Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy

Protein Engineering

Volumn 10, Issue 4, 1997, Pages 463-470

  Newton, Dianne L ^a   Xue, Ying ^b   Boqué, Lluís ^b   Wlodawer, Alexander ^b   Kung, Hsiang Fu ^b   Rybak, Susanna M ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anti tumor; Gene; Recombinant; Ribonuclease

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARTIC ACID; CHIMERIC PROTEIN; CYTOTOXIC AGENT; GLYCINE; NEUROTOXIN; POLYCLONAL ANTIBODY; RANPIRNASE; RIBONUCLEASE; SYNTHETIC DNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STRUCTURE; FROG; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOMBINANT GENE; STRUCTURE ACTIVITY RELATION;

ANURA;

EID: 0030916745     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.4.463     Document Type: Article

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