Cerebellar grafts partially reverse amino acid receptor changes observed in the cerebellum of mice with hereditary ataxia: Quantitative autoradiographic studies

Cell Transplantation

Volumn 6, Issue 3, 1997, Pages 347-359

  Stasi, Kalliope ^b   Mitsacos, Adamantia ^b   Triarhou, Lazaros C ^a   Kouvelas, Elias D ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

3H CNQX; 3H Flunitrazepam; 3H Muscimol; Cerebellar graft; GABA(A) receptors; Hereditary cerebellar ataxia; Non NMDA receptors; pcd mutant mouse; Purkinje cells

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMINO ACID RECEPTOR; CLONAZEPAM; FLUNITRAZEPAM; GLUTAMINE; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN GRAFT; CEREBELLUM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; GRANULE CELL; HEREDITARY ATAXIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; AUTORADIOGRAPHY; BRAIN TISSUE TRANSPLANTATION; CEREBELLAR ATAXIA; CEREBELLAR NUCLEI; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FETAL TISSUE TRANSPLANTATION; FLUNITRAZEPAM; GABA AGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCIMOL; PREGNANCY; PURKINJE CELLS; RADIOLIGAND ASSAY; RECEPTORS, AMINO ACID; TRITIUM;

ANIMALIA; ATAXIA; EPICOCCUM;

EID: 0030946874     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0963-6897(97)00036-5     Document Type: Article

References (68)

