-
1
-
-
15844381714
-
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients
-
Aebischer, P., M. Schluep, N. Deglon, et al.: Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nature Med. 2 (1996) 696-699
-
(1996)
Nature Med.
, vol.2
, pp. 696-699
-
-
Aebischer, P.1
Schluep, M.2
Deglon, N.3
-
2
-
-
0345509278
-
Recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis (ALS) patients: Phase I-II safety, tolerability and pharmacokinetic studies
-
ALS CNTF Treatment Study (ACTS): Recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis (ALS) patients: Phase I-II safety, tolerability and pharmacokinetic studies (abstract). Neurology 43 (1993) A416
-
(1993)
Neurology
, vol.43
-
-
-
3
-
-
0028788303
-
A phase 1 study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis
-
ALS CNTF Treatment Study (ACTS): A phase 1 study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. Clin. Neuropharmacol. 18 (1995) 515-532
-
(1995)
Clin. Neuropharmacol.
, vol.18
, pp. 515-532
-
-
-
4
-
-
2442646665
-
A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
-
ALS CNTF Treatment Study (ACTS): A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. Neurology 46 (1996) 1244-1249
-
(1996)
Neurology
, vol.46
, pp. 1244-1249
-
-
-
5
-
-
0028883432
-
Neurotrophic factors in the therapy of peripheral neuropathy
-
Apfel, S. C., J. A. Kessler.: Neurotrophic factors in the therapy of peripheral neuropathy. Bailliere's Clin. Neurol. 4 (1995) 593-606
-
(1995)
Bailliere's Clin. Neurol.
, vol.4
, pp. 593-606
-
-
Apfel, S.C.1
Kessler, J.A.2
-
6
-
-
0025514410
-
Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: Comparison with other neurotrophic factors and cytokines
-
Arakawa, Y., M. Sendtner, H. Thoenen: Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci. 10 (1990) 3507-3515
-
(1990)
J. Neurosci.
, vol.10
, pp. 3507-3515
-
-
Arakawa, Y.1
Sendtner, M.2
Thoenen, H.3
-
7
-
-
0000337980
-
The BDNF Trial Group: A phase I/II study of recombinant human brain-derived neurotrophic factor in patients with amyotrophic lateral sclerosis
-
Bradley, W. G.: The BDNF Trial Group: A phase I/II study of recombinant human brain-derived neurotrophic factor in patients with amyotrophic lateral sclerosis. Ann. Neurol. 38 (1995) 971
-
(1995)
Ann. Neurol.
, vol.38
, pp. 971
-
-
Bradley, W.G.1
-
8
-
-
0025234804
-
Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors
-
Caroni, P., P. Grandes: Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors. J. Cell Biol. 110 (1990) 1307-1317
-
(1990)
J. Cell Biol.
, vol.110
, pp. 1307-1317
-
-
Caroni, P.1
Grandes, P.2
-
9
-
-
0029869593
-
Selective activation of NF- kappa B by nerve growth factor through the neurotrophin receptor p75
-
Carter, B. D., C. Kaltschmidt, B. Kaltschmidt et al.: Selective activation of NF- kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272 (1996) 542-545
-
(1996)
Science
, vol.272
, pp. 542-545
-
-
Carter, B.D.1
Kaltschmidt, C.2
Kaltschmidt, B.3
-
10
-
-
0007101117
-
Pharmacokinctics of intrathecally applied BDNF and effects on spinal motoneurons
-
Dittrich, F., G. Ochs, A. Grosse-Wilde et al.: Pharmacokinctics of intrathecally applied BDNF and effects on spinal motoneurons. Exp. Neurol. 141 (1996) 225-239
-
(1996)
Exp. Neurol.
, vol.141
, pp. 225-239
-
-
Dittrich, F.1
Ochs, G.2
Grosse-Wilde, A.3
-
11
-
-
0028137577
-
Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat
-
Dittrich, F., H. Thoenen, M. Sendtner: Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat. Ann. Neurol. 35 (1994) 151-163
-
(1994)
Ann. Neurol.
