Metabolism of ganciclovir and cidofovir in cells infected with drug-resistant and wild-type strains of murine cytomegalovirus

Antiviral Research

Volumn 35, Issue 2, 1997, Pages 83-90

  Okleberry, Kevin M ^a   Warren, Reed P ^b   Smee, Donald F ^a,c  

^a Utah Sate University   (United States)

^b UTAH STATE UNIVERSITY   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Antiviral; Cidofovir; Drug resistance; Ganciclovir; Murine cytomegalovirus; Phosphorylation

Indexed keywords

CIDOFOVIR; DNA POLYMERASE; DRUG METABOLITE; GANCICLOVIR; RADIOISOTOPE; VIRUS ENZYME;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG METABOLISM; DRUG RESISTANCE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS PLAQUE; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; CYTOSINE; DRUG RESISTANCE, MICROBIAL; GANCICLOVIR; MICE; MUROMEGALOVIRUS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PHOSPHORYLATION; TIME FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MAIZE CHLOROTIC MOTTLE VIRUS; MOUSE CYTOMEGALOVIRUS 1; MURINAE;

EID: 0030952439     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00013-2     Document Type: Article

References (21)

1. Alford, C.A. and Britt, W.J. (1990) Cytomegaloviruses. In: B.N. Fields, D.M. Knipe, M.S. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath and B. Roizman (Eds.), Virology (2nd edition), pp. 1981-2010, Raven Press, New York.
2. Baldanti, F., Underwood, M.R., Stanat, S.C., Biron, K.K., Chou, S., Sarasini, A., Silini, E. and Gerna, G. (1996) Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. J. Virol. 70, 1390-1395.
3. Baldanti, F., Sarasini, A., Silini, E., Barbi, M., Lazzarin, A., Biron, K.K. and Gerna, G. (1995) Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively. Scand. J. Infect. Dis. (Suppl. 99), 103-104.
4. Biron, K.K. (1991) Ganciclovir-resistant human cytomegalovirus clinical isolates; resistance mechanisms and in vitro susceptibility to antiviral agents. Transplant. Proc. 23, 162-167.
5. Burns, W.H., Wingard, J.R., Sandford, G.R., Bender, W.J. and Saral, R. (1982) Acyclovir in mouse cytomegalovirus infections. Am. J. Med. 73 (Suppl. 1A), 118-124.
6. Freitas, V.R., Smee, D.F., Chernow, M., Boehme, R. and Matthews, T.R. (1985) Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey and rodent cytomegaloviruses. Antimicrob. Agents Chemother. 28, 240-245.
7. Ho, H.-T., Woods, K.L., Bronson, J.J., De Boeck, H., Martin, J.C. and Hitchcock, M.J.M. (1992) Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Mol. Pharmacol. 41, 197-202.
8. Kern, E.R. (1991) Value of animal models to evaluate agents with potential activity against human cytomegalovirus. Transplant. Proc. 23 (Suppl. 3), 152-155.
9. Laskin, O.L., Cederberg, D.M., Mills, J., Eron, L.J., Mildvan, D. and Spector, S.S. (1987) Ganciclovir for the treatment and suppression of serious infections caused by cytomegaloviruses. Am. J. Med. 83, 201-207.
10. Littler, E., Stuart, A.D. and Chee, M.S. (1992) Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analog ganciclovir. Nature (London) 358, 160-162.
11. Oberg, B. (1989) Antiviral effects of phosphonoformate (PFA, Foscarnet sodium). Pharmaceut. Ther. 40, 213-285.
12. Polis, M.A., Spooner, K.M., Baird, B.F., Manischewitz, J.F., Jaffe, H.S., Fisher, P.E., Falloon, J., Davey, R.T., Kovacs, J.A., Walker, R.E., Whitcup, S.M., Nussenblatt, R.B., Lane, H.C. and Masur, H. (1995) Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. Antimicrob. Agents Chemother. 39, 882-886.
13. Sandford, G.R., Wingard, J.R., Simons, J.W., Staal, S.P., Saral, R. and Burns, W.H. (1985) Genetic analysis of the susceptibility of mouse cytomegalovirus to acyclovir. J. Virol. 54, 104-113.
14. Smee, D.F., Barnett, B.B., Sidwell, R.W., Reist, E.J. and Holy, A. (1995) Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral Res. 26, 1-9.
15. Smee, D.F., Boehme, R., Chernow, M., Binko, B.P. and Matthews, T.R. (1985) Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem. Pharmacol. 34, 1049-1056.
16. Stinski, M.F. (1990) Cytomegalovirus and its replication. In: B.N. Fields, D.M. Knipe, M.S. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath and B. Roizman (Eds.), Virology (2nd edition), pp. 1959-1980, Raven Press, New York.
17. Sullivan, V. and Coen, D.M. (1991) Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs. J. Infect. Dis. 164, 781-784.
18. Sullivan, V., Biron, K.K., Talarico, C., Stanat, S.C., Davis, M., Pozzi, L.M. and Coen, D.M. (1993) A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob. Agents Chemother. 37, 19-25.
19. Sullivan, V., Talarico, C.L., Stanat, S.C., Davis, M., Coen, D.M. and Biron, K.K. (1992) A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature (London) 358, 162-164.
20. Tatarowicz, W.A., Lurain, N.S. and Thompson, K.D. (1992) A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors. J. Infect. Dis. 166, 904-907.
21. Walmsley, S.L., Chew, E., Fanning, M.M., Read, S.E., Vellend, H., Salit, I. and Rachlis, A. (1988) Treatment of cytomegalovirus retinitis with trisodium phosphonoformate hexahydrate (foscarnet). J. Infect. Dis. 157, 569-572.