1. Angelatou, F.; Mitsacos, A.; Goulas, V.; Kouvelas, E.D. L-Aspartate and L-glutamate binding sites in developing normal and 'nervous' mutant mouse cerebellum. Int. J. Dev. Neurosci. 5:373-381; 1987.
2. Björklund, A.; Lindvall, O.; Isacson, O.; Brundin, P.; Wictorin, K.; Strecker, R.E.; Clarke, D.J.; Dunnett, S.B. Mechanisms of action of intracerebral neural implants: Studies on nigral and striatal grafts to the lesioned striatum. Trends Neurosci. 10:509-516; 1987.
3. Bradley, P.; Berry, M. The Purkinje cell dendritic tree in mutant mouse cerebellum: A quantitative Golgi study of weaver and staggerer mice. Brain Res. 142:135-141; 1978.
4. Dawson, T.M.; Dawson, V.L.; Gage, F.H.; Fisher, L.J.; Hunt, M.A.; Wamsley, J.K. Functional recovery of supersensitive dopamine receptors after intrastriatal grafts of fetal substantia nigra. Exp. Neurol. 111:282-292; 1991.
5. Diener, H.C.; Dichgans, J. Pathophysiology of cerebellar ataxia. Movement Disord. 7:95-109; 1992.
6. Foster, A.C.; Fagg, G.E. Acidic amino acid binding sites in mammalian neuronal membranes: Their characteristics and relationship to synaptic receptors. Brain Res. Rev. 7:103-164; 1984.
7. Freed, W.J.; Ko, G.N.; Niehoff, D.L.; Kuhar, M.J.; Hoffer, B.J.; Olson, L.; Cannon-Spoor, E.; Morihisa, J.M.; Wyatt, R.J. Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra. Science 222:937-939; 1983.
8. A receptor messenger RNA expression in the deep cerebellar nuclei of Purkinje cell degeneration mutants is maintained following the loss of innervating Purkinje neurons. Neuroscience 52: 63-71; 1993.
9. Gardette, R.; Alvarado-Mallart, R.M.; Crepel, F.; Sotelo, C. Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of adult Purkinje cell degeneration mutant mouse. Neuroscience 24:777-789; 1988.
10. Gardette, R.; Crepel, F.; Alvarado-Mallart, R.M.; Sotelo, C. Fate of grafted embryonic Purkinje cells in the cerebellum of the adult "Purkinje cell degeneration" mutant mouse. II. Development of synaptic responses: An in vitro study. J. Comp. Neurol. 295:165-187; 1990.
11. Gasic, G.P.; Hollmann, M. Molecular neurobiology of glutamate receptors. Annu. Rev. Physiol. 54:507-536; 1992.
12. Ghetti, B.; Triarhou, L.C. The Purkinje cell degeneration mutant: A model to study the consequences of neuronal degeneration. In: Plaitakis, A., ed. Cerebellar degenerations: Clinical neurobiology. Boston: Kluwer Academic; 1992:159-181.
13. Green, M.C., ed. Genetic variants and strains of the laboratory mouse. Stuttgart: Gustav Fischer Verlag; 1981:185-186.
14. 3H]6-cyano-7-nitroquinoxaline-2,3-dione. J. Neurosci. Res. 37:392-397; 1994.
15. Hollmann, M.; O'Shea-Greenfield, A.; Rogers, S.W.; Heinemann, S. Cloning by functional expression of a member of the glutamate receptor family. Nature 342:643-648; 1989.
16. Hudson, D.B.; Valcana, T.; Bean, G.; Timiras, P.A. Glutamic acid: A strong candidate as the neurotransmitter of the cerebellar granule cell. Neurochem. Res. 1:73-81; 1976.
17. Kahle, G.; Kaulen, P.; Bruning, G.; Baumgarten H.G.; Grüsser-Cornehls, U. Autoradiographic analysis of benzodiazepine receptors in mutant mice with cerebellar defects. J. Chem. Neuroanat. 3:261-270; 1990.
18. 2 receptor binding in weaver mutant mice and effects of ventral mesencephalic grafts. Exp. Brain Res. 83:1-8; 1990.
19. Keinänen, K.; Wisden, W.; Sommer, B.; Werner, P.; Herb, A.; Verdoorn, T.A.; Sakmann, B.; Seeburg, P.H. A family of AMPA-selective glutamate receptors. Science 249:556-560; 1990.
20. Kouvelas, E.D.; Mitsacos, A.; Angelatou, F.; Hatziefthimiou, A.; Tsiotos, P.; Voukelatou, G. Glutamate receptors in mammalian cerebellum: Alterations in human ataxic disorders and cerebellar mutant mice. In: Plaitakis, A., ed. Cerebellar degenerations: Clinical neurobiology. Boston: Kluwer Academic; 1992:123-137.
21. Landis, D.M.D.; Reese, T.S. Structure of the Purkinje cell membrane in staggerer and weaver mutant mice. J. Comp. Neurol. 171:247-260; 1977.
