Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function

Nature Medicine

Volumn 2, Issue 1, 1996, Pages 65-71

  Zhang, Wei ^a   Lee, Wei Hua ^a   Triarhou, Lazaros C ^b,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MS A128 ^*  (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN GRAFT; CONTROLLED STUDY; GENE EXPRESSION; HEREDITARY ATAXIA; MOUSE; NONHUMAN; OLIVOPONTOCEREBELLAR ATROPHY; PRIORITY JOURNAL;

ANIMALS; BRAIN TISSUE TRANSPLANTATION; CEREBELLAR ATAXIA; CEREBELLUM; FETAL TISSUE TRANSPLANTATION; FUNCTIONAL LATERALITY; GENE EXPRESSION; GRAFT SURVIVAL; HUMANS; IN SITU HYBRIDIZATION; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; MOTOR ACTIVITY; NERVE DEGENERATION; PURKINJE CELLS; RNA, MESSENGER; SPINOCEREBELLAR DEGENERATIONS;

ANIMALIA; ATAXIA;

EID: 0030066723     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0196-65     Document Type: Article

References (12)

1. Harding, A.E. Clinical features and classification of inherited ataxias. in Inherited Ataxias (eds. Harding, A.E. & Deufel, T.) 1-14 (Raven, New York, 1993).
2. Holmes, G. A form of familial degeneration of the cerebellum. Brain 30, 467-489 (1907).
3. Poirier, J., Gray, F. & Escourolle, R. Manual of Basic Neuropathology 151-157 (Saunders, Philadelphia, 1990).
4. Mullen, R.J., Eicher, E.M. & Sidman, R.L. Purkinje cell degeneration, a new neurological mutation in the mouse. Proc. Natl. Acad. Sci. USA 73, 208-212 (1976).
5. Landis, S.C. & Mullen, R.J. The development and degeneration of Purkinje cells in pcd mutant mice. J. Comp. Neurol. 177, 125-144 (1978).
6. Ghetti, B. & Triarhou, L.C. The Purkinje cell degeneration mutant: A model to study the consequences of neuronal degeneration, in Cerebellar Degenerations: Clinical Neurobiology (ed. Plaitakis, A.) 159-181 (Kluwer Academic, Boston, 1992).
7. Dunnett, S.B. & Björklund, A. (eds.) Functional Neural Transplantation (Raven, New York, 1994).
8. Das, G.D. & Altman, J. Transplanted precursors of nerve cells: Their fate in the cerebella of young rats. Science 173, 637-638 (1971).
9. Wells, J. & McAllister, J.P. The development of cerebellar primordia trans-planted to the neocortex of the rat. Dev. Brain Res. 4, 167-179 (1982).
10. Alvarado-Mallart, R.M. & Sotelo, C. Differentiation of cerebellar anlage heterotopically transplanted to adult rat brain: A light and electron microscopic study. J. Comp. Neurol. 212, 247-267 (1982).
11. Sotelo, C. & Alvarado-Mallart, R.-M. Growth and differentiation of cerebellar suspensions transplanted into the adult cerebellum of mice with heredodegenerative ataxia. Proc. Natl. Acad. Sci. USA 83, 1135-1139 (1986).
12. Triarhou, L.C., Low, W.C. & Ghetti, B. Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat. Embryol. 176, 145-154 (1987).