-
1
-
-
0020694485
-
Phase I evaluation of oral tegafur
-
Bedikian A.Y., Bodey G.P., Valdivieso M., Burgess M.A.: Phase I evaluation of oral tegafur, Cancer Treat. Rep., 67: 81-84, 1983.
-
(1983)
Cancer Treat. Rep.
, vol.67
, pp. 81-84
-
-
Bedikian, A.Y.1
Bodey, G.P.2
Valdivieso, M.3
Burgess, M.A.4
-
2
-
-
1842342930
-
Modulation of the antitumor activity of ftorafur (FT) and uracil (U)-Ft combination (UFt) in rats bearing advanced colon carcinoma
-
Cao S., Durrani F., Maue R., Rustum Y.M.: Modulation of the antitumor activity of ftorafur (FT) and uracil (U)-Ft combination (UFt) in rats bearing advanced colon carcinoma, Proc. Am. Soc. Clin. Oncol., 12: 212, 1993.
-
(1993)
Proc. Am. Soc. Clin. Oncol.
, vol.12
, pp. 212
-
-
Cao, S.1
Durrani, F.2
Maue, R.3
Rustum, Y.M.4
-
3
-
-
0029128603
-
5-fluorouracil prodrug: Role of anabolic and catabolic pathway modulation in therapy of colorectal cancer
-
Cao S., Frank C., Shirasaka T., Rustum Y.: 5-fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer. Clinical Cancer Research., 1: 839-845, 1995.
-
(1995)
Clinical Cancer Research.
, vol.1
, pp. 839-845
-
-
Cao, S.1
Frank, C.2
Shirasaka, T.3
Rustum, Y.4
-
4
-
-
0028281781
-
5-ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
-
Cao S., Rustum Y.M., Spector T.: 5-ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Research., 54: 1507-1510, 1994.
-
(1994)
Cancer Research
, vol.54
, pp. 1507-1510
-
-
Cao, S.1
Rustum, Y.M.2
Spector, T.3
-
5
-
-
0018698406
-
A method for continuous drug infusion in unrestrained rats: Its application in evaluating the toxicity of 5-fluorouracil/thymidine combinations
-
Danhauser L.L., Rustum Y.M.: A method for continuous drug infusion in unrestrained rats: its application in evaluating the toxicity of 5-fluorouracil/thymidine combinations. J. Lab. & Clin. Med., 93: 1047-1053, 1979.
-
(1979)
J. Lab. & Clin. Med.
, vol.93
, pp. 1047-1053
-
-
Danhauser, L.L.1
Rustum, Y.M.2
-
6
-
-
0019275803
-
A review of the United States clinical experience of the fluoropyrimidine ftorafur NS-C148958
-
Friedman M.A., Ignoffo R.J.: A review of the United States clinical experience of the fluoropyrimidine ftorafur (NS-C148958. Cancer Treat. Rev., 7: 205-213, 1980.
-
(1980)
Cancer Treat. Rev.
, vol.7
, pp. 205-213
-
-
Friedman, M.A.1
Ignoffo, R.J.2
-
7
-
-
0019252664
-
Clinical study on the enhancement of drug delivery into tumor tissue by UFT
-
Fukui Y., Imabayashi N., Nishii M.: Clinical study on the enhancement of drug delivery into tumor tissue by UFT. Jpn. J. Cancer Chemother., 7: 2124-2129, 1980.
-
(1980)
Jpn. J. Cancer Chemother.
, vol.7
, pp. 2124-2129
-
-
Fukui, Y.1
Imabayashi, N.2
Nishii, M.3
-
8
-
-
0018757734
-
Effect of coadministration of uracil or cytosine on the antitumor activity of clinical dose of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents
-
Fujii S., Kitano S., Ikenaka K., Shirasaka T.: Effect of coadministration of uracil or cytosine on the antitumor activity of clinical dose of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents. Gann., 70: 209-214, 1978.
-
(1978)
Gann.
, vol.70
, pp. 209-214
-
-
Fujii, S.1
Kitano, S.2
Ikenaka, K.3
Shirasaka, T.4
-
9
-
-
0018757734
-
Effect of coadministration of uracil or cytosine on the antitumor activity of clinical dose of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents
-
Fujii S., Kitano S., Ikenaka K., Shirasaka T.: Effect of coadministration of uracil or cytosine on the antitumor activity of clinical dose of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents., Gann., 70: 209-214, 1979.
-
(1979)
Gann.
, vol.70
, pp. 209-214
-
-
Fujii, S.1
Kitano, S.2
Ikenaka, K.3
Shirasaka, T.4
-
10
-
-
0023502402
-
Bioavailability of high-dose oral leucovorin
-
Hines J.D., Zakem M.H., Adelstein D.J., Giroski P., Blum M.R., Rustum Y.M.: Bioavailability of high-dose oral leucovorin, NCI Monographs, 57-60, 1987.