22. Landis, D.M.D.; Sidman, R.L. Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J. Comp. Neurol. 179:831-863; 1978.
23. Landis, S.C.; Mullen, R.J. The development and degeneration of Purkinje cells in pcd mutant mice. J. Comp. Neurol. 177:125-144; 1978.
24. Lehmann, A. Atlas stéréotaxique du cerveau de la souris. Paris: Éditions du Centre National de la Recherche Scientifique; 1974.
25. 2 subunit gene expression in developing normal and mutant mouse cerebellum. Mol. Brain Res. 19:9-21; 1993.
26. Makowiec, R.L.; Cha, J.J.; Penney, J.B.; Young, A.B. Cerebellar excitatory amino acid binding sites in normal, granuloprival, and Purkinje cell-deficient mice. Neuroscience 42:671-681; 1991.
27. Monaghan, D.T.; Bridges, R.J.; Cotman, C.W. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:365-402; 1989.
28. Mullen, R.J. Site of pcd gene action and Purkinje cell mosaicism in the cerebella of chimaeric mice. Nature 270: 245-247; 1977.
29. Mullen, R.J.; Eicher, E.M.; Sidman, R.L. Purkinje cell degeneration, a new neurological mutation in the mouse. Proc. Natl. Acad. Sci. USA 73:208-212; 1976.
30. 3H]AMPA binding sites. J. Neurochem. 54:686-695; 1990.
31. Obata, K. GABA in Purkinje cells and motoneurons. Experientia 25:1285; 1969.
32. Ohishi, H.; Shigemoto, R.; Nakanishi, S.; Mizuno, N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study. J. Comp. Neurol. 335:252-266; 1993.
33. Palacios, J.M.; Mengod, G.; Vilaró, M.T.; Ramm, P. Recent trends in receptor analysis techniques and instrumentation. J. Chem. Neuroanat. 4:343-353; 1991.
34. Petralia, R.S.; Wenthold, R.J. Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J. Comp. Neurol. 318:329-354; 1992.
35. Rotter, A.; Frostholm, A. Cerebellar benzodiazepine receptor distribution: An autoradiographic study of the normal C57BL/6J and Purkinje cell degeneration mutant mouse. Neurosci. Lett. 71:66-71; 1986.
36. Rotter, A.; Frostholm, A. Cerebellar benzodiazepine receptors: Cellular localization and consequences of neurological mutations in mice. Brain Res. 444:133-146; 1988.
37. Rotter, A.; Gorenstein, C.; Frostholm, A. The localization of GABAA receptors in mice with mutations affecting the structure and connectivity of the cerebellum. Brain Res. 439:236-248; 1988.
38. Ryo, Y.; Miyawaki, A.; Furuichi, T.; Mikoshiba, K. Immunohistochemical localization of metabotropic and ionotropic glutamate receptors in the mouse brain. Ann. NY Acad. Sci. 707:554-556; 1993.
39. Ryo, Y.; Miyawaki, A.; Furuichi, T.; Mikoshiba, K. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J. Neurosci. Res. 36:19-32; 1993.
40. 2 receptor densities caused by 6-hydroxydopamine lesion of the nigrostriatal pathway in rats: An autoradiographic study. Neuroscience 46:729-738; 1991.
41. Sax, D.S.; Hirano, A.; Shofer, R.J. Staggerer, a neurological murine mutant: An electron microscopic study of the cerebellar cortex in the adult. Neurology 18:1093-1100; 1968.
42. Sidman, R.L.; Green, M.C. Nervous, a new mutant mouse with cerebellar disease. In: Sabourdy, M., ed. Les mutants pathologiques chez l' animal. Paris: Editions du Centre National de la Recherche Scientifique; 1970:69-79.
43. Sidman, R.L.; Lane, P.W.; Dickie, M.M. Staggerer, a new mutation in the mouse affecting the cerebellum. Science 137:610-612; 1962.
44. Sommer, B.; Seeburg, P.H. Glutamate receptor channels: novel properties and new clones. Trends Pharmacol. Sci. 13:291-296; 1992.
45. Sotelo, C. Dendritic abnormalities of Purkinje cells in the cerebellum of neurologic mutant mice (weaver and staggerer). Adv. Neurol. 12:335-351; 1975.
46. Sotelo, C.; Alvarado-Mallart, R.M. Growth and differentiation of cerebellar suspensions transplanted into the adult cerebellum of mice with heredodegenerative ataxia. Proc. Natl. Acad. Sci. USA 83:1135-1139; 1986.
47. Sotelo, C.; Alvarado-Mallart, R.M. Reconstruction of the defective cerebellar citrcuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants. Neuroscience 20:1-22; 1987.
