메뉴 건너뛰기




Volumn 386, Issue 2, 1997, Pages 131-140

DNA methylation in genomic imprinting

Author keywords

Chromosome 11p15.5; DNA methyltransferase; Genomic imprinting; Wilms' tumor

Indexed keywords

AZACITIDINE; DNA METHYLTRANSFERASE;

EID: 0030957564     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(96)00049-X     Document Type: Review
Times cited : (48)

References (75)
  • 1
    • 0023119242 scopus 로고
    • Temporal and regional changes in DNA methylation in the embryonic, extraembryonic, and germ cell lineages during mouse development
    • Monk, M., Boubelik, M. and S. Lehnert (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic, and germ cell lineages during mouse development, Development, 99, 371-382.
    • (1987) Development , vol.99 , pp. 371-382
    • Monk, M.1    Boubelik, M.2    Lehnert, S.3
  • 2
    • 0023503627 scopus 로고
    • Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse
    • Sanford, J.P., Clark, H.J., Chapman, V.M. and J. Rossant (1987) Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse, Genes Dev., 1, 1039-1046.
    • (1987) Genes Dev. , vol.1 , pp. 1039-1046
    • Sanford, J.P.1    Clark, H.J.2    Chapman, V.M.3    Rossant, J.4
  • 3
    • 0025322399 scopus 로고
    • Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations
    • Driscoll, D.J. and B.R. Migeon (1990) Sex difference in methylation of single-copy genes in human meiotic germ cells: implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations, Somatic Cell Mol. Genet., 16, 267-282.
    • (1990) Somatic Cell Mol. Genet. , vol.16 , pp. 267-282
    • Driscoll, D.J.1    Migeon, B.R.2
  • 4
    • 0025800593 scopus 로고
    • Methylation levels of maternal and paternal genomes during preimplantation development
    • Hewlett, S.K. and W. Reik (1991) Methylation levels of maternal and paternal genomes during preimplantation development, Development, 113, 119-127.
    • (1991) Development , vol.113 , pp. 119-127
    • Hewlett, S.K.1    Reik, W.2
  • 5
  • 7
    • 0021237658 scopus 로고
    • Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
    • Surani, M.A.H., Barton, S.C. and M.L. Norrris (1984) Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis, Nature, 308, 548-550.
    • (1984) Nature , vol.308 , pp. 548-550
    • Surani, M.A.H.1    Barton, S.C.2    Norrris, M.L.3
  • 8
    • 0021145377 scopus 로고
    • Role of paternal and maternal genomes in mouse development
    • Barton, S.C., Surani, M.A.H. and Norris, M.L. (1984) Role of paternal and maternal genomes in mouse development, Nature, 311, 374-376.
    • (1984) Nature , vol.311 , pp. 374-376
    • Barton, S.C.1    Surani, M.A.H.2    Norris, M.L.3
  • 9
    • 0021139084 scopus 로고
    • Completion of mouse embryogenesis requires both the maternal and paternal genomes
    • McGrath, J. and D. Solter (1984) Completion of mouse embryogenesis requires both the maternal and paternal genomes, Cell, 37, 179-183.
    • (1984) Cell , vol.37 , pp. 179-183
    • McGrath, J.1    Solter, D.2
  • 10
    • 0023196308 scopus 로고
    • Genomic imprinting determines methylation of parental alleles in transgenic mice
    • Reik, W., Collick, A., Norris, M.L., Barton, S.C. and M.A. Surani (1987) Genomic imprinting determines methylation of parental alleles in transgenic mice, Nature, 328, 248-251.
    • (1987) Nature , vol.328 , pp. 248-251
    • Reik, W.1    Collick, A.2    Norris, M.L.3    Barton, S.C.4    Surani, M.A.5
  • 11
    • 0023220910 scopus 로고
    • Degree of methylation of transgenes is dependent on gamete of origin
    • Sapienza, C., Peterson, A.C., Rossant, J. and R. Balling (1987) Degree of methylation of transgenes is dependent on gamete of origin, Nature, 328, 251-254.
