Glucocorticoids play an important role in mediating the enhanced metabolism of arginine and glutamine in enterocytes of postweaning pigs

Journal of Nutrition

Volumn 127, Issue 5, 1997, Pages 732-737

  Flynn, Nick E ^a   Wu, Guoyao ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

arginine; cortisol; glutamine; pigs; RU486; weaning

Indexed keywords

ARGININE; GLUTAMINE; HYDROCORTISONE; MIFEPRISTONE;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; DIGESTION; INTESTINE ABSORPTION; INTESTINE CELL; NONHUMAN; SWINE; WEANING;

EID: 0030950695     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.5.732     Document Type: Article

References (53)

1. Angel, J. F. & Back, D. W. (1985) Weaning and metabolic regulation in the rat Can. J. Physiol. Pharmacol. 63: 538-545.
2. Ball, R. O., Atkinson, J. L. & Bayley, H. S. (1986) Proline as an essential amino acid for the young pig. Br. J. Nutr 55: 659-668.
3. Barbul, A. (1995) The use of arginine in clinical practice. In: Amino Acid Metabolism and Therapy in Health and Nutritional Disease (Cynober, L. A., ed.), pp. 361-372, CRC Press, New York, NY.
4. Baulieu, E. E. (1989) Contragestion and other clinical applications of RU486, and antiprogesterone at the receptor. Science (Washington, DC) 245: 1351-1357.
5. Bertagna, X., Bertagna, C., Laudat, M., Husson, J., Girard, F. & Luton, J. (1986) Pituitary-adrenal response to the anti-glucocorticoid action of RU486 in Cashing's syndrome. J. Clin. Endocrinol. Metab. 63: 639-643.
6. Borbolla, A. G. (1994) Utilization of Nutrients by the Small Intestine of the Developing Pig and Role of Corticosteroids in Post-Weaning Lag in Pigs. Doctoral thesis, Texas & M University, College Station, TX.
7. Burgeon, K. G. (1990) The Digestible Tryptophan Requirements of Starter, Grower and Finisher Swine. Doctoral thesis, Texas & M University, College Station, TX.
8. Gallery, E. M. & Elinson, R. P. (1996) Developmental regulation of the urea-cycle enzyme arginase in the direct developing frog eleutherodactylus coqui. J. Exp. Zool. 275: 61-66.
9. Chappel, R. P., Cuaron, J. A. & Easter, R. A. (1989) Response of digestive carbohydrases and growth to graded doses and administration frequency of hydrocortisone and adrenocorticotropic hormone in nursing pigs. J. Anim. Sci. 67: 2974-2984.
10. Deschodt-Lankman M., Robberecht, P., Camus J., Baya J. & Christophe, J. (1974) Hormonal and dietary adaptation of rat pancreatic hydrolases before and after weaning. Am. J. Physiol. 226: 39-44.
11. Dugan, M.E.R, Knabe, D. A. & Wu, G. (1995) The induction of citrulline synthesis from glutamine in enterocytes of weaned pigs is not due primarily to age or change in diet. J. Nutr. 125: 2388-2393.
12. Elliott, R. F., Vander Noot, G. W., Gilbreath, R. L. & Fisher, H. (1971) Effect of dietary protein level on composition changes in sow colostrum and milk. J. Anim. Sci. 32: 1128-1137.
13. Flynn, N. E. & Wu, G. (1997) Enhanced metabolism of arginine and glutamine in enterocytes of cortisol-treated pigs. Am. J. Physiol. (in press).
14. Galea, E., Regunathan, S., Eliopoulos, V., Feinstein, D. L. & Reis, D. J. (1996) Inhibition of mammalian nitric oxide synthase by agmatine: an endogenous polyamine formed by decarboxylation of arginine. Biochem. J. 316: 247-249.
15. Ganong, W. F. (1991) Review of Medical Physiology, 15th ed., p. 340. Appleton & Lange, Norwalk, CT.
16. Gianotti, L., Alexander, J. W., Pyles, T. & Fukushima, R. (1993) Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance: the rote of nitric oxide. Ann. Surg. 217: 644-654.
17. 17a in rat and guinea pig gonads, adrenal glands and brain. J. Reprod. Fert. 93: 609-622.
18. Gutmann, I. & Bergmeyer, H. U. (1974) Urea. In: Methods of Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 1791 -1798. Verlag Chemie, Weinheim, Germany.
19. Henning, S. J. (1981) Postnatal development: coordination of feeding, digestion, and metabolism. Am. J. Physiol. 241: G199-G214.
20. Herzfeld, A. & Raper, S. M. (1979) Effects of cortisol or starvation on the activities of four enzymes in the small intestine and liver of the rat during development. J. Dev. Physiol, 1: 315-327.
21. Iwase, K., Yamauchi, K. & Ishikawa, K. (1995) Cloning of cDNAs encoding argininosuccinate lyase and arginase from Rana catesbiana liver and regulation of their mRNAs during spontaneous and thyroid hormone-induced metamorphosis. Biochim. Biophys. Acta 1260: 139-146.
22. Kandil, H. M., Argenzio, R. A., Chen, W., Berschneider, H. M., Stiles, A. D., West-wick, J. K., Rippe, R. A., Brenner, D. A. & Rhoads, J. M. (1995) L-Glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Am. J. Physiol. 269: G591-G599.