-
(1987)
NCI Monographs
, pp. 57-60
-
-
Hines, J.D.1
Zakem, M.H.2
Adelstein, D.J.3
Giroski, P.4
Blum, M.R.5
Rustum, Y.M.6
-
11
-
-
1842346780
-
Correlation of pharmacokinetics of FU with toxicity of patients treated orally with uracil and ftorafur (4:1 molar ratio) + leucovorin
-
Ho D.H., Prazdur R., Covington W., Brown N., Lassere Y., Lin S., Rustum Y., Creaven P., Newman R.A., Krakoff I., Kuritani: Correlation of pharmacokinetics of FU with toxicity of patients treated orally with uracil and ftorafur (4:1 molar ratio) + leucovorin. Proc. Am. Assoc. Cancer Res., 35: 241, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 241
-
-
Ho, D.H.1
Prazdur, R.2
Covington, W.3
Brown, N.4
Lassere, Y.5
Lin, S.6
Rustum, Y.7
Creaven, P.8
Newman, R.A.9
Krakoff, I.10
Kuritani11
-
12
-
-
0347924164
-
Phase 1 trial of UFT (ftorafur plus uracil) and leucovorin: 28 day schedule
-
Jaiyesimi I., Pazdur R., Ho D.H., Lassere Y., Moore D. Jr., Bready B., Krakoff I.H.: Phase 1 trial of UFT (ftorafur plus uracil) and leucovorin: 28 day schedule. Proc. Am. Soc. Clin. Oncol., 12: 152, 1993.
-
(1993)
Proc. Am. Soc. Clin. Oncol.
, vol.12
, pp. 152
-
-
Jaiyesimi, I.1
Pazdur, R.2
Ho, D.H.3
Lassere, Y.4
Moore Jr., D.5
Bready, B.6
Krakoff, I.H.7
-
13
-
-
0343744578
-
Phase I study of tegafur plus uracil co-administered with oral leucovorin
-
Jaiyesimi I., Pazdur R., Rhodes V., Lassere Y., Soo E., Bready B.: Phase I study of tegafur plus uracil co-administered with oral leucovorin. Proc. Am. Soc. Clin. Oncol., 13: 164, 1994.
-
(1994)
Proc. Am. Soc. Clin. Oncol.
, vol.13
, pp. 164
-
-
Jaiyesimi, I.1
Pazdur, R.2
Rhodes, V.3
Lassere, Y.4
Soo, E.5
Bready, B.6
-
14
-
-
0019155745
-
Clinical basis of chemotherapy for gastric cancer with uracil and 1(2′-tetrahydrofuryl)-5-fluorouracil
-
Kimura K., Suga S., Shimaji T., Kitamura M., Suzuoki Y., lsobe K.: Clinical basis of chemotherapy for gastric cancer with uracil and 1(2′-tetrahydrofuryl)-5-fluorouracil. Gastroenterol. Jpn., 15: 324-329, 1980.
-
(1980)
Gastroenterol. Jpn.
, vol.15
, pp. 324-329
-
-
Kimura, K.1
Suga, S.2
Shimaji, T.3
Kitamura, M.4
Suzuoki, Y.5
Lsobe, K.6
-
15
-
-
0026597027
-
Chemotherapeutic strategies in metastatic colorectal cancer: An overview of current clinical trials
-
Kohne-Wompner C.H., Schmoll H.J., Harstrick A., Rustum Y.M.: Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials. Semin. Oncol., 19: 105-125, 1992.
-
(1992)
Semin. Oncol.
, vol.19
, pp. 105-125
-
-
Kohne-Wompner, C.H.1
Schmoll, H.J.2
Harstrick, A.3
Rustum, Y.M.4
-
16
-
-
0027399158
-
Prophylactic oral UFT therapy for superficial bladder cancer
-
Kubota Y., Hosaka M., Fukushima S., Kondo I.: Prophylactic oral UFT therapy for superficial bladder cancer. Cancer, 71: 1842-1845, 1993.
-
(1993)
Cancer
, vol.71
, pp. 1842-1845
-
-
Kubota, Y.1
Hosaka, M.2
Fukushima, S.3
Kondo, I.4
-
17
-
-
0024246937
-
UFT is more antineoplastic against gastric carcinoma than 5-fluorouracil, (1-2-tetrahydrofuryl)-5-fluorouracil and 1-hexylcarbamoyl-5-fluorouracil
-
Maehara Y., Kusumoto T., Kusumoto H., Anai H., Sugimachi K.: UFT is more antineoplastic against gastric carcinoma than 5-fluorouracil, (1-2-tetrahydrofuryl)-5-fluorouracil and 1-hexylcarbamoyl-5-fluorouracil. Chemotherapy, 34: 484-489, 1988.
