In vivo effects of 5-hydroxytryptamine receptor activation on rat nucleus tractus solitarius neurones excited by vagal C-fibre afferents

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 489-498

  Wang, Yun ^a   Ramage, A G ^b   Jordan, D ^a  

^a Department of Physiology ^*  (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

5 HT; 5 HT receptors; Ionophoresis; Nucleus tractus solitarius (NTS); Vagal afferents

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ALPHA METHYLSEROTONIN; BUSPIRONE; PHENYLBIGUANIDE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; IONTOPHORESIS; MALE; NERVE CELL STIMULATION; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SINGLE UNIT ACTIVITY; SOLITARY TRACT NUCLEUS; VAGUS NERVE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ELECTRIC STIMULATION; EXTRACELLULAR SPACE; HEART; IONTOPHORESIS; MALE; NERVE FIBERS; NEURONS; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SOLITARY NUCLEUS; VAGUS NERVE;

EID: 0030915742     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00063-4     Document Type: Article

References (67)

1. Ashby C. R., Edwards E., Harkins K. and Wang R. Y. (1989) Effects of (±)-DOI on medial prefrontal cortical cells: a microionophoretic study. Brain Research 498: 393-396.
2. 1A receptors play a role in the von Bezold-Jarisch reflex in the rat. British Journal of Pharmacology 100: 757-760.
3. 3 receptors in the dorsal vagal complex. In: Serotonin and the Scientific Basis of Anti-emetic Therapy (Reynolds D. J. M., Andrews P. L. R. and Davis C. J. Eds), pp. 106-110. Oxford Clinical Communications, Oxford..
4. Bruinvels A. T., Lery H., Nozulak J., Palacios J. M. and Hoyer D. (1992) 5-HT1D binding sites in various species: similar pharmacological profile in dog, monkey, calf, guinea pig and human brain membranes. Naunyn-Schmiedeberg's Archives of Pharmacology 346: 243-248.
5. Calza L., Giardino L., Grimaldi R., Rigoli M., Steinbusch H. W. M. and Tiengo M. (1985) Presence of 5-HT-positive neurons in the medial nuclei of the solitary tract. Brain Research 347: 135-139.
6. Catelli J. M. and Sved A. F. (1988) Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat. European Journal of Pharmacology 151: 243-248.
7. Colino A. and Halliwell J. V. (1987) Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature 328: 73-77.
8. 1A receptors on reflex activation of cardiac vagal motoneurones in anaesthetized rabbits and rats. Journal of Physiology 479: 110-111P.
9. 1A binding sites in the brainstem of the cat. British Journal of Pharmacology 94: 386P.
10. 2 receptors on rat brainstem neurones. British Journal of Pharmacology 94: 483-491.
11. 1-like receptors on rat brainstem neurones. British Journal of Pharmacology 94: 492-499.
12. Feldman P. D. (1994) Electrophysiological effects of serotonin in the solitary tract nucleus of the rat. Naunyn-Schmiedeberg's Archives of Pharmacology 349: 447-454.
13. Feldman P. D. (1995) Effects of serotonin-1 and serotonin-2 receptor agonists on neuronal activity in the nucleus tractus solitarius. Journal of Autonomous Nervous Systems 56: 119-124.
14. Feldman P. D. and Galliano F. J. (1995) Cardiovascular effects of serotonin in the nucleus of the solitary tract. American Journal of Physiology 269: R48-R56.
15. Feldman P. D. and Moises H. C. (1987) Adrenergic responses of baroreceptive cells in the nucleus tractus solitarii of the rat: a microionophoretic study. Brain Research 420: 351-361.
16. Feldman P. D. and Moises H. C. (1988) Electrophysiological evidence for alpha 1- and alpha 2-adrenoceptors in solitary tract nucleus. American Journal of Physiology 254: H756-H762.
17. 1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways of anaesthetized rabbits with smoke. Brain Research 629: 349-354.
18. Garrat J. C., Kidd E. J., Wright I. K. and Marsden C. A. (1991) Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist DOI. European Journal of Pharmacology 199: 349-355.
19. Glaum S. R., Brooks P. A., Spyer K. M. and Miller R. J. (1992) 5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro. Brain Research 589: 62-68.
20. Hall M. E., Miley F. B. and Stewart J. M. (1989) Cardiovascular effects of substance P peptides in the nucleus of the solitary tract. Brain Research 497: 280-290.
21. Itoh H. and Bunag R. D. (1991) Cardiovascular and sympathetic effects of injecting serotonin into the nucleus tractus solitarius in rats. Journal of Pharmacology and Experimental Therapeutics 256: 1147-1153.
22. Jones J. F. X., Wang Y. and Jordan D. (1995) Dorsal medullary neurones activated by stimulation of the cardiac vagal branch of the anaesthetized rat, and their behaviour during the pulmonary chemoreflex. Journal of Physiology 483: 89P.
23. Jordan D., Mifflin S. W. and Spyer K. M. (1988) Hypothalamic inhibition of neurones in the nucleus tractus solitarius is GABA mediated. Journal of Physiology 399: 389-404.
