Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase

Tetrahedron Letters

Volumn 38, Issue 19, 1997, Pages 3349-3352

  Pei, Yazhong ^a   Houghten, Richard A ^a   Kiely, John S ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUINOLONE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0030919217     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00655-2     Document Type: Article

References (22)

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17. 2 and HCl generated in situ during the reduction. equation presented.
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19. LC-MS analyses were carried out on a Hewlett-Packard 1050 HPLC system coupled to a Finnigan LCQ mass spectrometer equipped with atmospheric pressure chemical ionization (APCI).
20. Under MS analytical conditions, dihydroquinolinones 7 undergo β-eliminations to give quinolinone 9 (as shown below). In some cases, the quinolinone fragment 9 is the major peak in mass spectrum. equation presented
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