Gene and other biological therapies for vascular diseases

Fundamental and Clinical Pharmacology

Volumn 11, Issue 2, 1997, Pages 97-110

  Stephan, D ^a,b   Nabel, E G ^b  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

angiogenesis; antisense oligonucleotides; gene expression; gene transfer; gene vectors; restenosis

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA; GANCICLOVIR; RNA;

ANGIOGENESIS; CELL CYCLE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HERPES SIMPLEX; HUMAN; ISCHEMIA; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; REVIEW; THROMBOSIS; VASCULAR DISEASE; VIRUS INFECTION;

EID: 0030966680     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1997.tb00175.x     Document Type: Review

References (85)

1. Barr E, Carroll J, Kalynych A et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1994;1:51-8
2. Bauters C, Asahara T, Lu Z et al. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 1995;91:2802-9
3. Bennet M, Anglin S, McEwan J, Jagoe R, Newby A, Evan G. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligonucleotides. J Clin Invest 1993;93:820-8
4. Bennet M, Schwartz S. Antisense therapy for angioplasty restenosis some critical considerations. Circulation 1995;92: 1981-93
5. Borrelli E, Heyman R, Hsi M, Evans R. Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA 1988;85:7572-6
6. Boussif O, Lezoualc'h F, Zanta MA et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995;92: 7297-301
7. Chang M, Barr E, Seltzer J et al. Cytostatic gene therapy for vascular proliferative disorders with a constituvely active form of the retinoblastoma gene product. Science 1995a; 267:518-22
8. Chang M, Ohno T, Gordon D et al. Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle proliferation and neointima formation following balloon angioplasty of the rat carotid artery. Mol Med 1995b;1:172-81
9. Chang M, Barr E, Lu M, Barton K, Leiden J. Adenovirus-mediated over-expression of the cyclin/cyclin-dependant kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest 1996;96:2260-8
10. Chen S, Wilson J, Muller D. Adenovirus-mediated gene transfer of soluble vascular cell adhesion molecule to porcine interposition vein grafts. Circulation 1994;89:1922-8
11. Connolly D. Vascular permeability factor a unique regulator of blood vessel function. J Cell Biochem 1991;47:219-23
12. Conte M, Birinyi L, Miyata T et al. Efficient repopulation of denuded rabbit arteries with autologous gentically modified endothelial cells. Circulation 1994;23:2161-9
13. Dichek D, Neville R, Zwiebel J, Freeman S, Leon M, Anderson F. Seeding of intravascular stents with gentically engineered endothelial cells. Circulation 1989;80:1347-53
14. Ellis S, Roubin G, Wilentz J, Douglas J, King S. Effect of 18-24 hour heparin administration for prevention of restenosis after uncomplicated coronary angioplasty. Am Heart J 1989;117:777-82
15. Engelhardt J, Ye X, Doranz B, Wilson J. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994;91:6196-200
16. European Working Group on Critical Limb Ishemia, and Ischemia. Second European consensus document on chronic critical leg ischemia. Circulation 1991;84(suppl IV):IV-1-IV-6
17. Feldman L, Steg P, Zheng L et al. Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. J Clin Invest 1995;95:2662-71
18. Felgner P. Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. Adv Drug Delivery Rev 1990;5:163-87
19. Felgner P, Ringold G. Cationic liposome-mediated transfection. Nature 1989;337:387-8
20. Felgner P, Gadek T, Holm M et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7
21. Fischman DL, Leon MB, Baim DS et al. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. (The STRESS trial). N Engl J Med 1994;331:496-501
22. French B, Mazur W, Ali N et al. Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis. Circulation 1994;90: 2402-13
23. Gellman J, Ezekowitz M, Sarembock I et al. Effect of lovastatin on intimai hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol 1991;17:251-9
24. Gerard R, Meidel R. Adenovirus-mediated gene transfer. Trends Cardiovasc Med 1993;3:171-7
