Both invariant chain isoforms Ii31 and Ii41 promote class II antigen presentation

International Immunology

Volumn 9, Issue 7, 1997, Pages 983-991

  Serwe, Matthias ^a   Reuter, Gabriele ^a   Sponaas, Anna ^a   Koch, Susanne ^a   Koch, Norbert ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Antigen presentation; Ii41 transgenic mice; Invariant chain

Indexed keywords

KEYHOLE LIMPET HEMOCYANIN; LYSOZYME; OVALBUMIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; DENDRITIC CELL; IMMUNOGENETICS; L CELL; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT GENE; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; DNA, COMPLEMENTARY; HISTOCOMPATIBILITY ANTIGENS CLASS II; ISOMERISM; L CELLS (CELL LINE); MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MURAMIDASE; T-LYMPHOCYTES; TRANSFECTION;

EID: 0030962092     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.7.983     Document Type: Article

References (45)

1. Viville, S., Neefjes, J., Lotteau, V., Dierich, A., Lemeur, M., Ploegh, H., Benoist, C. and Mathis, D. 1993. Mice lacking the MHC class II-associated invariant Chain. Cell 72:635.
2. Elliott, E. A., Drake, J. R., Amigorena, S., Elsemore, J., Webster, P., Mellman, I. and Flavell, R. A. 1994. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J. Exp. Med. 179:681.
3. + T cell selection in mice lacking invariant chain expression. J. Exp. Med. 177:1699.
4. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C. and Mathis, D. 1996. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84:531.
5. Martin, W. D., Hicks, G. G., Mendiratta, S. K., Leva, H. I., Ruley, H. E. and Van Kaer, L. 1996. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84:543.
6. Fung-Leung, W.-P., Surh, C. D., Liljedahl, M., Pang, J., Leturcq, D., Peterson, P. A., Webb, S. R. and Karlsson, L. 1996. Antigen presentation and T cell development in H2-M-deficient mice. Science 271:1278.
7. Shachar, I., Elliott, E. A., Chasnoff, B., Grewal, I. S. and Flavell, R. A. 1995. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms. Immunity 3:373.
8. + T cell function in mice lacking the p41 isoform of invariant chain. Immunity 3:385.
9. + T cell development. Immunity 3:359.
10. Anderson, M. S., and Miller, J. 1992. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc. Natl Acad. Sci. USA 89:2282.
11. Lamp, C. A., Yewdell, J. W., Bennink, J. R. and Cresswell, P. 1991. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus. Proc. Natl Acad. Sci. USA 88:5998.
12. Bakke, O. and Dobberstein, B. 1990. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63:707.
13. Blum, J. S. and Cresswell, P. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl Acad. Sci. USA 85:3975.
14. Calafat, J., Nijenhuis, M., Janssen, H., Tulp, A., Dusseljee, S., Wubbolts, R. and Neefjes, J. 1994. Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures. J. Cell Biol. 126:967.
15. Tulp, A., Verwoerd, D., Dobberstein, B., Ploegh, H. and Pieters, J. 1994. Isolation and characterization of the intracellular MHC class II compartment. Nature 369:120.
16. Denzin, L. K. and Cresswell, P. 1995. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell 82:155.
17. Sloan, V. S., Cameron, P., Porter, G., Gammon, M., Amaga, M., Mellins, E. and Zaller, D. M. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802.
18. Gosh, P., Amaga, M., Mellins, E. and Wiley, D. C. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457.
19. Vogt, A. B., Krobshofer, H., Moldenhauer, G. and Hämmerling, G. H. 1996. Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM. Proc. Natl Acad. Sci. USA 93:9724.
20. van Ham, S. M., Grüneberg, U., Malchereck, G., Bröker, I., Melms, A. and Trowsdale, J. 1996. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J. Exp. Med. 184:2019.
21. Katz, J. F., Stebbins, C., Appella, E. and Sant, A. J. 1996. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules. J. Exp. Med. 184:1747.
22. Weber, D. A., Evavold, B. D. and Jensen, P. E. 1996. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science 274:618.
