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Volumn 281, Issue 3, 1997, Pages 1446-1456

Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 7 (3 TERT BUTYLUREIDO) 6 (2,6 DICHLOROPHENYL)PYRIDO[2,3 D]PYRIMIDINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0030921482     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (62)
  • 1
    • 0028898383 scopus 로고
    • Sequence requirements for binding of src family tyrosine kinases to activated growth factor receptors
    • ALONSO, G., KOEGL, M., MAZURENKO, N. AND COURTNEIDGE, S. A.: Sequence requirements for binding of src family tyrosine kinases to activated growth factor receptors. J. Biol. Chem. 270: 9840-9848, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 9840-9848
    • Alonso, G.1    Koegl, M.2    Mazurenko, N.3    Courtneidge, S.A.4
  • 2
    • 0026594044 scopus 로고
    • Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products
    • ANTONIADES, H. N., GALANOPOULOS, T., NEVILLE-GOLDEN, J. AND O'HARA, C. J.: Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc. Natl. Acad. Sci. U.S.A. 89: 3942-3946, 1992.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 3942-3946
    • Antoniades, H.N.1    Galanopoulos, T.2    Neville-Golden, J.3    O'Hara, C.J.4
  • 3
    • 0028046579 scopus 로고
    • Platelet-derived growth factor stimulates phosphorylation of growth factor receptor-binding protein-2 in vascular smooth muscle cells
    • BENJAMIN, C. W., LINSEMAN, D. A. AND JONES, D. A.: Platelet-derived growth factor stimulates phosphorylation of growth factor receptor-binding protein-2 in vascular smooth muscle cells. J. Biol. Chem. 269: 31346-31349, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31346-31349
    • Benjamin, C.W.1    Linseman, D.A.2    Jones, D.A.3
  • 5
    • 0028330152 scopus 로고
    • Insulin-like growth factor-1 and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
    • BORNFELDT, K. E., RAINES, E. W., NAKANO, T., GRAVES, L. M., KREBS, E. G. AND Ross R.: Insulin-like growth factor-1 and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J. Clin. Invest. 93: 1266-1274, 1994.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1266-1274
    • Bornfeldt, K.E.1    Raines, E.W.2    Nakano, T.3    Graves, L.M.4    Krebs, E.G.5    Ross, R.6
  • 6
    • 0030039555 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Unusually steep structure-activity relationship for analogs of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor
    • BRIDGES, A. J., ZHOU, H., CODY, D. R., REWCASTLE, G. W., McMICHAEL, A., SHOWALTER, H. D., FRY, D. W., KRAKER, A. J. AND DENNY, W. A: Tyrosine kinase inhibitors: Unusually steep structure-activity relationship for analogs of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J. Med. Chem. 39: 267-276, 1996.
    • (1996) J. Med. Chem. , vol.39 , pp. 267-276
    • Bridges, A.J.1    Zhou, H.2    Cody, D.R.3    Rewcastle, G.W.4    McMichael, A.5    Showalter, H.D.6    Fry, D.W.7    Kraker, A.J.8    Denny, W.A.9
  • 7
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
    • BUCHDUNGER, E., ZIMMERMANN, J., METT, H., MEYER, T., MULLKR, M., REGENASS, U. AND LYDON, N.: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc. Natl. Acad. Sci. U.S.A. 92: 2258-2262, 1995.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 2258-2262
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Mullkr, M.5    Regenass, U.6    Lydon, N.7
  • 8
    • 0026578427 scopus 로고
    • Protein-tvrosine kinase inhibitors
    • BURKE, T. R.: Protein-tvrosine kinase inhibitors. Drugs Future 17: 119-131, 1992.
    • (1992) Drugs Future , vol.17 , pp. 119-131
    • Burke, T.R.1
  • 9
    • 0026510966 scopus 로고
    • Receptor tyrosine kinases
    • CADENA, D. L. AND GILL, G. N.: Receptor tyrosine kinases. FASEB J. 6: 2332-2337, 1992.
    • (1992) FASEB J. , vol.6 , pp. 2332-2337
    • Cadena, D.L.1    Gill, G.N.2
  • 10
    • 0028589148 scopus 로고
    • Platelet-derived growth factor receptor signals
    • CLAESSON-WELSH, L.: Platelet-derived growth factor receptor signals. J. Biol. Chem. 269: 32023-32026, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 11
    • 0018735516 scopus 로고
    • Statistical analysis of enzyme kinetic data
    • CLELAND, W. W.: Statistical analysis of enzyme kinetic data. Methods Enzymol. 63: 103-112, 1979.
