메뉴 건너뛰기




Volumn 38, Issue 2, 1997, Pages 391-400

Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: Bone marrow transplantation studies in the mouse

Author keywords

bone marrow transplantation; dyslipidemias; familial hypercholesterolemia; gene delivery; macrophages; mouse models

Indexed keywords

LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 0030965439     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (39)
  • 1
    • 0017719024 scopus 로고
    • Atherosclerosis: The low-density lipoprotein receptor hypothesis
    • Goldstein, J. L., and M. S. Brown. 1977. Atherosclerosis: the low-density lipoprotein receptor hypothesis. Metabolism. 26: 1257-1275.
    • (1977) Metabolism , vol.26 , pp. 1257-1275
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 0020694412 scopus 로고
    • Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism
    • Steinbrecher, U. P., J. L. Witztum, Y. A. Kesaniemi, and R. L. Elam. 1983. Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism. J. Clin. Invest. 71: 960-964.
    • (1983) J. Clin. Invest. , vol.71 , pp. 960-964
    • Steinbrecher, U.P.1    Witztum, J.L.2    Kesaniemi, Y.A.3    Elam, R.L.4
  • 3
    • 0002230202 scopus 로고
    • Familial hypercholesterolemia
    • C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, New York
    • Goldstein, J. L., and M. S. Brown. 1989. Familial hypercholesterolemia. In The Metabolic Basis of Inherited Disease. 6th edition. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, New York. 1215-1250.
    • (1989) The Metabolic Basis of Inherited Disease. 6th Edition , pp. 1215-1250
    • Goldstein, J.L.1    Brown, M.S.2
  • 4
    • 0020419250 scopus 로고
    • Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits
    • Pittman, R. C., T. E. Carew, A. D. Attie, J. L. Witztum, Y. Watanabe, and D. Steinberg. 1982. Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits. J. Biol. Chem. 257: 7994-8000.
    • (1982) J. Biol. Chem. , vol.257 , pp. 7994-8000
    • Pittman, R.C.1    Carew, T.E.2    Attie, A.D.3    Witztum, J.L.4    Watanabe, Y.5    Steinberg, D.6
  • 5
    • 0017161065 scopus 로고
    • Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes
    • Ho, Y. K., M. S. Brown, D. W. Bilheimer, and J. L. Goldstein. 1976. Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J. Clin. Invest. 58: 1465-1474.
    • (1976) J. Clin. Invest. , vol.58 , pp. 1465-1474
    • Ho, Y.K.1    Brown, M.S.2    Bilheimer, D.W.3    Goldstein, J.L.4
  • 6
    • 0017947456 scopus 로고
    • Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia
    • Bilheimer, D. W., Y. K. Ho, M. S. Brown, R. G. W. Anderson, and J. L. Goldstein. 1978. Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia. J. Clin. Invest. 61: 678-696.
    • (1978) J. Clin. Invest. , vol.61 , pp. 678-696
    • Bilheimer, D.W.1    Ho, Y.K.2    Brown, M.S.3    Anderson, R.G.W.4    Goldstein, J.L.5
  • 7
    • 0023644954 scopus 로고
    • Provision of cholesterol to lymphocytes by high density and low density lipoproteins
    • Cuthbert, J. A., and P. E. Lipsky. 1987. Provision of cholesterol to lymphocytes by high density and low density lipoproteins. J. Biol. Chem. 262: 7808-7818.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7808-7818
    • Cuthbert, J.A.1    Lipsky, P.E.2
  • 8
    • 0020315378 scopus 로고
    • Changes in metabolism of modified and unmodified low-density lipoproteins during the maturation of cultured blood monocyte-macrophages from normal and homozygous familial hypercholesterolemic subjects
    • Knight, B. L., and A. K. Soutar. 1982. Changes in metabolism of modified and unmodified low-density lipoproteins during the maturation of cultured blood monocyte-macrophages from normal and homozygous familial hypercholesterolemic subjects. Eur. J. Biochem. 125: 407-413.