-
(1988)
Chemotherapy
, vol.34
, pp. 484-489
-
-
Maehara, Y.1
Kusumoto, T.2
Kusumoto, H.3
Anai, H.4
Sugimachi, K.5
-
18
-
-
0024510302
-
5-fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase
-
Maechara Y., Kusumoto T., Kusumoto H., Anai H., Sakaguchi Y., Kiddo Y., Okamura T., Korenaga D., Sugimachi, K.: 5-fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase. Cancer, 63: 1693-1696, 1989.
-
(1989)
Cancer
, vol.63
, pp. 1693-1696
-
-
Maechara, Y.1
Kusumoto, T.2
Kusumoto, H.3
Anai, H.4
Sakaguchi, Y.5
Kiddo, Y.6
Okamura, T.7
Korenaga, D.8
Sugimachi, K.9
-
19
-
-
0025604967
-
Phase II trial of UFT in advanced colorectal and gastric cancer
-
Malik S.T.A., Talbot D., Clarke P.I., Osborne R., Reznek R., Wrigley P.F.M., Slevin M.L.: Phase II trial of UFT in advanced colorectal and gastric cancer. Br. J. Cancer, 62: 1023-1025, 1990.
-
(1990)
Br. J. Cancer
, vol.62
, pp. 1023-1025
-
-
Malik, S.T.A.1
Talbot, D.2
Clarke, P.I.3
Osborne, R.4
Reznek, R.5
Wrigley, P.F.M.6
Slevin, M.L.7
-
20
-
-
13144270346
-
A phase I and pharmacokinetics study of oral UFT and leucovorin (LV)
-
Meropol N.J., Creaven P.J., Petrelli N.J., Rodiguez-Bioas M., Frank C., Ho D.H., Rustum Y.M.: A phase I and pharmacokinetics study of oral UFT and leucovorin (LV). Proc. Am. Soc. Clin. Oncol., 13: 160, 1994.
-
(1994)
Proc. Am. Soc. Clin. Oncol.
, vol.13
, pp. 160
-
-
Meropol, N.J.1
Creaven, P.J.2
Petrelli, N.J.3
Rodiguez-Bioas, M.4
Frank, C.5
Ho, D.H.6
Rustum, Y.M.7
-
21
-
-
0023726563
-
Report on nationwide pooled data and cohort investigation in UFT phase II study
-
Ota K., Taguchi T., Kimura K.: Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother. Pharmacol., 22: 333-338, 1988.
-
(1988)
Cancer Chemother. Pharmacol.
, vol.22
, pp. 333-338
-
-
Ota, K.1
Taguchi, T.2
Kimura, K.3
-
22
-
-
0028099423
-
Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
-
Pazdur R., Lassere Y., Rhodes V., Ajani J.A., Sugarman S.M., Patt Y.Z., Jones D.V. Jr, Markowitz A.B., Abbruzzese J.L., Bready B., Levin B.: Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J. Clin. Oncol., 12: 2296-2300, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 2296-2300
-
-
Pazdur, R.1
Lassere, Y.2
Rhodes, V.3
Ajani, J.A.4
Sugarman, S.M.5
Patt, Y.Z.6
Jones Jr., D.V.7
Markowitz, A.B.8
Abbruzzese, J.L.9
Bready, B.10
Levin, B.11
-
23
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Piedbois P., Buyse M., Rustum Y., Machover D., Erlichman C., Carlson R.W., Valone F., Labianca R., Doroshow J.H., Petrelli N.: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J. Clin. Oncol., 10: 896-903, 1992.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
Piedbois, P.1
Buyse, M.2
Rustum, Y.3
Machover, D.4
Erlichman, C.5
Carlson, R.W.6
Valone, F.7
Labianca, R.8
Doroshow, J.H.9
Petrelli, N.10
-
24
-
-
0026701936
-
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
-
Porter D.J.T., Chestnut W.G., Merrill B.M., Spector T.: Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. J. Biol. Chem., 267: 5236-5242, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 5236-5242
-
-
Porter, D.J.T.1
Chestnut, W.G.2
Merrill, B.M.3
Spector, T.4
-
25
-
-
0024574150
-
Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Role of dose schedule and route of administration of leucovorin
-
Rustum Y.M.: Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Role of dose schedule and route of administration of leucovorin. Cancer, 63: 1013-1017, 1989.
-
(1989)
Cancer
, vol.63
, pp. 1013-1017
-
-
Rustum, Y.M.1
-
26
-
-
0011971440
-
5-ethynyluracil (776C85) is a potent modulator of the therapeutic activity of 5-fluorouracil
-
Rustum Y.M., Cao S., Spector T.: 5-ethynyluracil (776C85) is a potent modulator of the therapeutic activity of 5-fluorouracil. Proc. Am. Assoc. Cancer Res., 34: 283, 1993.
