAGONIST; POTASSIUM CHANNEL; TERFENADINE; TERFENADINE CARBOXYLATE; UNCLASSIFIED DRUG;

EID: 0030974081     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)85421-0     Document Type: Article
Times cited : (19)

References (42)
  • 1
    • 0028927451 scopus 로고
    • Regulation of potassium channels by nonsedating antihistamines
    • Berul C., Morad M. Regulation of potassium channels by nonsedating antihistamines. Circulation. 91:1995;2220-2225.
    • (1995) Circulation , vol.91 , pp. 2220-2225
    • Berul, C.1    Morad, M.2
  • 3
    • 0005937366 scopus 로고
    • Electrophysiological actions of astemizole
    • Chen Y., Woosley R. Electrophysiological actions of astemizole. Clin. Pharmacol. Ther. 55:1994;146.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 146
    • Chen, Y.1    Woosley, R.2
  • 4
    • 0025676658 scopus 로고
    • Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias
    • Colatsky T., Follmer C., Starmer C. Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation. 82:1990;2235-2242.
    • (1990) Circulation , vol.82 , pp. 2235-2242
    • Colatsky, T.1    Follmer, C.2    Starmer, C.3
  • 5
    • 0028838078 scopus 로고
    • Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: Possible mechanism for terfenadine-associated cardiotoxicity
    • Crumb W., Wible B., Arnold A., Payne J., Brown A. Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Mol. Pharmacol. 47:1995;181-190.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 181-190
    • Crumb, W.1    Wible, B.2    Arnold, A.3    Payne, J.4    Brown, A.5
  • 6
    • 0024533132 scopus 로고
    • Cardiotoxic effect with convulsions in terfenadine overdose
    • Davies A., Harindra V., McEwan A., Ghose R. Cardiotoxic effect with convulsions in terfenadine overdose. Br. Med. J. 298:1989;325.
    • (1989) Br. Med. J. , vol.298 , pp. 325
    • Davies, A.1    Harindra, V.2    McEwan, A.3    Ghose, R.4
  • 7
    • 0030025811 scopus 로고    scopus 로고
    • Molecular physiology of cardiac potassium channels
    • Deal K., England S., Tamkun M. Molecular physiology of cardiac potassium channels. Physiol. Rev. 76:1996;49-67.
    • (1996) Physiol. Rev. , vol.76 , pp. 49-67
    • Deal, K.1    England, S.2    Tamkun, M.3
  • 8
    • 0029928144 scopus 로고    scopus 로고
    • Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2
    • Delpón E., Valenzuela C., Pérez O., Franqueza L., Gay P., Snyders D., Tamargo J. Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2. Br. J. Pharmacol. 117:1996;1293-1301.
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 1293-1301
    • Delpón, E.1    Valenzuela, C.2    Pérez, O.3    Franqueza, L.4    Gay, P.5    Snyders, D.6    Tamargo, J.7
  • 10
    • 0019952111 scopus 로고
    • Pharmacokinetics and biotransformation studies of terfenadine in man
    • Garteiz D., Hook R., Walker B., Okerholm R. Pharmacokinetics and biotransformation studies of terfenadine in man. Arzneim.-Forsch. 32:1982;1185-1190.
    • (1982) Arzneim.-Forsch. , vol.32 , pp. 1185-1190
    • Garteiz, D.1    Hook, R.2    Walker, B.3    Okerholm, R.4
  • 11
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
    • Hamill O., Marty A., Neher E., Sackmann B., Sigworth F. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflüg. Arch. 391:1981;85-100.
    • (1981) Pflüg. Arch. , vol.391 , pp. 85-100
    • Hamill, O.1    Marty, A.2    Neher, E.3    Sackmann, B.4    Sigworth, F.5
  • 12
    • 0025164907 scopus 로고
    • Class III antiarrhythmic agents have a lot of potential, but a long way to go: Reduced effectiveness and dangers of reverse use-dependence
    • Hondeghem L., Snyders D. Class III antiarrhythmic agents have a lot of potential, but a long way to go: reduced effectiveness and dangers of reverse use-dependence. Circulation. 81:1990;686-690.
    • (1990) Circulation , vol.81 , pp. 686-690
    • Hondeghem, L.1    Snyders, D.2
  • 13
    • 0013636054 scopus 로고
    • Rôhne-Poulenc Rorer, Collegeville. Data on file.
    • Investigator's Brochure, 1995. Rôhne-Poulenc Rorer, Collegeville. Data on file.
    • (1995) Investigator's Brochure
  • 14
    • 0026451082 scopus 로고
    • Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization
    • Jeck C., Boyden P. Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ. Res. 71:1992;1390-1403.
    • (1992) Circ. Res. , vol.71 , pp. 1390-1403
    • Jeck, C.1    Boyden, P.2
  • 15
    • 0029130655 scopus 로고
    • + currents in nonfailing human hearts: Similarities between right septal subendocardial and left subepicardial ventricular myocytes
    • + currents in nonfailing human hearts: similarities between right septal subendocardial and left subepicardial ventricular myocytes. Circulation. 92:1995;1179-1187.
    • (1995) Circulation , vol.92 , pp. 1179-1187
    • Konarzewska, H.1    Peeters, G.2    Sanguinetti, M.3
  • 23
    • 0027213816 scopus 로고
    • Current status of class III antiarrhythmic drug therapy
    • Roden D. Current status of class III antiarrhythmic drug therapy. Am. J. Cardiol. 72:1993;44B-49B.