25. Glagov S. Intimai hyperplasia, vascular remodeling, and the restenosis problem. Circulation 1994;89:2888-91
26. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371-5
27. Grossman M, Raper S, Kozarsky K et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nature Genet 1994;6:335-41
28. Herz I, Gerard R. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90:2812-6
29. Horwitz M. Adenoviridae and their replication. In: Fields BN, Knipe DM et al, eds. Fundamental Virology, 2nd edn. New York: Raven Press, 1991;772-804
30. Huckle W, Drag M, Acker W et al. Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis. Circulation 1996;93:1009-19
31. Indolfi C, Avvedimento E, Rapacciuolo A et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Med 1995;1:541-5
32. Isner J, Walsh K, Symes J et al. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation 1995;91:2687-92
33. Kass-Eisler A, Falck-Pedersen E, Alvira M et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 1993;90:11498-502
34. Kass-Eisler A, Falck-Pedersen E, Elfenbein D, Alvira M, Buttrick P, Leinwand L. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther 1994;1:395-402
35. Kolberg R. Gene transfer virus contaminant linked to monkeys' cancer. J NIH Res 1992;4:43-4
36. Kozarsky K, Wilson J. Gene therapy: adenovirus vectors. Curr Opin Gen Dev 1993;3:499-503
37. Landau C, Lange R, Hillis L. Percutaneous transluminal coronary angioplasty. N Engl J Med 1994;330:981-93
38. Lasic D, Papahadjopoulos D. Liposomes revisited. Science 1995;267:1275-6
39. Leclerc G, Gal D, Takeshita S, Nikol S, Weir L, Isner J. Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. J Clin Invest 1992;90:936-44
40. Lemarchand P, Jaffe H, Danel C et al. Adenovirus-mediated transfer of a recombinant human a1-antitrypsin cDNA to human endothelial cells. Proc Natl Acad Sci USA 1992; 89:6482-6
41. Lemarchand P, Jones M, Yamada I, Crystal R. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ Res 1993;72:1132-8
42. Leyden H, Gibbons G, Morishita R et al. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. 1995;92:1137-41
43. Lynch C, Clowes M, Osborne W, Clowes A, Miller A. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model of gene therapy. Proc Natl Acad Sci USA 1992;89:1138-42
44. MERCATOR Study Group. Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the mercator study: a multicenter, randomized double-blind placebo controlled trial. Circulation 1992; 86:100-10
45. Morishita R, Gibbons G, Ellison K et al. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 1993a;90:8474-8
46. Morishita R, Gibbons G, Kaneda Y, Ogihara T, Dzau V. Novel and effective gene transfer technique for study of vascular renin angiotensin system. J Clin Invest 1993b;91: 2580-5
47. Morishita R, Gibbons G, Ellison K et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest 1994;93:1458-64
48. Muhlhauser J, Merrill M, Pili R et al. VEGF 165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo. Circ Res 1995;77:1077-86
49. Muller D, Ellis S, Topol E. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions. J Am Coll Cardiol 1991;17(Suppl B): 126B-31B
50. Nabel E, Plautz G, Boyce F, Stanley J, Nabel G. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989;244:1342-4
51. Nabel E, Plautz G, Nabel G. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 1990;249:1285-8
52. Nabel E, Gordon D, Yang Z et al. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther 1992a;3:649-56
53. Nabel E, Plautz G, Nabel G. Transduction of a foreign histocompatibility gene into the arterial wall. Proc Natl Acad Sci USA 1992b;89:5157-61
54. Nabel E, Shum L, Pompili V et al. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci USA 1993a;90: 10759-63
55. Nabel E, Yang Z, Liptay S et al. Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimai hyperplasia in vivo. J Clin Invest 1993b;1993: 1822-9
56. Nabel E, Yang Z, Plautz G et al. Recombinant fibroblast growth factor-1 promotes intimai hyperplasia and angiogenesis. Nature 1993c;362:844-6