    • (1982) Eur. J. Biochem. , vol.125 , pp. 407-413
    • Knight, B.L.1    Soutar, A.K.2
  • 9
    • 3042983426 scopus 로고
    • Low density lipoprotein receptor activity in human monocyte-derived macrophages and its relation to atheromatous lesions
    • Traber, M. G., and H. J. Kayden. 1980. Low density lipoprotein receptor activity in human monocyte-derived macrophages and its relation to atheromatous lesions. Proc. Natl. Acad. Sci. USA. 77: 5466-5470.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 5466-5470
    • Traber, M.G.1    Kayden, H.J.2
  • 10
    • 0024439075 scopus 로고
    • Macrophage foam cells from human aortic fatty streaks take up beta-VLDL and acetylated LDL in primary culture
    • Jaakkola, O., S. Yla-Herttuala, T. Sarkioja, and T. Nikkari. 1989. Macrophage foam cells from human aortic fatty streaks take up beta-VLDL and acetylated LDL in primary culture. Atherosclerosis. 79: 173-182.
    • (1989) Atherosclerosis , vol.79 , pp. 173-182
    • Jaakkola, O.1    Yla-Herttuala, S.2    Sarkioja, T.3    Nikkari, T.4
  • 11
    • 0017656801 scopus 로고
    • Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia
    • Ho, Y. K., J. R. Faust, D. W. Bilheimer, M. S. Brown, and J. L. Goldstein. 1977. Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia. J. Exp. Mud. 145: 1531-1549.
    • (1977) J. Exp. Mud. , vol.145 , pp. 1531-1549
    • Ho, Y.K.1    Faust, J.R.2    Bilheimer, D.W.3    Brown, M.S.4    Goldstein, J.L.5
  • 12
    • 0022531553 scopus 로고
    • Low apparent affinity for low-density lipoprotein of receptors expressed by human macrophages maintained with whole serum
    • Knight, B. L., and A. K. Soutar. 1986. Low apparent affinity for low-density lipoprotein of receptors expressed by human macrophages maintained with whole serum. Eur. J. Biochem. 156: 205-210.
    • (1986) Eur. J. Biochem. , vol.156 , pp. 205-210
    • Knight, B.L.1    Soutar, A.K.2
  • 13
    • 0009627006 scopus 로고
    • Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein, J. L., Y. K. Ho, S. K. Basu, and M. S. Brown. 1979. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA. 76: 333-337.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 333-337
    • Goldstein, J.L.1    Ho, Y.K.2    Basu, S.K.3    Brown, M.S.4
  • 14
    • 0023775730 scopus 로고
    • Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor
    • Nimer, S. D., R. E. Champlin, and D. W. Golde. 1988. Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor. J. Am. Med. Assoc. 260: 3297-3300.
    • (1988) J. Am. Med. Assoc. , vol.260 , pp. 3297-3300
    • Nimer, S.D.1    Champlin, R.E.2    Golde, D.W.3
  • 15
    • 0025139320 scopus 로고
    • Impact of RLA matching and cyclosporine on long-term survival in transplanted rabbits
    • Bigelow, C. L., L. T. Adler, and F. R. Appelbaum. 1990. Impact of RLA matching and cyclosporine on long-term survival in transplanted rabbits. Exp. Hematol. 18: 3-6.
    • (1990) Exp. Hematol. , vol.18 , pp. 3-6
    • Bigelow, C.L.1    Adler, L.T.2    Appelbaum, F.R.3
  • 16
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    • Ishibashi, S., J. L. Goldstein, M. S. Brown, J. Herz, and D. K. Burns. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93: 1885-1893.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3    Herz, J.4    Burns, D.K.5
  • 17
    • 0025992469 scopus 로고
    • Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
    • Friedrich, G., and P. Soriano. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5: 1513-1523.
    • (1991) Genes Dev. , vol.5 , pp. 1513-1523
    • Friedrich, G.1    Soriano, P.2
  • 18
    • 0020962232 scopus 로고
    • H-2 haplotypes, genes and antigens: Second listing
    • Klein, J., F. Figueroa, and C. David. 1983. H-2 haplotypes, genes and antigens: second listing. Immunogenetics. 17: 553-596.
