Differentiation and transdifferentiation of the retinal pigment epithelium

International Review of Cytology

Volumn 171, Issue , 1997, Pages 225-266

  Zhao, Shulei ^a   Rizzolo, Lawrence J ^a   Barnslable, Colin J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell culture; Cell polarity; Development; Gene expression; Organ culture; Retina; Retinal pigment epithelium; Transdifferentiation

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; TRANSCRIPTION FACTOR;

CELL POLARITY; CHOROID; DEVELOPMENTAL GENETICS; EMBRYO DEVELOPMENT; GENE EXPRESSION; NERVE CELL DIFFERENTIATION; NEUROEPITHELIUM; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; RETINA DEVELOPMENT; RETINA NEUROEPITHELIAL LAYER; RETINA ROD; REVIEW;

MAMMALIA;

EID: 0030949745     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7696(08)62589-9     Document Type: Review

References (199)

1. Agata, K., Kobayashi, H., Itoh, Y., Mochii, M., Sawada, K., and Eguchi, G. (1993). Genetic characterization of the multipotent dedifferentiated state of pigmented eepithelial cells in vitro. Development 118,1025-1030.
2. Anderson, D., Stern, W., Fisher, S., Erickson, P., and Borgula, G. (1983). Retinal detachment in the cat: The pigment epithelial-photoreceptor interface. Invest. Opthalmol. Vis. Sei. 24, 906-926.
3. Balda, M. S., and Anderson, J. M. (1993). Two classes of tight junctions are revealed by ZO1 isoforms. Am J. Physiol. 264 (Cell Physiol. 33), C918-C924.
4. Barnstable, C. J. (1987). A molecular view of mammalian retinal development. Mol. Neiirobiol. 1, 9-46.
5. Barnstable, C. J. (1991). Molecular aspects of development of mammalian optic cup and formation of retinal cell types. Prog. Retina Res. 10, 45-67.
6. Barnstable, C. J., and Drager, U. C. (1984). Thy-1 antigen: A ganglion cell specific marker in rodent retina. Neuroscience 11, 847-855.
7. Barnstable, C. J., Hofstein, R., and Akagawa, K. (1985). A marker of early amacrine cell development in rat retina. Dev. Brain Res. 20, 286-290.
8. Båvik, C.-O., Levy, F., Hellman, U., Wernstedt, C., and Eriksson, U. (1993). The retinal pigment epithelial membrane receptor for plasma retinol-binding protein: Isolation and cDNA cloning of the 63-kDa protein. /. Biol. Chem. 268, 20540-20546.
9. Beermann, F., Ruppert, S., Hummler, E., Bosch, F. X., Muller, G., Ruther, U., and Schütz, G. (1990). Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J. 9, 2819-2826.
10. Beermann, F., Schmid, E., Ganss, R., Schütz, G., and Ruppert, S. (1992a). Molecular characterization of the mouse tyrosinase gene: Pigment cell-specific expression in transgenic mice. Pigment Cell Res. 5, 295-299.
11. Beermann, F., Schmid, E., and Schütz, G. (1992b). Expression of the mouse tyrosinase gene during embryonic development: Recapitulation of the temporal regulation if transgenic mice. Proc. Nail. Acad. Sei. USA 89, 2809-2813.
12. Bentley, N. J., Eisen, T., and Coding, C. R., (1994). Melanocyte-specific expression of the human tyrosinase promoter: Activation by the microphthalmia gene procuct and role of the initiator. Mol. Cell. Biol 14, 7996-8006.
13. Bernard, O., Drago, J., and Sheng, H. (1992). L-myc and N-myc influence lineage determination in the central nervous system. Neuron 9,1217-1224.
14. Bhatt, N. S., Newsome, D. A., French, T., Hessburg, T. P., Diamond, J. G., Miceli, M. V., Kratz, K. E., and Oliver, P. D. (1994). Experimental transplantation of human retinal pigment epithelial cells on collagen substrates. Am. J. Ophthalmol. 117, 214-221.
15. Bok, D. (1982). Autoradiographic studies on the polarity of plasma membrane receptors in retinal pigment epithelial cells. In The Structure of the Eye. (J. Hollyfield, Ed.), pp. 247-256. Elsevier Biomédical, New York.
16. Bok, D., O'Day, W., and Rodriguez-Boulan, E. (1992). Polarized budding of vesicular stomatitis and influenza virus from cultured human and bovine retinal pigment epithelium. Exp. Eye Res. 55, 853-860.
17. Bradl, M., Klein-Szanto, A., Porter, S., and Mintz, B. (1991). Malignant melanoma in transgenic mice. Proc. Nail. Acad. Sei. USA 88,164-168.
18. Burke, J. M., Skumatz, C. M. B., Irving, P. E., and McKay, B. S. (1996). Phenotypic heterogeneity of retinal pigment epithelial cells in vitro and in situ. Exp. Eye Res. 62, 63-73.
19. Burmeister, M., Novak, J., Liang, M.-Y., Basu, S., Ploder, L., Hawes, N. L., Vidgen, D., Hoover, F., Goldman, D., Kalnins, V. I., Roderick, T. H., Taylor, B. A., Hankin, M. H., and Mclnnes, R. R. (1996). Ocular retardation mouse caused by ChxlO homeobox null allele: Impaired retinal progenitor proliferation and bipolar cell differentiation. Nature Genet. 12,376-384.
