Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure

Cardiovascular Drugs and Therapy

Volumn 10, Issue 6, 1997, Pages 735-742

  Thadani, Udho ^a,b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Heart failure; Nitrate tolerance; Rebound; Stable angina pectoris; Unstable angina

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLYCERYL TRINITRATE; HYDRALAZINE; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; MEMBRANE RECEPTOR; NEUROHORMONE; NITRATE; NITRIC OXIDE; OXYGEN RADICAL; THIOL GROUP; THIOL REAGENT;

ANGINA PECTORIS; CLINICAL TRIAL; DRUG EFFECT; DRUG FORMULATION; DRUG TOLERANCE; EXERCISE; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MEDICAL DECISION MAKING; NONHUMAN; PRIORITY JOURNAL; REBOUND; RECEPTOR DOWN REGULATION; REVIEW; SLOW RELEASE FORMULATION; SURVIVAL; UNSTABLE ANGINA PECTORIS;

EID: 0030937905     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00053031     Document Type: Review

References (65)

1. Thadani U, Whitsett T, Hamilton SF. Nitrate therapy for myocardial ischemic syndromes: Current perspectives including tolerance. Curr Prob Cardiol 1988;13:725-784.
2. Schwartz AM. The cause, relief and prevention of headaches arising from contact with dynamite. N Engl J Med 1946;235:651.
3. Stewart DD. Tolerance to nitroglycerin. JAMA 1910;54: 783.
4. Bogaert MA, DeSchaepdryver AF. Tolerance towards glyceryl trinitrate (Trinitrin) in dogs. Arch Int Pharmacodyn Ther 1968;171:221-224.
5. Needleman P. Tolerance to the vascular effects of glyceryl trinitrin. J Pharmacol Exp Ther 1970;171:98-102.
6. Crandall LA, Leake CD, Loevenhart AS, et al. Acquired tolerance to and cross tolerance between the nitrates and nitric oxide esters and sodium nitrate in man. J Pharmacol Exp Ther 1981;41:103-119.
7. Schelling JL, Lasagne L. A study of cross tolerance to circulatory effects of organinitrates. Clin Pharmacol Ther 1967;8:256-260.
8. Thadani U, Manyari D, Parker JO, et al. Tolerance to the circulatory effects of oral isosorbide dinitrate: Rate of development and cross tolerance to glyceryl trinitrate. Circulation 1980;61:526-535.
9. Abrams J. Nitrate tolerance and dependence. Am Heart J 1980;99:113-123.
10. Abrams J. Nitroglycerin and long-acting nitrates in clinical practice. Am J Med 1983;74:85-94.
11. Thadani U, Fung HL, Darke AC, et al. Oral isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy. Am J Cardiol 1982;49:411-419.
12. Rudolph W, Blasini R, Reinger G, et al. Tolerance development during dinitrate treatment: Can it be circumvented? Z Kardiol 1983;72(Suppl 3):195-198.
13. Steering Committee; Transdermal Nitroglycerin Cooperative Study. Acute and chronic antianginal efficacy of continuous 24-hour application of transdermal nitroglycerin. Am J Cardiol 1991;63:1263-1273.
14. Thadani U, Lipicky RJ. Short and long-acting nitrates for stable angina pectoris. Cardiovasc Drugs Ther 1994;8: 611-623.
15. Thadani U, Lipicky RJ. Ointments and transdermal nitroglycerin patches for stable angina pectoris. Cardiovasc Drugs Ther 1994;8:625-633.
16. Thadani U, Sharma M, Thompson D, et al. Intravenous nitroglycerin and tolerance in unstable angina (abstr). Circulation 1987;76:(Suppl IV):IV128.
17. Curfman GD, Heinsimer JA, Lozner EC, et al. Intravenous nitroglycerin in the treatment of spontaneous angina pectoris: A prospective, randomized trial. Circulation 1983;67: 276-283.
18. Thadani, U, Opie LH. Nitrates for unstable angina. Cardiovasc Drugs Ther 1994;8:719-726.
19. Packer M, Lee WH, Kessler PD, et al. Prevention and reversal of nitrate tolerance in patients with congestive heart failure. N Engl J Med 1987;317:799-804.
