TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia

Leukemia

Volumn 11, Issue 8, 1997, Pages 1220-1223

  Takeuchi, S ^a,e   Seriu, T ^c   Bartram, C R ^c   Golub, T R ^b   Reiter, A ^d   Miyoshi, I ^e   Gilliland, D G ^b   Koeffler, H P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

12p; ALL; LOH; Rearrangement; TEL

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; B CELL LEUKEMIA; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 12P; DIMERIZATION; FEMALE; GENE; GENE DELETION; GENE REARRANGEMENT; HOMOZYGOTE; HUMAN; HUMAN CELL; MALE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; T CELL LEUKEMIA; TUMOR SUPPRESSOR GENE;

EID: 0030928638     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400743     Document Type: Article

References (27)

1. Rowley JD. Recurring chromosome abnormalities in leukemia and lymphoma. Semin Hematol 1990; 27: 122-136.
2. Machnicki JL, Bloomfield CD. Clinical significance of the cytogenetics of acute leukemias. Oncology 1990; 4: 25-30.
3. Baer MR, Bloomfield CD. Cytogenetics and oncogenes in leukemia. Curr Opin Oncol 1992; 4: 24-32.
4. Johansson B, Mertens F, Mitelman F. Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci. Genes Chromos Cancer 1993; 8: 205-218.
5. Raimondi SC. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237-2251.
6. Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RS, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 1994; 84: 3473-3482.
7. Kobayashi H, Rowley JD. Identification of cytogenetically undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization. Genes Chromos Cancer 1995; 12: 66-69.
8. Sato Y, Suto Y, Pietenpol J, Golub TR, Gilliland DC, Davis EM, Le Beau MM, Roberts JM, Vogelstein B, Rowley JD, Bohlander SK. TEL and KIP1 define the smallest region of deletions in hematopoietic malignancies. Blood 1995; 86: 1525-1533.
9. Höglund M, Johansson B, Pedersen-Bjergaard J, Marynen P, Mitelman F. Molecular characterization of 12p abnormalities in hematologic malignancies: deletions of KIP1, rearrangement of TEL, and amplification of CCND2. Blood 1996; 8: 324-330.
10. Stegmaier K, Pendse S, Barker GF, Bray-Ward P, Ward DC, Montgomery KT, Krauter KS, Reynolds C, Sklar J, Donnelly M, Bohlander SK, Rowley JD, Sallan SE, Gilliland DG, Golub TR. Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood 1995; 86: 38-44.
11. KIP1. Blood 1995; 86: 3869-3875.
12. Takeuchi S, Bartram CR, Wada M, Reiter A, Hatta Y, Seriu T, Lee E, Miller CW, Miyoshi I, Koeffler HP. Allelotype analysis of childhood acute lymphoblastic leukemia. Cancer Res 1995; 55: 5377-5382.
13. Takeuchi S, Bartram CR, Miller CW, Reiter A, Seriu T, Zimmermann M, Schrappe M, Mori N, Slater J, Miyoshi I, Koeffler HP. Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletions on the short arm of chromosome 12 in the region of TEL and KIP1. Blood 1996; 87: 3368-3374.
14. Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77: 307-316.
15. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 1995; 55: 34-38.
16. Wlodarska I, Mecucci C, Marynen P, Guo C, Franckx D, La Starza R, Aventin A, Bosly A, Martelli MF, Cassiman JJ, Van den Berghe H. TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13). Blood 1995; 85: 2848-2852.
17. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A. Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 1995; 10: 1511-1519.
18. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
19. Romana SP, Mauchauffé M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 1995; 85: 3662-3670.
20. Romana SP, Poirel H, Leconiat M, Flexor M-A, Mauchauffé M, Jonveaux P, Macintyre EA, Berger R, Bernard OA. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 1995; 86: 4263-4269.
21. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC-F, Pui C-H, Grosveld G, Downing JR. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 1995; 9: 1985-1989.
22. Mclean TW, Ringold S, Stegmaier K, Neuberg D, Tantravahi R, Ritz J, Koeffler HP, Takeuchi S, Janssen JWG, Seriu T, Bartram CR, Sallan SE, Gilliland DG, Golub TR. TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood 1996; 88: 4252-4258.
23. Stegmaier K, Takeuchi S, Golub TR, Bohlander SK, Bartram CR, Koeffler HP, Gilliland DG. Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia. Cancer Res 1996; 56: 1413-1417.
24. Raynaud S, Cavé H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroux C, Guo C, Vilmer E, Marynen P, Grandchamp B. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequent associated alterations found in childhood acute lymphoblastic leukemia. Blood 1996; 87: 2891-2899.
25. Golub TR, Goga A, Barker GF, Afar DEH, Mclaughlin J, Bohlander S, Rowley JD, Witte ON, Gilliland DG. Oligomerization of the ABL tyrosine kinase by the ets protein TEL in human leukemia. Mol Cell Biol 1996; 16: 4107-4116.
26. Wlodarska I, Baens M, Peeters P, Aerssens J, Mecucci C, Brock P, Marynen P, Van den Berghe H. Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case. Cancer Res 1996; 56: 2655-2661.
27. Kawamata N, Morosetti R, Miller CW, Park D, Spirin KS, Nakamaki T, Takeuchi S, Hatta Y, Simpson J, Wilczynski S, Lee YY, Bartram CR, Koeffler HP. Molecular analysis of the cyclin-dependent kinase inhibitor p27/kip1 gene in human malignancies. Cancer Res 1995; 55: 2266-2269.