    • (1987) Nature , vol.328 , pp. 251-254
    • Sapienza, C.1    Peterson, A.C.2    Rossant, J.3    Balling, R.4
  • 12
    • 0023274924 scopus 로고
    • Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation
    • Hadchouel, M., Farza, H., Simon, D., Tiollais, P. and C. Pourcel (1987) Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation, Nature, 329, 454-456.
    • (1987) Nature , vol.329 , pp. 454-456
    • Hadchouel, M.1    Farza, H.2    Simon, D.3    Tiollais, P.4    Pourcel, C.5
  • 13
    • 0023614187 scopus 로고
    • Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting
    • Swain, J.L., Stewart, T.A. and P. Leder (1987) Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting, Cell, 50, 719-727.
    • (1987) Cell , vol.50 , pp. 719-727
    • Swain, J.L.1    Stewart, T.A.2    Leder, P.3
  • 14
    • 0029054424 scopus 로고
    • Regulation of genomic imprinting by gametic and embryonic processes
    • Chaillet, R., Bader, D.S. and P. Leder (1995) Regulation of genomic imprinting by gametic and embryonic processes, Genes Dev., 9, 1177-1187.
    • (1995) Genes Dev. , vol.9 , pp. 1177-1187
    • Chaillet, R.1    Bader, D.S.2    Leder, P.3
  • 15
    • 0028245837 scopus 로고
    • Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage
    • Michaud, E.J., van Vugt, M.J., Bultman, S.J., Sweet, H.O., Davisson, M.T. and R.P. Woychik (1994) Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage, Genes Dev., 8, 1463-1472.
    • (1994) Genes Dev. , vol.8 , pp. 1463-1472
    • Michaud, E.J.1    Van Vugt, M.J.2    Bultman, S.J.3    Sweet, H.O.4    Davisson, M.T.5    Woychik, R.P.6
  • 17
    • 0025716294 scopus 로고
    • DNA methylation: Evolution of a bacterial immune function into a regulator of genome structure and activity in higher eukaryotes
    • Bestor, T.H. (1990) DNA methylation: evolution of a bacterial immune function into a regulator of genome structure and activity in higher eukaryotes, Phil. Trans. Royal Soc. Lond. B326, 179-187.
    • (1990) Phil. Trans. Royal Soc. Lond. , vol.B326 , pp. 179-187
    • Bestor, T.H.1
  • 18
    • 0027280881 scopus 로고
    • Methylation and imprinting: From host defense to gene regulation?
    • Barlow, D.P. (1993) Methylation and imprinting: from host defense to gene regulation?, Science, 260, 309-10.
    • (1993) Science , vol.260 , pp. 309-310
    • Barlow, D.P.1
  • 20
    • 0030115772 scopus 로고    scopus 로고
    • Creation of genomic methylation patterns
    • Bestor, T.H. and B. Tycko (1996) Creation of genomic methylation patterns. Nature Genet., 12, 363-367.
    • (1996) Nature Genet. , vol.12 , pp. 363-367
    • Bestor, T.H.1    Tycko, B.2
  • 21
    • 0028004378 scopus 로고
    • Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
    • Moretti, P., Freeman, K., Coodly, L. and D. Shore (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1, Genes Dev., 8, 2257-2269.
    • (1994) Genes Dev. , vol.8 , pp. 2257-2269
    • Moretti, P.1    Freeman, K.2    Coodly, L.3    Shore, D.4
  • 22
    • 0025967857 scopus 로고
    • Paternal imprinting of the mouse insulin-like growth factor II gene
    • DeChiara, T.M., Robertson, E.J. and A. Efstratiadis (1991) Paternal imprinting of the mouse insulin-like growth factor II gene, Cell, 64, 849-859.
    • (1991) Cell , vol.64 , pp. 849-859
    • Dechiara, T.M.1    Robertson, E.J.2    Efstratiadis, A.3
  • 23
    • 0026098090 scopus 로고
    • The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus
    • Barlow, D,P, Stoger, R., Hermann, B.G., Saito, K. and N. Schweifer (1991) The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus, Nature, 349, 84-87.
