Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin

Toxicology and Applied Pharmacology

Volumn 138, Issue 1, 1996, Pages 31-42

  Moolgavkar, Suresh H ^a   Luebeck, E Georg ^a   Buchmann, Albrecht ^b   Bock, Karl Walter ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; RATTUS NORVEGICUS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DIETHYLNITROSAMINE; POLYCHLORINATED DIBENZODIOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER CARCINOGENESIS; LIVER FOCAL NODULAR HYPERPLASIA; NONHUMAN; RAT; STATISTICAL ANALYSIS; TECHNIQUE; TUMOR PROMOTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; APOPTOSIS; CARCINOGENS; CELL DIVISION; DIETHYLNITROSAMINE; FEMALE; LIKELIHOOD FUNCTIONS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MODELS, STATISTICAL; RATS; RATS, WISTAR; TETRACHLORODIBENZODIOXIN;

EID: 0030014635     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0094     Document Type: Article

References (34)

1. Buchmann, A., Schwarz, M., Schmitt, R., Wolf, C. R., Oesch, F., and Kunz, W. (1987). Development of cytochrome P-450 altered preneoplastic and neoplastic lesions during nitrosoamine-induced hepatocarcinogenesis in the rat. Cancer Res. 47, 2911-2918.
2. Buchmann, A., Stinchcombe, S., Kürner, W., Hagenmaier, H. P., and Bock, K. W. (1994). Effects of 2,3,7,8-tetrachloro- and 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin on the proliferation of preneoplastic liver cells in the rat. Carcinogenesis 15, 1143-1150.
3. Bursch, W., Lauer, B., Timmermann-Trosiener, I., Barthel, G., Schuppler, J., and Schulte-Hermann, R. (1984). Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5, 453-458.
4. Bursch, W., Taper, N. S., Lauer, B., and Schulte-Hermann, R. (1985). Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. Virchows Arch. (Cell Pathol.) 50, 153-166.
5. Bursch, W., Putz, B., Barthel, G., and Schulte-Hermann, R. (1990). Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 11, 847-853.
6. Chambers, J. M., Cleveland, W. S., Kleiner, B., and Tukey, P. A. (1983). Graphical methods for data analysis. In Wadsworth Statistics/Probability Series. Duxbury, Boston.
7. Cox, D. R., and Miller, H. D. (1972). The Theory of Stochastic Processes. Chapman & Hall, London.
8. Dewanji, A., Venzon, D. J., and Moolgavkar, S. H. (1989). A stochastic two-stage model for cancer risk assessment. II. The number and size of premalignant clones. Risk Anal. 9, 179-187.
9. Dragan, Y. P., Hully, J. R., Nakamura, J., Mass, M. J., Swenberg, J. A., and Pitot, H. C. (1994). Biochemical events during initiation of rat hepatocarcinogenesis. Carcinogenesis 15, 1451-1458.
10. Emmelot, P., and Scherer, E. (1980). The first relevant cell stage in rat liver carcinogenesis: A quantitative approach. Biochem. Biophys. Acta 605, 247-304.
11. Farber, E., and Cameron, R. (1980). The sequential analysis of cancer development. Adv. Cancer Res. 31, 125-226.
12. Goldfarb, S., and Pugh, T. D. (1981). Enzyme histochemical phenotypes in primary hepatocellular carcinomas. Cancer Res. 41, 2092-2095.
13. Goldsworthy, T. L., Hanigan, M. H., and Pitot, H. C. (1986). Models of hepatocarcinogenesis in the rat - Contrasts and comparisons. CRC Crit. Rev. Toxicol. 17, 61-89.
14. Jack, E. M., Bentley, P., Bieri, F., Muakkassah-Kelly, S. F., Stäubli, W., Suter, J., Waechter, F., and Cruz-Orive, L. M. (1990). Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method. Hepatology 11, 286-297.