20. Cavallaro, T., Marione, R. L., Dwork, A. J., Schon, E. A., and Herbert, J. (1990). The retinal pigment epithelium is the unique site of transthyretin synthesis in the rat eye. Invest. Ophthalmol. Vis. Sei. 31, 497-501.
21. Chang, C. W., Roque, R. S., Defoe, D. M., and Caldwell, R. B. (1991). An improved method for isolation and culture of pigment epithelial cells from rat retina. Ctirr. Eye Res. 10,1081-1086.
22. Chu, P., and Grunvvald, G. B. (1990a). Identification of an adhesion-associated protein of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sei. 31, 847-855.
23. Chu, P., and Grunwald, G. B. (1990b). Generation and characterization of monoclonal antibodies specific for the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sei. 31, 856-862.
24. Chu, P., and Grunwald, G. B. (1991). Identification of the 2A10 antigen of retinal pigment epithelium as a \subunit of integrin. Invest. Ophthalmol. Vis. Sei. 32, 1757-1762.
25. Clark, V. M. (1986). The cell biology of the retinal pigment epithelium. In The Retina: A Model for Cell Biology Studies, Part II. (A. Ruben and D. Farber, Eds.), pp. 129-168. Academic Press, Orlando.
26. Cooper, G. M. (1990). Oncogenes. Jones and Bartlett, Boston.
27. Coulombre, J. L., and Coulombre, A. J. (1965). Regeneration of neural retina from the pigmented epithelium in the chick embryo. Dev. Biol. 12, 79-92.
28. Davis, A. A., Bernstein, P. S., Bok, D., Turner, J., Nachtigal, M., and Hunt, R.C. (1995). A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest. Opthalmol. Vis. Sei. 36, 955-964.
29. De longh, R., and McAvoy, J. W. (1993). Spatio-temporal distrbution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis. Dev. Dynamics 198, 190-202.
30. DePinho, R. A, Legouy, E., Feldman, L. B., Kohl, N. K., Yancopoulos, G. D., and Alt, F. W. (1986). Structure and expression of the murine N-myc gene. Proc. Natl. Acad. Sei. USA 83,1827-1831.
31. Dermietzel, R., and Krause, D. (1991). Molecular anatomy of the blood-retinal barrier as defined by immunocytochemistry. Int. Rev. Cytol. 127, 57-109.
32. Dionne, C. A., Jaye, M., and Schlessinger, J. (1991), Structural diversity and binding of FGF receptors. Ann. N.Y. Acad. Sei. 638, 161-166.
33. Donoso, L. A., Braunagel, S. C., Newsome, D. A., and Organisciak, D. T. (1988). Retinal pigment epithelial cell plasma membrane: A monoclonal antibody study. Hybridoma 7, 265-272.
34. Dunn, K. C., Aotaki-Keen, A. E., Putkey, F. R., and Hjelmeland, L. M. (1996). ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp. Eye Res. 62, 155-169.
35. Dutt K., Scott, M., Sternberg, P. P., Linser, P. J., and Srinivasan, A. (1993). Transdifferentiation of adult human pigment epithelium into retinal cells by transfection with an activated H-ras proto-oncogen. DNA Cell Biol. 12, 667-673.
36. Eguchi, G., (1987). Instability in cell commitment of vertebrate pigmented epithelial cells and their transdifferentiation into lens cells. Curr. Topics. Dev. Biol. 20, 21-37.
37. Eguchi, G., and Kodama, R. (1993). Transdifferentiation. Curr. Opin. Cell Biol. 5,1023-1028.
38. Einer, S. G., Einer, V. M., Nielsen, J. C., Torczynski, E., Yu, R., and Franklin, W. A. (1992). CD68 antigen expression by human retinal pigment epithelial cells. Exp. Eye Res. 55,21-28.
39. Fadool, J. M., and Linser, P. J. (1993). 5A11 Antigen is a cell recognition molecule which is involved in neuronal-glial interactions in avian neural retina. Dev. Dynamics 196,252-262.
40. Fadool, J. M., and Linser, P. J. (1994). Spatial and temporal expression of the 5A11/HT7 antigen in the chick embryo: Association with morphogenetic events and tissue maturation. Roux's Arch. Dev. Biol. 203, 328-339.
41. Fujisawa, H., Morioka, H., Watanabe, K., and Nakamura, H. (1976). A decay of gap junctions in association with cell differentiation of neural retina in chick embryonic development. J. Cell Sei. 22, 585-596.
42. Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., and Tsukita, S. (1993). Occludin: A novel integral membrane protein localizing at tight junctions. J. Cell Biol. 123, 1777-1788.
43. Ganss, R., Montoliu, L., Monaghan, A. P., and Schütz, G. (1994a). A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice. EMBO J. 13, 3083-3093.
44. Ganss, R., Schmidt, A., Schütz, G., and Beermann, F. (1994b). Analysis of the mouse tyrosinase promoter in vitro and in vivo. Pigment Cell Res. 7, 275-278.
45. Ganss, R., Schütz, G., and Beermann, F. (1994c). The mouse tyrosinase gene: Promoter modulation by positive and negative regulatory elements. J. Biol. Chem. 269,29808-29816.
46. Green, M. C. (1989). Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse. (M. F. Lyon and A. G. Searle, Eds.), pp. 12-403. Oxford Univ. Press, Oxford, UK.