    • (1979) Methods Enzymol. , vol.63 , pp. 103-112
    • Cleland, W.W.1
  • 12
    • 0025832207 scopus 로고
    • Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia: a review
    • CLOWES, A. W. AND REIDY, M. A.:Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia: A review. J. Vasc. Surg. 13: 885-891, 1991.
    • (1991) J. Vasc. Surg. , vol.13 , pp. 885-891
    • Clowes, A.W.1    Reidy, M.A.2
  • 19
    • 0026418308 scopus 로고
    • Inhibition of neointimal smooth muscle accumulation after angio-plasty by an antibody to PDGF
    • FERNS, G. A. A., RAINES, E. W., SPRUGEL, K. H., MOTANI, A. S., REIDY, M. A. AND Ross, R.: Inhibition of neointimal smooth muscle accumulation after angio-plasty by an antibody to PDGF. Science 253: 1129-1132, 1991.
    • (1991) Science , vol.253 , pp. 1129-1132
    • Ferns, G.A.A.1    Raines, E.W.2    Sprugel, K.H.3    Motani, A.S.4    Reidy, M.A.5    Ross, R.6
  • 20
    • 0029143960 scopus 로고
    • Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction
    • FRIESEL, R. E. AND MACIAG, T.: Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction. FASEB J. 9: 919-925, 1995.
    • (1995) FASEB J. , vol.9 , pp. 919-925
    • Friesel, R.E.1    Maciag, T.2
  • 23
    • 0024434810 scopus 로고
    • Tyrphostins. I: Synthesis and biological activity of protein tyrosine kinase inhibitors
    • GAZIT, A., YAISH, P., GILON, C. AND LEVITZKI, A.: Tyrphostins. I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32: 2344-2352, 1989.
    • (1989) J. Med. Chem. , vol.32 , pp. 2344-2352
    • Gazit, A.1    Yaish, P.2    Gilon, C.3    Levitzki, A.4
  • 24
    • 0023989757 scopus 로고
    • Basic fibroblast growth factor: Expression in cultured bovine vascular smooth muscle cells
    • GOSPODAROWICZ, D., FERRARA, N., HAAPARANTA, T. AND NEUFELD, G.: Basic fibroblast growth factor: Expression in cultured bovine vascular smooth muscle cells. Eur. J. Cell Biol. 46: 144-151, 1988.
    • (1988) Eur. J. Cell Biol. , vol.46 , pp. 144-151
    • Gospodarowicz, D.1    Ferrara, N.2    Haaparanta, T.3    Neufeld, G.4
  • 25
    • 0026673511 scopus 로고
    • Signal transduction in atherosclerosis: Integration of cytokines and the eicosanoid network
    • HAJJAR, D. P. AND POMERANTZ, K. B.: Signal transduction in atherosclerosis: Integration of cytokines and the eicosanoid network. FASEB J. 6: 2933-2941, 1992.
    • (1992) FASEB J. , vol.6 , pp. 2933-2941
    • Hajjar, D.P.1    Pomerantz, K.B.2
  • 26
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • HANKS, S. K., QUINN, A. M., HUNTER, T.: The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241: 42-52, 1988.
    • (1988) Science , vol.241 , pp. 42-52
    • Hanks, S.K.1    Quinn, A.M.2    Hunter, T.3
  • 27
    • 0028670125 scopus 로고
    • The biology of the erbB2/neu/HER-2 and its role in cancer
    • HYNES, N. E. AND TERN, D. F.: The biology of the erbB2/neu/HER-2 and its role in cancer. Biochem. Biophys. Acta 1198: 165-184, 1994.
    • (1994) Biochem. Biophys. Acta , vol.1198 , pp. 165-184
    • Hynes, N.E.1    Tern, D.F.2
  • 28
    • 0027261204 scopus 로고
    • Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury
    • JACKSON, C. J., RAINES, E. W., Ross, R. AND REIDY, M. A.: Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscler. Thromb. 13: 1218-1226, 1993.
    • (1993) Arterioscler. Thromb. , vol.13 , pp. 1218-1226
    • Jackson, C.J.1    Raines, E.W.2    Ross, R.3    Reidy, M.A.4
  • 29
    • 0026495734 scopus 로고
    • Pharmacology of smooth muscle cell replication
    • JACKSON, C. L. AND SCHWARTZ, S. M.: Pharmacology of smooth muscle cell replication. Hypertension 20: 713-734, 1992.
    • (1992) Hypertension , vol.20 , pp. 713-734
    • Jackson, C.L.1    Schwartz, S.M.2
  • 30
    • 0026649742 scopus 로고
    • Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction
    • JAYE, M., SCHLESSINGER, J. AND DIONNE, C. A.: Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction. Biochem. Biophys. Acta 1135: 185-199, 1992.
