Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: The anomalous behaviour of cholesteryl linolenate

Free Radical Research

Volumn 26, Issue 4, 1997, Pages 351-362

  Hardwick, Simon J ^a   Carpenter, Keri L H ^a   Law, Nadine S ^a   Van Der Veen, Carina ^a   Marchant, Christine E ^a   Hird, Rachel ^a   Mitchinson, Malcolm J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Atherosclerosis; Cytotoxicity; Linolenate; Monocyte macrophages (human); Oxidation; Polyunsaturated fatty acid esters

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL ESTER; FATTY ACID ESTER; POLYUNSATURATED FATTY ACID; PROBUCOL; TRIACYLGLYCEROL; TRIOLEIN;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; FATTY ACID OXIDATION; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIPID OXIDATION; MACROPHAGE; MONOCYTE; NORMAL HUMAN;

EID: 0030949092     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.3109/10715769709097815     Document Type: Article

References (32)

1. M. J. Mitchinson (1983). Macrophages, oxidised lipids and atherosclerosis. Medical Hypotheses, 12, 171-178.
2. D. Steinberg, S. Parthasarathy, T. E. Carew, J. C. Khoo and J. L. Witztum (1989). Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity. New England Journal of Medicine, 320, 915-924.
3. K. L. H. Carpenter, S. E. Taylor, C. van der Veen, B. K. Williamson, J. A. Ballantine and M. J. Mitchinson (1995). Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. Biochimica et Biophysica Acta, 1256, 141-150.
4. R. Y. Ball, E. C. Stowers, J. H. Burton, N. R. B. Cary, J. N. Skepper and M. J. Mitchinson (1995). Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma. Atherosclerosis, 114, 45-54.
5. J. R. Hessler, D. W. Morel, L. J. Lewis and G. M. Chisolm (1983). Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis, 3, 215-222.
6. D. W. Morel, J. R. Hessler and G. M. Chisolm (1983). Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. Journal of Lipid Research, 24, 1070-1076.
7. M. K. Cathcart, D. W. Morel and G. M. Chisolm (1985). Monocytes and neutrophils oxidise low density lipoprotein making it cytotoxic. Journal of Leukocyte Biology, 38, 341-350.
8. V. C. Reid and M. J. Mitchinson (1993). Toxicity of oxidised low density lipoprotein towards mouse peritoneal macrophages. Atherosclerosis, 98, 17-24.
9. V. C. Reid, C. E. Brabbs and M. J. Mitchinson (1992). Cellular damage in mouse peritoneal macrophages exposed to cholesteryl linoleate. Atherosclerosis, 92, 251-260.
10. S. J. Hardwick, L. Hegyi, K. Clare, N. S. Law, K. L. H. Carpenter, M. J. Mitchinson and J. N. Skepper (1996). Apoptosis in human monocyte-macrophages exposed to oxidised low density lipoprotein. Journal of Pathology, 179, 294-302.
11. C. E. Marchant, N. S. Law, C. van der Veen, S. J. Hardwick, K. L. H. Carpenter and M. J. Mitchinson (1995). Oxidised low density lipoprotein is cytotoxic to human monocyte-macrophages: protection with lipophilic antioxidants. Federation of the European Biochemical Society Letters, 358, 175-178.
12. K. Clare, S. J. Hardwick, K. L. H. Carpenter, N. Weeratunge and M. J. Mitchinson (1995). Toxicity of oxysterols to human monocyte-macrophages. Atherosclerosis, 118, 67-75.
13. J. L. Goldstein, H. F. Hoff, Y. K. Ho, S. K. Basu and M. S. Brown (1981). Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters. Arteriosclerosis, 1, 210-226.
14. R. Y. Ball, K. L. H. Carpenter and M. J. Mitchinson (1988). Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipoproteins: Ultrastructural observations. British Journal of Experimental Pathology, 69, 43-56.
