Laminin-6 and laminin-5 are recognized by autoantibodies in a subset of cicatricial pemphigoid

Journal of Investigative Dermatology

Volumn 108, Issue 6, 1997, Pages 848-853

  Chan, Lawrence S ^a,b,g   Majmudar, Arpana A ^b   Tran, Hoang H ^c   Meier, Friedegund ^d   Schaumburg Lever, Gundula ^d   Chen, Mei ^b   Anhalt, Grant ^e   Woodley, David T ^a,b   Marinkovich, M Peter ^c,f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^g NONE   (United States)

Author keywords

Blister; Epidermolysis bullosa

Indexed keywords

AUTOANTIBODY; BASEMENT MEMBRANE ANTIBODY; COLLAGEN TYPE 4; ENTACTIN; IMMUNOGLOBULIN G ANTIBODY; KALININ; LAMININ;

ADULT; ANTIBODY LABELING; ANTIGEN RECOGNITION; ARTICLE; BASEMENT MEMBRANE; CASE REPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOPRECIPITATION; KERATINOCYTE; MUCOUS MEMBRANE PEMPHIGOID; PRIORITY JOURNAL;

EID: 0030970587     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12292578     Document Type: Article

References (44)

1. Aberdam D, Galliano M-F, Vailly J, Pulkkinen L, Bonifas J, Christiano AM, Tryggvason K, Uitto J, Epstein EH Jr, Ortonne J-P, Meneguzzi G: Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAM1NIN-5). Nat Genet 6:299-304, 1994
2. Aumailley M, Wiedemann H, Mann K, Timpl R: Binding of nidogen and the laminin-nidogen complex to hasement membrane collagen IV. Eur J Biochem 184:241-248, 1989
3. Aumailley M, Krieg T: Laminins: a family of diverse multifunctional molecules of basement membrane. J Invest Dermatol 106:209-214, 1996
4. Brown JC, Wiedemann H, Timpl R: Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1 sB2e) from human placenta. J Cell Sci 107:329-338, 1994
5. Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J, Timpl P, Tryggvason K, Yamada Y, Yurchenco PD: A new nomenclature for the laminins. Matrix Biol 14:209-211, 1994
6. Carter WG, Ryan MC, Gahr PJ: Epiligrin, a new cell adhesion ligand for α3β1 in epithelial basement membranes. Cell 65:599-610, 1991
7. Champliaud M-F, Lunstrum GP, Rousselle P, Nishiyama T, Keene DR, Burgeson RE: Human amnion contains a novel laminin variant, laminin-7, which like laminin-6, covalently associates with laminin-5. J Cell Biol 132:1189-1198, 1996
8. Chan LS, Fine J-D, Briggaman RA, Woodley DT, Hammerberg C, Drugge RJ, Cooper KD: Identification and partial characterization of a novel 105-kDalton lower lamina lucida autoantigen associated with a novel immune-mediated subepidermal blistering disease. J Invest Dematol 101:262-267, 1993
9. Chan LS, Wang X-S, Lapiere JC, Marinkovich MP, Jones JCR, Woodley DT: A newly identified 105-kD lower lamina lucida autoantigen is an acidic protein distinct from the 105-kD γ2 chain of laminin-5. J Invest Dermatol 105:75-79, 1995a
10. Chan LS, Traczyk T, Taylor TB, Eramo LR, Woodley DT, Zone JJ: Linear IgA bullous dermatosis: characterization of a subset of patients with concurrent IgA and IgG anti-basement membrane autoantibodies. Arch Dermatol 131:1432-1437, 1995b
11. Chan LS, Woodley DT: The 105-kDa basement membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen. J Invest Dermatal 107:209-214, 1996
12. Chen M, Chan LS, Cai X, O'Toole EA, Samples JC, Woodley DT: Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita. J Invest Dermatol 108:68-72, 1997a
13. Chen M, Marinkovich MP, Veis A, Cai X, Rao CN, O'Toole EA, Woodley DT: Interactions of the amino-terminus noncollagenous (NC1) domain of type VII collagen with extracellular matrix components: a potential role in epidermaldermal adherence in human skin. J Biol Chem in press, 1997b
14. Domloge-Hultsch N, Gammon WR, Briggaman RA, Gil SG, Carter WG, Yancey KB: Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease. J Clin Invest 90:1628-1633, 1992
15. Gammon WR, Briggaman RA, Inman AO, Queen LL, Wheeler CE: Differentiating anti-lamina lucida and anti-sublamina densa anti-BMZ antibodies by indirect immunofluorescence on 1.0 M sodium chloride-separated skin. J Invest Dermatol 82:139-144, 1984
16. Holubar K, Wolff K, Konrad K, Beutner EG: Ultrastructural localization of immunoglobulins in bullous pemphigoid skin: employment of a new peroxidase-antiperoxidase multistep method. J Invest Dermatol 64:220-227, 1975
17. Iozzo RV: Perlecan: a gem of a proteoglycan. Matrix Biol 14:203-208, 1994