15. Kohn, M. C., Lucier, G. W., Clark, G. C., Sewall, C., Tritscher, A. M., and Portier, C. J. (1993). A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol. Appl. Pharmacol. 120, 138-154.
16. Kopp-Schneider, A. (1992). Birth-death processes with piecewise constant rates. Stat. Prob. Lett. 13, 121-127.
17. Kunz, W., Schaude, G., Schwarz, M., and Tennekes, H. (1982). Quantitative aspects of drug-mediated tumor promotion in liver and its toxicological implications. Carcinogenesis 7, 111-125.
18. Luebeck, E. G., and Moolgavkar, S. H. (1991). Stochastic analysis of intermediate lesions in carcinogenesis experiments. Risk Anal. 11, 149-157.
19. Luebeck, E. G., Moolgavkar, S. H., Buchmann, A., and Schwarz, M. (1991). Effects of polychlorinated biphenyls in rat liver: Quantitative analysis of enzyme-altered foci. Toxicol. Appl. Pharmacol. 111, 469-484.
20. Luebeck, E. G., Grasl-Kraupp, B., Timmermann-Trosiener, I., Bursch, W., Schulte-Hermann, R., and Moolgavkar, S. H. (1995). Growth kinetics of enzyme-altered liver foci in rats treated with phenobarbital or α-hexachlorocyclohexane. Toxicol. Appl. Pharmacol. 130, 304-315.
21. Moolgavkar, S. H., Luebeck, E. G., De Gunst, M., Port, R. E., and Schwarz, M. (1990). Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments I: Single agent regimen. Carcinogenesis 11, 1271-1278.
22. Nebert, D. W., Petersen, D. D., and Puga, A. (1991). Human AH locus polymorphism and cancer: Inducibility of CYP1A1 and other genes by combustion products and dioxin. Pharmacogenetics 1, 68-78.
23. Pitot, H. C., Goldsworthy, T. L., Moran, S., Kennan, W., Glauert, H. P., Maronpot, R. R., and Campbell, H. A. (1987). A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci. Carcinogenesis 8, 1491-1499.
24. Portier, C., Tritscher, A., Kohn, M., Sewall, C., Clark, G., Edler, L., Hoel, D., and Lucier, G. (1993). Ligand/receptor binding for 2,3,7,8-TCDD: Implications for risk assessment. Fundam. Appl. Toxicol. 20, 48-56.
25. Press, W. H., Flannery, B. P., Teukolsky, S. A., and Vetterling, W. T. (1986). Numerical Recipes: The Art of Scientific Computing. Cambridge Univ. Press, Cambridge, UK.
26. Pugh, T. D., and Goldfarb, S. (1992). Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice. Cancer Res. 52, 280-284.
27. Satoh, K., Hatayama, I., Tateoka, N., Tamai, K., Shimizu, T., Tatematsu, M., Ito, N., and Sato, K. (1989). Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis 10, 2107-2111.
28. Schrenk, D., Lipp, H.-P., Wiesmüller, T., Hagenmaier, and Bock, K. W. (1991). Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: Comparison between defined mixtures and their constituents. Arch. Toxicol. 65, 114-118.
29. Schulte-Hermann, R., Parzefall, W., Bursch, W., and Timmermann-Trosiener, I. (1989). Hepatocarcinogenesis by non-genotoxic compounds. In Biologically Based Methods for Cancer Risk Assessment (C. C. Travis, Ed.), NATO ASI Series A, Life Sciences, Vol. 159, pp. 155-163. Plenum, New York.
30. Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., and Bursch, W. (1990). DNA synthesis, apoptosis and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res. 50, 5127-5135.
31. Schwarz, M., Buchmann, A., Schulte, M., Pearson, D., and Kunz, W. (1989). Heterogeneity of enzyme-altered foci in rat liver. Toxicol. Lett. 49, 297-317.
32. Tan, W. Y. (1986). A stochastic Gompertz birth-death process. Stat. Prob. Lett. 4, 25-28.
33. Wachstein, M., and Meisel, E. (1957). Histochemistry of hepatic phosphatases at a physiological pH. Am. J. Clin. Pathol. 27, 13-23.
34. Wicksell, D. S. (1925). The corpuscle problem: Part I. Biometrika 17, 87-97.