1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1β production

Journal of Clinical Investigation

Volumn 100, Issue 7, 1997, Pages 1716-1724

  Peleg, Sara ^a   Qiu, Haiyen ^a   Reddy, Saravathy ^a   Harris, David ^a   Van, Quin ^a   Estey, Elihu H ^a   Talpaz, Moshe ^a   Estrov, Zeev ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

1716 1724 vitamin D; Acute myelogenous leukemia; Analogues; IL 1 ; IL 1 converting enzyme

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEXACALCITOL; MESSENGER RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CALCIUM HOMEOSTASIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030930363     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119696     Document Type: Article

References (51)

1. Norman, A.W. 1979. Vitamin D: The Calcium Homeostatic Steroid Hormone. Academic Press, Inc., New York. 490 pp.
2. 3. Proc. Natl. Acad. Sci. USA. 78:4990-4994.
3. 3. Proc. Natl. Acad. Sci. USA. 80:5907-5911.
4. Walters, M.R. 1992. Newly identified actions of the vitamin D endocrine system. Endocr. Rev. 13:719-764.
5. Hoang, T., A. Haman, O. Goncalves, and S.C. Clark. 1988. Interleukin-6 enhances growth-factor dependent proliferation of the blast cells of acute myeloblastic leukemia. Blood. 72:823-826.
6. Begley, C.G., D. Metcalf, and N.A. Nicola. 1987. Primary human myeloid leukemia cell: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors. Leukemia (Baltimore). 2:382-387.
7. Miyauchi, J., C.A. Kelleher, G.G. Wong, Y.C. Yang, S.C. Clark, M.D. Minkin, and E.A. McCulloch. 1988. The effects of combinations of the recombinant growth factors GM-CSF, G-CSF, IL-3, and CSF-1 on leukemic blast cells in suspension culture. Leukemia (Baltimore). 2:382-387.
8. Young, D.C., and J.D. Griffin. 1986. Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood. 68:1178-1181.
9. Souza, L.M., T.C. Boone, J. Gabrilove, P.H. Lai, K.M. Zsebo, D.C. Murdock, V.R. Chazin, J. Bruszewski, H. Lu, K.K. Chen, et al. 1986. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science (Wash. DC). 232:61-65.
10. Rodriguez-Cimadevilla, J.C., V. Beauchemin, L. Villencuve, F. Letendre, A. Shaw, and T. Hoang. 1990. Coordinate secretion of interleukin-1β and granulocyte-macrophage colony-stimulating factor by the blast cells of acute myeloblastic leukemia: role of interleukin-1 as an endogenous inducer. Blood. 76:1481-1489.
11. Segal, G.M., E. McCall, T. Stueve, and G.C. Bagby, Jr. 1987. Interleukin 1 stimulates endothelial cells to release multilineage human colony-stimulating activity. J. Immunol. 138:1772-1778.
12. Dinarello, C.A. 1996. Biologic basis for IL-1 in disease. Blood. 86:2095-2147.
13. Estrov, Z., R.A. Black, P.R. Sleath, D. Harris, Q. Van, R. LaPushin, E.H. Estey, and M. Talpaz. 1995. Effect of interleukin-1β converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation. Blood. 86: 4594-4602.
14. Cozzolino, F., A. Rubartelli, D. Aldinucci, R. Sitia, M. Torcia, A. Shaw, and R. Di Guglielmo. 1989. Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells. Proc. Natl. Acad. Sci. USA. 86:2369-2373.
15. Bradbury, D., S. Rogers, I.A. Reilly, R. Kozlowski, N.H. Russell. 1992. Role of autocrine and paracrine production of granulocyte-macrophage colony-stimulating factor and interleukin-1 beta in the autonomous growth of acute myeloblastic leukaemia cells - studies using purified CD34-positive cells. Leukemia (Baltimore). 6:562-566.