18. Kirtschig G, Marinkovich MP, Burgeson RE, Yancey KB: Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the a subunit of laminin-5. J Invest Dermatol 105:543-548, 1995
19. Kuhn K: Basement membrane (type IV) collagen. Matrix Biol 14:439-445, 1994
20. Labib RS, Anhalt GJ, Patel HP, Mutasim DF, Diaz LA: Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 136: 1231-1235, 1986
21. Laemmli UK: Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
22. Lazarova L, Yee Carole, Darling T, Briggaman RA, Yancey KB: Passive transfer of anti-laminin-5 antibodies induces subepidermal blisters in neonatal mice. J Clin Invest 98:1509-1518, 1996
23. Liu CG, Maercker C, Gastanon MJ, Hauptmann R, Wiche G: Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24). Proc Natl Acad Sci USA 93:4278-4283, 1996
24. Marinkovich MP, Lunstrum GP, Keene DR, Burgeson RE: The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol 119:695-703, 1992a
25. Marinkovich MP, Lunstrum BP, Burgeson RE: The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor. J Biol Chem 267:17900-17906, 1992b
26. Marinkovich MP: The molecular genetics of basement membrane diseases. Arch Dermatol 129:1557-1565, 1993
27. Marinkovich MP, Verrando P, Keene DR, Meneguzzi G, Lunstrum GP, Ortonne JP, Burgeson RE: Basement membrane proteins kalinin and nicein are structurally and immunologically identical. Lab Invest 69:295-299, 1993
28. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ: LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol 106:734-738, 1996
29. Matsui C, Nelson CF, Hernandez GT, Herron GS, Bauer EA, Hoeffler WK: Gamma 2 chain of laminin-5 is recognized by monoclonal antibody GB3. J Invest Dermatol 105:648-652, 1995
30. Mayer U, Nischt R, Poschl E, Mann K, Fukuda K, Gerl M. Yamada Y, Timpl R: A single EGF-like motif of laminin is responsible for high affinity nidogen binding. EMBOJ 12:1879-1885, 1993
31. Mayer J, Poschl E, Gerecke DR, Wagman DW, Burgeson RE, Timpl R: Low nidogen affinity of laminin-5 can be attributed to two serine residues in EGF-like motif gamma 21114. FEBS Lett 365:129-132, 1995
32. Meneguzzi G, Marinkovich MP, Aberdam D, Pisani A, Burgeson R, Ortonne JP: Kalinin is abnormally expressed in epithelial basement membranes of Herlitz's junctional epidermolysis bullosa patients. Exp Dermatol 1:221-229, 1992
33. Miquel C, Gagnoux-Palacios L, Durand-Clement M, Marinkovich P, Ortonne JP, Meneguzzi G: Establishment and characterization of cell line LSV5 that retains the altered adhesive properties of human junctional epidermolysis bullosa keratinocytes. Exp Cell Res 224:279-290, 1996
34. Niessen CM, Hogervorst F, Jaspars LH, De Melker AA, Delwel GO, Hulsman EHM, Kuikman I, Sonnenberg A: The α6β4 integrin is a receptor for both laminin and kalinin. Exp Cell Res 211:360-367, 1994
35. Pulkkinen L, Christiano AM, Gerecke D, Wagman DW, Burgeson RE, Pittelkow MR, Uitto J: A homozygous nonsense mutation in the beta 3 chain gene of laminn 5 (LAMB3) iin Herlitz junctional epidermolysis bullosa. Genomics 24:357-360, 1994
36. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE: Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114:567-576, 1991
37. Schaumburg-Lever G, Fehrenbacher B, Moller H, Nau P: Techniques in immunoelectron microscopy. J Cutan Pathot 21:330-338, 1994
38. Stanley JR, Hawley-Nelson P, Yuspa SH, Shevach EM, Katz SI: Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified sqamous epithelia. Cell 24:897-903, 1981
39. Stepp MA, Spurr-Michaud S, Tisdale A, Elwell J, Gipson IK: α6β4 integrin heterodimer is a component of hemidesmosomes, Proc Natl Acad Sci USA 87:8970-8974, 1990
40. Timpl R, Brown JC: The laminins. Matrix Biol 14:275-281, 1994
41. Towbin H, Staehelim TT, Jordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
42. Tsao T, Hsieh J-C, Durkin ME, Wu C, Chakravarti S, Dong L-J, Lewis M, Chung AE: Characterization of the basement membrane glycoprotein entactin synthesized in a Baculovirus expression system. J Biol Chem 265:5188-5191, 1990
43. Woodley DT, Briggaman RA, O'Keefe EJ, Inman AO, Queen LL, Gammon WR: Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita. N Engl J Med 310:1007-1013, 1984
44. Zone JJ, Taylor TB, Kadunce DP, Meyer LJ: Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. J Clin Invest 85:812-820, 1990