Is strong hydrogen bonding in the transition state enough to account for the observed rate acceleration in a mutant of papain?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 9, 1997, Pages 4285-4288

  Zheng, Ya Jun ^a   Bruice, Thomas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cysteine protease; enzyme catalysis; nitrile hydratase; transition state stabilization

Indexed keywords

CYSTEINE PROTEINASE; HYDROLASE; PAPAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME CONFORMATION; ENZYME STABILITY; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CYSTEINE PROTEINASE INHIBITORS; HYDROGEN BONDING; HYDROLYSIS; MODELS, CHEMICAL; MUTATION; NITRILES; PAPAIN;

EID: 0030940114     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.9.4285     Document Type: Article

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