Mechanisms and treatment options for bone loss in anorexia nervosa

Psychopharmacology Bulletin

Volumn 33, Issue 3, 1997, Pages 399-404

  Grinspoon, Steven ^a   Herzog, David ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Anorexia nervosa; Bone; Insulin like growth factor I (IGF I); Nutrition; Osteoporosis

Indexed keywords

CALCIUM; DEOXYPYRIDINOLINE; ESTROGEN; OSTEOCALCIN; SOMATOMEDIN C;

ANOREXIA NERVOSA; BONE ATROPHY; BONE DENSITY; CALCIUM INTAKE; CLINICAL TRIAL; ESTROGEN DEFICIENCY; FEMALE; GONAD FUNCTION; HUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW; WEIGHT GAIN;

ANOREXIA NERVOSA; CALCIUM; ESTROGENS; FEMALE; HUMANS; OSTEOPOROSIS;

EID: 0030930240     PISSN: 00485764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. Ayers, JWT; Gidwani, GP; Schmidt, IMV; and Gross, M. Osteopenia in hypoestrogenemic young women with anorexia nervosa. Fertil. Steril. 41:224-228, 1984.
2. Bachrach, LK; Guido, D; Katzman, D; Litt, IF; and Marcus, R. Decreased bone density in adolescent girls with anorexia nervosa. Pediatrics 86:440-447, 1990.
3. Bachrach, L; Katzman, D; Litt, I; Guido, D; and Marcus, R. Recovery from osteopenia in adolescent girls with anorexia nervosa. J. Clin. Endocrinol. Metab. 72:602-606, 1991.
4. Biller, BMK; Coughlin, JF; Saxe, V; Schoenfeld, D; Spratt, DI; and Klibanski, A. Osteopenia in women with hypothalamic amenorrhea. Obstet. Gynecol. 78:996-1001, 1991.
5. Biller, BMK; Saxe, V; Herzog, DB; Rosenthal, DI; Holzman, S; and Klibanski, A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J. Clin. Endocrinol. Metab. 68:548-554, 1989.
6. Boyar, RM; Hellman, LD; Roffwarg, H; Katz, J; Zumoff, B; O'Connor, J; Bradlow, HL; and Fukushima, DK. Cortisol secretion and metabolism in anorexia nervosa. N. Engl. J. Med. 296:190-193, 1977.
7. Brotman, AW, and Stern, TA. Osteoporosis and pathological fractures in anorexia nervosa. Am. J. Psychiatry 142:495-496, 1985.
8. Carmichael, KA, and Carmichael, DH. Bone metabolism and osteopenia in eating disorders. Medicine 74:254-267, 1995.
9. Christiansen, C; Christiansen, MS; and Transbol, I. Bone mass in post-menopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet 1:459-461, 1981.
10. Counts, DR; Gwirtsman, H; Carlsson, LMS; Lesem, M; and Cutler, GB. The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J. Clin. Endocrinol. Metab. 75:762-767, 1992.
11. Delmas, PD. Biochemical markers of bone turnover: I. Theoretical considerations and clinical use in osteoporosis. Am. J. Med. 95:11S-16S, 1993.
12. Drinkwater, B; Bruemner, B; and Chestnut, C. Menstrual history as a determinant of current bone density in young athletes. JAMA 263:545-548, 1990.
13. Garnero, P; Shih, WJ; Gineyts, E; Karpf, DB; and Delmas, PD. 1990 Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J. Clin. Endocrinol. Metab. 79:1693-1700, 1990.
14. Grinspoon, S; Baum, H; Kim, V; Coggins, C; and Klibanski, A. Decreased bone formation and increased mineral dissolution during acute fasting in young women. J. Clin. Endocrinol. Metab. 80:3628-3633, 1995.
15. Grinspoon, S; Baum, H; Lee, K; Anderson, E; Herzog, D; and Klibanski, A. Effects of short-term rhIGF-I administration on bone turnover in osteopenic women with anorexia nervosa. J. Clin. Endocrinol. Metab. 81:3864-3870, 1996a.
