Regulation of cholesterol synthesis: Of SCAP, SREBP, CBP and more

European Journal of Endocrinology

Volumn 136, Issue 3, 1997, Pages 271-272

  Meier, Christoph A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPOPROTEIN RECEPTOR;

CHOLESTEROL SYNTHESIS; HOMEOSTASIS; HUMAN; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0030932237     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1360271     Document Type: Short Survey

References (5)

1. Hua X, Nohturfft A, Goldstein JL & Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 1996 87 415-426.
2. Oliner JD, Andresen JM, Hansen SK, Zhou S & Tjian R. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes and Development 1996 10 2903-2911.
3. Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M et al. Rubinstein-taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 1995 376 348-351.
4. Kim JB & Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes and Development 1996 10 1096-1107.
5. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS & Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. Journal of Clinical Investigation 1996 98 1575-1584.