Synthesis and characterization of composite nucleic acids containing 2',5'-oligoriboadenylate linked to antisense DNA

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 4, 1996, Pages 247-258

  Xiao, Wei ^a   Player, Mark R ^a   Li, Guiying ^a   Zhang, Weiteng ^a   Lesiak, Krystyna ^a   Torrence, Paul F ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLIC ACID; COMPLEMENTARY DNA; HYDROLASE; NUCLEASE; NUCLEIC ACID; PHOSPHODIESTERASE I; PHOSPHORAMIDIC ACID DERIVATIVE; SNAKE VENOM;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; DNA PURIFICATION; DRUG SYNTHESIS; GEL ELECTROPHORESIS; HYDROLYSIS; ION PAIR CHROMATOGRAPHY; METHODOLOGY; NUCLEIC ACID SYNTHESIS; NUCLEOTIDE SEQUENCE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0030475052     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.247     Document Type: Article

References (5)

1. n A-binding protein and interferon-related enzymes in animals, plants and lower animal organisms. Biochem. Biophys. Res. Commun. 108, 1243-1250.
2. CHEBATH, J., BENECH, P., REVEL, M.. and VIGNERON, M. (1987). Constitutive expression of (2′-5′)oligo A synthetase confers resistance to picomavirus infection. Nature 330, 587-588.
3. ETIENNE-SMEKENS, M., VANDENBUSSCHE, P., CONTENT, J., and DUMONT, J.E. (1983). (2′-5′)Oligoadenylate in rat liver: Modulation after partial hepatectomy. Proc. Natl. Acad. Sci. USA 80, 4609-4613.
4. JANIK, B. (1971). Physicochemical Characteristics of Oligonucleotides and Polynucleotides. (IFI Plenum, New York), pp 33-96.
5. ZHOU, A., HASSEL, B.A., and SILVERMAN, R.H. (1993). Expression cloning of a 2-5A-dependent RNase: A uniquely regulated mediator of interferon action. Cell 72, 753-765.