Aminothiol multidentate chelators as antimalarials

Biochemical Pharmacology

Volumn 54, Issue 4, 1997, Pages 451-458

  Loyevsky, Mark ^a,b   John, Christy ^a   Zaloujnyi, Ivan ^a   Gordeuk, Victor ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Antimalarial drugs; Iron; Iron chelators; Malaria; Multidentate aminothiols

Indexed keywords

ANTIMALARIAL AGENT; DEFEROXAMINE; IRON CHELATE; THIOL DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; CELL LINE; HETEROCYCLIC COMPOUNDS; HUMANS; IRON; IRON CHELATING AGENTS; PLASMODIUM FALCIPARUM; SULFHYDRYL COMPOUNDS;

EID: 0030959680     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00185-8     Document Type: Article

References (25)

1. Clyde DF, Recent trends in the epidemiology and control of malaria. Epidemiol Rev 9: 219-243, 1987.
2. Gordeuk V, Thuma PE, Brittenham GM, Zulu S, Simwanza G, Mhangu A, Flesch G and Parry D, Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia. Blood 79: 308-312, 1992.
3. Gordeuk V, Thuma P, Brittenham G, McLaren C, Parry D, Backenstose A, Biemba G, Msiska R, Holmes L, McKinley E, Vargas L, Gilkeson R and Poltera AA, Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. New Engl J Med 327: 1474-1477, 1992.
4. Shanzer A, Libman J, Lytton SD, Glickstein H and Cabantchik ZI, Reversed siderophores act as antimalarial agents. Proc Natl Acad Sci USA 88: 6585-6589, 1991.
5. Tsafack A, Loyevsky M, Ponka P and Cabantchik ZI, Mode of action of iron (III) chelators as antimalarials. IV. Potentiation of desferal action by benzoyl and isonicotinoyl hydrazone derivatives. J Lab Clin Med 127: 574-582, 1996.
6. Lytton SD, Loyevsky M, Mester B, Libman J, Landau I, Shanzer A and Cabantchik ZI, In vivo antimalarial action of a lipophilic iron (III) chelator: Suppression of Plasmodium vinckei infection by reversed siderophore. Am J Hematol 43: 217-220, 1993.
7. Nyholm S, Mann GI, Johanson AG, Bergeron RJ, Graslund A and Thelander L, Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J Biol Chem 268: 26200-26205, 1993.
8. 59Fe in Plasmodium falciparum in the presence of oxines. In: Malaria and the Red Cell. 2. Proceedings of the Second Workshop on Malaria and the Red Cell, Ann Arbor, Michigan, October 24, 1988. (Eds. Eaton JW, Meshnik SR and Brewer GJ), pp. 119-149. Alan R. Liss, New York, 1989.
9. Lytton SD, Mester B, Dayan I, Glickstein H, Libman J, Shanzer A and Cabantchik ZI, Mode of action of iron (III) chelators as antimalarials: I. Membrane permeation properties and cytotoxic activity. Blood 81: 214-221, 1993.
10. Glickstein H, Breuer B, Loyevsky M, Konijn AM, Libman J, Shanzer A and Cabantchik ZI, Differential cytotoxicity of iron chelators on malaria-infected cells versus mammalian cells. Blood 87: 4871-4878, 1996.
11. Cabantchik ZI, Iron chelators as antimalarials: The biochemical basis of selective cytotoxicity. Parasitol Today 11: 74-78, 1995.
12. Modell B and Berdoukas V, The Clinical Approach to Thalassemia. Grune & Stratton, London, 1984.
13. Loyevsky M, Lytton S, Mester B, Libman J, Shanzer A and Cabantchik ZI, The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites. J Clin Invest 91: 218-224, 1993.
14. Goldberg DE, Slater AFG, Cerami A and Henderson GB, Hemoglobin degradation in the malaria parasite Plasmodium falciparum: An ordered process in a unique organelle. Proc Natl Acad Sci USA 87: 2931-2935, 1990.
15. Cabantchik ZI, Glickstein H, Milgram P and Breuer W, A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells. Anal Biochem 233: 221-227, 1996.
16. Cabantchik ZI, Glickstein H, Golenser J, Loyevsky M and Tsafack A, Iron chelators: Mode of action as antimalarials. Acta Haematol 95: 70-77, 1996.
17. John CS, Costello CE and Schlemper EO, Synthesis and characterization of a cationic tin(IV) complex: Relevance to nuclear medicine. Polyhedron 11: 2651-2655, 1992.
18. Kung HF, Molnar M, Billings J, Wicks R and Blau M, Synthesis and biodistribution of neutral lipid-soluble Tc-99m complexes that cross the blood-brain barrier. J Nucl Med 25: 326-332, 1984.
19. John CS, Francesconi LC, Kung HF, Wehrli S, Graczyk G and Carrol P, Synthesis and characterization of neutral oxotechnetium(V) bisaminoethanethiol complexes: Potential brain imaging agents. Polyhedron 11: 1145-1155, 1992.
20. Richardson DR, Tran EH and Ponka P, The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents. Blood 86: 4295-4306, 1995.
21. Halliwell B and Gutteridge MC, Formation of a thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts. The role of superoxide and hydroxyl radicals. FEBS Letters 128: 347-352, 1981.
22. Trager W and Jensen JB, Continuous culture of human malaria parasites. Science 193: 673-675, 1976.
23. Lambros C and Vanderberg JP, Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420, 1979.
24. Benting J, Ansorge I, Paprotka K and Lingelbach KR, Chemical and thermal inhibition of protein secretion have stage specific effects on the intraerythrocytic development of Plasmodium falciparum in vitro. Trop Med Parasitol 45: 303-307, 1994.
25. Breuer W, Epszteijn S and Cabantchik ZI, Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J Biol Chem 270: 24209-24215, 1995.