Specificity determinants in neurotrophin-3 and design of nerve growth factor-based trkC agonists by changing central β-strand bundle residues to their neurotrophin-3 analogs

Biochemistry

Volumn 36, Issue 16, 1997, Pages 4775-4781

  Urfer, Roman ^a,c   Tsoulfas, Pantelis ^b   O'Connell, Lori ^a   Presta, Leonard G ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN 3; PROTEIN KINASE; RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL DIFFERENTIATION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEUROTROPHIN 3; PROTEIN CONFORMATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; SEQUENCE ALIGNMENT;

ANIMALIA;

EID: 0030963477     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962877+     Document Type: Article

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