-
1
-
-
0028927451
-
Regulation of potassium channels by nonsedating antihistamines
-
Berul C., Morad M. Regulation of potassium channels by nonsedating antihistamines. Circulation. 91:1995;2220-2225.
-
(1995)
Circulation
, vol.91
, pp. 2220-2225
-
-
Berul, C.1
Morad, M.2
-
3
-
-
0005937366
-
Electrophysiological actions of astemizole
-
Chen Y., Woosley R. Electrophysiological actions of astemizole. Clin. Pharmacol. Ther. 55:1994;146.
-
(1994)
Clin. Pharmacol. Ther.
, vol.55
, pp. 146
-
-
Chen, Y.1
Woosley, R.2
-
4
-
-
0025676658
-
Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias
-
Colatsky T., Follmer C., Starmer C. Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation. 82:1990;2235-2242.
-
(1990)
Circulation
, vol.82
, pp. 2235-2242
-
-
Colatsky, T.1
Follmer, C.2
Starmer, C.3
-
5
-
-
0028838078
-
Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: Possible mechanism for terfenadine-associated cardiotoxicity
-
Crumb W., Wible B., Arnold A., Payne J., Brown A. Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Mol. Pharmacol. 47:1995;181-190.
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 181-190
-
-
Crumb, W.1
Wible, B.2
Arnold, A.3
Payne, J.4
Brown, A.5
-
6
-
-
0024533132
-
Cardiotoxic effect with convulsions in terfenadine overdose
-
Davies A., Harindra V., McEwan A., Ghose R. Cardiotoxic effect with convulsions in terfenadine overdose. Br. Med. J. 298:1989;325.
-
(1989)
Br. Med. J.
, vol.298
, pp. 325
-
-
Davies, A.1
Harindra, V.2
McEwan, A.3
Ghose, R.4
-
7
-
-
0030025811
-
Molecular physiology of cardiac potassium channels
-
Deal K., England S., Tamkun M. Molecular physiology of cardiac potassium channels. Physiol. Rev. 76:1996;49-67.
-
(1996)
Physiol. Rev.
, vol.76
, pp. 49-67
-
-
Deal, K.1
England, S.2
Tamkun, M.3
-
8
-
-
0029928144
-
Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2
-
Delpón E., Valenzuela C., Pérez O., Franqueza L., Gay P., Snyders D., Tamargo J. Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2. Br. J. Pharmacol. 117:1996;1293-1301.
-
(1996)
Br. J. Pharmacol.
, vol.117
, pp. 1293-1301
-
-
Delpón, E.1
Valenzuela, C.2
Pérez, O.3
Franqueza, L.4
Gay, P.5
Snyders, D.6
Tamargo, J.7
-
10
-
-
0019952111
-
Pharmacokinetics and biotransformation studies of terfenadine in man
-
Garteiz D., Hook R., Walker B., Okerholm R. Pharmacokinetics and biotransformation studies of terfenadine in man. Arzneim.-Forsch. 32:1982;1185-1190.
-
(1982)
Arzneim.-Forsch.
, vol.32
, pp. 1185-1190
-
-
Garteiz, D.1
Hook, R.2
Walker, B.3
Okerholm, R.4
-
11
-
-
0019441262
-
Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
-
Hamill O., Marty A., Neher E., Sackmann B., Sigworth F. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflüg. Arch. 391:1981;85-100.
-
(1981)
Pflüg. Arch.
, vol.391
, pp. 85-100
-
-
Hamill, O.1
Marty, A.2
Neher, E.3
Sackmann, B.4
Sigworth, F.5
-
12
-
-
0025164907
-
Class III antiarrhythmic agents have a lot of potential, but a long way to go: Reduced effectiveness and dangers of reverse use-dependence
-
Hondeghem L., Snyders D. Class III antiarrhythmic agents have a lot of potential, but a long way to go: reduced effectiveness and dangers of reverse use-dependence. Circulation. 81:1990;686-690.
-
(1990)
Circulation
, vol.81
, pp. 686-690
-
-
Hondeghem, L.1
Snyders, D.2
-
13
-
-
0013636054
-
-
Rôhne-Poulenc Rorer, Collegeville. Data on file.
-
Investigator's Brochure, 1995. Rôhne-Poulenc Rorer, Collegeville. Data on file.
-
(1995)
Investigator's Brochure
-
-
-
14
-
-
0026451082
-
Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization
-
Jeck C., Boyden P. Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ. Res. 71:1992;1390-1403.
-
(1992)
Circ. Res.