47. Grierson, I., Hiscott, P., Hogg, P., Robey, H., Mazure, A., and Larkin, G. (1994). Development, repair and regeneration of the retinal pigment epithelium. Eye 8, 255-262.
48. Grisanti, S., and Guidry, C. (1995). Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype. Invest. Ophthalmol. Vis. Sei. 36,391-405.
49. Guérin, C. J., Anderson, D. H., and Fisher, S. K. (1990). Changes in intermediate filament immunolabeling occur in response to retinal detachment and reattachment in primates. Invest. Ophthalmol. Vis. Sei. 31,1474-1482.
50. Guillemot, F., and Cepko, C. L. (1992). Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vivo assay of early retinal development. Development 114, 743-754.
51. Gundersen, D., Orlowski, J., and Rodriguez-Boulan, E. (1991). Apical polarity of Na,K-ATPase in retinal pigment epithelium is linked to a reversal of the ankyrin-fodrin submembrane cytoskeleton. J. Cell Biol. 112, 863-872.
52. Gundersen, D., Powell, S. K., and Rodriguez-Boulan, E. (1993). Apical polarization of NCAM in retinal pigment epithelium is dependent on contact with the neural retina. J. Cell Biol. 121, 335-343.
53. Hamburger, V., and Hamilton, H. L. (1951). A series of normal stages in the development of the chick embryo. J. Morph. 88, 49-82.
54. Hamel, C. P., Tsilou, E., Harris, E., Pfeffer, B. A., Hooks, J. J., Detrick, B., and Redmond, T. M. (1993a). A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina. J. Neurosd. Res. 34, 414-425.
55. Hamel, C. P., Tsilou, E., Pfeffer, B. A., Hooks, J. J., Detrick, B., and Redmond, T. M. (1993b). Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptonally regulated in vitro. J. Biol. Chem. 268,15751-15757.
56. Hamel, C. P., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Redmond, T. M. (1994). The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1q31 and mouse 3. Cenomics 20, 509-512.
57. +-ATPase in polarized epithelial cells. Science 254, 847-850.
58. Hasson, T., Heintzelman, M. B., Santos-Sacchi, J., Corey, D. P., and Mooseker, M. S. (1995). Expression in cochlea and retina of myosin Vila, the gene product defective in Usher syndrome type IB. Proc. Natl. Acad. Sei. USA 92, 9815-9819
59. Hearing, V. J., and King, R. A. (1993). Determinants of skin color: Melanocytes and melanization. In Pigmentation and Pigmentary Disorders (N. Levine, Ed.). CRC Press, Boca Raton, FL
60. Hearing, V. J., and Tsukamoto, K. (1991). Enzymatic control of pigmentation in mammals. FASEB J. 5, 2902-2909.
61. Hemesath, T. J., Steingrimsson, E., McGill, G., Hansen, M. J., Vaught, J., Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., Jenkins, N. A., and Fisher, D. E. (1994). Microphthal-mia, a critical factor in melanocute development, defines a discrete transcription factor family. Genes Dev. 8, 2770-2780.
62. Hero, I., Farjah, M., and Scholtz, C. L. (1991). The prenatal development of the optic fussure in colobomatous microphthalmia. Invest. Ophthalmol. Vis. Sei. 32, 2622-2635.
63. Hertwig, P. (1942). Neue mutationen und kopplungsgruppen bei der hausmaus. Z. Inditkt. Abstammungs-Vererbungsl. 80, 220-246.
64. Hilfer, S. R., Brady, R. C, and Wang, J. J. W. (1981). Intracellular and extracellular changes during early ocular development in the chick embryo. In Ocular Size and Shape: Regulation during Development. (S. R. Hilfer and J. B. Sheffield, Eds.), pp. 47-78. Springer-Verlag, New York.
65. Hodgkinson, C. A., Moore, K. J., Nakayama, A., Steingrimsson, E., Copeland, N. G., Jenkins, N. A., and Arnheiter, H. (1993). Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74, 395-404.
66. Höfer, D., and Drenckhahn, D. (1993). Molecular heterogeneity of the actin filament cytoskeleton associated with microvilli of photoreceptors, Muller's glial cells and pigment epithelial cells of the retina. Histochemistry 99, 29-35.
67. Hooks, J. J., Detrick, B., Percopo, C, Hamel, C, and Siraganian, R. P. (1989). Development of characterization of monoclonal antibodies directed against the retinal pigment epithelial cell. Invest. Ophthalmol. Vis. Sei. 30, 2106-2113.
68. Hu, J. G., Gallemore, R. P., Bok, D., Lee, A. Y., Frambach, D. A. (1994). Localization of Na-K ATPase on cultured human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sei. 35, 3582-3888.
69. Hudspeth, A. J., and Yee, A. G. (1973). The intercellular junctional complexes of retinal pigment epithelia. Invest. Ophthalmol. 12, 354-365.
70. Hughes, A. E., Newton, V. E., Liu, X. Z., and Read, A. P. (1994). A gene for Waardenburg syndrome type 2 maps close to the human homologue of the microthalmia gene at chromo-some 3pl2-pl4.1. Nature Genet. 7, 509-512.
71. Hughes, M. J., Lingrel, J. B., Krakowsky, J. M., and Anderson, K. P. (1993). A helix-loop-helix transcription factor-like gene is located at the mi locus. J. Biol. Chem. 268,20687-20690.
72. Hunt, R. C, and Davis, A. A. (1990). Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J. Cell. Physiol. 145,187-199.