-
(1993)
Proc. Am. Assoc. Cancer Res.
, vol.34
, pp. 283
-
-
Rustum, Y.M.1
Cao, S.2
Spector, T.3
-
27
-
-
9344248389
-
Antitumor activity of IM tegafur-0.4 M 5-chloro-2-4-dihydroxypyrimidine-1M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats
-
Shirasaka T., Nakano K., Takechi T., Satake H., Uchida J., Fujioka A., Saito H., Okabe H., Oyama K., Takeda S., Unemi N., Fukushima M.: Antitumor activity of IM tegafur-0.4 M 5-chloro-2-4-dihydroxypyrimidine-1M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. Cancer Res., 56: 2602-2606, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 2602-2606
-
-
Shirasaka, T.1
Nakano, K.2
Takechi, T.3
Satake, H.4
Uchida, J.5
Fujioka, A.6
Saito, H.7
Okabe, H.8
Oyama, K.9
Takeda, S.10
Unemi, N.11
Fukushima, M.12
-
28
-
-
0027742647
-
5-ethynyluracil (776C85): An inactivator of uracil reductase that potentiates the antitumor activity of 5-fluorouracil
-
Spector T.: 5-ethynyluracil (776C85): an inactivator of uracil reductase that potentiates the antitumor activity of 5-fluorouracil. Curr. Opin. Ther. Patients, 3: 1751-1754, 1993.
-
(1993)
Curr. Opin. Ther. Patients
, vol.3
, pp. 1751-1754
-
-
Spector, T.1
-
29
-
-
0027135995
-
5-ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
-
Spector T., Harrington J.A., Porter D.J.T.: 5-ethynyluracil (776C85): inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem. Pharmacol., 46: 2243-2248, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 2243-2248
-
-
Spector, T.1
Harrington, J.A.2
Porter, D.J.T.3
-
30
-
-
0001108830
-
Determination of 5-fluorouracil levels in tumors, blood and other tissues
-
Taguchi T., Nakano Y., Fuji S., Shirasaka T.: Determination of 5-fluorouracil levels in tumors, blood and other tissues. Cancer Chemother., 5: 1167-1172, 1978.
-
(1978)
Cancer Chemother.
, vol.5
, pp. 1167-1172
-
-
Taguchi, T.1
Nakano, Y.2
Fuji, S.3
Shirasaka, T.4
-
31
-
-
0010264506
-
Effect of uracil on the antitumor activity of ftoraful
-
Taguchi T., Nakano Y., Jikuya K., Fujii S., Ikenaka K., Fukushima M., Shirasaka T.: Effect of uracil on the antitumor activity of ftoraful. Gan To Kagaku Ryoho, 5: 1161-1163, 1978.
-
(1978)
Gan to Kagaku Ryoho
, vol.5
, pp. 1161-1163
-
-
Taguchi, T.1
Nakano, Y.2
Jikuya, K.3
Fujii, S.4
Ikenaka, K.5
Fukushima, M.6
Shirasaka, T.7
-
32
-
-
0017739409
-
Comparative studies on metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil
-
Toide H., Aklyoshi H., Minato Y., Okuda H., Fujii S.: Comparative studies on metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. Gann., 68: 553-560, 1977.
-
(1977)
Gann.
, vol.68
, pp. 553-560
-
-
Toide, H.1
Aklyoshi, H.2
Minato, Y.3
Okuda, H.4
Fujii, S.5
-
33
-
-
0019463497
-
Studies on combination therapy with 1-(tetrahydro-2-furanyl)-5-fluorouracil plus uracil
-
Unemi N., Takeda S., Tajima K., Kawaguchi Y., Yasuda A.: Studies on combination therapy with 1-(tetrahydro-2-furanyl)-5-fluorouracil plus uracil. Chemotherapy, 29: 164-175, 1981.
-
(1981)
Chemotherapy
, vol.29
, pp. 164-175
-
-
Unemi, N.1
Takeda, S.2
Tajima, K.3
Kawaguchi, Y.4
Yasuda, A.5
-
34
-
-
0026540496
-
Modulation of fluoropyrimidines: Role of dose and schedule of leucovorin administration
-
Zhang Z.G., Harstrick A., Rustum Y.M.: Modulation of fluoropyrimidines: role of dose and schedule of leucovorin administration. Semin. Oncol., 19: 10-15, 1992.
-
(1992)
Semin. Oncol.
, vol.19
, pp. 10-15
-
-
Zhang, Z.G.1
Harstrick, A.2
Rustum, Y.M.3
|