    • (1992) Biochem. Biophys. Acta , vol.1135 , pp. 185-199
    • Jaye, M.1    Schlessinger, J.2    Dionne, C.A.3
  • 31
    • 0026461137 scopus 로고
    • Characterization of baculovirus-expressed human α and β platelet-derived growth factor receptors
    • JENSEN, R. A., BEELER, J. F., HEIDARAN, M. A. AND LAROCHELLE, W. J.: Characterization of baculovirus-expressed human α and β platelet-derived growth factor receptors. Biochemistry 31: 10887-10892, 1992.
    • (1992) Biochemistry , vol.31 , pp. 10887-10892
    • Jensen, R.A.1    Beeler, J.F.2    Heidaran, M.A.3    Larochelle, W.J.4
  • 33
    • 0025172811 scopus 로고
    • Association between the PDGF receptor and members of the src family of tyrosine kinases
    • KYPTA, R. M., GOLDBERG, Y., ULUG, E. T. AND COURTNEIDGE, S. A.: Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62: 481-492, 1990.
    • (1990) Cell , vol.62 , pp. 481-492
    • Kypta, R.M.1    Goldberg, Y.2    Ulug, E.T.3    Courtneidge, S.A.4
  • 35
    • 0026451516 scopus 로고
    • A cascade model for restenosis: A special case of atherosclerosis progression
    • LIBBY, P., SCHWARTZ, D., BROGI, E., TANAKA, H. AND CLINTON S. K.: A cascade model for restenosis: A special case of atherosclerosis progression. Circulation 86: 47-52, 1992.
    • (1992) Circulation , vol.86 , pp. 47-52
    • Libby, P.1    Schwartz, D.2    Brogi, E.3    Tanaka, H.4    Clinton, S.K.5
  • 36
    • 0029050865 scopus 로고
    • A subpopulation of smooth muscle cells in injured rat arteries expresses plateletderived growth factor-B chain mRNA
    • LINDNER, V., GIACHELLI, C. M., SCHWARTZ, S. M. AND REIDY, M. A.: A subpopulation of smooth muscle cells in injured rat arteries expresses plateletderived growth factor-B chain mRNA. Circ. Res. 76: 951-957, 1995.
    • (1995) Circ. Res. , vol.76 , pp. 951-957
    • Lindner, V.1    Giachelli, C.M.2    Schwartz, S.M.3    Reidy, M.A.4
  • 37
    • 0025817390 scopus 로고
    • Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor
    • LINDNER, V. AND REIDY, M. A.: Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc. Natl. Acad. Sci. U.S.A. 88: 3739-3743, 1991.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 3739-3743
    • Lindner, V.1    Reidy, M.A.2
  • 38
    • 0027239809 scopus 로고
    • Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries
    • LINDNER, V. AND REIDY, M.: Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. Circ. Res. 73: 589-595, 1993.
    • (1993) Circ. Res. , vol.73 , pp. 589-595
    • Lindner, V.1    Reidy, M.2
  • 39
    • 0024385914 scopus 로고
    • Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation
    • LYALL, R. M., ZILBERSTEIN, A., GAZIT, A., GILON, C., LEVITZKI, A. AND SCHLESSINGER, J.: Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J. Biol. Chem. 264: 14503-14509, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14503-14509
    • Lyall, R.M.1    Zilberstein, A.2    Gazit, A.3    Gilon, C.4    Levitzki, A.5    Schlessinger, J.6
  • 41
    • 0024504732 scopus 로고
    • Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones
    • OGAWARA, H., AKIYAMA, T. AND WATANABE, S.-I.: Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones. J. Antibiot. 42: 340-343, 1988.
    • (1988) J. Antibiot. , vol.42 , pp. 340-343
    • Ogawara, H.1    Akiyama, T.2    Watanabe, S.-I.3
  • 42
    • 0025609724 scopus 로고
    • Inhibition of tyrosine kinase and epidermal growth factor receptor internalization by lavendustin: A methyl ester in cultured A431 cells
    • ONODA, T., ISHIKI, K., TAKEUCHI, T., TATSUTA, K. AND UMEZAWA, K.: Inhibition of tyrosine kinase and epidermal growth factor receptor internalization by lavendustin: A methyl ester in cultured A431 cells. Drugs Exp. Clin. Res. 16: 249-253, 1990.
