Correlation of selective modifications to a 2',5'-oligoadenylate-3',5'- deoxyribonucleotide antisense chimera with affinity for the target nucleic acid and with ability to activate RNase L

Journal of Medicinal Chemistry

Volumn 40, Issue 8, 1997, Pages 1195-1200

  Xiao, Wei ^a   Li, Guiying ^a   Maitra, Ratan K ^b   Maran, Avudaiappan ^b   Silverman, Robert H ^b   Torrence, Paul F ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ANTISENSE OLIGONUCLEOTIDE; RIBONUCLEASE; RNA;

ARTICLE; BASE MISPAIRING; CHIMERA; ENZYME LOCALIZATION; ENZYME STRUCTURE; GENE EXPRESSION REGULATION; NUCLEIC ACID BASE SUBSTITUTION; RNA DEGRADATION; RNA SEQUENCE;

ADENINE NUCLEOTIDES; EIF-2 KINASE; ENDORIBONUCLEASES; ENZYME ACTIVATION; HELA CELLS; HUMANS; NUCLEIC ACID HETERODUPLEXES; OLIGONUCLEOTIDES, ANTISENSE; OLIGORIBONUCLEOTIDES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES;

EID: 0030937421     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960748l     Document Type: Article

References (22)

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