    • (1993) Am. J. Cardiol. , vol.72
    • Roden, D.1
  • 24
    • 0029761822 scopus 로고    scopus 로고
    • HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
    • Roy M.-L., Dumaine R., Brown A. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation. 94:1996;817-823.
    • (1996) Circulation , vol.94 , pp. 817-823
    • Roy, M.-L.1    Dumaine, R.2    Brown, A.3
  • 26
    • 0029130666 scopus 로고
    • Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel
    • Snyders D., Yeola S. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circ. Res. 77:1995;575-583.
    • (1995) Circ. Res. , vol.77 , pp. 575-583
    • Snyders, D.1    Yeola, S.2
  • 27
    • 0026603450 scopus 로고
    • Time-, state- And voltage-dependent block by quinidine of a cloned human cardiac channel
    • Snyders D., Knoth K., Roberds S., Tamkun M. Time-, state- and voltage-dependent block by quinidine of a cloned human cardiac channel. Mol. Pharmacol. 41:1992;332-339.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 332-339
    • Snyders, D.1    Knoth, K.2    Roberds, S.3    Tamkun, M.4
  • 28
    • 0027321972 scopus 로고
    • A rapidly activating and slowly inactivating potassium channel cloned from human heart
    • Snyders D., Tamkun M., Bennett P. A rapidly activating and slowly inactivating potassium channel cloned from human heart. J. Gen. Physiol. 101:1993;513-543.
    • (1993) J. Gen. Physiol. , vol.101 , pp. 513-543
    • Snyders, D.1    Tamkun, M.2    Bennett, P.3
  • 29
    • 0029131555 scopus 로고
    • Clinical importance of hepatic cytochrome P450 in drug metabolism
    • Spatzenegger M., Jaegger W. Clinical importance of hepatic cytochrome P450 in drug metabolism. Drug Metab. Rev. 25:1995;397-417.
    • (1995) Drug Metab. Rev. , vol.25 , pp. 397-417
    • Spatzenegger, M.1    Jaegger, W.2
  • 32
    • 0029095234 scopus 로고
    • Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers
    • Valenzuela C., Delpón E., Tamkun M., Tamargo J., Snyders D. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys. J. 69:1995;418-427.
    • (1995) Biophys. J. , vol.69 , pp. 418-427
    • Valenzuela, C.1    Delpón, E.2    Tamkun, M.3    Tamargo, J.4    Snyders, D.5
  • 34
    • 0029790924 scopus 로고    scopus 로고
    • Class III antiarrhythmic effects of zatebradine: Time-, state-, use- And voltage-dependent block of hKv1.5 channels
    • Valenzuela C., Delpón E., Franqueza L., Gay P., Pérez O., Tamargo J., Snyders D. Class III antiarrhythmic effects of zatebradine: time-, state-, use- and voltage-dependent block of hKv1.5 channels. Circulation. 94:1996;562-570.
    • (1996) Circulation , vol.94 , pp. 562-570
    • Valenzuela, C.1    Delpón, E.2    Franqueza, L.3    Gay, P.4    Pérez, O.5    Tamargo, J.6    Snyders, D.7
  • 35
    • 0024203291 scopus 로고
    • The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects
    • Vincent J., Liminana R., Meredith P., Reid J. The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects. Br. J. Clin. Pharmacol. 26:1988;497-501.
    • (1988) Br. J. Clin. Pharmacol. , vol.26 , pp. 497-501
    • Vincent, J.1    Liminana, R.2    Meredith, P.3    Reid, J.4
  • 36
    • 0027376226 scopus 로고
    • + current similar to Kv1.5 cloned channel currents
    • + current similar to Kv1.5 cloned channel currents. Circ. Res. 73:1993;1061-1076.
    • (1993) Circ. Res. , vol.73 , pp. 1061-1076
    • Wang, Z.1    Fermini, B.2    Nattel, S.3
  • 37
    • 0021922070 scopus 로고
    • + channels: Ionic and gating current studies
    • + channels: ionic and gating current studies. J. Gen. Physiol. 85:1985;539-554.
    • (1985) J. Gen. Physiol. , vol.85 , pp. 539-554
    • White, M.1    Bezanilla, F.2
  • 38
    • 0030074361 scopus 로고    scopus 로고
    • Ebastine: A review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders
    • Wiseman L., Faulds D. Ebastine: a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders. Drugs. 51:1996;260-277.
    • (1996) Drugs , vol.51 , pp. 260-277
    • Wiseman, L.1    Faulds, D.2
  • 39
    • 0015879604 scopus 로고
    • Ionic blockade of sodium channels in nerve
    • Woodhull A. Ionic blockade of sodium channels in nerve. J. Gen. Physiol. 61:1973;687-708.
    • (1973) J. Gen. Physiol. , vol.61 , pp. 687-708
    • Woodhull, A.1
  • 40
  • 42
    • 0029006843 scopus 로고
    • Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
    • Yang T., Prakash C., Roden D., Snyders D. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br. J. Pharmacol. 115:1995;267-274.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 267-274
    • Yang, T.1    Prakash, C.2    Roden, D.3    Snyders, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.