, vol.35
, pp. 151-163
-
-
Dittrich, F.1
Thoenen, H.2
Sendtner, M.3
-
12
-
-
0028291238
-
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
-
Ernfors, P., K. Lee, J. Kucera et al.: Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77 (1994) 503-512.
-
(1994)
Cell
, vol.77
, pp. 503-512
-
-
Ernfors, P.1
Lee, K.2
Kucera, J.3
-
13
-
-
0029978443
-
Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration
-
Galpern, W. R., D. M. Frim, S. B. Tatter et al.: Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplant 5 (1996) 225-232
-
(1996)
Cell Transplant
, vol.5
, pp. 225-232
-
-
Galpern, W.R.1
Frim, D.M.2
Tatter, S.B.3
-
14
-
-
0026667103
-
Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor
-
Gurney, M. E., H. Yamamoto, Y. Kwon: Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. J. Neurosci. 12 (1992) 3241-3247
-
(1992)
J. Neurosci.
, vol.12
, pp. 3241-3247
-
-
Gurney, M.E.1
Yamamoto, H.2
Kwon, Y.3
-
15
-
-
0028307157
-
Systemic administration of ciliary neurotrophic factor induces cachexia in rodents
-
Henderson, J. T., N. A. Seniuk, P. M. Richardson et al.: Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J. Clin. Invest. 93 (1994) 2632-2638
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 2632-2638
-
-
Henderson, J.T.1
Seniuk, N.A.2
Richardson, P.M.3
-
16
-
-
0027131764
-
Members of several gene families influence survival of rat motoneurons in vitro and in vivo
-
Hughes, R. A., M. Sendtner, H. Thoenen: Members of several gene families influence survival of rat motoneurons in vitro and in vivo. J. Neurosci. Res. 36 (1993) 663-671
-
(1993)
J. Neurosci. Res.
, vol.36
, pp. 663-671
-
-
Hughes, R.A.1
Sendtner, M.2
Thoenen, H.3
-
17
-
-
0028916844
-
Effects of brain-derived neurotrophic factor on motor dysfunction Wobbler mouse motor neuron disease
-
Ikeda, K., B. Klinkosz, T. Greene et al: Effects of brain-derived neurotrophic factor on motor dysfunction Wobbler mouse motor neuron disease. Ann. Neurol. 37 (1995) 505-511
-
(1995)
Ann. Neurol.
, vol.37
, pp. 505-511
-
-
Ikeda, K.1
Klinkosz, B.2
Greene, T.3
-
18
-
-
0029916808
-
Liposome-mediated BDNF cDNA transfer in intact and injured rat brain
-
Iwamoto, Y., K. Yang, G. L. Clifton et al.: Liposome-mediated BDNF cDNA transfer in intact and injured rat brain. Neuroreport 7 (1996) 609-612
-
(1996)
Neuroreport
, vol.7
, pp. 609-612
-
-
Iwamoto, Y.1
Yang, K.2
Clifton, G.L.3
-
19
-
-
0024391282
-
Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve
-
Kanje, M., A. Skottner, J. Sjoberg et al.: Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve. Brain Res. 486 (1989) 396-398
-
(1989)
Brain Res.
, vol.486
, pp. 396-398
-
-
Kanje, M.1
Skottner, A.2
Sjoberg, J.3
-
20
-
-
0011849128
-
A double-blind, placebo-controlled study of recombinant human insulin-like growth factor in the treatment of amyotrophic lateral sclerosis
-
Lai, E. C., K. Felice, B. W. Festoff et al.: A double-blind, placebo-controlled study of recombinant human insulin-like growth factor in the treatment of amyotrophic lateral sclerosis. Ann. Neurol. 38 (1995) 971
-
(1995)
Ann. Neurol.
