A single in vivo administration of bombesin antagonist RC-3095 reduces the levels and mRNA expression of epidermal growth factor receptors in MXT mouse mammary cancers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 20, 1997, Pages 10913-10918

  Szepeshazi, Karoly ^a   Schally, Andrew V ^a,b   Halmos, Gabor ^a   Lamharzi, Najib ^a   Groot, Kate ^a   Horvath, Judit E ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blood levels of bombesin antagonist; Gastrin releasing peptide antagonist; Receptor down regulation

Indexed keywords

BOMBESIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN RELEASING PEPTIDE; MESSENGER RNA; RC 3095;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CELL TYPE; CONTROLLED STUDY; DNA CONTENT; FETUS LUNG MATURATION; GASTRIN RELEASE; GROWTH INHIBITION; MOUSE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; TUMOR GROWTH;

ANIMALS; ANTICARCINOGENIC AGENTS; BOMBESIN; CRICETINAE; FEMALE; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MESOCRICETUS; MICE; MICE, NUDE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER;

ANIMALIA; CRICETINAE;

EID: 0030928577     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.20.10913     Document Type: Article

References (53)

1. Tache, Y., Melchiorri, P. & Negri, L., eds. (1988) Ann. N.Y. Acad. Sci. 547, 1-538.
2. Bunnett, N. (1994) in Gut Peptides: Biochemistry and Physiology, eds. Walsh, J. H. & Dockray, G. J. (Raven, New York), pp. 423-445.
3. Thomas, F., Mormont, C. & Morgan, B. (1994) Drugs Future 19, 349-359.
4. Rozengurt, E., Fabregat, I., Coffer, A., Gil, J. & Sinnett-Smith, J. (1990) J. Cell Sci. Suppl. 13, 43-56.
5. Cuttitta, F., Carney, D. N., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A. & Minna, J. D. (1985) Nature (London) 316, 823-826.
6. Schally, A. V. & Comaru-Schally, A. M. (1997) in Cancer Medicine, eds. Holland, J. F., Frei, E., III, Bast, R. C., Jr., Kufe, D. E., Morton, D. L. & Weichselbaum, R. R. (Williams and Wilkins, Baltimore), pp. 1067-1085.
7. Radulovic, S., Cai, R.-Z., Serfozo, F., Groot, K., Redding, T. W., Pinski, J. & Schally, A. V. (1991) Int. J. Peptide Protein Res. 38, 593-600.
8. Szepeshazi, K., Schally, A. V., Cai, R.-Z., Radulovic, S., Milovanovic, S. & Szoke, B. (1991) Cancer Res. 51, 5980-5986.
9. Szepeshazi, K., Schally, A. V., Groot, K. & Halmos, G. (1993) Int. J. Cancer 54, 282-289.
10. Szepeshazi, K., Schally, A. V., Halmos, G., Groot, K. & Radulovic, S. (1992) J. Natl. Cancer Inst. 84, 1915-1922.
11. Pinski, J., Halmos, G., Szepeshazi, K. & Schally, A. V. (1993) Cancer 72, 3263-3270.
12. Qin, Y., Ertl, T., Cai, R.-Z., Horvath, J. E., Groot, K. & Schally, A. V. (1995) Int. J. Cancer 63, 257-262.
13. Shirahige, Y., Cai, R.-Z., Szepeshazi, K., Halmos, G., Pinski, J., Groot, K. & Schally, A. V. (1994) Biomed. Pharmacother. 48, 465-472.
14. Pinski, J., Halmos, G., Yano, T., Szepeshazi, K., Qin, Y., Ertl, T. & Schally, A. V. (1994) Int. J. Cancer 57, 574-580.
15. Radulovic, S., Schally, A. V., Reile, H., Halmos, G., Szepeshazi, K., Groot, K., Milovanovic, S., Miller, G. & Yano, T. (1994) Acta Oncol. 33, 693-701.
16. Halmos, G. & Schally, A. V. (1997) Proc. Natl. Acad. Sci. USA 94, 956-960.
17. Pinski, J., Schally, A. V., Halmos, G. & Szepeshazi, K. (1993) Int. J. Cancer 55, 963-967.
18. Yano, T., Pinski, J., Szepeshazi, K., Halmos, G., Radulovic, S., Groot, K. & Schally, A. V. (1994) Cancer 73, 1229-1238.
19. Davis, T. P., Crowell, S., Taylor, J., Clark, D. L., Coy, D., Staley, J & Moody, T. W. (1992) Peptides 13, 401-407.
20. Groot, K., Horvath, J. E., Cai, R.-Z. & Schally, A. V. (1995) Int. J. Peptide Protein Res. 45, 561-566.
