A molecular switch of chemokine receptor selectivity: Chemical modification of the interleukin-8 Leu25 → Cys mutant

Journal of Biological Chemistry

Volumn 271, Issue 6, 1996, Pages 3148-3153

  Lusti Narasimhan, Manjula ^a   Chollet, André ^a   Power, Christine A ^a   Allet, Bernard ^a   Proudfoot, Amanda E I ^a   Wells, Timothy N C ^a  

^a GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CYSTEINE; CYTOKINE RECEPTOR; FLUORESCENT DYE; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; LEUCINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ARTICLE; CIRCULAR DICHROISM; DISULFIDE BOND; HUMAN; HUMAN CELL; MUTANT; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; RECEPTOR BINDING;

4-CHLORO-7-NITROBENZOFURAZAN; AMINO ACID SEQUENCE; ANTIGENS, CD; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CHEMOTAXIS, LEUKOCYTE; CLONING, MOLECULAR; CYSTEINE; DNA PRIMERS; HL-60 CELLS; HUMANS; INTERLEUKIN-8; LEUCINE; MOLECULAR SEQUENCE DATA; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; NEUTROPHILS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RANTES; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-8A; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0030020555     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.6.3148     Document Type: Article

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