, vol.71
, pp. 1390-1403
-
-
Jeck, C.1
Boyden, P.2
-
15
-
-
0029130655
-
+ currents in nonfailing human hearts: Similarities between right septal subendocardial and left subepicardial ventricular myocytes
-
+ currents in nonfailing human hearts: similarities between right septal subendocardial and left subepicardial ventricular myocytes. Circulation. 92:1995;1179-1187.
-
(1995)
Circulation
, vol.92
, pp. 1179-1187
-
-
Konarzewska, H.1
Peeters, G.2
Sanguinetti, M.3
-
16
-
-
0019951137
-
Metabolic disposition of terfenadine in laboratory animals
-
Leeson G., Chan K., Knapp W., Biedenbach S., Wright G., Okerholm R. Metabolic disposition of terfenadine in laboratory animals. Arzneim.-Forsch. 32:1982;1173-1178.
-
(1982)
Arzneim.-Forsch.
, vol.32
, pp. 1173-1178
-
-
Leeson, G.1
Chan, K.2
Knapp, W.3
Biedenbach, S.4
Wright, G.5
Okerholm, R.6
-
18
-
-
0028010859
-
1-receptor antagonist ebastine and its metabolite carebastine in rats, guinea pigs, dogs and monkeys
-
1-receptor antagonist ebastine and its metabolite carebastine in rats, guinea pigs, dogs and monkeys. Arzneim.-Forsch. 44:1994;55-59.
-
(1994)
Arzneim.-Forsch.
, vol.44
, pp. 55-59
-
-
Matsuda, M.1
Sakashita, M.2
Mikuzi, Y.3
Yamaguchi, T.4
Fujii, T.5
Sekine, Y.6
-
20
-
-
0025222965
-
Torsades de pointes occurring in association with terfenadine use
-
Monahan B., Ferguson C., Killeavy E., Lloyd B., Troy J., Cantilena L. Torsades de pointes occurring in association with terfenadine use. J. Am. Med. Assoc. 264:1990;2788-2790.
-
(1990)
J. Am. Med. Assoc.
, vol.264
, pp. 2788-2790
-
-
Monahan, B.1
Ferguson, C.2
Killeavy, E.3
Lloyd, B.4
Troy, J.5
Cantilena, L.6
-
22
-
-
0027469480
-
Molecular biology of the voltaged-gated potassium channels of the cardiovascular system
-
Roberds S.L., Knoth K.M., Po S., Blair T.A., Bennett P.B., Hartshorne R.P., Snyders D.J., Tamkun M.M. Molecular biology of the voltaged-gated potassium channels of the cardiovascular system. J. Cardiovasc. Electrophysiol. 4:1993;68.
-
(1993)
J. Cardiovasc. Electrophysiol.
, vol.4
, pp. 68
-
-
Roberds, S.L.1
Knoth, K.M.2
Po, S.3
Blair, T.A.4
Bennett, P.B.5
Hartshorne, R.P.6
Snyders, D.J.7
Tamkun, M.M.8
-
23
-
-
0027213816
-
Current status of class III antiarrhythmic drug therapy
-
Roden D. Current status of class III antiarrhythmic drug therapy. Am. J. Cardiol. 72:1993;44B-49B.
-
(1993)
Am. J. Cardiol.
, vol.72
-
-
Roden, D.1
-
24
-
-
0029761822
-
HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
-
Roy M.-L., Dumaine R., Brown A. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation. 94:1996;817-823.
-
(1996)
Circulation
, vol.94
, pp. 817-823
-
-
Roy, M.-L.1
Dumaine, R.2
Brown, A.3
-
26
-
-
0029130666
-
Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel
-
Snyders D., Yeola S. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circ. Res. 77:1995;575-583.
-
(1995)
Circ. Res.
, vol.77
, pp. 575-583
-
-
Snyders, D.1
Yeola, S.2
-
27
-
-
0026603450
-
Time-, state- And voltage-dependent block by quinidine of a cloned human cardiac channel
-
Snyders D., Knoth K., Roberds S., Tamkun M. Time-, state- and voltage-dependent block by quinidine of a cloned human cardiac channel. Mol. Pharmacol. 41:1992;332-339.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 332-339
-
-
Snyders, D.1
Knoth, K.2
Roberds, S.3
Tamkun, M.4
-
28
-
-
0027321972
-
A rapidly activating and slowly inactivating potassium channel cloned from human heart
-
Snyders D., Tamkun M., Bennett P. A rapidly activating and slowly inactivating potassium channel cloned from human heart. J. Gen. Physiol. 101:1993;513-543.
