The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep

Anesthesiology

Volumn 86, Issue 6, 1997, Pages 1317-1325

  Upton, Richard N ^a   Ludbrook, Guy L ^a   Gray, Elke C ^a   Granf, Clifford ^a  

^a NONE

Author keywords

Brain; Meperidine; Pharmacokinetics: alfentanil; modelling

Indexed keywords

ALFENTANIL; PETHIDINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN BLOOD FLOW; CONSCIOUSNESS; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; FEMALE; NONHUMAN; PRIORITY JOURNAL; SHEEP;

ALFENTANIL; ANALGESICS, OPIOID; ANIMALS; BODY FLUID COMPARTMENTS; BRAIN; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; CONSCIOUSNESS; FEMALE; MEPERIDINE; MODELS, BIOLOGICAL; OXYGEN; SHEEP;

EID: 0030939279     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199706000-00013     Document Type: Article

References (32)

1. Scott JC, Ponganis KV, Stanski DR: EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. ANESTHESIOLOGY 1985; 62:234-41
2. Qiao GL, Fung KF: Pharmacokinetic-pharmacodynamic modelling of meperidine in goats (II): modelling. J Vet Pharmacol Ther 1994; 17:127-34
3. Gardmark M, Ekhlom M, Bouw R, Hammarlund-Udenaes M: Quantitation of effect delay and acute tolerance development to morphine in the rat. J Pharmacol Exp Ther 1993; 267:1061-7
4. Hug CC: Lipid solubility, pharmacokinetics and the EEG: Are you better off today than you were four years ago? [Editorial] ANESTHESIOLOGy 1985; 62:221-6
5. Stanski DR: Narcotic pharmacokinetics and dynamics: the basis of infusion applications. Anaesth Intensive Care 1987; 15:23-6
6. Runciman WB, Upton RN: Pharmacokinetics and pharmacodynamics - What is of value to anaesthetists? Anaesth Pharmacol Rev 1994; 2:280-93
7. Bjorkman S, Wada DR, Stanski DR, Ebling WF: Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single tissue models. J Pharmacokinet Biopharm 1994; 22:381-10
8. Bjorkman S, Stanski DR, Harashima II, Dowrie R, Harapat SR, Wada DR, Ebling WF: Tissue distribution of fentanyl and alfentanil cannot be described by a blood flow limited model. J Pharmacokinet Biopharm 1994; 21:255-79
9. Davis NR, Mapleson WW: A physiological model for the distribution of injected agents, with special reference to meperidine. Br J Anaesth 1993; 70:248-58
10. Ebling WF, Wada DR, Stanski DR: From piecewise to full physiologic modeling: applied to thiopentone disposition in the rat. J Pharmacokinet Biopharm 1994; 22:259-92
11. Upton RN, Ludbrook GL, Grant C, Gray EC: In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration. J Pharmacokin Biopharm 1996; 24:1-18
12. Ludbrook GL, Upton RN, Grant C, Gray EC: The blood and brain concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects. Anaesth Intensive Care 1996; 24:445-52
13. Upton RN, Grant C, Ludbrook GL: An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. J Cereb Blood Flow Metab 1994; 14:680-8
14. Wood M: Opioid agonists and antagonists, Drugs and Anesthesia - Pharmacology for Anesthesiologists. Edited by Wood M, Wood AJJ. Baltimore, Williams and Wilkins, 1990, pp. 129-78
15. Lindsay DB, Setchell BP: Cannulation of the sagittal sinus for the determination of cerebral ketone body metabolism in sheep. J Physiol 1972; 226:51P
16. Hales JRS: Chronic catheterization for sampling venous blood from the brain of sheep. Pflugers Arch 1972; 337:81-5
17. Runciman WB, Ilsley AH, Mather LE, Carapetis RJ, Rao MM: A sheep preparation for studying interactions between blood flow and drug disposition I: Physiological profile. Br J Anaesth 1984; 56:1015-28
18. Livingston A, Acevedo MEG, Kyles A, Waterman A: The effects of droperidol on fentanyl induced dysphoria in the sheep. Acta Vet Scand Syppl 1991; 87:170-2
19. Haywood JR, Shaffer RA, Fastenow C, Fink GO, Brody MJ: Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am J Physiol 1981; 241H:273-8
20. Mather LE, Tucker GT: Meperidine and other basic drugs: general method for their determination in plasma. J Pharm Sci 1974; 63:306-7
21. Kumar K, Morgan DJ, Crankshaw DP: Determination of fentanyl and alfentanil in plasma by high performance liquid chromatography with ultraviolet detection. J Chromatog (Biomed Appl) 1987; 419:464-8
22. Altman PL, Oittmer DS: Biological handbooks - respiration and circulation. Bethesda, MD, Federation of American Societies for Experimental Biology, 1971, pp. 383-5
23. Intaglietta M, Johnson PC: Principles of capillary exchange, Peripheral Circulation. Edited by Johnson PC. New York, Wiley, 1978, pp. 141-66
24. 2 uptake in hypoxia. Respir Physiol 1981; 46:193-208
25. Shipley RA, Clark RE: Tracer methods for in vivo kinetics, Theory and Applications. New York, Academic Press, 1972, pp. 111-27
26. Hecker JF: The sheep as an experimental animal. London, Academic Press, 1983
27. Wilkinson GR: Plasma and tissue binding considerations in drug disposition. Drug Metabolism Reviews 1983; 14:427-65
28. Diaz-Garcia JM, Evans AM, Rowland M: Application of the axial dispersion model of hepatic drug elimination in the kinetics of diazepam in the isolated perfused rat liver. J Pharmacokinet Biopharm 1992; 20:171-93
29. Bjorkman S, Akeson J, Nilsson F, Messeter K, Roth B: Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: an application of mass balance pharmacokinetics with a changing regional blood flow. J Pharmacokinet Biopharm 1992; 6:637-52
30. Milde LN, Milde JH, Gallagher WJ: Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg 1990; 70:138-46
31. Marx W, Shah N, Long C: Sufentanil, alfentanil and fentanyl: impact on cerebrospinal fluid pressure in patients with brain tumours. J Neurosurg Anesth 1989; 1:3-7
32. Herrick IA, Gelg AW, Manninen PH, Reichman H, Lownie S: Effects of fentanyl, sufentanil, and alfentanil on brain retractor pressure. Anesth Analg 1991; 72:359-63