48. Sotelo, C.; Alvarado-Mallart, R.M. Embryonic and adult neurons interact to allow Purkinje cell replacement in mutant cerebellum. Nature 327:421-423; 1987.
49. Sotelo, C.; Alvarado-Mallart, R.M. The reconstruction of cerebellar circuits. Trends Neurosci. 14:350-355; 1991.
50. Sotelo, C.; Alvarado-Mallart, R.M.; Gardette, R.; Crepel, F. The fate of grafted embryonic Purkinje cells in the cerebellum of the adult "Purkinje cell degeneration" mutant mouse. I. Development of reciprocal graft-host interactions. J. Comp. Neurol. 295:165-187; 1990.
51. Sotelo, C.; Changeux, J.-P. Transsynaptic degeneration 'en cascade' in the cerebellar cortex of staggerer mutant mice. Brain Res. 67:519-526; 1974.
52. Sternberger, L.A.; Hardy, P.H., Jr.; Cuculis, J.J.; Meyer, H.G. The unlabeled antibody-enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J. Histochem. Cytochem. 18:315-333; 1970.
53. Triarhou, L.C. The cerebellar model of neural grafting: Structural integration and functional recovery. Brain Res. Bull. 39:127-138; 1996.
54. Triarhou, L.C.; Low, W.C.; Ghetti, B. Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat. Embryol. 176:145-154; 1987.
55. Triarhou, L.C.; Low, W.C.; Ghetti, B. Intraparenchymal grafting of cerebellar cell suspensions to the deep cerebellar nuclei of pcd mutant mice, with particular emphasis on reestablishment of a Purkinje cell cortico-nuclear projection. Anat. Embryol. 185:409-420; 1992.
56. Triarhou, L.C.; Low, W.C.; Ghetti, B. Serotonin fiber innervation of cerebellar cell suspensions intraparenchymally grafted to the cerebellum of pcd mutant mice. Neurochem. Res. 17:475-482; 1992.
57. Triarhou, L.C., Solà, C.; Mengod, G.; García-Ladona, F.J.; Landwehrmeyer, B.; Ghetti, B.; Palacios, J.M. Ventral mesencephalic grafts in the neostriatum of the weaver mutant mouse: Structural molecule and receptor studies. Cell Transplant. 4:39-48; 1995.
58. Triarhou, L.C.; Zhang, W.; Lee, W.-H. Graft-induced restoration of function in hereditary cerebellar ataxia. Neuroreport 6:1827-1832; 1995.
59. Triarhou, L.C.; Zhang, W.; Lee, W.-H. Amelioration of the behavioral phenotype in genetically ataxic mice through bilateral intracerebellar grafting of fetal Purkinje cells. Cell Transplant. 5:269-277; 1996.
60. Vaccarino, F.M.; Ghetti, B.; Nurnberger, J.I. Residual benzodiazepine binding in the cortex of pcd mutant cerebella and qualitative binding in the deep cerebellar nuclei of control and mutant mice: An autoradiographic study. Brain Res. 343:70-78; 1985.
61. Wamsley, J.K.; Palacios, J.M. Amino acid and benzodiazepine receptors. In: Björklund, A.; Hökfelt, T.; Kuhar, M.J., eds. Handbook of chemical neuroanatomy, vol. 3: Classical transmitters and transmitter receptors in the CNS, part II. Amsterdam: Elsevier Science Publishers BV; 1984: 352-385.
62. Wenthold, R.J.; Hunter, C.; Wada, K.; Dechesne, C.J. Antibodies to a C-terminal peptide of the rat brain glutamate receptor subunit, GluR-A, recognize a subpopulation of AMPA binding sites but not kainate sites. FEBS Lett. 276: 147-150; 1990.
63. Wenthold, R.J.; Yokotani, N.; Doi, K.; Wada, K. Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies: Evidence for a hetero-oligomeric structure in rat brain. J. Biol. Chem. 267:501-507; 1992.
64. Yoon, C.H. Developmental mechanism for changes in cerebellum of 'staggerer' mouse, a neurological mutant of genetic origin. Neurology 22:743-754; 1972.
65. Yoon, C.H. Pleiotropic effect of the staggerer gene. Brain Res. 109:206-215; 1976.
66. 3H]6-cyano-7-nitroquinoxaline-2,3-dione binding sites in adult chick brain. Neuroscience 63:955-962; 1994.
67. 3H]flunitrazepam binding sites during postnatal development of the mouse cerebellum. Dev. Brain Res. 61:63-71; 1991.
68. Zhang, W.; Lee, W.-H.; Triarhou, L.C. Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. Nature Med. 2:65-71; 1996.