Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion

European Journal of Pharmacology

Volumn 305, Issue 1-3, 1996, Pages 31-38

  Shinoda, Masahiko ^a   Matsuo, Akira ^a   Toide, Katsuo ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

JTP 4819; middle cerebral artery occlusion; Morris water maze task; passive avoidance task; prolyl endopeptidase; TRH (thyrotropin releasing hormone)

Indexed keywords

ARGIPRESSIN; N BENZYL 2 [[2 (HYDROXYACETYL) 1 PYRROLIDINYL]CARBONYL] 1 PYRROLIDINECARBOXAMIDE; NEUROPEPTIDE; PROLYL ENDOPEPTIDASE INHIBITOR; PROTIRELIN; SUBSTANCE P;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOREACTIVITY; LEARNING; MALE; MAZE TEST; MEMORY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT;

EID: 0029938257     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00173-2     Document Type: Article

References (33)

1. Biggins, J.A., E.K. Perry, J.R. Mcdermott, A.I. Smith, R.H. Perry and J.A. Edwardson, 1983, Post mortem levels of TRH and neurotensin in the amygdala in Alzheimer's disease schizophrenia and depression, J. Neurol. Sci. 58, 117.
2. Cantor, P., 1986, Evaluation of a radioimmunoassay for cholecystokinin in human plasma, Scand. J. Clin. Lab. Invest. 46, 213.
3. Dalmaz, C., C.A. Netto, N. Volkmer, R.D. Dias and I. Izquierdo, 1986, Distribution of prolyl endopeptidase activity in sub-synaptosomal fractions of rat hypothalamus, Braz. J. Med. Biol. Res. 19, 685.
4. De Wied, D., O. Gaffori, J.M. Van Ree and W. De Jong, 1984, Central target for the behavioral effects of vasopressin neuropeptides, Nature 308, 276.
5. Dresdner, K., L.A. Barker, M. Orlowski and S. Wilk 1982, Subcellular distribution of prolyl endopeptidase and cation-sensitive neutral endopeptidase in rabbit brain, J. Neurochem. 38, 1151.
6. Griffiths, E.C., C. Baris, T.J. Visser and W. Klootwijk, 1985, Thyrotropin-releasing hormone inactivation by human postmortem brain, Regul. Pept. 10, 145.
7. Hirakawa, M., A. Tamura, H. Nagashima, H. Nakayama and K. Sano, 1994, Disturbance of retention of memory after focal cerebral ischemia in rats. Stroke 25, 2471.
8. Husain, M.M. and C.B. Nemeroff, 1990, Neuropeptides and Alzheimer's disease, J. Am. Geriatr. Soc. 38, 918.
9. Huston, J.P., R.U. Hasenohrl, P. Gerhaedt and R.K.W. Schwarting, 1993, Sequence-specific effects of neurokinin substance P on memory, reinforcement and brain dopamine activity, Psychopharmacology 112, 147.
10. Kato, T., T. Nakano, K. Kojima, T. Nagatsu and S. Sakakibara, 1980, Changed in prolyl endopeptidase during maturation of rat brain and hydrolysis of Substance P by the purified enzyme, J. Neurochem. 35, 527.
11. Lathamn, A., R.H. Lye, J. Schrewsbury-Gee and P. Slater, 1985, Evaluation of the effects of two TRH analogues on cerbral ischemia (Abstract), Regul. Pept. 13, 80.
12. Mazurek, M.F., M.F. Beal and J.B. Martin, 1985, Vasopressin in post-mortem Alzheimer brain, Ann. Neurol. 18, 143.
13. Morris, R.G.M., 1981, Spatial localization does not require the presence of local cues, Learn. Motiv. 12, 239.
14. Ono, S., K. Kitamura, M. Maekawa, K. Hirata, M. Ano, W. Ueki, T. Yamafuji and H. Narita, 1993, Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]-ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia, Jpn. J. Pharmacol. 62, 81.
15. Rossor, M.N., P.C. Emson, D. Dawbarn, C.Q. Mountjoy and M. Roth, 1986, Neuropeptides and dementia, Progr. Brain Res. 66, 143.
16. Saito, K., S. Honda, A. Toba and I. Yanagiya, 1985, Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils, Jpn. J. Pharmacol. 38, 375.
17. Shinoda, M., K. Okamiya and K. Toide, 1995, Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats, Jpn. J. Pharmacol. 69, 273.
18. Tamura, A., D.I. Graham, J. McCulloch and G.M. Teasdale, 1981, Focal cerbral ischemia in the rat. 1: Description of technique and early neuropathological consequences following middle cerbral artery occlusion, J. Cereb. Blood Flow Metab. 1, 53.
19. Tamura, A., M. Miyamoto, M. Shimizu, T. Kirino and K. Sano, 1985, Behavioral change after focal cerebral ischemia in the rat, J. Cereb. Blood Flow Metab. 5 (Suppl. 1), s379.
20. Tamura, A., T. Kirino, K. Sano, K. Takagi and H. Oka, 1990, Atrophy of the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat, Brain Res. 510, 154.
21. Toide, K., M. Shinoda, M. Takase, K. Iwata and H. Yoshida, 1993, Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippopcampus, Eur. J. Pharmacol. 233, 21.
22. Toide, K., Y. Iwamoto, T. Fujiwara and H. Abe, 1995a, JTP-4819: a novel proryl endopeptidase inhibitor with potential as a cognitive enhancer, J. Pharmacol. Exp. Ther. 274, 1370.
23. Toide, K., K. Okamiya, Y. Iwamoto and T. Kato, 1995b, Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on PEP activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats, J. Neurochem. 65, 234.
24. Toide, K., T. Fujiwara, Y. Iwamoto, M. Shinoda, K. Okamiya and T. Kato, 1996, Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain, Naunyn-Schmiedeberg's Arch. Pharmacol. 353, 355.
25. Turner, A.J., 1986, Processing and metabolism of neuropeptides, Essays Biochem. 22, 69.
26. Walter, R., W.H. Simmons and T. Yoshimoto, 1980, Proline specific endo- and exopeptidases, Mol. Cell. Biochem. 30, 111.
27. Wilk, S., 1983, Mini review prolyl endopeptidase, Life Sci. 33, 2149.
28. Yamamoto, M. and M. Shimizu, 1989, Effects of a new analogue of thyrotropin-releasing hormone on pentobarbital-induced sleeping time in rodents, Neuropharmacology 28, 863.
29. Yamamoto, M., A. Tamura, T. Kirino, M. Shimizu and K. Sano, 1988, Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats, Brain Res. 452, 323.
30. Yamamoto, M., A. Tamura, T. Kirino, M. Shimizu-Sasamata and K. Sano, 1991, Effects of thyrotropin-releasing hormone on behavioral disturbances in middle cerebral artery-occluded rats, Eur. J. Pharmacol. 238, 117.
31. Yamamoto, T., M. Ohno, I. Kitajima, S. Yatsugi and S. Ueki, 1993, Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats, Physiol. Behav. 53, 5.
32. Yamamura, M., H. Kinoshita, H. Nakagawa and R. Ishida, 1991, Pharmacological study of TA-0910, a new thyrotropin-releasing hormone (TRH) analogue (IV): effects on experimental memory impairment in mice and rats, Jpn. J. Pharmacol. 55, 241.
33. Yoshimoto, T., T. Nishimura, T. Kita and D. Tsuru, 1983, Post-proline cleaving enzyme (prolyl endopeptidase) from bovine brain, J. Biochem. 94, 1179.