    • (1983) Immunogenetics , vol.17 , pp. 553-596
    • Klein, J.1    Figueroa, F.2    David, C.3
  • 19
    • 0024842651 scopus 로고
    • Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes
    • Thiele, D. L., M. L. Eigenbrodt, and S. E. Bryde. 1989. Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes. J. Clin. Invest. 84: 1947-1956.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1947-1956
    • Thiele, D.L.1    Eigenbrodt, M.L.2    Bryde, S.E.3
  • 20
    • 0023989715 scopus 로고
    • Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transduction of Escherichia coli lacZ
    • Nolan, G. P., S. Fiering, J-F. Nicolas, and L. A. Herzenberg. 1988. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transduction of Escherichia coli lacZ. Proc. Natl. Acad. Sci. USA. 85: 2603-2607.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2603-2607
    • Nolan, G.P.1    Fiering, S.2    Nicolas, J.-F.3    Herzenberg, L.A.4
  • 21
    • 84873783240 scopus 로고
    • The differentiation of mononuclear phagocytes. Morphology, cytochemistry, and biochemistry
    • Cohn, Z. A., and B. Benson. 1965. The differentiation of mononuclear phagocytes. Morphology, cytochemistry, and biochemistry. J. Exp. Med. 121: 153-170.
    • (1965) J. Exp. Med. , vol.121 , pp. 153-170
    • Cohn, Z.A.1    Benson, B.2
  • 22
    • 0027216450 scopus 로고
    • Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
    • Fazio, S., Y-L. Lee, Z-S. Ji, and S. C. Rall, Jr. 1993. Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E. J. Clin. Invest. 92: 1497-1503.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1497-1503
    • Fazio, S.1    Lee, Y.-L.2    Ji, Z.-S.3    Rall Jr., S.C.4
  • 23
    • 0025101682 scopus 로고
    • Genetic heterogeneity of lipoproteins in inbred strains of mice: Analysis by gel-permeation chromatography
    • Jiao, S., T. G. Cole, R. T. Kitchens, B. Pfleger, and G. Schonfeld. 1990. Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography. Metabolism. 39: 155-160.
    • (1990) Metabolism , vol.39 , pp. 155-160
    • Jiao, S.1    Cole, T.G.2    Kitchens, R.T.3    Pfleger, B.4    Schonfeld, G.5
  • 24
    • 34548003946 scopus 로고
    • Efficient trace-labelling of proteins with iodine
    • McFarlane, A. S. 1958. Efficient trace-labelling of proteins with iodine. Nature. 132: 53-57.
    • (1958) Nature , vol.132 , pp. 53-57
    • McFarlane, A.S.1
  • 25
    • 0015518106 scopus 로고
    • The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations
    • Bilheimer, D. W., S. Eisenberg, and R. I. Levy. 1972. The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. Biochim. Biophys. Acta. 260: 212-221.
    • (1972) Biochim. Biophys. Acta , vol.260 , pp. 212-221
    • Bilheimer, D.W.1    Eisenberg, S.2    Levy, R.I.3
  • 28
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi, S., M. S. Brown, J. L. Goldstein, R. D. Gerard, R. R. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92: 883-893.
    • (1993) J. Clin. Invest. , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.R.5    Herz, J.6
  • 29
    • 0028314348 scopus 로고
    • Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant
    • Fazio, S., Y. Horie, W. S. Simonet, K. H. Weisgraber, J. M. Taylor, and S. C. Rall, Jr. 1994. Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant. J. Lipid Res. 35: 408-416.
    • (1994) J. Lipid Res. , vol.35 , pp. 408-416
    • Fazio, S.1    Horie, Y.2    Simonet, W.S.3    Weisgraber, K.H.4    Taylor, J.M.5    Rall Jr., S.C.6
  • 30
    • 0018883209 scopus 로고
    • Evolution of the LDL receptor concept - From cultured cells to intact animals
    • Brown, M. S., P. T. Kovanen, and J. L. Goldstein. 1980. Evolution of the LDL receptor concept - from cultured cells to intact animals. Ann. N. Y. Acad. Sci. 348: 48-68.