    • (1990) Drugs Exp. Clin. Res. , vol.16 , pp. 249-253
    • Onoda, T.1    Ishiki, K.2    Takeuchi, T.3    Tatsuta, K.4    Umezawa, K.5
  • 44
    • 0023225322 scopus 로고
    • Frequent expression of growth factors of mesenchymal cells in human mammary carcinoma cell lines
    • PEREZ, R., BETSHOLTZ. C., WESTERMARK, B. AND HELDIN C. H.: Frequent expression of growth factors of mesenchymal cells in human mammary carcinoma cell lines. Cancer Res. 47: 3425-3429, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 3425-3429
    • Perez, R.1    Betsholtz, C.2    Westermark, B.3    Heldin, C.H.4
  • 45
    • 0024383718 scopus 로고
    • Platelet derived growth factor
    • Ross, R.: Platelet derived growth factor. Lancet 1: 1179-1182, 1989.
    • (1989) Lancet , vol.1 , pp. 1179-1182
    • Ross, R.1
  • 46
    • 0025933874 scopus 로고
    • Polypeptide growth factors and atherosclerosis
    • Ross, R.: Polypeptide growth factors and atherosclerosis. Trends Cardiovasc. Med. 1: 277-282, 1991.
    • (1991) Trends Cardiovasc. Med. , vol.1 , pp. 277-282
    • Ross, R.1
  • 47
    • 0015097243 scopus 로고
    • The smooth muscle cell. II: Growth of smooth muscle in culture and formation of elastic fibers
    • Ross, R. R.: The smooth muscle cell. II: Growth of smooth muscle in culture and formation of elastic fibers. J. Cell Biol. 50: 172-186, 1971.
    • (1971) J. Cell Biol. , vol.50 , pp. 172-186
    • Ross, R.R.1
  • 49
    • 0029098078 scopus 로고
    • The intima: Soil for atherosclerosis and restenosis
    • SCHWARTZ, S. M., DEBLOIS, D. AND O'BRIAN, E. R. M.: The intima: Soil for atherosclerosis and restenosis. Circ. Res. 77: 445-465, 1995.
    • (1995) Circ. Res. , vol.77 , pp. 445-465
    • Schwartz, S.M.1    Deblois, D.2    O'Brian, E.R.M.3
  • 50
    • 0026612517 scopus 로고
    • The restenosis paradigm revisited: An alternative proposal for cellular mechanisms
    • SCHWARTZ, R. S., HOLMES, D. R. AND TOPOL, E. J.: The restenosis paradigm revisited: An alternative proposal for cellular mechanisms. J. Am. Coll. Cardiol. 20: 1284-1293, 1992.
    • (1992) J. Am. Coll. Cardiol. , vol.20 , pp. 1284-1293
    • Schwartz, R.S.1    Holmes, D.R.2    Topol, E.J.3
  • 51
    • 0023951176 scopus 로고
    • Constitutive production of platelet-derived growth factor like proteins by human prostate carcinoma cell lines
    • SITARAS, N. M., SARIBAN, E., BRAVO, M., PANTAZIS, P. AND ANTONIADES, H. N.: Constitutive production of platelet-derived growth factor like proteins by human prostate carcinoma cell lines. Cancer Res. 48: 1930-1935, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 1930-1935
    • Sitaras, N.M.1    Sariban, E.2    Bravo, M.3    Pantazis, P.4    Antoniades, H.N.5
  • 52
    • 0028273336 scopus 로고
    • Tyrosine kinase inhibitors. 2: Synthesis of 2.2́-dithiobis-(1H-indole-3-alkanmides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases
    • THOMPSON, A. M., FRY, D. W., KRAKER, A. J. AND DENNY, W. A.: Tyrosine kinase inhibitors. 2: Synthesis of 2.2́-dithiobis-(1H-indole-3-alkanmides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases. J. Med. Chem. 37: 598-608, 1994.
    • (1994) J. Med. Chem. , vol.37 , pp. 598-608
    • Thompson, A.M.1    Fry, D.W.2    Kraker, A.J.3    Denny, W.A.4
  • 53
    • 0030008414 scopus 로고    scopus 로고
    • 4-(Phenylamino)pyrrolopyrimidines: Potent and selective, ATP site-directed inhibitors of the EGF-receptor protein tyrosine kinase
    • TRAXLER, P. M., FURET, P., METT, H., BUCHDUNGER, E., MEYER, T. AND LYDON, N.: 4-(Phenylamino)pyrrolopyrimidines: Potent and selective, ATP site-directed inhibitors of the EGF-receptor protein tyrosine kinase. J. Med. Chem. 39: 2285-2292, 1996.