-
(1993)
J. Gen. Physiol.
, vol.101
, pp. 513-543
-
-
Snyders, D.1
Tamkun, M.2
Bennett, P.3
-
29
-
-
0029131555
-
Clinical importance of hepatic cytochrome P450 in drug metabolism
-
Spatzenegger M., Jaegger W. Clinical importance of hepatic cytochrome P450 in drug metabolism. Drug Metab. Rev. 25:1995;397-417.
-
(1995)
Drug Metab. Rev.
, vol.25
, pp. 397-417
-
-
Spatzenegger, M.1
Jaegger, W.2
-
32
-
-
0029095234
-
Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers
-
Valenzuela C., Delpón E., Tamkun M., Tamargo J., Snyders D. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys. J. 69:1995;418-427.
-
(1995)
Biophys. J.
, vol.69
, pp. 418-427
-
-
Valenzuela, C.1
Delpón, E.2
Tamkun, M.3
Tamargo, J.4
Snyders, D.5
-
33
-
-
4244207384
-
Comparative effects of nonsedating histamine H1-receptor antagonist on human Kv1.5 channels
-
Valenzuela C., Delpón E., Franqueza L., Gay P., Snyders D., Tamargo J. Comparative effects of nonsedating histamine H1-receptor antagonist on human Kv1.5 channels. Br. J. Pharmacol. 118:1996;105P.
-
(1996)
Br. J. Pharmacol.
, vol.118
-
-
Valenzuela, C.1
Delpón, E.2
Franqueza, L.3
Gay, P.4
Snyders, D.5
Tamargo, J.6
-
34
-
-
0029790924
-
Class III antiarrhythmic effects of zatebradine: Time-, state-, use- And voltage-dependent block of hKv1.5 channels
-
Valenzuela C., Delpón E., Franqueza L., Gay P., Pérez O., Tamargo J., Snyders D. Class III antiarrhythmic effects of zatebradine: time-, state-, use- and voltage-dependent block of hKv1.5 channels. Circulation. 94:1996;562-570.
-
(1996)
Circulation
, vol.94
, pp. 562-570
-
-
Valenzuela, C.1
Delpón, E.2
Franqueza, L.3
Gay, P.4
Pérez, O.5
Tamargo, J.6
Snyders, D.7
-
35
-
-
0024203291
-
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects
-
Vincent J., Liminana R., Meredith P., Reid J. The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects. Br. J. Clin. Pharmacol. 26:1988;497-501.
-
(1988)
Br. J. Clin. Pharmacol.
, vol.26
, pp. 497-501
-
-
Vincent, J.1
Liminana, R.2
Meredith, P.3
Reid, J.4
-
36
-
-
0027376226
-
+ current similar to Kv1.5 cloned channel currents
-
+ current similar to Kv1.5 cloned channel currents. Circ. Res. 73:1993;1061-1076.
-
(1993)
Circ. Res.
, vol.73
, pp. 1061-1076
-
-
Wang, Z.1
Fermini, B.2
Nattel, S.3
-
37
-
-
0021922070
-
+ channels: Ionic and gating current studies
-
+ channels: ionic and gating current studies. J. Gen. Physiol. 85:1985;539-554.
-
(1985)
J. Gen. Physiol.
, vol.85
, pp. 539-554
-
-
White, M.1
Bezanilla, F.2
-
38
-
-
0030074361
-
Ebastine: A review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders
-
Wiseman L., Faulds D. Ebastine: a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders. Drugs. 51:1996;260-277.
-
(1996)
Drugs
, vol.51
, pp. 260-277
-
-
Wiseman, L.1
Faulds, D.2
-
39
-
-
0015879604
-
Ionic blockade of sodium channels in nerve
-
Woodhull A. Ionic blockade of sodium channels in nerve. J. Gen. Physiol. 61:1973;687-708.
-
(1973)
J. Gen. Physiol.
, vol.61
, pp. 687-708
-
-
Woodhull, A.1
-
41
-
-
0028014426
-
1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects
-
1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects. Arzneim.-Forsch. 44:1994;59-64.
-
(1994)
Arzneim.-Forsch.
, vol.44
, pp. 59-64
-
-
Yamaguchi, T.1
Hashizume, T.2
Matsuda, M.3
Sakashita, M.4
Fujii, T.5
Sekine, Y.6
Nakashima, M.7
Uematsu, T.8
-
42
-
-
0029006843
-
Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
-
Yang T., Prakash C., Roden D., Snyders D. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br. J. Pharmacol. 115:1995;267-274.
-
(1995)
Br. J. Pharmacol.
, vol.115
, pp. 267-274
-
-
Yang, T.1
Prakash, C.2
Roden, D.3
Snyders, D.4
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