16. Estrov, Z., R. Kurzrock, E. Estey, M. Wetzler, A. Ferrajoli, D. Harris, M. Blake, J.U. Gutterman, and M. Talpaz. 1992. Inhibition of acute myelogenous leukemia blast proliferation by IL-1 receptor antagonist and soluble IL-1 receptors. Blood. 79:1938-1945.
17. Rambaldi, A., M. Torcia, S. Bettoni, E. Vannier, T. Barbui, A.R. Shaw, C.A. Dinarello, and F. Cozzolino. 1991. Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells. Blood. 78:3248-3253.
18. Yin, M., V. Gopal, S. Banavali, P. Gartside, and H. Preisler. 1992. Effects of an IL-1 receptor antagonist on acute myeloid leukemic cells. Leukemia (Baltimore). 6:898-901.
19. Dinarello, CA. 1991. Interleukin-1 and interleukin-1 antagonism. Blood. 77:1627-1652.
20. Miller, D.K., J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, S.M. Molineaux, and N.A. Thornberry. 1993. The IL-1β converting enzyme as a therapeutic agent. Ann. NY Acad. Sci. 696:133-148.
21. Cerretti, D.P., C.J. Kozlosky, B. Mosley, N. Nelson, K. Van Ness, T.A. Greenstreet, C.J. March, S.R. Kronheim, T. Druck, L. Cammizzarro, et al. 1992. Molecular cloning of the interleukin-1β converting enzyme. Science (Wash. DC). 256:97-100.
22. Black, R.A., S.R. Kronheim, M. Cantrell, M.C. Defley, C.J. March, K.S. Pickett, J. Wignall, P.J. Conlon, D. Cosman, T.P. Hopp, and D.Y. Mochizuki. 1988. Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J. Biol. Chem. 263:9437-9442.
23. Kostura, M.J., M.J. Tocci, G. Limjuxo, J. Chin, P. Comeron, A.G. Hillman, N.A. Chartrain, and J.A. Schmidt. 1989. Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc. Natl. Acad. Sci. USA. 86: 5227-5231.
24. Thornberry, N.A., H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins, et al. 1992. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature (Lond.) 356:768-774.
25. Papayannopoulou, T., B. Nakamoto, S. Kurachi, M. Tweeddale, and H. Messner. 1988. Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations. Blood. 72: 1029-1038.
26. Sone, T., S. Kerner, and J.W. Pike. 1991. Vitamin D receptor interaction with specific DNA: association as a 1,25-dihydroxyvitamin D3-modulated heterodimer. J. Biol. Chem. 266:23296-23305.
27. Peleg, S., R.V. Abruzzese, G.J. Cote, and R.F. Gagel. 1990. Transcription of the human calcitonin gene is mediated by a C-cell-specific enhancer containing E-box-like elements. Mol. Endocrinol. 4:1750-1757.
28. Gorman, C.M., L.F. Moffat, and B.H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
29. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
30. Estrov, Z., A. Cohen, E.W. Gelfand, and M.H. Freedman. 1988. Synergistic antiproliferative effects on HL-60 cells: deferoxamine enhances cytosine arabinoside, methotrexate, and daunorubicin cytotoxicity. Am. J. Pediatr. Hematol. Oncol. 10:288-291.
31. Gershoni, J.M., and G.E. Palade. 1983. Protein blotting: principles and applications. Anal. Biochem. 131:1-15.
32. Shaw, G., P.C. Levy, and A.F. LoBuglio. 1978. Human monocyte antibody-dependent cell-mediated cytotoxicity to tumor cells. J. Clin. Invest. 62: 1172-1180.
33. Estrov, Z., T. Grunberger, H.S.L. Chan, and M.H. Freedman. 1986. Juvenile chronic myelogenous leukemia: characterization of the disease using cell cultures. Blood. 67:1382-1387.
34. Bertoncello, I., R. Bradley, S.M. Watt. 1991. An improved negative immunomagnetic selection strategy for the purification of primitive hemopoietic cells from normal bone marrow. Exp. Hematol. 19:95-100.
35. Buick, R.N., J.E. Till, and E.A. McCulloch. 1977. A colony assay for proliferative blast cells circulating in myeloblastic leukemia. Lancet. 1:862-864.