    • (1996) J. Med. Chem. , vol.39 , pp. 2285-2292
    • Traxler, P.M.1    Furet, P.2    Mett, H.3    Buchdunger, E.4    Meyer, T.5    Lydon, N.6
  • 54
    • 0029556753 scopus 로고
    • Recent advances in protein tyrosine kinase inhibitors
    • TRAXLER, P. AND LYDON, N.: Recent advances in protein tyrosine kinase inhibitors. Drugs Future 20: 1261-1274, 1995.
    • (1995) Drugs Future , vol.20 , pp. 1261-1274
    • Traxler, P.1    Lydon, N.2
  • 55
    • 0028263055 scopus 로고
    • Dianilinopthalimides: Potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase
    • TRINKS, U., BUCHDUNGER, E. AND FURET, P.: Dianilinopthalimides: Potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase. J. Med. Chem. 37: 1015-1027, 1994.
    • (1994) J. Med. Chem. , vol.37 , pp. 1015-1027
    • Trinks, U.1    Buchdunger, E.2    Furet, P.3
  • 56
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • ULLRICH, A. AND SCHLESSINGER, J.: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212, 1990.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 57
    • 0027211693 scopus 로고
    • Phospholipase C-y and phosphatidylinositol 3 kinase are downstream mediators of the PDGF receptor's mitogenic signal
    • VALIUS, M. AND KAZLAUSKAS, A.: Phospholipase C-y and phosphatidylinositol 3 kinase are downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334, 1993.
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius, M.1    Kazlauskas, A.2
  • 58
    • 0023180670 scopus 로고
    • Aortic endothelial cells synthesize basic fibroblast growth factor, which remains cell associated, and platelet-derived growth factor like protein, which is secreted
    • VLODAVSKY, I., FRIEDMAN, R., SULLIVAN, R., SASSE, J. AND KLAGSBRUN, M.: Aortic endothelial cells synthesize basic fibroblast growth factor, which remains cell associated, and platelet-derived growth factor like protein, which is secreted. J. Cell. Physiol. 131: 402-428, 1987.
    • (1987) J. Cell. Physiol. , vol.131 , pp. 402-428
    • Vlodavsky, I.1    Friedman, R.2    Sullivan, R.3    Sasse, J.4    Klagsbrun, M.5
  • 59
    • 0028106163 scopus 로고
    • Epidermal growth factor receptor tyrosine kinase: Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor
    • WARD, W. H. J., COOK, P. N., SLATER, A. M., DAVIES, H., HOLDGATE, G. A AND GREEN, L. R.: Epidermal growth factor receptor tyrosine kinase: Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor. Biochem. Pharmacol. 48: 659-666, 1994.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 659-666
    • Ward, W.H.J.1    Cook, P.N.2    Slater, A.M.3    Davies, H.4    Holdgate, G.A.5    Green, L.R.6
  • 60
    • 0025247892 scopus 로고
    • Expression of acidic and basic fibroblast growth factors in human and bovine vascular smooth muscle cells
    • WEICH, H. A., IBERG, N., KLAGSBRUN, M. AND FOLKMAN, J.: Expression of acidic and basic fibroblast growth factors in human and bovine vascular smooth muscle cells. Growth Factors 2: 313-320, 1990.
    • (1990) Growth Factors , vol.2 , pp. 313-320
    • Weich, H.A.1    Iberg, N.2    Klagsbrun, M.3    Folkman, J.4
  • 61
    • 0028089005 scopus 로고
    • Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol-3́-kinase
    • WENNSTRöM, S., SIEGBAHN, A., YOKOTE, K., ARVIDSSON, A.-K., HELDIN, C.-H., MORI, S. AND CLAESSON-WELSH, L.: Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol-3́-kinase. Oncogene 9: 651-660, 1994.
    • (1994) Oncogene , vol.9 , pp. 651-660
    • Wennström, S.1    Siegbahn, A.2    Yokote, K.3    Arvidsson, A.-K.4    Heldin, C.-H.5    Mori, S.6    Claesson-Welsh, L.7
  • 62
    • 0029951570 scopus 로고    scopus 로고
    • Phenylamino-pyrimidine (PAP)-derivatives: A new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors
    • ZIMMERMANN, J., BUCHDUNGER, E., METT, H., MEYER, T., LYDON, N. B. AND TRAXLER, P.: Phenylamino-pyrimidine (PAP)-derivatives: A new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors. Bioorg. Med. Chem. Lett. 6: 1221-1226, 1996.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1221-1226
    • Zimmermann, J.1    Buchdunger, E.2    Mett, H.3    Meyer, T.4    Lydon, N.B.5    Traxler, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.