20. Dupuis J, Lalonde G, Lemieux R, et al. Tolerance to intravenous nitroglycerin in patients with congestive heart failure: Role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. J Am Coll Cardiol 1990;16:923-931.
21. Elkayam U. Tolerance to organic nitrates: Evidence, mechanisms, clinical evidence and strategies for prevention. Ann Intern Med 1991;114:667-677.
22. Morton WE. Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension. J Occup Med 1977;19:197-199.
23. Klock JC. Nonocclusive coronary disease after chronic exposure to nitrates for physiologic nitrate dependence. Am Heart J 1975;89:510.
24. Demots H, Glasser SP, and the Transderm Nitro Study Group. Intermittent nitroglycerin therapy in treatment of stable angina. J Am Coll Cardiol 1989;13:786-793.
25. Ahlner J, Andersson RCG, Torfgard K, Axelsson KL. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol Rev 1991;43:351-423.
26. Fung H-L, Bauer JA. Mechanisms of nitrate tolerance. Cardiovasc Drugs Ther 1994;8:489-499.
27. Kowaluk E, Hough K, Fung H-L. Effect of intermittent exposure and drug-free intervals on the in vitro vascular tolerance to nitroglycerin. Life Sci 1989;44:1157-1163.
28. Needleman P, Johnson EM Jr. Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 1973; 184:709-715.
29. Fung H-L, Chong S, Kowaluk E. Mechanisms of nitrate action and vascular tolerance. Eur Heart J 1989;10 (Suppl. A):2-6.
30. Münzel T, Sayegh H, Freeman BA, et al. Evidence for enhanced vascular super oxide anion production in nitrate tolerance: A novel mechanism of tolerance and cross tolerance. J Clin Invest 1995;95:187-194.
31. Lam JY, Chesebro JH, Fuster V. Platelets, vasoconstriction and nitroglycerin during arterial wall injury. A new antithrombotic role of an old drug. Circulation 1988;78: 712-716.
32. Folts JD, Stamler J, Loscalzo J. Intravenous nitroglyerin infusion inhibits cyclic flow response caused by periodic platelet thrombus formation in stenosed coronary arteries. Circulation 1991;83:2122-2127.
33. Diodati, Theroux P, Latour J-G, et al. Effects of nitroglycerin at therapeutic doses on platelet aggregation: Unstable angina and acute myocardial infarction. Am J Cardiol 1990; 66:683-688.
34. Zelis R, Mason DT. Isosorbide dinitrate: Effects on the vasodilator response to nitroglycerin. JAMA 1975;234: 166-170.
35. Manyari DE, Smith ER, Spragg J. Isosorbide dinitrate and glyceryl trinitrate: Demonstration of cross tolerance in the capacitance vessels. Am J Cardiol 1985;55:927-931.
36. Ghio S, Deservi S, Perotti S, et al. Differential susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans: Effects of N-acetylcysteine administration. Circulation 1992;86:798-802.
37. Makhoul N, Dakak N, Flugelman MY, et al. Nitrate tolerance in heart failure - differential venous, pulmonary and systemic arterial effects. Am J Cardiol 1990;65:J28-J32.
38. Leier CV, Huss P, Magorien RD, Unverferth DV. Improved exercise capacity and differing arterial and venous tolerance during chronic isosorbide dinitrate therapy for congestive heart failure. Circulation 1983;67:817-822.
39. Steward DJ, Elsner D, Sommer O, Holtz J, Bassange E. Altered spectrum of nitroglycerin action in long-term treatment: Nitroglycerin specific venous tolerance with maintenance of arterial vasodepressor potency. Circulation 1986; 74:573-582.
40. Jeserich M, Münzel T, Pape L, et al. Absence of vascular tolerance in conductance vessels after 48 hours intravenous nitroglycerin in patients with coronary artery disease. Am J Coll Cardiol 1995;26:50-56.
41. Münzel T, Heitzer T, Kurzs, et al. Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease. J Am Coll Cardiol 1996;27:297-303.
42. Kai H, Yamamoto H, Nomo H, et al. Effects of continuous intravenous infusion of isosorbide dinitrate on development of tolerance to vasodilating action in human epicardial coronary arteries. Am Heart J 1994;128:230-236.