73. Huotari, V., Sormunen, R., Lehto, V.P., and Eskelinen, S. (1995). The polarity of the membrane skeleton in retinal pigment epithelial cells of developing chicken embryos and in primary culture. Differentiation 58, 205-215.
74. Ito, S. (1993). Biochemistry and physiology of melanin. In Pigmentation and Pigmentary Disorders. (N. Levine, Ed.), pp. 33-59. CRC Press, Boca Raton, FL.
75. Janssen, J. J., Janssen, B. P., and Vugt, A. H. (1994). Characterization of monoclonal antibodies recognizing retinal pigment epithelial antigens. Invest. Ophthalmol. Vis. Sei. 35, 189-198.
76. Kapur, R. P., Bigler, S. A., Skelly, M., and Gown, A. M. (1992). Anti-melanoma monoclonal antibody HMB45 identifies an oncofetal glycoconjugate associated with immature melanosomes. J. Histochem. Cytochem. 40, 207-212.
77. Khosravi-Far, R., and Der, C. J. (1994). The Ras signal transdcution pathway. Cancer Metastasis Rev. 13, 67-89.
78. Kim, R. Y., and Wistow, G. J. (1992). The cDNA RPE1 and monoclonal antibody HMB-50 define gene products preferentially expressed in retinal pigment epithelium. Exp. Eye Res. 55, 657-662.
79. Kitaoka, T., Sharif, M., Hanley, M. R., and Hjelmeland, L. M. (1994). Expression of the MAS proto-oncogene in the retinal pigment epithelium of the rhesus macaque. Curr. Eye Res. 13,345-351.
80. Klein, L. R., MacLeish, P. R., and Wiesel, T. N. (1990). Immunolabelling by a newt retinal pigment epithelium antibody during retinal development and regeneration./. Comp. Neural. 293, 331-339.
81. Klein-Szanto, A., Bradl, M, Porter, S., and Mintz, B. (1991). Melanosis and associated tumors in transgenic mice. Proc. Natl. Acad. Sei. USA 88, 169-173.
82. Klüppel, M., Beermann, F., Ruppert, S., Schmid, E., Hummler, E., and Schütz, G. (1991). The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the reina. Proc. Natl. Acad. Sei. USA 88, 3777-3781.
83. Kobayashi, H., Ueda, M., and Honda, Y. (1991). Molecules specific to pigment epithelial cells: Expression durng in situ development and in vitro lens transdifferentiation of chick emryo pigment epithelium. Ophthal. Res. 23, 309-319.
84. Kobayashi, T., Urabe, K., Winder, A., Tsukamoto, K., Brewington, T., Imokawa, G., Potterf, B., and Hearing, V. J. (1994a). DHICA oxidase activity of TRP1 and interactions with other melanogenic enzymes. Pigment Cell Res. 7, 227-234.
85. Kobayashi, T., Urabe, K., Winder, A., Jimenez-Cervantes, C., Imokawa, G., Brewington, T., Solano, F., Garcia-Borron, J. C, and Hearing, V. J. (1994b). Tyrosinase related protein (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J. 13, 5818-5825.
86. +-ATPase in regenerating retinal pigment epithelium in the rabbit. A study by electron microscopic cytochemistry. Exp. Eye Res. 56, 219-229.
87. Korte, G. E., Perlman, J. I., and Pollack, A. (1994). Regeneration of mammalian retinal pigment epithelium. Int. Rev. Cytol. 152, 223-263.
88. Krakowsky, J. M., Boissy, R. E., Neuman, J. C., and Lingrel, J. B. (1993). A DNA insertinal muation results in microphthalmia in transgenic mice. Transgenic Res. 2, 14-20.
89. Kwon, B. S. (1993). Pigmentation genes: The tyrosinase gene family and the pml 17 gene family. J. Invest. Dermatol. 100(Suppl. 2), 134S-140S.
90. La Vail, M. M., Li, L., Turner, J. E., and Yasumura, D. (1992). Retinal pigment epithelial cell transplantation in RCS rats: Normal metabolism in rescued photoreceptors. Exp. Eye Res. 55, 555-562.
91. Li, H-S., Yang, J. M., Jacobson, R. D., Pasko, D., and Sundin, O. (1994), Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: Implications for stepwise determunation of the lens. Dev. Biol. 162, 181-194.
92. Lin, W. L., and Essner, E. (1994). Differential localization of type IV collagen in Bruch's membrane of the eye: Comparison of two polyclonal antibodies. Cell. Mol. Biol. 40,851-858.
93. Liu, I., Chen, J-D., Ploder, L., Vidgen, D., van der Kooy, D., Kalnins, V. I., and Mclnnes, R. R. (1994), Developmental expression of a novel murine homeobox gene (ClucIO): Evidence for roles in deternimation of the neroretina and inner nuclear layer. Neuron 13, 377-393.
94. Lopashov, G. V., and Sologub, A. A. (1972). Artificial metaplasia of pigmented epithelium into retina in tadpoles and adult frogs. /. Embryol. Exp. Morphol. 28, 521-546.
95. Lopez, R., Gouras, P., Brittis, M., and Kjeldbye, H. (1987). Transplantation of cultured rabbit retinal epithelium to rabbit retina using a closed-eye method. Invest. Ophthalmol. Vis. Sei. 28,1131-1137.
96. Machemer, R. (1988). Proliferative vitreoretinopathy (PVR): A personal account of its pathogenesis and treatment. Invest. Ophthalmol. Vis. Sei. 29, 1771-1783.