15. Z. Werb and Z. A. Cohn (1972). Cholesterol metabolism in the macrophage. III. Ingestion and intracellular fate of cholesterol and cholesterol esters. Journal of Experimental Medicine, 13, 21-44.
16. K. L. H. Carpenter, J. A. Ballantine, B. Fussell, J. H. Enright and M. J. Mitchinson (1990). Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro. Atherosclerosis, 83, 217-229.
17. K. L. H. Carpenter, G. M. Wilkins, B. Fussell, J. A. Ballantine, S. E. Taylor, M. J. Mitchinson and D. S. Leake (1994). Production of oxidised lipids during modification of low density lipoproteins by macrophages or copper. Biochemical Journal, 304, 625-633.
18. 3-adenine and lactate dehydrogenase. Journal of Laboratory Clinical Medicine, 106, 253-261.
19. G. M. Chisolm, G. Ma, K. C. Irwin, L. L. Martin, K. G. Gunderson, L. F. Linberg, D. W. Morel and P. E. Di Corleto (1994). 7β-Hydroperoxycholest-5-en-β-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidised human low density lipoprotein. Proceedings of the National Academy of Sciences USA, 91, 11452-11456.
20. E. Lund, U. Diczfalusy and I. Bjorkhem (1992). On the mechanism of oxidation of cholesterol at C-7 in a Hpoxygenase system, Journal of Biological Chemistry, 267, 12462-12467.
21. H. Esterbauer and P. Ramos (1995). Chemistry and pathophysiology of oxidation of LDL. Reviews in Physiology Biochemistry and Pharmacology, 127, 31-64.
22. K. Müller, S. J. Hardwick, C. E. Marchant, N. S. Law, G. Waeg, H. Esterbauer, K. L. H. Carpenter and M. J. Mitchinson (1996). Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages. Federation of the European Biochemical Society Letters 388, 165-168.
23. J. H. Braesen, U. Beisiegel and A. Niendorf (1995). Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbit. Virchows Archives, 426, 179-188.
24. K. F. Gey, P. Puska, P. Jordan and U. K. Moser (1991). Inverse correlation between plasma vitamin E and mortality from ischaemic heart disease in cross cultural epidemiology. American Journal of Clinical Nutrition, 53, 326-334.
25. N. G. Stephens, A. Parsons, P. M. Schofield, F. Kelly, K. H. Cheeseman, M. J. Mitchinson and M. J. Brown (1996). A randomized controlled trial of vitamin E in patients: The Cambridge Heart Antioxidant Study (CHAOS) Lancet, 347, 781-786.
26. C. E. Marchant, C. van der Veen, N. S. Law, S. J. Hardwick, K. L. H. Carpenter and M. J. Mitchinson (1996). Oxidation of low density lipoprotein by human monocyte-macrophages results in toxicity to the oxidizing culture. Free Radical Research, 24, 333-342.
27. C. Tejada, J. P. Strong, M. R. Montenegro, C. Restrepo and L. A. Solberg (1968). Distribution of coronary and aortic atherosclerosis by geography, race and sex. Laboratory Investigation, 18, 509-526.
28. H. Esterbauer, R. J. Schaur and H. Zollner (1991). Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radical Biology and Medicine, 11, 81-128.
29. H. Esterbauer, G. Jurgens, O. Quehenberger and E. Koller (1987). Autoxidation of human LDL: Loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. Journal of Lipid Research, 28, 495-509.
30. M. de Lorgeril, S. Renaud, N. Mamelle, P. Salen, J.-L. Martin, I. Monjaud, J. Guidollet, P. Touboul and J. Delaye (1994). Mediterranean α-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet, 343, 1454-1459.
31. M. Suzukawa, M. Abbey, P. R. C. Howe and P. J. Nestel (1995). Effects of fish oil fatty acids on low density lipoprotein size, oxidisability, and uptake by macrophages. Journal of Lipid Research, 36, 473-484.
32. K. L. H. Carpenter, K. H. Cheeseman, C. van der Veen, S. E. Taylor, M. K. Walker and M. J. Mitchinson (1995). Depletion of alpha-tocopherol in human atherosclerotic lesions. Free Radical Research, 23, 549-558.