23. Klemcke, H. G., Lunstra, D. D., Brown-Borg, H. M., Bork, K. E. & Christensen, R. K. (1993) Association between low birth weight and increased adrenocortical function in neonatal pigs. J. Anim. Sci. 71: 1010-1018.
24. Klemcke, H. G., Nienaber, J. A. & Hahn, G. L. (1989) Plasma adrenocorticotropic hormone and cortisol in pigs: effects of time of day on basal and stressor-altered concentrations. Proc. Soc. Exp. Biol. Med. 190: 42-53.
25. Klobasa, F., Werhahn, E. & Butler, J. E. (1987) Composition of sow milk during lactation. J. Anim. Sci. 64: 1458-1466.
26. Lacey, J. M. & Wilmore, D. W. (1990) Is glutamine a conditionally essential amino acid? Nutr. Rev. 48: 297-309.
27. Lund, E. K. & Smith, M. W. (1987) Rat jejunal disaccharidase activity increases biphasically during early post-natal development. J. Physiol. 391: 487-497.
28. Markwell, M.A.K., Haas, S. M., Bieber, L. L. & Tolbert, N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87: 206-210.
29. Mertz, E. T., Beeson, W. M. & Jackson, H. D. (1952) Classification of essential amino acids for weanling pigs. Arch. Biochem. Biophys. 38: 121-128.
30. Morris, S. M., Jr. (1992) Regulation of enzymes of urea and arginine synthesis. Anna Rev. Nutr. 12: 81-101.
31. M'Rabet-Touil, H., Lerminiaux, H., Duee, P. H. & Blachier, F. (1996) Evidence for increased anionic arginase activity in pig enterocytes during development. Biochem. Mol. Biol. Int. 38: 197-204.
32. Noblet, J. & Etienne, M. (1989) Estimation of sow milk nutrient output J. Anim. Sci. 67: 3352-3359.
33. Pluske, J. R., Williams, I. H. & Aherne, F. X. (1995) Nutrition of the neonatal pig. In: The Neonatal Pig: Development and Survival (Varley, M. A., ed.), pp. 187-235. CAB International, Wallingford, Oxon, UK.
34. Reeds, P. J., Burrin, D. G., Jahoor, F., Wykes, L., Henry, J. & Frazer, E. M. (1996) Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. Am. J. Physiol. 270: E413-E418.
35. Sangild, P. T, Sjostrom, H., Noren, O., Fowden, A. L. & Silver M. (1995) The prenatal development and glucocorticoid control of brush-border hydrolases in the pig small intestine, Pediatr. Res. 37: 207-212.
36. Speiser, P. W., Riddick, L. M., Martin, K. & Lew, M. I. (1993) Investigation of the mechanism of hypertension in apparent mineralocorticoid excess. Metabolism 42: 843-845.
37. Steel, R.G.D. & Tome, J. H. (1980) Principles and Procedures of Statistics. McGraw Hill, New York NY.
38. Visek, W. J. (1984) An update of concepts of essential amino acids. Annu. Rev. Nutr. 4: 137-155.
39. Wakabayashi, Y. (1995) The glutamate crossway. In: Amino Acid Metabolism and Therapy in Health and Nutritional Disease (Cynober, L. A., ed.), pp. 88-98. CRC Press, New York, NY.
40. Wakabayashi, V., Yamade, E., Yoshida, T. & Takahashi, H. (1994) Arginine becomes an essential amino acid after massive resection of rat small intestine. J. Biol. Chem. 269: 32667-32671.
41. Warshaw J. B. , Terry, M. L. & Ranis M. B. (1980) Metabolic adaptation in developing lung. Pediatr. Res. 14: 296-299.
42. Watford, M., Lund, P. & Krebs, H. A. (1979) Isolation and metabolic characterization of rat and chicken enterocytes. Biochem. J. 178: 589-596.
43. Windmueller, H. G. (1902) Glutamine utilization by the small intestine. Adv. Enzymol. 53: 201-237.
44. Windmueller, H. G. & Spaeth, A. E. (1976) Metabolism of absorbed aspartate, asparagine, and arginine by rat small intestine in vivo. Arch. Biochem. Biophys. 175: 670-676.
45. Worsae, H. & Schmidt, M. (1980) Plasma cortisol and behaviour in early weaned piglets. Acta Vet. Scand. 21: 640-657.
46. Wu, G. (1995) Urea synthesis in enterocytes of developing pigs. Biochem. J. 312: 717-723.
47. Wu, G., Borbolla, A. G. & Knabe, D. A. (1994a)The uptake of glutamine and release of arginine, citrulline and praline by the small intestine of developing pigs. J. Nutr. 124: 2437-2444.
48. Wu, G. & Knabe, D. A. (1994) Free and protein-bound amino acids in sow's colostrum and milk. J. Nutr. 124: 415-424.
49. Wu, G. & Knabe, D. A. (1995) Arginine synthesis in enterocytes of neonatal pigs. Am. J. Physiol. 269: R621-R629.
50. Wu, G., Knabe, D. A. & Flynn, N. E. (1994b) Synthesis of citrulline from glutamine in pig enterocytes. Biochem. J. 299: 115-121.
51. Wu, G., Knabe, D. A., Flynn, N. E., Yan, W. & Flynn, S. P. (1996a) Arginine degradation in developing porcine enterocytes Am. J. Physiol. 271: G913-G919.
52. Wu, G., Knabe, D. A., Yan, W. & Flynn, N. E. (1995) Glutamine and glucose metabolism in enterocytes of the neonatal pig. Am. J. Physiol. 268: R334-R342.
53. Wu, G., Meier, S. A. & Knabe, D. A. (1996b) Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs. J. Nutr. 126: 2578-2584.