    • (1991) Nature , vol.349 , pp. 84-87
    • Barlow, D.1    Stoger, R.2    Hermann, B.G.3    Saito, K.4    Schweifer, N.5
  • 24
    • 0025809321 scopus 로고
    • Parental imprinting of the mouse H19 gene
    • Bartolomei, M.S., Zemel, S. and S.M. Tilghman (1991) Parental imprinting of the mouse H19 gene, Nature, 351, 153-155.
    • (1991) Nature , vol.351 , pp. 153-155
    • Bartolomei, M.S.1    Zemel, S.2    Tilghman, S.M.3
  • 25
    • 0026849544 scopus 로고
    • Monoallelic expression of the human H19 gene
    • Zhang, Y. and B. Tycko (1992) Monoallelic expression of the human H19 gene. Nature Genet., 1, 40-44.
    • (1992) Nature Genet. , vol.1 , pp. 40-44
    • Zhang, Y.1    Tycko, B.2
  • 27
    • 0027496294 scopus 로고
    • Imprinting of human H19: Allele-specific CpG methylation, loss of the active allele in Wilms' tumor and potential for somatic allele switching
    • Zhang, Y., Shields, T., Crenshaw, T., Hao, Y., Moulton, T. and B. Tycko (1993) Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms' tumor and potential for somatic allele switching, Am. J. Hum. Genet., 53, 113-124.
    • (1993) Am. J. Hum. Genet. , vol.53 , pp. 113-124
    • Zhang, Y.1    Shields, T.2    Crenshaw, T.3    Hao, Y.4    Moulton, T.5    Tycko, B.6
  • 30
    • 0027018063 scopus 로고
    • Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region
    • Leff, S.E., Brannan, C.I., Reed, M.L., Ozcelik, T., Francke, U., Copeland, N.J and N.A. Jenkins (1992) Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region, Nature Genet., 2, 259-264.
    • (1992) Nature Genet. , vol.2 , pp. 259-264
    • Leff, S.E.1    Brannan, C.I.2    Reed, M.L.3    Ozcelik, T.4    Francke, U.5    Copeland, N.J.6    Jenkins, N.A.7
  • 32
    • 0027172684 scopus 로고
    • Parental-origin-specific epigenetic modification of the mouse H19 gene
    • Ferguson-Smith, A.C., Sasaki, H., Cattanach, B.M. and M.A. Surani (1993) Parental-origin-specific epigenetic modification of the mouse H19 gene, Nature, 362, 751-755.
    • (1993) Nature , vol.362 , pp. 751-755
    • Ferguson-Smith, A.C.1    Sasaki, H.2    Cattanach, B.M.3    Surani, M.A.4
  • 33
    • 0027236694 scopus 로고
    • The ontogeny of allele-specific methylation associated with imprinted genes in the mouse
    • Brandeis, M., Kafri, T., Ariel, M., Chaillet, J.R., McCarrey, J., Razin, A. and H. Cedar (1993) The ontogeny of allele-specific methylation associated with imprinted genes in the mouse, EMBO J., 12, 3669-3677.
    • (1993) EMBO J. , vol.12 , pp. 3669-3677
    • Brandeis, M.1    Kafri, T.2    Ariel, M.3    Chaillet, J.R.4    McCarrey, J.5    Razin, A.6    Cedar, H.7
  • 34
    • 0027203606 scopus 로고
    • Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
    • Bartolomei, M.S., Webber, A.L., Brunkow, M.E. and S.M. Tilghman (1993) Epigenetic mechanisms underlying the imprinting of the mouse H19 gene, Genes Dev., 7, 1663-1673.
