Central nervous system and body weight regulation

Annales d'Endocrinologie

Volumn 58, Issue 2, 1997, Pages 137-142

  Rohner Jeanrenaud, F ^a   Jeanrenaud, B ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

adipose and muscle metabolism; adrenalectomy; glucocorticoids; insulin; leptin; neuropeptide Y (NPY); obesity

Indexed keywords

GLUCOCORTICOID; INSULIN; LEPTIN; NEUROPEPTIDE Y;

ADIPOSE TISSUE; ADRENALECTOMY; CENTRAL NERVOUS SYSTEM; HUMAN; HYPERPHAGIA; HYPOTHALAMUS; OBESITY; PATHOGENESIS; REVIEW;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; LEPTIN; MICE; MICE, OBESE; MUSCLE, SKELETAL; NEUROPEPTIDE Y; OBESITY; PROTEINS;

EID: 0030972265     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. BCHINI-HOOFT VAN HUIJSDUIJNEN O, ROHNER-JEANRENAUD F, JEANRENAUD B. Hypothalamic Neuropeptide Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats ; potential regulation thereof by corticotrophin-releasing factor. J Neuroendocrinol 1993 ; 5 : 381-6.
2. BECK B, BURLET A, NICOLAS JP, BURLET C. Hypothalamic neuropeptide Y in obese Zucker rats : Implications in feeding and sexual behaviors. Physiol Behav 1990 ; 47 : 449-53.
3. BESTETTI GE, ABRAMO F, GUILLAUME-GENTIL C, ROHNER-JEANRENAUD F, JEANRENAUD B, ROSSI GL. Changes in the hypothalamo-pituitary-adrenal axis of genetically obese fa/fa rats : a structural, immunocytochemical, and morphometrical study. Endocrinology 1990 ; 126 : 1880-7.
4. BRAY GA. Obesity, a disorder of nutrient partitioning : The Mona Lisa hypothesis. J Nutr 1991 ; 121 : 1146-62.
5. CAMPFIELD LA, SMITH FJ, GUISEZ Y, DEVOS R, BURN P. Recombinant mouse OB protein : Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995 ; 269 : 546-9.
6. CHEN H, CHARLAT O, TARTAGLIA LA et al. Evidence that the diabetes gene encodes the leptin receptor : Identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996 ; 84 : 491-5.
7. CONSIDINE RV, SINHA MK, HEIMAN ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996 ; 334 : 292-5.
8. CUSIN I, TERRETTAZ J, ROHNER-JEANRENAUD F, JEANRENAUD B. Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver. Biochem J 1990 ; 267 : 99-03.
9. CUSIN I, TERRATTAZ J, ROHNER-JEANRENAUD F, ZARJEVSKI N, ASSIMACOPOULOS-JEANNET F, JEANRENAUD B. Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles a clue for increased fat depot and insulin resistance. Endocrinology 1990 ; 127 : 3246-8.
10. CUSIN I, ROHNER-JEANRENAUD F, TERRETTAZ J, JEANRENAUD B. Hyperinsulinemia and its impact on obesity and insulin resistance. Int J Obes 1992 ; 16 (Suppl. 4) . S1-S11.
11. CUSIN I, SAINSBURY A, DOYLE P, ROHNER-JEANRENAUD F, JEANRENAUD B. The ob gene and insulin. A relationship leading to clues to the understanding of obesity. Diabetes 1995 ; 44 : 1467-70.
12. CUSIN I, ROHNER-JEANRENAUD F, STRICKER-KRONGRAD A, JEANRENAUD B. Weight-reducing effect of intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats : reduced sensitivity compared to lean animals. Diabetes 1996 ; 45 : 1446-1451
13. DE VOS P, SALADIN R, AUWERX J, STAELS B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995 ; 270 : 15958-61.
14. DOYLE P, ROHNER-JEANRENAUD F, JEANRENAUD B. Local cerebral glucose utilization in brains of lean and genetically obese (fa/fa) rats Am J Physiol 1993 ; 264 : E29-36.
15. DRYDEN S, FRANKISH H, WANG Q WILLIAMS G. Neuropeptide Y and energy balance : one way ahead for the treatment of obesity ? Eur J Clin Invest 1994 ; 24 : 293-308
16. FELDKIRCHER KM, MISTRY AM, ROMSOS DR. Adrenalectomy reverses pre-existing obesity in adult genetically obese (ob/ob) mice. Int J Obes 1996 ; 20 : 232-5.
17. GUILLAUME-GENTIL C, ROHNER-JEANRENAUD F, ABRAMO F, BESTETTI GE, ROSSI GL, JEANRENAUD B. Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology 1990 ; 126 : 1873-9.
18. GUILLAUME-GENTIL C, ASSIMACOPOULOS-JEANNET F, JEANRENAUD B. Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats. Diabetologia 1993 ; 36 : 899-906.
19. HALAAS JL, GAJIWALA KS, MAFFEI M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995 ; 269 : 543-6.
20. JEANRENAUD B. Central nervous system and peripheral abnormalities : Clues to the understanding of obesity and NIDDM. Diabetologia 1994 ; 37 : S169-78.
21. LEE G-H, PROENCA R, MONTEZ JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996 ; 379 : 632-5.