, vol.38
, pp. 971
-
-
Lai, E.C.1
Felice, K.2
Festoff, B.W.3
-
21
-
-
0347686420
-
A double-blind, placebo-controlled therapeutic trial to assess the efficacy of recombinant human insulin-like growth hormone
-
Dublin
-
Lange, D. J., K. J. Felice, M. J. Grewal et al.: A double-blind, placebo-controlled therapeutic trial to assess the efficacy of recombinant human insulin-like growth hormone (abstract). 6th International Symposium on ALS/MND, Dublin 30.10.-1.11.1995
-
(1995)
6th International Symposium on ALS/MND
, pp. 3010-3111
-
-
Lange, D.J.1
Felice, K.J.2
Grewal, M.J.3
-
22
-
-
0026462896
-
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
-
LaVail, M. M., K. Unoki, D. Yasumura et al.: Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. USA 89 (1992) 11249-11253
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11249-11253
-
-
Lavail, M.M.1
Unoki, K.2
Yasumura, D.3
-
23
-
-
0028279370
-
Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse
-
Li, L., R. W. Oppenheim, M. Lei et al.: Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J. Neurobiol. 25 (1994) 759-766
-
(1994)
J. Neurobiol.
, vol.25
, pp. 759-766
-
-
Li, L.1
Oppenheim, R.W.2
Lei, M.3
-
24
-
-
0344596271
-
Safety, tolerability and pharmacokinetics of recombinant human ciliary neurotrophic factor (rhCNTF) in patients with amyotrophic lateral sclerosis
-
Miller, R. G., W. W. Bryan, M. Dietz et al.: Safety, tolerability and pharmacokinetics of recombinant human ciliary neurotrophic factor (rhCNTF) in patients with amyotrophic lateral sclerosis (abstract). Ann. Neurol. 34 (1993) 304
-
(1993)
Ann. Neurol.
, vol.34
, pp. 304
-
-
Miller, R.G.1
Bryan, W.W.2
Dietz, M.3
-
25
-
-
9044219848
-
A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis
-
Miller, R. G., J. H. Petajan, W. W. Bryan et al.: A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. Ann. Neurol. 39 (1996) 256-260
-
(1996)
Ann. Neurol.
, vol.39
, pp. 256-260
-
-
Miller, R.G.1
Petajan, J.H.2
Bryan, W.W.3
-
26
-
-
0028027060
-
Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF
-
Mitsumoto, H., K. Ikeda, B. Klinkosz et al.: Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 265 (1994) 1107-1110
-
(1994)
Science
, vol.265
, pp. 1107-1110
-
-
Mitsumoto, H.1
Ikeda, K.2
Klinkosz, B.3
-
27
-
-
0030052736
-
Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and colocalization with substantia nigra dopamine-containing neurons
-
Mufson, E. J., J. S. Kroin, Y. T. Liu et al.: Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and colocalization with substantia nigra dopamine-containing neurons. Neuroscience 71 (1996) 179-191
-
(1996)
Neuroscience
, vol.71
, pp. 179-191
-
-
Mufson, E.J.1
Kroin, J.S.2
Liu, Y.T.3
-
28
-
-
0029983422
-
Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord
-
Nakahara, Y., F. H. Gage, M. H. Tuszynski: Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant 5 (1996) 191-204
-
(1996)
Cell Transplant
, vol.5
, pp. 191-204
-
-
Nakahara, Y.1
Gage, F.H.2
Tuszynski, M.H.3
-
29
-
-
0027094145
-
Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death
-
Oppenheim, R. W., Y. Qin Wei, D. Prevette et al.: Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature 360 (1992) 755-757
-
(1992)
Nature
, vol.360
, pp. 755-757
-
-
Oppenheim, R.W.1
Qin Wei, Y.2
Prevette, D.3
-
30
-
-
0000767210
-
An overview of the clinical experience with systematic administration of nerve growth factor in treating peripheral nervous system disorders
-
Rask, C., S. C. Apfel, B. T. Adornato et al.: An overview of the clinical experience with systematic administration of nerve growth factor in treating peripheral nervous system disorders. Ann. Neurol. 38 (1995) 317
-
(1995)
Ann. Neurol.
, vol.38
, pp. 317
-
-
Rask, C.1
Apfel, S.C.2
Adornato, B.T.3
-
31
-
-
0029005234
-
CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction
-
Saggio, I., I. Gloaguen, G. Poiana et al.: CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction. Embo J. 14 (1995) 3045-3054
-
(1995)
Embo J.