57. Nabel E, Pompili V, Plautz G, Nabel G. Gene transfer and vascular disease. Cardiovasc Res 1994;28:445-55
58. Nabel E, Nabel G. Complex models for the study of gene function in cardiovascular biology. Annu Rev Physiol 1994;56: 741-61
59. Nakajima M, Hutchinson H, Fujinaga M et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995;92:10663-7
60. Newman K, Dunn P, Owens J et al. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest 1995;96:2955-65
61. Ohno T, Gordon D, San H et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 1994;265:781-4
62. Prince G, Porter D, Jenson A, Horswood R, Chanock R, Ginsberg H. Pathogenesis of adenovirus type 5 pnemonia in cotton rats (Sigmodon hipsidus). J Virol 1993;67:101-11
63. Rade J, Schulick A, Virmani R, Dichek D. Local adenoviral-mediated expression of recombinant hirudin reduces neointima after arterial injury. Nature Med 1996;2:293-8
64. Riessen R, Rahimizadeh H, Blessing E, Takeshita S, Barry J, Isner J. Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon. Hum Gene Ther 1993;4:749-58
65. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature 1993;362:801-9
66. Sahni R, Maniet A, Voci G, Banka V. Prevention of restenosis after successful coronary angioplasty. Am Heart J 1991; 121:1600-8
67. San H, Yang Z, Pompili V et al. Safety and toxicity of a novel cationic lipid formulation of human gene therapy. Hum Gene Ther 1993;4:781-8
68. Schulick A, Newman K, Virmani R, Dichek D. In vivo gene transfer into injured carotid arteries. Circulation 1995;91: 2407-14
69. Schwartz R, Holmes D, Topol E. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol 1992;20:1284-93
70. Serruys PW, de Jaegere P, Kiemeneij C et al. A comparison of balloon expandable stent implantation with balloon angioplasty in patients with coronary artery disease. (The Benestent study). N Engl J Med 1994;331:489-95
71. Shi Y, Fard A, Vermani P, Zalewski A. Transgene expression in the coronary circulation: transcatheter gene delivery. Gene Ther 1994;1:408-14
72. Simari R, San H, Rekhter M et al. Regulation of cellular proliferation and intimai formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest 1996;98: 218-39
73. Simons M, Edelman E, DeKeyser J, Langer R, Rosenberg R. Antisense c-myb oligonucleotides inhibit intimai arterial smooth muscle cell accumulation in vivo. Nature 1992;359: 67-70
74. Smith K, Galloway K, Kennel W, Ogilvie K, Radatus B. A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl) ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2. Antimicrob Agents Chemother 1982;22:55-61
75. Steg P, Feldman L, Scoazec J et al. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation 1994;90: 1648-56
76. Stephan D, Yang ZY, San H et al. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther 1996;7:1803-12
77. Stewart M, Plautz G, Buono L et al. Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum Gene Ther 1992;3:267-75
78. Takeshita S, Pu L, Stein L et al. Intramuscular administration of vascular endothelial growth factor induces dose-dependant collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 1994;90:II-228-34
79. Thornton M, Gruntzig A, Hollman J, King S, Douglas J. Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized trial. Circulation 1984;69:721-7
80. Villa A, Guzman L, Poptic E et al. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ Res 1995;76:505-13
81. Wagner R. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994;372:333-5
82. Wilson J. Adenoviruses as gene-delivery vehicles. N Engl J Med 1996;334:1185-7
83. Wilson J, Birinyi L, Salomon R, Libby P, Callow A, Mulligan R. Implantation of vascular grafts lined with genetically modified endothelial cells. Science 1989;244:1344-6
84. Yang Y, Nunes F, Berencsi K, Gonczol E, Engelhardt J, Wilson J. Inactivation of E2A in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet 1994;7:362-9
85. Yang ZY, Simari R, Perkins N et al. Role of the p21 cyclin-dependant kinase inhibitor in limiting intimai cell proliferation in response to arterial injury. Proc Natl Acad Sci USA 1996;93:7905-10