23. Koch, N., Lauer, W., Habicht, J. and Dobberstein, B. 1987. Primary structure of the gene for the murine la antigen-associated invariant chains (li). An alternatively spliced exon encodes a cysteinerich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J. 6:1677.
24. Koch, N., Pessara, U., Schenck, K. and Wraight, C. 1991. Antigen Processing and Recognition, 1st edn. CRC Press, Boca Raton, FL.
25. Peterson, M. and Miller, J. 1992. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 357:596.
26. Stockinger, B., Pessara, U., Lin, R. H., Habicht, J., Grez, M. and Koch, N. 1989. A role of la-associated invariant chains in antigen processing and presentation. Cell 56:683.
27. Landais, D., Beck, B. N., Buerstedde, J.-M., Degraw, S., Klein, J., Koch, N., Murphy, D., Pierres, M., Tada, T., Yamamoto, K., Benoist, C. and Mathis, D. 1986. The assignment of chain specificities for anti-la monoclonal antibodies using L cell transfectants. J. Immunol. 137:3002.
28. Allen, P. M., Matsueda, G. R., Haber, E. and Unanue, E. R. 1985. Specificity of the T cell receptor: two different determinants are generated by the same peptide and the I-Ak molecule. J. Immunol. 135:368.
29. Lorenz, R. G., Tyler, A. N. and Allen, P. M. 1988. T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-Ak molecule. J. Immunol. 141:4124.
30. Calin-Laurens, V., Forquet, F., Mottez, E., Kanellopoulos, J., Godeau, F., Kourilsky, P., Gerlier, D. and Rabourdin-Combe, C. 1991. Cytosolic targeting of hen egg lysozyme gives rise to a short-lived protein presented by class I but not class II major histocompatibility complex molecules. Eur J. Immunol. 21:761.
31. Roehm, N. W., Marrack, P. and Kappler, J. W. 1982. Antigen-specific, H-2-restricted helper T cell hybridomas. J. Exp. Med. 156:191.
32. Hugo, P., Kappler, J. W., Godfrey, D. J. and Marrack, P. C. 1992. A cell line that can induce thymocyte positive selection. Nature 360:679.
33. Hitzel, C., van Endert, P. and Koch, N. 1995. Acquisition of peptides by MHC class II polypeptides in the absence of invariant chain. J. Immunol. 154:1048.
34. Freisewinkel, I. M., Schenck, K. and Koch, N. 1993. The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc. Natl Acad. Sci. USA 90:9703.
35. Hogan, B., Constantini, F. and Levy, E. 1986. Manipulating the Mouse Embryo, 2nd edn. Cold Spring Habor Laboratory, Cold Spring Harbor, NY.
36. Bertolino, P., Forquet, F., Pont, S., Koch, N., Gerlier, D. and Rabourdin-Combe, C. 1991. Correlation between invariant chain expression level and capability to present antigen to MHC class II-restricted T cells. Int. Immunol. 3:435.
37. Nadimi, F., Moreno, J., Momburg, F., Heuser, A., Fuchs, S., Adorini, L. and Hämmerling, G. J. 1991. Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain. Eur J. Immunol. 21:1255.
38. Peterson, M. and Miller, J. 1990. Invariant chain influences the immunological recognition of MHC class II molecules. Nature 345:172.
39. Kämpgen, E., Koch, N., Koch, F., Stöger, P., Heufler, C., Schuler, G. and Romani, N. 1991. Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialysation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc. Natl Acad. Sci. USA 88:3014.
40. Romagnoli, P., Layet, C., Yewdell, J., Bakke, O. and Germain, R. N. 1993. Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments. J. Exp. Med. 177:583.
41. Ogrinc, T., Dolenc, I., Ritonja, A. and Turk, V. 1993. Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney. FEBS Lett. 336:555.
42. Bevec, T., Stoka, V., Puncercic, G., Dolenc, I. and Turk, V. 1996. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L. J. Exp. Med. 183:1331.
43. Arunachalam, B., Lamb, C. A. and Cresswell, P. 1994. Transport properties of free and MHC class II-associated oligomers containing different isoforms of human invariant chain. Int. Immunol. 6:439.
44. Fineschi, B., Arneson, L. S., Naujokas, M. F. and Miller, J. 1995. Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41. Proc. Natl Acad. Sci. USA 92:10257.
45. Takaesu, N. T., Lower, J. A., Yelon, D., Robertson, E. J. and Bikoff, E. K. 1997. In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J. Immunol. 158:187.