97. Machemer, R., and Laqua, H. (1975). Pigment epithelial proliferaiton in retinal detachment (massive periretinal proliferation). Am. J. Ophthalmol. 80, 1-23.
98. Machemer, R., van Horn, D., and Aaberg, T. M. (1978). Pigment epithelial proliferation in human retinal detachment and massive periretinal proliferation. Am. J. Ophthalmol. 85, 181-191.
99. Mandelcorn, M. S., Machemer, R., Fineberg, E., and Hersch, S. B. (1975). Proliferation and meaplasia of intrvitreal retinal pgmnet epithelial cell autotransplants. Am. J. Ophthalmol. 80, 227-237.
100. Marcu, K. B., Bossone, S. A., and Patel, A. J. (1992). myc function and regulation. Annu. Rev. Biochem. 61, 809-860.
101. Martin, P., Carriere, C., Dozier, C, Quatannens, B., Mirabel, M., Vandenbunder, B., Stehelin, D., and Saule, S. (1992). Characterization of a paired box- and homeobox-containing quail gene (Pax-QNR) expressed in the neuroretina. Oncogene 7, 1721-1728.
102. Mathers, P. H., and Jamrich, M. (1995). Induction of a novel homeodomain gene, Rx, in the anterior neural plate and its role in retinal proliferation. Invest. Ophthalmol. Vis. Sei. 36, S213.
103. Mazure, A., and Grierson, I. (1992). In vivo studies of the contractility of cell types involved in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sei. 33, 3407-3416.
104. McCormick, F. (1994). Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev. 4, 71-76.
105. McKay, B. S., and Burke, J. M. (1994). Separation of phenotypically distinct subpopulations of cultured human retinal pigment epithelial cells. Exp. Cell Res. 213, 85-92.
106. McKay, B. S., Suson, J. D., and Burke, J. M. (1992). Subpopulations of human RPE in vitro. Invest. Opthalmol. Vis. Sei. 33, 1204.
107. Miller, K., and Rizzino, A. (1994). Developmental regulation and signal transductuion pathways of fibroblast growth factors and their receptors. In Growth Factors and Signal Transduction in Development (M. Nilsen-Hamilton, Ed.) Wiley-Liss, New York.
108. Mircheff, A. K., Miller, S. S., Farber, D. B., Bradley, M. E., O'Day, W. T., and Bok, D. (1990). Isolation and provisional identification of plasma membrane populations from cultured human retinal pigment epithelium. Invest. Ophihalmol. Vis. Sei. 31, 863-878.
109. Mizuno, R., Cavallaro, T., and Herbert, J. (1992). Temporal expression of the transthyretin gene in the developing rat eye. Invest. Ophthalmol. Vis. Sei. 33, 341-349.
110. Monaghan, A. P., Davidson, D. R., Sime, C., Graham, E., Baidock, R., Bhattacharya, S. S, and Hill, R. E. (1991). The Msh-like homeobox genes define domains in the developing vertebrate eye. Development 112,1053-1061.
111. Morse, D. E., and McCann, P. S. (1984). Neuroectoderm of the early embryonic rat eye. Invest. Ophthalmol. Vis. Sei. 25, 899-907.
112. Nabi, I. R., Mathews, A. P., Cohen-Gould, L., Gundersen, D., and Rodriguez-Boulan, E. (1993). Immortalization of polarized rat retinal pigment epithelium. J. Cell Sei. 104,37-49.
113. Neill, J. M., and Barnstable, C. J. (1990). Expression of the cell surface antigens RET-PE2 and N-CAM by rat retinal pigment epithelial cells during development and in tissue culture. Exp. Eye Res. 51, 573-583.
114. Neill, J. M., Thornquist, S. C, Raymond, M. C, Thompson, J. T., and Barnstable, C. J. (1993), RET-PE10: A 61 kD polypeptide epitope expressed late during vertebrate RPE maturation. Invest. Ophthalmol. Vis. Sei. 34, 453-462.
115. Nornes, H. O., Dressler, G. R., Knapik, E. W., Deutsch, U., and Gruss, P. (1990). Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development 109, 797-809.
116. Okami, T., Yamamoto, A., Omori, K., Takada, T., Uyama, M., and Tashiro, Y. (1990). Immunocytochemical localization of Na+,K+-ATPase in rat retinal pigment epithelial cells. J. Histochem. Cytochem. 38, 1267-1275.
117. Opas, M., and Dziak, E. (1994). bFGF-induced transdifferentiation of RPE to neuronal progenitors is regulated by the mechanical properties of the substratum. Dev. Biol. 161, 440-454.
118. Packer, S. O. (1967). The eye and skeletal defects of two mutants alleles at the microphthalmia locus of Mus musculus. /. Exp. Zoo/. 165, 21-45.
119. Park, C. M., and Hollenberg, M. J. (1989). Basic fibroblast growth factor induces retinal regeneration in vivo. Dev. Biol. 134, 201-205.
120. Park, C. M., and Hollenberg, M. J. (1991). Induction of retinal regeneration in vivo by growth factors. Dev. Biol. 148, 322-333.
121. Park, C. M., and Hollenberg, M. J. (1993). Growth factor-induced retinal regeneration in vivo. Int. Rev. Cytol. 146, 49-74.
122. Philp, N. J., and Nachmias, V. T. (1987). Polarized distribution of integrin and fibronectin in retinal pigment epithelium. Invest. Ophlhalmol. Vis. Sei. 28, 1275-1280.