    • (1993) Genes Dev. , vol.7 , pp. 1663-1673
    • Bartolomei, M.S.1    Webber, A.L.2    Brunkow, M.E.3    Tilghman, S.M.4
  • 35
  • 36
    • 0027400888 scopus 로고
    • Maternal-specific methylation of the imprinted Igf2r locus identifies the expressed locus as carrying the imprinting signal
    • Stoger, R., Kubicka, P., Liu, C.-G., Kafri, T., Razin, A., Cedar, H. and D.P. Barlow (1993) Maternal-specific methylation of the imprinted Igf2r locus identifies the expressed locus as carrying the imprinting signal, Cell, 73, 61-72.
    • (1993) Cell , vol.73 , pp. 61-72
    • Stoger, R.1    Kubicka, P.2    Liu, C.-G.3    Kafri, T.4    Razin, A.5    Cedar, H.6    Barlow, D.P.7
  • 37
    • 0028143457 scopus 로고
    • Comparative analysis of the Igf-2/H19 imprinted domain: Identification of a highly conserved intergenic DNase I hypersensitive region
    • Koide, T., Ainscough, J., Wijgerde, M. and M.A. Surani (1994) Comparative analysis of the Igf-2/H19 imprinted domain: identification of a highly conserved intergenic DNase I hypersensitive region, Genomics, 24, 1-8.
    • (1994) Genomics , vol.24 , pp. 1-8
    • Koide, T.1    Ainscough, J.2    Wijgerde, M.3    Surani, M.A.4
  • 38
    • 0028862472 scopus 로고
    • Imprinting mutations in the Beckwith-Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2-H19 domain
    • Reik, W., Brown, K.W., Schneid, H., Le Bouc, Y, Bickmore W. and E.R. Maher (1995) Imprinting mutations in the Beckwith-Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2-H19 domain, Hum. Mol. Genet., 4, 2379-2385.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2379-2385
    • Reik, W.1    Brown, K.W.2    Schneid, H.3    Le Bouc, Y.4    Bickmore, W.5    Maher, E.R.6
  • 40
    • 0028859287 scopus 로고
    • Gamete-specific methylation correlates with imprinting of the murine Xist gene
    • Ariel, M., Robinson, E., McCarrey, J.R. and H. Cedar, (1995) Gamete-specific methylation correlates with imprinting of the murine Xist gene, Nature Genet., 9, 312-315.
    • (1995) Nature Genet. , vol.9 , pp. 312-315
    • Ariel, M.1    Robinson, E.2    McCarrey, J.R.3    Cedar, H.4
  • 41
    • 0028809295 scopus 로고
    • Methylation of the mouse Xist gene in spern and eggs correlates with imprinted Xist expression and paternal X-inactivation
    • Zuccotti, M. and M. Monk (1995) Methylation of the mouse Xist gene in spern and eggs correlates with imprinted Xist expression and paternal X-inactivation, Nature Genet., 9, 316-320.
    • (1995) Nature Genet. , vol.9 , pp. 316-320
    • Zuccotti, M.1    Monk, M.2
  • 44
    • 0028980026 scopus 로고
    • Genomic imprinting of p57Kip2, a cyclin-dependent kinase inhibitor, in mouse
    • Hatada, I. and T. Mukai (1995) Genomic imprinting of p57Kip2, a cyclin-dependent kinase inhibitor, in mouse, Nature Genet., 11, 204-206.
    • (1995) Nature Genet. , vol.11 , pp. 204-206
    • Hatada, I.1    Mukai, T.2
  • 46
    • 0029847299 scopus 로고    scopus 로고
    • Chromosome 11p15.5 regional imprinting: Comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors
    • Chung, W.-Y., Yuan, L., Feng, L., Hensle, T. and B. Tycko (1996) Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors. Hum. Mol. Genet., 8, 1101-1108.
    • (1996) Hum. Mol. Genet. , vol.8 , pp. 1101-1108
    • Chung, W.-Y.1    Yuan, L.2    Feng, L.3    Hensle, T.4    Tycko, B.5
  • 49
    • 0024619007 scopus 로고
    • Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion
    • Knoll, J.H.M., Nicholls, R.D., Magenis, R.E., Graham, J.M. Jr, Lalande, M. and S.A. Latt (1989) Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion., Am. J. Med. Genet., 32, 285-290.