43. Zimrin D, Reichek M, Bogin KT, et al. Antianginal effects of intravenous nitroglycerin over 24 hours. Circulation 1988;77:1376-1384.
44. Parker JO, Fung HL. Transdermal nitroglycerin in angina pectoris. Am J Cardiol 1984;54:471-476.
45. Scardi S, Camareni F, Pandullo G, et al. Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort induced angina pectoris: A multicenter study. Int J Cardiol 1991;32:241-248.
46. Bassan MM. The day long pattern of antianginal effect of long term three times daily administration of isosorbide dinitrate. J Am Coll Cardiol 1990;16:936-940.
47. Thadani U, Fung HL, Darke AC, et al. Oral isosorbide dinitrate in the treatment of angina pectoris: Dose-response relationship and duration of action during acute therapy. Circulation 1980;62:491-502.
48. Parker JO, Farrell B, Lahey KA, et al. Effect of interval between doses on the development of tolerance to isosorbide dinitrate. N Engl J Med 1987;816:1440-1444.
49. Tauchert M, Jansen W, Osterspey A, et al. Dose dependence of tolerance during treatment with mononitrates. Z Kardiol 1983;73(Suppl 3):218-228.
50. Parker JO, Farrell LB, Lahey KA, et al. Nitrate tolerance: The lack of effect of N-acetylcysteine. Circulation 1987;76: 572-576.
51. Dakak N, Makhoul N, Flugelman MY, et al. Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease. Am J Cardiol 1990;66:608-612.
52. Parker JO, Farrell B, Fenton T, et al. Effects of diuretic therapy on the development of tolerance during continuous therapy with nitroglycerin. J Am Coll Cardiol 1992;20: 616-620.
53. Seth P, Fung HL. Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells. Biochem Pharmacol 1993;46:1481-1486.
54. Thadani U, Opie LH. Nitrates. In: Opie LH, ed. Drugs for the Heart, 4th ed. Philadelphia: WB Saunders, 1995:31-48.
55. Thadani U, Maranda C, Amsterdam E, et al. Lack of pharmacologic tolerance and rebound angina pectoris during twice daily therapy with isosorbide-5-mononitrate. Ann Intern Med 1994;120:353-359.
56. Parker JO and the Isosorbide-5-mononitrate Study Group. Eccentric dosing with isosorbide-5-mononitrate in angina pectoris. Am J Cardiol 1993;72:871-876.
57. Chrysant SG, Glasser SP, Bittar N, et al. Efficacy and safety of extended release isosorbide mononitrate for stable effort angina pectoris. Am J Cardiol 1993;72:1249-1256.
58. Thadani U, Bittar N. Effects of 8:00 am and 2:00 pm doses of isosorbide-5-mononitrate during twice daily therapy in stable angina pectoris. Am J Cardiol 1992;70:286-292.
59. Davis MJ, Thomas AC. Plaque fissuring - the cause of acute myocardial infarction, sudden ischemic death, and crescendo angina. Br Heart J 1985;53:363-373.
60. Fuster V, Chesebro JH. Mechanisms of unstable angina. N Engl J Med 1986;315:1023-1025.
61. Cohn JN, Archibald D, Ziesche S, et al. Effect of vasodilator therapy on mortality in chronic heart failure. Results of a Veterans Administration Cooperative Study (V-Heft) N Eng J Med 1986;314:1547-1552.
62. Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine - isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303-310.
63. Bauer JA, Fung H-L. Concurrent administration of hydralazine prevents nitroglycerin-induced hemodynamic tolerance in experimental heart failure. Circulation 1991;84: 35-39.
64. Gogia H, Mehra A, Parikh S, et al. Prevention of tolerance to hemodynamic effects of nitrates with concomitant use of hydralazine in patients with chronic heart failure. J Am Coll Cardiol 1995.
65. Holdright DR, Katz RJ, Wright CA, et al. Lack of rebound during intermittent transdermal treatment with glyceryl trinitrate in patients with stable angina on background β blocker. Br Heart J 1993;69:223-227.