123. Philp, N. J., Yoon, M. Y., and Hock, R. S. (1990). Identification and localication of talin in chick retinal pigment epithelial cells. Exp. Eye Res. 51, 191-198.
124. Philp, N., Chu, P., Pan, T.-C, Zhang, R. Z., Chu, M.-L., Stark, K., Boettiger, D., Yoon, H., and Kieber-Emmons, T. (1995). Developmental expression and molecular cloning of REMP, a novel retinal epithelial membrane protein. Exp. Cell Res. 219, 64-73.
125. Pittack, C, Jones, M., and Reh, T. A. (1991). Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro. Development 113, 577-588.
126. Ponnazhagan, S., Hou, L., and Kwon, B. S. (1994). Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region. J. Invest. Dematol. 102, 744-748.
127. Prota, G. (1992). Melanins and Melanogenesis. Academic Press, San Diego.
128. Quiring, R., Walldorf, U., Kloter, U., and Gehring, W. J. (1994). Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265,785-789.
129. Reh, T. A., and Nagy, T. (1987). A possible role for the vascular membrane in retinal regeneration in Rana catesbienna tadpoles. Dev. Biol. 122, 471-482.
130. Rizzolo, L. J. (1990). The distribution of Na+K+-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture. Exp. Eye Res. 5, 435-446.
131. Rizzolo, L. J. (1991). Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium. Cell Regul. 2, 939-949.
132. Rizzolo, L. J., and Heiges, M. (1991). The polarity of the retinal pigment epithelium is developmentally regulated. Exp. Eye Res. 53, 549-553.
133. Rizzolo, L. J., and Joshi, H. C. (1993). Apical orientation of the microtubule organizing center and associated y-tubulin during the polarization of the pigment epithelium in vivo. Dev, Biol. 157, 147-156.
134. Rizzolo, L. J., and Li, Z.-Q. (1993). Diffusible, retinal factors stimulate the barrier properties of junctional complexes in the retinal pigment epithelium. /. Cell Sei. 106, 859-867.
135. Rizzolo, L. J., and Zhou, S. (1995). The distribution of Na+,K+-ATPase and 5A11 antigen in apical microvilli of the retinal pigment epithelium is unrelated to a-spectrin. J. Cell Sei. 108, 3623-3633.
136. Rizzolo, L. J., Zhou, S., and Li, Z. Q. (1994). The neural retina manitains integrins in the apical membrane of the RPE early in development. Invest. Ophlhalmol. Vis. Sei. 35, 2567-2576.
137. Rodriguez-Boulan, E., and Nelson, W. J. (1989). Morphogenesis of the polarized epithelial cell phenotype. Science 245,: 718-725.
138. Rubin, L. L., Hall, D. E., Porter, S., Barbu, K., Cannon, C., Horner, H. C., Janatpour, M., Liaw, C. W., Manning, K., Morales, J., Tanner, L. I., Tomaselli, K. J.,. and Bard, F. (1991). A cell culture model of the blood-brain barrier. J. Cell Biol. 115, 1725-1735.
139. Ryeom, S. W., Sparrow, J. R., and Silverstein, R. L. (1996). CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. J. Cell Sei. 109, 387-395.
140. Sagara, H., and Hirosawa, K. (1991). Monoclonal antibodies which recognize endoplasmic reticulum in the retinal pigment epithelium. Exp. Eye Res. 53, 765-771.
141. Sandig, M., and Kalnins, V. I. (1988). Subunits in zonulae adhaerentes and striations in the associated circumferential microfilament bundles in chicken retinal pigment epithelial cells in situ. Exp. Cell Res. 175, 1-14.
142. Sandig, M., and Kalnins, V. I. (1990). Morphological changes in the zonula adhaerens during embryonic development of chick retinal pigment epithelial cells. Cell Tissue Res. 259, 455-461.
143. Sarna, T. (1992). Properties and functions of the ocular melanin: a photobiophysical view. /. Photochem. Photobiol.-B (Biol.) 12, 215-258.
144. Sasai, Y., Lu, B., Steinbeisser, H., and De Roberts, E. M. (1995). Regulation of neural induction by Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376, 333-336.
145. Sawai, S., Shimono, A., Hanaoka, K., and Kondoh, H. (1991). Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol, 3, 861-869.
146. Scott, M. P. (1992). Vertebrate homeobox gene nomenclature. Cell 71, 551-553.
147. Seaton, A. D., Sheedlo, H. J., and Turner, J. E. (1994). A primary role for RPE transplants in the inhibition and regression of neovascularization in the RCS rat. Invest. Ophthatmol. Vis. Sei. 35, 162-169.
148. Seulberger, H., Lottspeich, F., and Risau, W. (1990). The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein. EMBO J. 9, 2151-2158.
149. Seulberger, H., Unger, C. M., and Risau, W. (1992). HT7, neurothelin, basigin, gp-42 and OX-47-Many names for one developmentally regulated immuno-globulin-Iike surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons. Neurosci. Lett. 140, 93-97.
150. Sheedlo, H. J., Li, L., Gaur, V. P., Young, R. W., Seaton, A. D., Stovall, S. V., Jaynes, C. D., and Turner, J. E. (1992). Photoreceptor rescue in the dystrophic retina by transplantation of retinal pigment epithelium. Int. Rev. Cytol. 138, 1-49.