36. Minden, M.D., R.N. Buick, and E.A. McCulloch. 1979. Separation of blast cell and T-lymphocyte progenitors in the blood of patients with acute myeloblastic leukemia. Blood. 54:186-195.
37. Freedman, M.H., H.S.L. Chan, and L. Chang. 1986. Childhood erythro-leukemia. Studies on pathogenesis using colony assays. Am. J. Pediatr. Hematol. Oncol. 8:2-9.
38. Haussler, M.R., C.A. Donaldson, S.L. Marion, E.A. Allegretto, and M.A. Kelly. 1986. Receptors for the vitamin D hormone: characterization and functional involvement in 1,25-dihydroxyvitamin D3 regulated events. In The Role of Receptors in Biology and Medicine. M. Gotto and B.W. O'Malley, editors. Raven Press, Ltd., New York. 91-104.
39. Mengelsdorf, D.J., H.P. Koeffler, C.A. Donaldson, J.W. Pike, and M.R. Haussler. 1984. 1,25-dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemic cell line (HL-60): receptor-mediated maturation to macrophage-like cells. Endocrinology. 98:391-398.
40. Peleg, S., Y.-Y. Liu, S. Reddy, R.L. Horst, and G.H. Posner. 1996. A 20-epi side chain restores growth inhibitory and transcriptional activity of an A ring-modified hybrid analog of 1α,25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor. J. Cell. Biochem. 63:149-161.
41. Liu, Y.-Y., E.D. Collins, A.W. Norman, and S. Peleg. 1997. Differential interaction of 1α,25-dihydroxyvitamin D3 analogues and their 20-epi homologues with the vitamin D receptor. J. Biol. Chem. 272:3336-3345.
42. Studzinski, G.P., J.A. McLane, and M.R. Uskokovic. 1993. Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferate and neoplastic disease. Crit. Rev. Eukaryotic Gene Expr. 3:279-312.
43. Reitsma, P.H., P.G. Rothherg, S.M. Astrni, Z. Bar-Shavit, A. Hall, S.L. Teitelhaum, and A.J. Kahn. 1983. Regulation of myc gene expression in HL-60 leukemia cells by a vitamin D metabolite. Nature (Lond). 306:492-494.
44. Boise, L.H., K.M. Gorse, and E.H. Westin. 1942. Multiple mechanisms of regulation of the human c-myb gene during myelomomicytic differentiation. Oncogene. 7:1817-1825.
45. Liu, M., M.-H. Lee, M. Cohen, M. Bommakanti, and L.P. Freedman. 1996. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev. 10:142-153.
46. Nell, M.A., D.P. Cerretti, D.R. Berson, J. Seavitt, D.J. Gilbert, N.A Jenkins, N.G. Copeland, R.A. Black, and D.D. Chaplin. 1992. Molecular cloning of the murine IL-1 beta converting enzyme cDNA. J. Immunol. 149:3254-3259.
47. Miossec, C., L.-D. Decoen, F. Fassy, and A. Diu-Hercend. 1996. Use of monoclonal antibodies to study interleukin-1β-converting enzyme expression: only precursor forms are detected in inrerleukin-1β-secreting cells. Eur. J. Immunol. 26:1032-1042.
48. Wang, S., M. Miura, Y.-K. Jung, H. Zhu, V. Gagliardini, L. Shi, A.H. Greenherg, and J. Yuan. 1996. Identification and characterization of Ich-3, a member of the interleukin-2β converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 272:20580-20587.
49. Komiyama, T., C.A. Ray, D.J. Pickup, A.D. Howard, N.A. Thornberry, E.P. Peterson, and G. Salvesen. 1994. Inhibition of interleukin-1β converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J. Biol. Chem. 269:19331-19337.
50. Bar-Shavit, Z., A.J. Kahn, K.R. Stone, J. Trial, T. Milliard, P.H. Reitsma, and S.L. Teitelbaum. 1986. Reversibility of vitamin D-induced human leukemia cell-line maturation. Endocrinology. 118:679-686.
51. Bouillon, R., W.H. Okamura, and A.W. Norman. 1995. Structure function relationships in the vitamin D endocrine system. Endocr. Rev. 16:200-257.