The effect of omeprazole on gastric juice viscosity, pH and bacterial counts

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 1, 1996, Pages 105-109

  Goddard, A F ^a   Spiller, R C ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OMEPRAZOLE;

ADULT; ARTICLE; BACTERIAL OVERGROWTH; HELICOBACTER PYLORI; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH JUICE; STOMACH PH; VISCOSITY; VOLUNTEER;

EID: 0030039576     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.1996.tb00183.x     Document Type: Article

References (27)

1. Forstner JF, Forstner GG. Gastrointestinal mucus. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. 3rd edition. New York: Raven Press, 1994: 1255-83.
2. Bhaskar KR, Gong D, Bansil R, et al. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol 1991; 261: G827-32.
3. Bhaskar KR, Garik P, Turner BS, et al. Viscous lingering of HCl through gastric mucin. Nature 1992; 360: 458-61.
4. Goggin P, Northfield T. Mucosal defence. In: Northfield TC, Mendall M, Goggin PM, eds. Helicobacter pylori Infection. Lancaster: Kluwer Academic Publishers, 1993: 62-74.
5. MacAdam A. The effect of gastro-intestinal mucus on drug absorption. Adv Drug Del 1993; 11: 201-20.
6. Brown DT, Marriott C, Beeson MF. Antibiotic binding to purified mucus glycoproteins. J Pharm Pharmacol 1983; 35: 80P.
7. Thomson AB, Dietschy JM. Derivation of the kinetics that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine. J Theor Biol 1977; 64: 277-94.
8. 13C-urea breath test for the detection of Helicobacter pylori. Eur J Gastroenterol Hepatol 1991; 3: 915-22.
9. Hirst BH, Kaura R, Allen A. Secretin stimulation of gastric mucus secretion in the cat: the viscosity of gastric juice in relation to glycoprotein structure and concentration. Adv Physiol Sci 1981; 12: 237-42.
10. Allen A, Carroll NJH, Hirst BH, Kaura R. High viscosity mucous glycoprotein aggregate in cat gastric juice following secretin. J Physiol 1984; 346: 111P.
11. Ichikawa T, Ishihara K, Saigenji K, Hotta K. Effects of acid-inhibitory antiulcer drugs on mucin biosynthesis in the rat stomach. Eur J Pharmacol 1994; 251: 107-11.
12. Allen A, Carroll NJH. Adherent and soluble mucus in the stomach and duodenum. Dig Dis Sci 1985: 30: 55S-62S.
13. Delbarre SG, Yoshimura K, Borland CR. Do famotidine and omeprazole have an effect on the mucin carbohydrate content? Gastroenterology 1991; 100: A53.
14. Matsumota A, Asada S, Okumura Y, Takiuchi H, Hirata I, Ohshiba S. Effects of anti-secretory agents on various types of gastric mucus. J Clin Gastroenterol 1992; 14: S94-7.
15. Bell AE, Sellers LA, Allen A, Cunliffe WJ, Morris ER, Ross-Murphy SB. Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol, and hypertonicity on mucus gel structure. Gastroenterology 1985; 88: 269-80.
16. Sharma BK, Santana IA, Wood EC et al. Intragastric bacterial activity and nitrosation before, during and after treatment with omeprazole. BMJ 1984; 289: 717-9.
17. Verdu E, Viani F, Armstrong D, et al. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut 1994; 35: 455-60.
18. Curt JRN, Pringle R. Viscosity of gastric mucus in duodenal ulcer. Gut 1969; 10: 931-4.
19. Markesich DC, Anand BS, Lew GM, Graham DY. Helicobacter pylori infection does not reduce the viscosity of human gastric mucus gel. Gut 1995; 36: 327-9.
20. Axon ATR. The role of acid inhibition in the treatment of Helicobacter pylori infection. Scand J Gastroenterol 1994; 29: Suppl 201: 16-23.
21. Tytgat GNJ. Review article: treatments that impact favourably on the eradication of Helicobacter pylori and ulcer recurrence. Aliment Pharmacol Ther 1994; 8: 359-68.
22. Goddard A, Logan R. One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. Eur J Gastroenterol Hepatol 1995; 7: 1-3.
23. Goodwin CS, McNulty CAM. Bacteriological and pharmacological basis for the treatment of Helicobacter pylori infection. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylori and Gastroduodenal Disease, 2nd edn. Oxford: Blackwell, 1992: 224-31.
24. Loo VG, Sherman P, Matlow AG. Helicobacter pylori infection in a pediatric population: in vitro susceptibilities to omeprazole and eight antimicrobial agents. Antimicrob Agents Chemother 1992; 36: 1133-5.
25. Logan RPH, Walker MM, Misiewicz JJ, Gummett PA, Karim QN, Baron JH. Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut 1995; 36: 12-6.
26. Sarosiek J, Slomiany A, Slomiany BL. Evidence of weakening of gastric mucosal integrity by Campylobacter pylori. Scand J Gastroenterol 1988; 23: 585-90.
27. Moss SF, Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori. Gut 1993; 34: 888-92.