    • (1980) Ann. N. Y. Acad. Sci. , vol.348 , pp. 48-68
    • Brown, M.S.1    Kovanen, P.T.2    Goldstein, J.L.3
  • 31
    • 0019423143 scopus 로고
    • The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages
    • Schechter I., A. M. Fogelman, M. E. Haberland, J. Seager, M. Hokom, and P. A. Edwards. 1981. The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages. J. Lipid. Res. 22: 63-71.
    • (1981) J. Lipid. Res. , vol.22 , pp. 63-71
    • Schechter, I.1    Fogelman, A.M.2    Haberland, M.E.3    Seager, J.4    Hokom, M.5    Edwards, P.A.6
  • 32
    • 0024576223 scopus 로고
    • Regulation of low density lipoprotein receptor gene expression in human lymphocytes
    • Cuthbert, J. A., D. W. Russell, and P. E. Lipsky. 1989. Regulation of low density lipoprotein receptor gene expression in human lymphocytes. J. Biol. Chem. 264: 1298-1304.
    • (1989) J. Biol. Chem. , vol.264 , pp. 1298-1304
    • Cuthbert, J.A.1    Russell, D.W.2    Lipsky, P.E.3
  • 33
    • 0022384877 scopus 로고
    • Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: Evidence from studies in patients with leukaemia
    • Vitols, S., G. Gahrton, M. Bjorkholm, and C. Peterson. 1985. Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: evidence from studies in patients with leukaemia. Lancet. ii: 1150-1154.
    • (1985) Lancet , vol.2 , pp. 1150-1154
    • Vitols, S.1    Gahrton, G.2    Bjorkholm, M.3    Peterson, C.4
  • 34
    • 0029328404 scopus 로고
    • Mechanism behind hypocholesterolaemia in hairy cell leukaemia
    • Juliusson, G., S. Vitols, and J. Liliemark. 1995. Mechanism behind hypocholesterolaemia in hairy cell leukaemia. Br. Med. J. 311: 27.
    • (1995) Br. Med. J. , vol.311 , pp. 27
    • Juliusson, G.1    Vitols, S.2    Liliemark, J.3
  • 35
    • 0028944150 scopus 로고
    • Prevention of atherosclerosis in apoE-deficient mice by bone marrow transplantation
    • Linton, M. F., J. B. Atkinson, and S. Fazio. 1995. Prevention of atherosclerosis in apoE-deficient mice by bone marrow transplantation. Science. 267: 1034-1037.
    • (1995) Science , vol.267 , pp. 1034-1037
    • Linton, M.F.1    Atkinson, J.B.2    Fazio, S.3
  • 36
    • 0029081525 scopus 로고
    • Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
    • Boisvert, W. A., J. Spangerberg, and L. K. Curtiss. 1995. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation. J. Clin. Invest. 96: 1118-1124.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1118-1124
    • Boisvert, W.A.1    Spangerberg, J.2    Curtiss, L.K.3
  • 37
    • 0029876310 scopus 로고    scopus 로고
    • Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis
    • Fazio, S., and M. F. Linton. 1996. Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis. Trends Cardiovasc. Med. 6: 58-65.
    • (1996) Trends Cardiovasc. Med. , vol.6 , pp. 58-65
    • Fazio, S.1    Linton, M.F.2
  • 39
    • 0018827061 scopus 로고
    • Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine β-very low density lipoproteins
    • Goldstein, J. L., Y. K. Ho, M. S. Brown, T. L. Innerarity, and R. W. Mahley. 1980. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine β-very low density lipoproteins. J. Biol. Chem. 255: 1839-1848.
    • (1980) J. Biol. Chem. , vol.255 , pp. 1839-1848
    • Goldstein, J.L.1    Ho, Y.K.2    Brown, M.S.3    Innerarity, T.L.4    Mahley, R.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.