151. Sheedlo, H. J., Li, L., Barnstable C. J., and Turner J. E. (1993). Synaptic and photoreceptor components in retinal pigment epithelial cell transplanted retinas of Royal College of Surgeons dystrophic rats. /. Neurosci. Res. 36, 423-431.
152. Sheng, Y., Gouras, P., Cao, H., Berglin, L., Kjeldbye, H., Lopez, R., and Rosskothen, H. (1995). Patch transplants of human fetal retinal pigment epithelium in rabbit and monkey retina. Invest. Ophthalmol. Vis. Sei. 36, 381-390.
153. Silvers, W. K. (1979). The Coat Colors of Mice. A Model for Mammalian Gene Action and Interaction. Springer-Verlag, New York.
154. Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., Rosaria D'Apice, M., Nigro, V., and Boncinelli, E. (1993), A vertebrate gene related to orthodentide contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735-2747.
155. Sologub, A. A. (1975). The development of differentiation of pigment epithelium in teleosts and its stimulation to metaplasia. Ontogenez 6, 39-46.
156. Sparrow, J. R., Hicks, D., and Barnstable, C. J. (1990). Cell commitment and differentiation in expiants of embryonic rat retina. Comparison to the developmental potential of dissociated retina. Dev. Brain Res. 51, 69-84.
157. Sparrow, J. R., Ryeom, S. W., Abumrad, N. A., Ibrahimi, A., and Silverstein, R. L. (1996). CD36 expression is altered in retinal pigment epithelial cells of the RCS rat. Exp. Eye Res. In press.
158. Stanton, B. R., Perkins, A. S., Tessarollo, L., Sassoon, D. A., and Parada, L. F. (1992). Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6, 2235-2246.
159. Steinberg, R. H., and Wood, I. (1979). The relationship of the retinal pigment epithelium to photoreceptor outer segments in human retina. In The Retinal Pigment Epithelium (K. M. Zinn and M. F. Marmor, Eds.), pp. 32-44. Harvard Univ. Press, Cambridge, MA.
160. Steingrimsson, E., Moore, K. J., Lamoreux, M. L., Ferre-D'Amare, A. R., Burlwy, S. K., Sanders Zimring, D. C, Skow, L. C, Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., and Jenkins, N. A. (1994). Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nature Genet. 8, 256-263.
161. Stone, L. S. (1950). The role of retinal pigment cells in regenerating neuyral retinae of adult salamander eyes. J. Exp. Zool. 113, 9-32.
162. Stone, L. S., and Steinitz, H. (1957). Regeneration of neural retina and lens from retina pigment cell grafts in adult newts. /. Exp. Zoo/. 135, 301-318.
163. Stroeva, O. G. (1960). Experimental analysis of the eye morphogenesis in mammals. J. Embryol. Exp. Morphol. 8, 349-368.
164. Stroeva, O. G., and Mitashov, V. I. (1983). Retinal pigment epithelium: proliferation and differentiation during development and regeneration. Int. Rev. Cytol. 83, 221-293.
165. Sundin, O., Yang, J-M-, and Kang. R. (1995). Homeobox gene expression during establishment of the eye primordia. Invest. Ophthalmol. Vis. Sei. 36, S213.
166. Suzuki, Y., Ishiguro, S., and Tamai, M. (1993). Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium. Biochim. Biophys. Acta 1163, 201-208.
167. Tachibana, M., Hara, Y., Vyas, D., Hodgkinson, C., Fex, J., Grundfast, K., and Arnheiter, H. (1992). Cochlear disorder associated with melanocyte anomaly in mice with a transgenic insertional mutation. Mol. Cell. Neurosci. 3, 433-445.
168. Tachibana, M., Perez-Jurado, L. A., Nakayama, A., Hodgkinson, C. A., Li, X., Schneider, M., Mili, T., Fex, J., Francke, U., and Arnheiter, H. (1994). Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3pl4.1-pl2.3. Hum. Mol. Genet. 3, 553-557.
169. Tanaka, S., Yamamoto, H., Takeuchi, S., and Takeuchi, T. (1990). Melanization in albino mice trandformed by introducing clined mouse tyrosinase gene. Development 108,223-227.
170. Tarnowski, B. I., Shepherd, V. L., and McLaughlin, B. J. (1988). Expression of mannose receptors for pinocytosis and phagocytosis on rat retinal pigment epithelium. Invest. Ophthalmol. Vis. Sei. 29, 742-748.
171. Tassabehji, M., Newton, V. E., and Read, A. P. (1994). Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nature Genet. 8, 251-255.
172. Tcheng, M., Fuhrmann, G., Hartmann, M-P., Courtois, Y., and Jeanny, J-C. (1994). Spatial and temporal expression patterns of FGF receptor genes type 1 and type 2 in the developing chick retina. Exp. Eye Res. 58, 351-358.
173. Tomasz, M., Lipman, R., Chowdary, D., Pawlak, J., Verdine, G. L., and Nakanishi, K. (1987). Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Science 235,1204-1208.
174. Tso, M. (1979). Developmental, reactive, and neoplastic proliferation of the retinal pigment epithelium, in The Retinal Pigment Epithelium (K. M. Zinn and M. F. Marmor Eds.), pp 267-276. Harvard Univ. Press, Cambridge, MA.
175. Tsukamoto, K., Jackson, I. J., Urabe, K., Montague, P. N., and Hearing, V. J. (1992). A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J. 11, 519-526.