    • (1989) Am. J. Med. Genet. , vol.32 , pp. 285-290
    • Knoll, J.H.M.1    Nicholls, R.D.2    Magenis, R.E.3    Graham J.M., Jr.4    Lalande, M.5    Latt, S.A.6
  • 50
    • 0024440608 scopus 로고
    • Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome
    • Nicholls, R.D., Knoll, J.H.M., Butler, M.G., Karam, S. and M. Lalande (1989) Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome, Nature, 342, 281-285.
    • (1989) Nature , vol.342 , pp. 281-285
    • Nicholls, R.D.1    Knoll, J.H.M.2    Butler, M.G.3    Karam, S.4    Lalande, M.5
  • 52
    • 0026893703 scopus 로고
    • Maternal but not paternal transmission of 15q11-13-linked nondeletion Angleman syndrome leads to phenotypic expression
    • Wagstaff, J., Knoll, J.H.M., Glatt, K.A., Shugart, Y.Y., Sommer, A. and M. Lalande (1992) Maternal but not paternal transmission of 15q11-13-linked nondeletion Angleman syndrome leads to phenotypic expression, Nature Genet., 1, 291-294
    • (1992) Nature Genet. , vol.1 , pp. 291-294
    • Wagstaff, J.1    Knoll, J.H.M.2    Glatt, K.A.3    Shugart, Y.Y.4    Sommer, A.5    Lalande, M.6
  • 53
    • 0027738562 scopus 로고
    • Molecular definition of the Prader-Willi syndrome chromosome region and orientation of the SNRPN gene, Hum
    • Buiting, K. Dittrich, B., Gross, S., Greger, V., Lalande, M., Robinson, W., Mutirangura, A. et al. (1993) Molecular definition of the Prader-Willi syndrome chromosome region and orientation of the SNRPN gene, Hum. Mol. Genet., 2, 1991-1994.
    • (1993) Mol. Genet. , vol.2 , pp. 1991-1994
    • Buiting, K.1    Dittrich, B.2    Gross, S.3    Greger, V.4    Lalande, M.5    Robinson, W.6    Mutirangura, A.7
  • 54
  • 55
    • 0028124726 scopus 로고
    • Identification of a novel paternally expressed gene in the Prader-Willi syndrome region
    • Wevrick, R., Kerns, J.A. and U. Francke (1994) Identification of a novel paternally expressed gene in the Prader-Willi syndrome region, Hum. Mol. Genet., 3, 1877-1882.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1877-1882
    • Wevrick, R.1    Kerns, J.A.2    Francke, U.3
  • 57
    • 0028939902 scopus 로고
    • Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15
    • Buiting, K., Saitoh, S., Gross, S., Dittrich, B., Schwartz, S., Nicholls, R.D. and B. Horsthemke (1995) Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15, Nature Genet., 9, 395-400.
    • (1995) Nature Genet. , vol.9 , pp. 395-400
    • Buiting, K.1    Saitoh, S.2    Gross, S.3    Dittrich, B.4    Schwartz, S.5    Nicholls, R.D.6    Horsthemke, B.7
  • 58
    • 0029063587 scopus 로고
    • Visualization of chromosomal domains with boundary element-associated factor BEAF-32
    • Zhao, K., Hart, C.M. and U.K. Laemmli (1995) Visualization of chromosomal domains with boundary element-associated factor BEAF-32, Cell, 81, 879-889.
    • (1995) Cell , vol.81 , pp. 879-889
    • Zhao, K.1    Hart, C.M.2    Laemmli, U.K.3
  • 59
    • 0013280347 scopus 로고    scopus 로고
    • Genomic imprinting in Wilms' tumor
    • in press
    • Tycko, B. (1996) Genomic imprinting in Wilms' tumor. Med. Ped. Oncol., in press.
    • (1996) Med. Ped. Oncol.