16. Grinspoon, S; Gulick, T; Askari, H; Landolt, M; Lee, K; Anderson, E; Ma, Z; Vignati, L; Bowsher, R; Herzog, D; and Klibanski, A. Serum leptin levels in anorexia nervosa. J. Clin. Endocrinol. Metab. 81:3861-3863, 1996b.
17. Herzog, W; Minne, H; Deter, C; Leidig, G; Schellberg, D; Wuster, C; Grunwald, R; Sarenberg, E; Kruger, F; and Bergman, G. Outcome of bone mineral density in anorexia nervosa patients 11.7 years after first admission. J. Bone Miner. Res. 8:597-605, 1993.
18. Hock, JM; Centrella, M; and Canalis, E. Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260, 1988.
19. Hui, SL; Siemenda, CW; and Johnston, CC. Age and bone mass as predictors of fracture in a prospective study. J. Clin. Invest. 81:1804-1809, 1988.
20. Joyce, J; Warren, D; Humphries, L; Smith, AJ; and Coon, JS. Osteoporosis in women with eating disorders: Comparison of physical parameters, exercise and menstrual status with SPA and DPA evaluation. J. Nucl. Med. 31:325-331, 1990.
21. Klibanski, A; Biller, BMK; Rosenthal, DI; Schoenfeld, DA; and Saxe, V. Effects of prolactin and estrogen deficiency in amenorrheic bone loss. J. Clin. Endocrinol. Metab. 67:124-130, 1988.
22. Klibanski, A; Biller, BMK; Schoenfeld, DA; Herzog, DB; and Saxe, VC. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J. Clin. Endocrinol. Metab. 80:898-904, 1995.
23. Klibanski, A, and Greenspan, SL. Increase in bone mass after treatment of hyperprolactinemic amenorrhea. N. Engl. J. Med. 315:542-546, 1986.
24. Lindberg, J; Fears, W; Hunt, M; Powell, MR; Boll, D; and Wade, CE. Exercise-induced amenorrhea and bone density. Ann. Intern. Med. 101:647-648, 1984.
25. Lucas, AR; Beard, CM; O'Fallon, WM; and Kurland, LT. 50-year trends in the incidence of anorexia nervosa in Rochester, MN: A population-based study. Am. J. Psychiatry 148:917-922, 1991.
26. Marcus, R; Cann, C; Madvig, P; Minkoff, J; Goddard, M; Bayer, M; Martin, M; et al. Menstrual function and bone mass in elite women distance runners. Ann. Intern. Med. 102:158-163, 1985.
27. McCarthy, TL; Centrella, M; and Canalis, E. Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:301-309, 1989.
28. Pope, GH, Jr; Hudson, JI; and Yurgelun-Todd, D. Prevalence of anorexia nervosa and bulimia in three student populations. Int. J. Eat. Disord. 3(3):45-51, 1984.
29. Rigotti, NA; Neer, RM; Skates, SJ; Herzog, DB; and Nussbaum, SR. The clinical course of osteoporosis in anorexia nervosa. JAMA 265:1133-1138, 1991.
30. Rigotti, NA; Nussbaum, SR; Herzog, DB; and Neer, RM. Osteoporosis in women with anorexia nervosa. N. Engl. J. Med. 311:1601-1606, 1984.
31. Rodan, GA, and Fleisch, HA. Bisphosphonates: Mechanisms of action. J. Clin. Invest. 97:2692-2696, 1996.
32. Salisbury, JJ, and Mitchell, JE. Bone mineral density and anorexia nervosa in women. Am. J. Psychiatry 148:768-774, 1991.
33. Szmukler, GI; Brown, SW; Parson, V; and Darby, A. Premature loss of bone in chronic anorexia nervosa. Br. Med. J. 290:26-27, 1985.
34. Treasure, J; Fogelman, I; and Russell, GFM. Osteopenia of the lumbar spine and femoral neck in anorexia nervosa. Scott. Med. J. 31:206-207, 1986.
35. Winterer, J; Gwirtsman, HE; George, DT; Kay, YH; Loriaux, DL; and Cutler, GB. Adrenocorticotropin-stimulated adrenal androgen secretion in anorexia nervosa: Impaired secretion at low weight with normalization after long-term weight recovery. J. Clin. Endocrinol. Metab. 61:693-697, 1985.