21. Paria, B. C. Das, S. K., Andrews, G. K. & Dey, S. K. (1993) Proc. Natl. Acad. Sci. USA 90, 55-59.
22. Woll, P. J. & Rozengurt, E. (1988) Growth Factors 1, 75-83.
23. Mahmoud, S., Palaszynski, E., Fiskum, G., Coy, D. H. & Moody, T. W. (1989) Life Sci. 44, 367-373.
24. Campbell, B. J., Garner, A., Dockray, G. J., Hughes, J. & Dimaline, R. (1994) Regul. Pept. 49, 249-255.
25. Okubo, K., Miyasaka, K., Matsumoto, M. & Funakoshi, A. (1994) Pancreas 9, 585-590.
26. Guo, Y.-S., Thompson, J. C. & Singh, P. (1990) Gastroenterology 99, 1297-1302.
27. Varga, G., Liehr, R.-M., Scarpignato, C. & Coy, D. H. (1995) Eur. J. Pharmacol. 286, 109-112.
28. Pinski, J., Yano, T., Groot, K., Cai, R.-Z., Radulovic, S. & Schally, A. V. (1992) Am. J. Physiol. 263, E712-E717.
29. Pinski, J., Yano, T., Rekasi, Z., Cai, R.-Z., Radulovic, S. & Schally, A. V. (1992) Regul. Pept. 41, 185-193.
30. Liehr, R.-M., Reidelberger, R. D., Rosewitz, S., Bussjaeger, L. J. & Solomon, T. E. (1992) Regul. Pept. 38, 207-219.
31. Camble, R., Cotton, R., Dutta, A. S., Garner, A., Hayward, C. F., Moore, V. E. & Scholes, P. B. (1989) Life Sci. 45, 1521-1527.
32. Budillon, A., Tagliaferi, P., Caraglia, M., Torrisi, M. R., Normanno, N., Iacobelli, S., Palmieri, G., Stoppelli, M. P., Frati, L. & Bianco, A. R. (1991) Cancer Res. 51, 1294-1299.
33. Peng, D., Fan, Z., Lu, Y., DeBlasio, T., Scher, H. & Mendelsohn, J. (1996) Cancer Res. 56, 3666-3669.
34. Robertson, K. W., Reeves, J. R., Smith, G., Keith, W. N., Ozanne, B. W., Cooke, T. G. & Stanton, P. D. (1996) Cancer Res. 56, 3823-3830.
35. Sainsbury, J. R. C., Farndon, J. R., Needham, G. K., Malcolm, A. J. Harris, A. L. (1987) Lancet i, 1398-1402.
36. Nicholson, S., Sainsbury, J. R. C., Halcrow, P., Chambers, P., Farndon, J. R. & Harris, A. L. (1989) Lancet i, 182-184.
37. Dickson, R. B. & Lippman, M. E. (1995) Endocr. Rev. 16, 559-589.
38. Clark, A. J. L., Ishii, S., Richert, N., Merlino, G. T. & Pastan, I. (1985) Proc. Natl. Acad. Sci. USA 82, 8374-8378.
39. Countaway, J. L., Girones, N. & Davis, R. J. (1989) J. Biol. Chem. 264, 13642-13647.
40. Krane, J. F., Murphy, D. P., Carter, D. M. & Krueger, J. G. (1991) J. Invest. Dermatol 96, 419-424.
41. Zachary, I., Sinnett-Smith, J. W. & Rozengurt, E. (1986) J. Cell Biol. 102, 2211-2222.
42. Epstein, R. (1995) Cell. Signalling 7, 377-388.
43. Ouyang, X., Gulliford, T., Zhang, H., Huang, G. C. & Epstein, R. (1996) J. Biol. Chem. 271, 21786-21792.
44. Ewing, T. M., Murphy, L. J., Ng, M.-L., Pang, G. Y. N., Lee, C. S. L., Watts, K. W. & Sutherland, R. L. (1989) Int. J. Cancer 44, 744-752.
45. Yarden, R. I., Lauber, A. H., El-Ashry, D. & Chrysogelos, S. A. (1996) Endocrinology 137, 2739-2747.
46. Grandis, J. R., Zeng, Q. & Tweardy, D. J. (1996) Nat. Med. 2, 237-240.
47. Miller, D. L., el-Ashry, D., Cheville, A. L., Liu, Y., McLeskey, S. W. & Kern, F. G. (1994) Cell Growth Differ. 5, 1263-1274.
48. Chaidarun, S. S., Eggo, M. C., Stewart, P. M. & Sheppard, M. C. (1994) Endocrinology 143, 489-496.
49. Casanueva, F. F., Perez, F. R., Casabiell, X., Camina, J. P., Cai, R.-Z. * Schally, A. V. (1996) Proc. Natl. Acad. Sci. USA 93, 1406-1411.
50. Hirai, M., Ishizuka, J., Bold, R. J., Townsend, C. M., Jr. & Thompson, J. C. (1993) Life Sci. 53, 1859-1865.
51. Liebow, C., Crean, D. H., Lee, M. T., Kamer, A. R., Mang, T. S. & Schally, A. V. (1994) Proc. Natl. Acad. Sci. USA 91, 3804-3808.
52. Dhanasekaran, N., Heasley, L. E. & Johnson, G. L. (1995) Endocr. Rev. 16, 259-270.
53. Takuwa, N., Takuwa, Y., Ohue, Y., Mukai, H., Endoh, K., Yamashita, K., Kumada, M. & Munekata, E. (1990) Cancer Res. 50, 240-244.