Preparation of excipient-free recombinant human tissue-type plasminogen activator by lyophilization from ammonium bicarbonate solution: An investigation of the two-stage sublimation phenomenon

Journal of Pharmaceutical Sciences

Volumn 86, Issue 4, 1997, Pages 455-459

  Overcashier, David E ^a   Brooks, Dennis A ^a   Costantino, Henry R ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; AMMONIA; AMMONIUM DERIVATIVE; BICARBONATE; CARBON DIOXIDE; EXCIPIENT;

ARTICLE; ATMOSPHERIC PRESSURE; DRUG SYNTHESIS; ENTHALPY; FREEZE DRYING; PHYSICAL CHEMISTRY; POWDER; PRESSURE CHAMBER;

EID: 0030964876     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js960339c     Document Type: Article

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