The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice

British Journal of Clinical Pharmacology

Volumn 44, Issue 3, 1997, Pages 245-253

  Jessa, M J ^a   Goddard, A F ^b   Barrett, D A ^a   Shaw, P N ^a   Spiller, R C ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Gastric juice; Gastric transfer; Helicobacter pylori; Human volunteer study; Hydroxymetronidazole; Metronidazole; Omeprazole; Pharmacokinetics; Plasma; Saliva

Indexed keywords

DRUG METABOLITE; METRONIDAZOLE; OMEPRAZOLE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PLASMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SALIVA; STATISTICAL ANALYSIS; STOMACH JUICE;

EID: 0030921544     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1997.t01-1-00572.x     Document Type: Article

References (30)

1. Glupcynski Y, Burette A. Drug therapy for Helicobacter pylori infection: problems and pitfalls. Am J Gastroenterol 1990; 85: 1545-1551.
2. Marshall BJ. Treatment strategies for Helicobacter pylori infection. Gastroenterol Clin N Am 1993; 22: 183-198.
3. Chiba N, Rao BV, Rademaker JW, Hunt RH. Meta-aualysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori. Am J Gastroenterol 1990; 87: 1716-1727.
4. Hosking SW, Ling TKW, Yung MY, Cheng A, Chung SCS, Leung JWC. Randomised controlled trial of short term treatment to eradicate Helicobacter pylori in patients with duodenal ulcer. Br Med J 1992; 305: 502-504.
5. Borody TJ, Andrews P, Fracchia G, Brandl S, Shortis NP, Bae H. Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori. Gut 1995; 37: 477-481.
6. Bazzoli F, Zagari RM, Fossi S, et al. Short-term low-dose triple therapy for the eradication of helicobacter pylori; a randomised double blind controlled study. Gastroenterology 1996; 110: A61.
7. Lind T, Veldhuyzen Van Zanten SJO, Unge P, et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH 1 study. Helicobacter 1996; 1: 138-144.
8. Sharma BK, Walt RP, Pounder RE, Gomes M De FA, Wood EC, Logan LH. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut 1984; 25: 957-964.
9. Stambaugh JE, Feo LG, Manthei RW. The isolation and identification of the urinary oxidative metabolites of metronidazole in man. J Pharmacol Exp Ther 1968; 161: 373-381.
10. Haller I. In-vitro activity of the two principal oxidative metabolites of metronidazole against Bacteroides fragilis and related species. Antimicrob Agents Chemother 1982; 22: 165-166.
11. Pendland SL, Piscitelli SC, Schreckenberger PC, Danziger LH. In-vivo activities of metronidazole and its hydroxymetabolite against Bacteroides spp, Antimicrob Agents Chemother 1994; 38: 2106-2110.
12. Pavicic MJAMP, Namavar F, Verboom T, Van Winkelhoff AJ, De Graaff J. In-vitro susceptibility of Helicobacter pylori to several antimicrobial combinations. Antimicrob Agents Chemother 1993; 37: 1184-1186.
13. Goddard AF, Jessa MJ, Barren DA, et al. The effect of omeprazole on the distribution of amoxycillin, metronidazole and clarithromycin in gastric juice, plasma and saliva. Gastroenterology 1996; 111: 358-367.
14. Kellosalo J, Alavaikko M, Laitinen S. Effect of biliary tract procedures on duodenogastric reflux and gastric mucosa. Scand J Gastroenterol 1991; 12: 1272-1278.
15. Hobsley M, Silen W. Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies. Gut 1969; 10: 787-795.
16. Erah PO, Goddard AF, Barrett DA, Shaw PN, Spiller RC. The stability of amoxycillin, clarithromycin, and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection. J Antimicrob Chemother 1997; 39: 5-12.
17. Jessa MJ, Barrett DA, Shaw PN, Spiller RC. A rapid and selective HPLC method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice. J Chromatogr (B) 1996; 677: 374-379.
18. Gibaldi M. Pharmacokinetics. In Biopharmaceutics and clinical pharmacokinetics 1994, Fourth edition. Raven press: New York. Chapters 2 and 11.
19. Amon I, Amon K, Huller H. Pharmacokinetics and therapeutic efficacy of metronidazole at different dosages. Int J Clin Pharmacol Biopharm 1978; 16: 384-386.
20. Jensen JC, Gugler R. Single-and multiple-dose metronidazole kinetics. Clin Pharmacol Ther 1983; 34: 481-487.
21. Houghton GW, Smith J, Thorne PS, Templeton R. The pharmacokinetics of oral and intravenous metronidazole in man. J Antimicrob Chemother 1979; 5: 621-623.
22. Loft S, Døssing M, Poulsen HE, et al. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. Eur J Clin Pharmacol 1986; 30: 467-473.
23. Lau AH, Lam NP, Piscitelli SC, Wilkes L, Danziger LH. Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. Clin Pharmacokinet 1992; 23: 328-364.
24. Mustofa, Suryawati S, Santoso B. Pharmacokinetics of metronidazole in saliva. Int J Clin Pharmacol Ther Toxicol 1991; 29: 474-478.
25. Loft S, Poulsen HE, Sonne J, Døssing M. Metronidazole clearance: a one-simple method and influencing factors. Clin Pharmacol Ther 1988; 43: 420-428.
26. Veldhuyzen Van Zanten SJO, Goldie J, Hollingsworth J, Silletti C, Richardson H, Hunt RH. Secretion of intravenously administered antibiotics in gastric juice: implications for management of Helicobacter pylori. J Clin Pathol 1992; 45: 225-227.
27. Kapoor H, Yeung PK, Pollak PT, Veldhuyzen Van Zanten SJ. The effect of omeprazole on the secretion of intravenously administered metronidazole into gastric juice. Am J Gastroenterol 1994; 89: 1375.
28. Veldhuyzen Van Zanten SJO, Pollak PT, Kapoor H, Yeung PKF. Pharmacokinetic modelling of the effects of omeprazole on secretion of intravenous metronidazole into gastric fluid. Gut 1995; 37: Suppl. 1: A45.
29. Shore PA, Brodie BB, Hogben CAM. The gastric secretion of drugs: a pH partition hypothesis. J Pharmacol Exp Ther 1957; 119: 361-369.
30. Goddard AF, Spiller RC. The effect of omeprazole on gastric juice viscosity, pH and bacterial counts. Aliment Pharmacol Ther 1996; 10: 105-109.