176. Turksen, K., Opas, M., Aubin, J. E., and Kalnins, V. I. (1983). Microtubules, microfilaments and adhesion patterns in differentiating chick retinal pigmented epithelial (RPE) cells in in vitro. Exp. Cell Res. 147, 379-391
177. Turksen, K., Aubin, J. E., Sodek, J., and Kalnins, V. I. (1985). Localization of laminin, type IV collagen, fibronectin, and heparan sulfate proteoglycan in chick retinal pigment epithelium basement membrane during embryonic development. /. Histochem. Cytochem. 33, 665-671.
178. Turner, E. E., Jenne, K. J., and Rosenfeld, M. G. (1994). Brn-3.2: A Brn-3-related transcription factor with distinctive cental nercous sustem ecpression and regulation by retinoic acid. Neuron 12, 205-218.
179. Vinores, S. A., Orman, W., Hooks, J. J., Detrick, B., and Campochiaro, P. A. (1993). Ultrastructural localization of RPE-associated epitopes recognized by monoclonal antibodies in human RPE and their induction in human fibroblasts by vitreous. Graefes Arch. Clin. Exp. Ophthal-mol. 231, 395-401.
180. Vinores, S. A., Derevjanik, N. L., Mahlow, J., Hackett, S. F., Haller, J. A., deJuan, E., Frankfurter, A., and Campochiaro, P.A. (1995). Class III /3-tubulin in human retinal pigment epithelial cells in culture and in epiretinal membranes. Exp. Eye Res. 60, 385-400.
181. Wakamatsu, Y., Watanabe, Y., Shimono, A., and Kondoh, H. (1993). Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons. Neuron 10,1-9.
182. Walther, C., and Gruss, P. (1991). Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113,1435-1449.
183. Wilcox, D. K., and Vergnes, J. P. (1989). Differential expression of N-ras in metaplastic retinal pigmented epithelium. Exp. Eye Res. 48, 271-280.
184. Williams, C. D., and Rizzolo, L J. (1995). Molecular remodeling of tight junctions during development of the blood-retinal barier. Mol. Biol. Cell 6,193a.
185. Wilson, P. A., and Hemmati-Brivanlou, A. (1995). Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376, 331-333.
186. Wongpichedchai, S., Weiter, J. J., Weber, P., and Dorey, C. K. (1992). Comparison of external and internal approaches for transplantation of autologous retinal pigment epithelium. Invest. Ophthalmol. Vis. Sei. 33, 3341-3352.
187. Xiang, M., Zhou, L., Macke, J. P., Peng, Y-W., Eddy, R. L., Shows, T. B., and Nathans, J. (1993). Brn-3b: A POU-domain gene expressed in a subset of retinal ganglion cells. Neuron 11, 689-701.
188. Xiang, M., Zhou, L., Macke, J. P., Yoshioka, T., Hendry, S., Eddy, R. L., Shows, T. B., and Nathans, J. (1995). The Brn-3 family of POU-domain factors: Primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosd. 15, 4762-4785.
189. Yamaguchi, K., Yamaguchi, K, Gaur, V. P., and Turner, J .E. (1993). Retinal pigment epithelial cell transplantation into aging retina: a possible approach to delay age-related cell death. Jpn J. Ophthalmol. 37, 16-27.
190. Yamamoto, S., Du, J., Gouras, P., and Kjeldbye, H. (1993). Retinal pigment epithelial transplants and retinal function in RCS rats. Invest. Ophthalmol. Vis. Sei. 34, 3068-3075.
191. Yasumoto, K-L, Yokoyama, K., Shibata, K., Tomita, Y., and Shibahara, S. (1994). Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol. Cell. Biol. 14, 8058-8070.
192. Yavuzer, U., Keenan, E., Lowings, P., Vachtenheim, J., Currie, G., and Coding, C. R. (1995). The microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregualtion of melanocyte-specific transcription. Oncogene 10,123-134.
193. Yokoyama, T., Silversides, D. W., Waymire, K. G., Kwon, B. S., Takeuchi, T., and Overbeek, P. A. (1990). Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res. 18, 7293-7298.
194. Yu, H. S., Hernandez, V., Haywood, M., and Wong, C. G. (1993). Melatonin inhibits the proliferation of retinal pigment epithelial cells in vitro. In Vitro Cell. Dev. Biol. Anim. 29A, 415-418.
195. Zhao, S., and Barnstable, C. J. (1996). Differential effects of bFGF on development of the rat retina. Brain Res. 723, 169-176.
196. Zhao, S., Thornquist, S. C., and Barnstable, C. J. (1995). In vitro transdifferentiation of embryonic rat pigment epithelium to neural retina. Brain Res., 677, 300-310.
197. Zhou, Y., and Opas, M. (1994). Cell shape, intracellular pH, and fibroblast growth factor responsiveness during transdifferentiation of retinal pigment epithelium into neuroepithelium in vitro. Biochem. Cell Biol. 72,257-265.
198. Zhou, Y., Moszczynska, A., and Opas, M. (1994). Generation and characterization of antibodies to adhesion-related molecules of retinal pigment epithelial cells. Exp. Eye Res. 58, 585-593.
199. Zinn, K. M., and Benjamin-Henkind, J. V. (1979). Anatomy of the human retinal pigment epithelium. In The Retinal Pigment Epithelium (K. M. Zinn and M. F. Marmor, Eds.), pp. 3-31. Harvard Univ. Press, Cambridge, MA.