Garlic: The key to sophisticated lowering of hepatocellular lipid

Nutrition

Volumn 13, Issue 4, 1997, Pages 379-380

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALLICIN; ALLIIN; ANTILIPEMIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA GLUTAMYLCYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MECYSTEINE; ORGANOSULFUR DERIVATIVE;

CHOLESTEROL SYNTHESIS; DRUG MECHANISM; EDITORIAL; ENZYME PHOSPHORYLATION; GARLIC; GENE EXPRESSION REGULATION; HUMAN; HYPERLIPIDEMIA; LIPID BLOOD LEVEL; LIVER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRADITIONAL MEDICINE;

ALLIUM SATIVUM;

EID: 0030965837     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(97)00066-X     Document Type: Note

References (19)

1. Silagy C. Neil A. Garlic as a lipid lowering agent—a meta-analysis J Royal Coll Phys Lond 28 1994 39
2. Lawson L.D. Bioactive organosulfur compounds of garlic and garlic products Kinghom A.D. Balandrin M.F. Human medicinal agents from plants 1993 American Chemical Society Washington, DC 306
3. Sticher O. Beurteilung von Knoblauchprdparaten Dtsch Apoth Ztg 131 1991 403
4. Lawson L.D. Hughes B.G. Characterization of the formation of allicin and other thiosulfinates from garlic Planta Med 58 1992 345
5. Pentz R. Guo Z. Siegers C.-P. Bioavailability and metabolism of thio compounds from different garlic preparations Med Welt 42 suppl 7a 1991 46
6. Egen-Schwind C. Eckard R. Kemper F.H. Metabolism of garlic constituents in the isolated perfused rat liver Planta Med 58 1992 301
7. Egen-Schwind C. Eckard R. Jekat F.W. Winterhoff H. Pharmacokinetics of vinyldithiins, transformation products of allicin Planta Med 58 1992 8
8. Cavallito C.J. Buck J.S. Suter M.J. Allicin, the antibacterial principle of Allium sativum II. Determination of the chemical structure J Am Chem Soc 8 1944 444
9. Lawson L.D. Ransom D.K. Hughes B.G. Inhibition of whole blood platelet-aggregation by compounds of garlic clove extracts and commercial garlic products Thromb Res 65 1992 141
10. Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes Lipids 28 1993 613
11. Goldstein J.L. Brown M.S. Regulation of the mevalonate pathway Nature 343 1990 425
12. Hardie D.G. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase Biochim Biophys Acta 1123 1992 231
13. Gebhardt R. Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived organosulfur compounds Phytomedicine 2 1995 29
14. Gebhardt R. Beck H. Wagner K.G. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells Biochim Biophys Acta 1213 1994 57
15. Gebhardt R. Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures Lipids 31 1996 1269
16. Gibbons G.F. Pullinger C.R. Chen H.W. Cavenee Yi.K. Kandutsch A.A. Regulation of cholesterol biosynthesis in cultured cells by probable natural precursor sterols J Biol Chem 255 1980 395
17. Gebhardt R. Synergismus von Adenosin und Allicin bei der Steigerung der CAMP-Bildung und der Hemmung der Cholesterinbiosynthese in kultivierten Hepatocyten Z Gastroenterol 33 1996 64
18. Edwards P.A. The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methyl-glutaryl Coenezyme A reductase activity and lipid biosynthesis in isolated rathepatocytes Arch Biochem Biophys 170 1975 188
19. Sistaer F.D. Picking R.A. Haynes R.C. Jr Sensitivity of the response of cytosolic calcium in quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides J Biol Chem 260 1985 12744