    • Tycko, B.1
  • 60
    • 0028316620 scopus 로고
    • Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia
    • Mannens, M., Hoovers, J.M., Redeker, E., Verjaal, M., Feinberg, A.P., Little, P. et al. (1994) Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia, Eur. J. Hum. Genet., 2, 3-23.
    • (1994) Eur. J. Hum. Genet. , vol.2 , pp. 3-23
    • Mannens, M.1    Hoovers, J.M.2    Redeker, E.3    Verjaal, M.4    Feinberg, A.P.5    Little, P.6
  • 61
    • 0027420362 scopus 로고
    • Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome
    • Weksberg, R., Shen, D.R., Fei, Y.L., Song, Q.L. and J. Squire (1993) Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome, Nature Genet., 5, 143-150.
    • (1993) Nature Genet. , vol.5 , pp. 143-150
    • Weksberg, R.1    Shen, D.R.2    Fei, Y.L.3    Song, Q.L.4    Squire, J.5
  • 62
    • 0028356544 scopus 로고
    • Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumor
    • Steenman, M.J.C., Rainier, S., Dobry, C.J., Grundy, P., Horon, I.L. and A.P. Feinberg (1994) Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumor, Nature Genet., 7, 433-439.
    • (1994) Nature Genet. , vol.7 , pp. 433-439
    • Steenman, M.J.C.1    Rainier, S.2    Dobry, C.J.3    Grundy, P.4    Horon, I.L.5    Feinberg, A.P.6
  • 64
    • 0028935017 scopus 로고
    • Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor
    • Taniguchi, T., Sullivan, M.J., Osamu, O. and A. Reeve (1995) Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor, Proc. Natl. Acad. Sci. USA, 92, 2159-2163.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2159-2163
    • Taniguchi, T.1    Sullivan, M.J.2    Osamu, O.3    Reeve, A.4
  • 68
    • 0020986251 scopus 로고
    • 5-methylcytosine, gene regulation and cancer
    • Riggs, A.D. and P.A. Jones (1983) 5-methylcytosine, gene regulation and cancer, Adv. Cancer Res., 40, 1-28.
    • (1983) Adv. Cancer Res. , vol.40 , pp. 1-28
    • Riggs, A.D.1    Jones, P.A.2
  • 69
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E., Bestor, T.H. and R. Jaenisch (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality, Cell, 69, 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 70
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li, E., Beard C. and R. Jaenisch. (1993) Role for DNA methylation in genomic imprinting, JOURNAL, 366, 362-365.
    • (1993) JOURNAL , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 71
    • 0027274649 scopus 로고
    • Treatment with azacytidine of patients with end-stage beta-thalassemia
    • Lowrey, C.H. and A.W. Nienhuis (1993) Treatment with azacytidine of patients with end-stage beta-thalassemia, New Engl. J. Med., 329, 845-848.
    • (1993) New Engl. J. Med. , vol.329 , pp. 845-848
    • Lowrey, C.H.1    Nienhuis, A.W.2
  • 72
    • 0023657424 scopus 로고
    • Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation
    • Lock, L.F., Takagi, N. and G.R. Martin (1987) Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation, Cell, 48, 39-46.
    • (1987) Cell , vol.48 , pp. 39-46
    • Lock, L.F.1    Takagi, N.2    Martin, G.R.3
  • 73
    • 0029360421 scopus 로고
    • Imprinted chromosomal regions of the human genome display sex-specific meiotic recombination frequencies
    • Paldi, A., Gyapay, G. and J. Jami (1995) Imprinted chromosomal regions of the human genome display sex-specific meiotic recombination frequencies, Curr. Biol., 5, 1030-1035.
    • (1995) Curr. Biol. , vol.5 , pp. 1030-1035
    • Paldi, A.1    Gyapay, G.2    Jami, J.3
  • 74
    • 0025965092 scopus 로고
    • Sex, maps, and imprinting
    • Thomas, B.J. and R. Rothstein (1991) Sex, maps, and imprinting, Cell, 64, 1-3.
    • (1991) Cell , vol.64 , pp. 1-3
    • Thomas, B.J.1    Rothstein, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.