Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 4, 1997, Pages 277-284

  Stribbling, Stephen M ^a   Martin, Janet ^a   Pedley, R Barbara ^b   Boden, Joan A ^b   Sharma, Surinder K ^b   Springer, Caroline J ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

ADEPT; Biodistribution; Carboxypeptidase G2; Mice; Xenograft

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CARBOXYPEPTIDASE G2; CARCINOEMBRYONIC ANTIGEN; DRUG METABOLITE; METHOTREXATE; MONOCLONAL ANTIBODY; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ARTICLE; CANCER GRAFT; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TARGETING; DRUG TISSUE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TISSUE DISTRIBUTION; XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOEMBRYONIC ANTIGEN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; FEMALE; GAMMA-GLUTAMYL HYDROLASE; GLUTAMATES; IMMUNOCONJUGATES; MICE; MICE, NUDE; NITROGEN MUSTARD COMPOUNDS; PRODRUGS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030971725     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050659     Document Type: Article

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