22. LEVINE AS, MORLEY JE. Neuropeptide Y : A potent inducer of consummatory behavior in rats. Peptides 1984 ; 5 : 1025-9.
23. MAFFEI M, HALAAS J, RAVUSSIN E, et al. Leptin levels in human and rodent : measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1995 ; 1 : 1155-61.
24. MARCHINGTON D, ROTHWELL NJ, STOCK MJ YORK DA. Energy balance, diet-induced thermogenesis and brown adipose tissue in lean and obese (fa/fa) Zucker rats after adrenalectomy. J Nutr 1983 ; 113 : 1395-402.
25. MURAKAMI T, IIDA M SHIMA K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem Biophys Res Commun 1995 ; 214 : 1260-7.
26. PEISEN JN, MCDONNELL KJ, MULRONEY SE, LUMPKIN MD. Endotoxin-induced suppression of the somatotropic axis is mediated by Interleukin-1β and corticotropin-releasing factor in the juvenile rat. Endocrinology 1995 ; 136 : 3378-90.
27. PELLEYMOUNTER MA, CULLEN MJ, BAKER MB et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995 ; 269 : 540-3.
28. PHILLIPS MS, LIU Q, HAMMOND HA, et al. Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 1996 ; 13 : 18-19.
29. ROHNER-JEANRENAUD F, JEANRENAUD B. Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic preobesity. Endocrinology 1985 ; 116 : 830-4.
30. ROHNER-JEANRENAUD F. A neuroendocrine reappraisal of the dual-centre hypothesis : its implications for obesity and insulin resistance. Int J Obes 1995 ; 79 : 517-34.
31. ROHNER-JEANRENAUD F, JEANRENAUD B. Obesity, leptin, and the brain. N Engl J Med 1996 ; 334 : 324-5.
32. SAINSBURY A, CUSIN I, DOYLE P, ROHNER-JEANRENAUD F, JEANRENAUD B. Intracerebroventricular administration of neuropeptide Y to normal rats increases obese gene expression in white adipose tissue. Diabetologia 1996 ; 39 : 359-6.
33. SAINSBURY A, ROHNER-JEANRENAUD F, CUSIN I, JEANRENAUD B. Longitudinal study of hormonal and metabolic defects during chronic central neuropeptide Y infusion in normal rats. 1996 ; submitted for publication.
34. SAINSBURY A, CUSIN I, ROHNER-JEANRENAUD F, JEANRENAUD B. Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats. Diabetes 1997 ; 46 : 209-14.
35. SANACORA G, KERSHAW M, FINKELSTEIN JA, WHITE JD. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 1990 ; 127 : 730-7.
36. SCHWARTZ MW, FIGLEWICZ DP, BASKIN DG, WOODS SC, PORTE D. Jr. Insulin in the brain : a hormonal regulator of energy balance. Endocrine Rev 1992 ; 13 . 387-414.
37. SCHWARTZ MW, MARKS JL, SIPOLS AJ, et al. Central insulin administration reduces NPY mRNA expression in the arcuate nucleus of food deprived lean (FA/FA) but not obese (fa/fa) Zucker rats. Endocrinology 1991 ; 128 : 2645-7.
38. SCHWARTZ MW, SIPOLS AJ, MARKS JL, et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 1992 ; 130 : 3608-16.
39. SCHWARTZ MW, PESKIND E, RASKIND M, BOYKO EJ, PORTE D. Jr Cerebrospinal fluid leptin levels : relationship to plasma levels and to adiposity in humans. Nature Medicine 1996 ; 2 : 589-93.
40. STANLEY BG, KYRKOULI SE, LAMPERT S, LEIBOWITZ SF. Neuropeptide Y chronically injected into the hypothalamus : A powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986 ; 7 : 1189-92.
41. STANLEY BG, LEIBOWITZ SF. Neuropeptide Y injected into the paraventricular hypothalamus : a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 1985 ; 82 : 3940-3.
42. STEPHENS TW, BASINSKI M, BRISTOW PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995 ; 377 : 530-2.
43. SWEEP CGJF, VAN DER MEER MJM, HERMUS ADRMM, et al. Chronic stimulation of the pituitary-adrenal axis in rats by Interleukin-1β infusion : in vivo and in vitro studies. Endocrinology 1992 ; 130 : 1153-64.
44. TATEMOTO K, CARLOUIST M, MUTT V. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 1982 ; 296 : 659-60.
45. VETTOR R, ZARJEVSKI N, CUSIN I, ROHNER-JEANRENAUD F, JEANRENAUD B. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia 1994 ; 37 : 1202-8.
46. ZARJEVSKI N, CUSIN I, VETTOR R, ROHNER-JEANRENAUD F, JEANRENAUD B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993 ; 133 : 1753-8.
47. ZARJEVSKI N, CUSIN I, VETTOR R, ROHNER-JEANRENAUD F, JEANRENAUD B. Intracerebroventricular administration of neuropeptide Y to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle. Diabetes 1994 ; 43 : 764-9.
48. ZHANG Y, PROENCA R, MAFFEI M, BARONE M, LEOPOLD L, FRIEDMAN JM Positional cloning of the mouse obese gene and its human homologue. Nature 1994 ; 372 : 425-32.