, vol.14
, pp. 3045-3054
-
-
Saggio, I.1
Gloaguen, I.2
Poiana, G.3
-
32
-
-
0029077018
-
Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse
-
Sagot, Y., S. A. Tan, E. Baetge et al.: Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur. J. Neurosci. 7 (1995) 1313-1322
-
(1995)
Eur. J. Neurosci.
, vol.7
, pp. 1313-1322
-
-
Sagot, Y.1
Tan, S.A.2
Baetge, E.3
-
33
-
-
0028016137
-
CNTF potentiates peripheral nerve regeneration
-
Sahenk, Z., J. Seharaseyon, J. R. Mendell: CNTF potentiates peripheral nerve regeneration. Brain Res. 655 (1994) 246-250
-
(1994)
Brain Res.
, vol.655
, pp. 246-250
-
-
Sahenk, Z.1
Seharaseyon, J.2
Mendell, J.R.3
-
34
-
-
0028839237
-
Molecular biology of neurotrophic factors
-
Sendtner, M.: Molecular biology of neurotrophic factors. Bailliere's Clin. Neurol. 4 (1995) 575-591
-
(1995)
Bailliere's Clin. Neurol.
, vol.4
, pp. 575-591
-
-
Sendtner, M.1
-
35
-
-
0027070473
-
Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
-
Sendtner, M., B. Holtmann, R. Kolbeck et al.: Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 360 (1992) 757-759
-
(1992)
Nature
, vol.360
, pp. 757-759
-
-
Sendtner, M.1
Holtmann, B.2
Kolbeck, R.3
-
36
-
-
0025325548
-
Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
-
Sendtner, M., G. W. Kreutzberg, H. Thoenen: Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345 (1990) 440-441
-
(1990)
Nature
, vol.345
, pp. 440-441
-
-
Sendtner, M.1
Kreutzberg, G.W.2
Thoenen, H.3
-
37
-
-
0026749255
-
Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
-
Sendtner, M., H. Schmalbruch, K. A. Stöckli et al.: Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358 (1992) 502 -504
-
(1992)
Nature
, vol.358
, pp. 502-504
-
-
Sendtner, M.1
Schmalbruch, H.2
Stöckli, K.A.3
-
38
-
-
0026694239
-
Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration
-
Sendtner, M., K. A. Stöckli, H. Thoenen: Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration. J. Cell Biol. 118 (1992) 139-148
-
(1992)
J. Cell Biol.
, vol.118
, pp. 139-148
-
-
Sendtner, M.1
Stöckli, K.A.2
Thoenen, H.3
-
39
-
-
0029134998
-
NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants
-
Staecker, H., W. Liu, C. Hartnick et al.: NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants. Neuroreport 6 (1995) 1533-1537
-
(1995)
Neuroreport
, vol.6
, pp. 1533-1537
-
-
Staecker, H.1
Liu, W.2
Hartnick, C.3
-
40
-
-
0027756168
-
Trophic support of motoneurons: Physiological, pathophysiological, and therapeutic implications
-
Thoenen, H., R. A. Hughes, M. Sendtner: Trophic support of motoneurons: Physiological, pathophysiological, and therapeutic implications. Exp. Neurol. 124 (1993) 47-55
-
(1993)
Exp. Neurol.
, vol.124
, pp. 47-55
-
-
Thoenen, H.1
Hughes, R.A.2
Sendtner, M.3
-
41
-
-
0029114190
-
Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult
-
Tomac, A., J. Widenfalk, L. Lin et al.: Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc. Natl. Acad. Sci. USA 92 (1995) 8274-8278
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8274-8278
-
-
Tomac, A.1
Widenfalk, J.2
Lin, L.3
-
42
-
-
0028289716
-
Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression
-
Yan, Q., C. Matheson, J. Sun et al.: Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression. Exp. Neurol. 127 (1994) 23-36
-
(1994)
Exp. Neurol.
, vol.127
, pp. 23-36
-
-
Yan, Q.1
Matheson, C.2
Sun, J.3
|