Direct demonstration of persistent Epstein-Barr virus gene expression in peripheral blood of infected common marmosets and analysis of virus-infected tissues in vivo

Journal of General Virology

Volumn 78, Issue 6, 1997, Pages 1417-1424

  Farrell, Paul J ^a   Hollyoake, Martine ^a   Niedobitek, Gerald ^b   Agathanggelou, Angelo ^b   Morgan, Andrew ^c   Wedderburn, Nina ^d  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EPSTEIN BARR VIRUS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MARMOSET; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS GENE; VIRUS INFECTION;

EID: 0030950022     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-6-1417     Document Type: Article

References (31)

1. Arrand, J. R., Young, L. S. & Tugwood, J. D. (1989). Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) correlate with EBV types A and B. Journal of Virology 63, 983-986.
2. Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Seguin, C., Tufnell, P. S. & Barrell, B. G. (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310, 207-211.
3. Banerjee, S., Livanos, E. & Vos, J. H. (1995). Therapeutic gene delivery in human B-lymphoblastoid cells by engineered non-transforming infectious Epstein-Barr virus. Nature Medicine 1, 1303-1308.
4. Cox, C., Chang, S., Karran, L., Griffin, B. & Wedderburn, N. (1996). Persistent Epstein-Barr virus infection in the common marmoset (Callithrix jacchus). Journal of General Virology 77, 1173-1180.
5. Decker, L. L., Klaman, L. D. & Thorley-Lawson, D. A. (1996). Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals. Journal of Virology 70, 3286-3289.
6. Desgranges, C., Lenoir, G., de The, G., Seigneurin, J. M., Hilgers, J. & Dubouch, P. (1976). In vitro transforming activity of EBV. I-Establishment and properties of two EBV strains (M81 and M72) produced by immortalized Callithrix jacchus lymphocytes. Biomedicine 25, 349-352.
7. de The, G., Dubouch, P., Fontaine, C., Wedderburn, N., Carter, R. L., Edwards, M. B. & Cohen, B. (1980). Natural antibodies to EBV-VCA antigens in common marmosets (Callithrix jacchus) and response after EBV inoculation. Intervirology 14, 284-291.
8. Emini, E. A., Luka, J., Armstrong, M. E., Banker, F. S., Provost, P. J. & Pearson, G. R. (1986). Establishment and characterization of a chronic infectious mononucleosis-like syndrome in common marmosets. Journal of Medical Virology 18, 369-379.
9. Evans, T. J., Brooks, L. & Farrell, P. J. (1997). A strategy for specific targeting of therapeutic agents to tumour cells of virus-associated cancers. Gene Therapy 4, 264-267.
10. Franken, M., Estabrooks, A., Cavacini, L., Sherburne, B., Wang, F. & Scadden, D. T. (1996). Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Nature Medicine 2, 1379-1382.
11. Greenspan, D., Greenspan, J. S., Conart, M., Petersen, V., Silverman, S. & de Souza, Y. (1985). Replication of Epstein-Barr virus within the epithelial cells of oral 'hairy' leukoplakia, an AIDS associated lesion. New England Journal of Medicine 313, 1564-1571.
12. Gutierrez, M. I., Judde, J. G., Magrath, I. T. & Bhatia, K. G. (1996). Switching viral latency to viral lysis: a novel therapeutic approach for Epstein-Barr virus-associated neoplasia. Cancer Research 56, 969-972.
13. Kempkes, B., Pich, D., Zeidler, R., Sugden, B. & Hammerschmidt, W. (1995). Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA. Journal of Virology 69, 231-238.
14. Khan, G., Miyashita, E. M., Yang, B., Babcock, G. J. & Thorley-Lawson, D. A. (1996). Is EBV persistence in vivo a model for B cell homeostasis? Immunity 5, 173-180.
15. Levitskaya, J., Coram, M., Levitsky, V., Imreh, S., Steigerwald-Mullen, P. M., Klein, G., Kurilla, M. G. & Masucci, M. G. (1995). Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375, 685-688.
16. Mackett, M., Cox, C., Pepper, S. de V., Lees, J. F., Naylor, B. A., Wedderburn, N. & Arrand, J. R. (1996). Immunisation of common marmosets with vaccinia virus expressing Epstein-Barr virus (EBV) gp340 and challenge with EBV. Journal of Medical Virology 50, 263-271.
17. Miyashita, E. M., Yang, B., Lam, K. M., Crawford, D. H. & Thorley-Lawson, D. A. (1995). A novel form of Epstein-Barr virus latency in normal B cells in vivo. Cell 80, 593-601.
18. Niedobitek, G. & Young, L. S. (1994). Epstein-Barr virus persistence and virus-associated tumours. Lancet 343, 333-335.
19. Niedobitek, G., Young, L. S., Lau, R., Brooks, L., Greenspan, D., Greenspan, J. S. & Rickinson, A. B. (1991). Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase. Journal of General Virology 72, 3035-3046.
20. Niedobitek, G., Herbst, H., Young, L. S., Brooks, L., Masucci, M. G., Crocker, J., Rickinson, A. B. & Stein, H. (1992). Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 79, 2520-2526.
21. Niedobitek, G., Agathanggelou, A., Finerty, S., Tierney, R., Watkins, P., Jones, E. L., Morgan, A., Young, L. S. & Rooney, N. (1994). Latent Epstein-Barr virus infection in cottontop tamarins. A possible model for Epstein-Barr virus infection in humans. American Journal of Pathology 145, 969-978.
22. Qu, L. & Rowe, D. T. (1992). Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. Journal of Virology 66, 3715-3724.
23. Rickinson, A. B. & Kieff, E. (1996). Epstein-Barr virus. In Fields Virology, 3rd edn, pp. 2397-2446. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia: Lippincott-Raven.
24. Robertson, E. S., Ooka, T. & Kieff, E. D. (1996). Epstein-Barr virus vectors for gene delivery to B lymphocytes. Proceedings of the National Academy of Sciences, USA 93, 11334-11340.
25. Rowe, M., Evans, H. S., Young, L. S., Hennessy, K., Kieff, E. & Rickinson, A. B. (1987). Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells. Journal of General Virology 68, 1575-1586.
26. Tierney, R. J., Steven, N., Young, L. S. & Rickinson, A. B. (1994). Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. Journal of Virology 68, 7374-7385.
27. Watkins, D. I., Chen, Z. W., Hughes, A. L., Hodi, F. S. & Letvin, N. L. (1990). Genetically distinct cell populations in naturally occurring bone marrow chimaeric primates express similar MHC class I gene products. Journal of Immunology 144, 3726-3735.
28. Wedderburn, N., Edwards, J. M., Desgranges, C., Fontaine, C., Cohen, B. & de The, G. (1984). Infectious mononucleosis-like response in common marmosets infected with Epstein-Barr virus. Journal of Infectious Diseases 150, 878-882.
29. Yao, Q. Y., Rickinson, A. B. & Epstein, M. A. (1985). A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals. International Journal of Cancer 35, 35-42.
30. Young, L., Alfieri, C., Hennessy, K., Evans, H., O'Hara, C., Anderson, K. C., Ritz, J., Shapiro, R. S., Rickinson, A., Kieff, E. & Cohen, J. I. (1989). Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. New England Journal of Medicine 321, 1080-1085.
31. Young, L. S., Lau, R., Rowe, M., Niedobitek, G., Packham, G., Shanahan, F., Rowe, D. T., Greenspan, D., Greenspan, J. S., Rickinson, A. B. & Farrell, P. J. (1991). Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. Journal of Virology 65, 2868-2874.