24. Jordan D. and Spyer K. M. (1986) Brainstem integration of cardiovascular and pulmonary afferent activity. Progressive Brain Research 67: 295-314.
25. Jordan D., Wang Y., Jones J. F. X. and Ramage A. G. (1995) Serotonin excites nucleus tractus solitarius (NTS) neurones receiving inputs from cardiac vagal C-fibre afferents in rats. Social Neuroscience Abstracts 21: 353.11.
26. King M. S., Wang L. and Bradley R. M. (1993) Substance P excites neurons in the gustatory zone of the rat nucleus tractus solitarius. Brain Research 619: 120-130.
27. Kubo T. and Kihara M. (1987) Blood pressure modulation by substance P in the rat nucleus tractus solitarius. Brain Research 413: 379-383.
28. 2 adrenergic agents injected into the nucleus tractus solitarii. Naunyn-Schmiedebergs Archives of Pharmacology 335: 274-277.
29. Kubo T. and Misu Y. (1981) Pharmacological characterisation of the α-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat. Naunyn-Schmiedebergs Archives of Pharmacology 317: 120-125.
30. Laguzzi R., Reis D. J. and Talman W. (1984) Modulation of cardiovascular and electrocortical activity through serotonergic mechanisms in the nucleus tractus solitarius of the rat. Brain Research 304: 321-328.
31. Laubie M., Drouillat M., Dabire H., Cherqui C. and Schmitt H. (1989) Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (±)8-OH-DPAT in anaesthetised dogs. European Journal of Pharmacology 160: 385-394.
32. Lawrence A. J. and Jarrott B. (1996) Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Progressive Neurobiology 48: 21-53.
33. Lewis D. I. and Coote J. H. (1990) The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo. British Journal of Pharmacology 99: 667-672.
34. Lovenberg T. W., Baron B. M., deLecca L., Miller J. D., Prosser R. A., Rea M. A., Foye P. E., Racke M., Slone A. L., Siegel B. W., Danielson P. E., Sutcliffe J. G. and Erlander M. G. (1993) A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the rgulation of mammalian circadian rhythms. Neuron 11: 449-458.
35. Lukovic L., Jong W. de and Weid D. de (1987) Cardiovascular effects of substance P and capsaicin microinjected into the nucleus tractus solitarii of the rat. Brain Research 422: 312-318.
36. Maley B. and Elde R. (1982) The ultrastructural localization of serotonin immunoreactivity within the nucleus of the solitary tract of the cat. Journal of Neuroscience 2: 1499-1506.
37. Manaker S. and Verderame H. M. (1990) Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. Journal of Comparative Neurology 301: 535-553.
38. 3 receptor stimulation in the nucleus tractus solitarius of spontaneously hypertensive rats. Brain Research 669: 130-134.
39. 2 receptors in the nucleus tractus solitarius: characterisation and role in cardiovascular regulation in the rat. Brain Research 575: 74-78.
40. 3 receptors in the nucleus tractus solitarius of the rat. Neuroscience 46: 91-100.
41. Morin-Surun M. P., Jordan D., Champagnat J., Spyer K. M. and Denavit-Saubie M. (1984) Excitatory effects of ionophoretically applied substance P on neurons in the nucleus tractus solitarius of the cat: lack of interaction with opiates and opioids. Brain Research 307: 388-392.
42. Nosjean A., Compoint C., Buisseret-Delamas C., Orer H. C., Merahi N., Puizillout J. and Laguzzi R. (1990) Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labelling study in the rat. Neuroscience Letters 114: 22-26.
43. Oleskevich S. and Lacaille J. C. (1992) Reduction of GABA-B inhibitory postsynaptic potentials by serotonin via pre- and postsynaptic mechanisms in CA3 pyramidal cells of rat hippocampus in vitro. Synapse 12: 173-188.
44. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates, Second Edn. Academic Press, New York.
45. Penington N. J. and Reiffenstein R. J. (1986) Direct comparison of hallucinogenic phenethylamines and D-amphetamine on dorsal raphe neurons. European Journal of Pharmacology 122: 373-377.
46. 3H]BRL 43694 binds to presynaptic sites in the nucleus tractus solitarius of the rat. Neuropharmacology 28: 1367-1376.
47. Schaffar N., Kessler J. P., Bosler O. and Jean A. (1988) Central serotonergic projections to the nucleus tractus solitarii: evidence from a double labelling study in the rat. Neuroscience 26: 951-958.
48. + entry. Brain Research 701: 249-254.
49. Segal M. (1990) Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons. Neuroscience 36: 631-641.
50. Sessle B. J. and Henry J. L. (1985) Effects of enkephalin and 5-hydroxytryptamine on solitary tract neurones involved in respiration and respiratory reflexes. Brain Research 327: 221-230.
51. Shvaloff A. and Laguzzi R. (1986) Serotonin receptors in the rat nucleus tractus solitarii and cardiovascular regulation. European Journal of Pharmacology 132: 283-288.
52. Steinbusch H. W. M. (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat - cell bodies and terminals. Neuroscience 6: 557-618.
53. 3H]metachlorophenylbiguanide. European Journal of Pharmacology 243: 13-18.
54. Sykes R. M., Spyer K. M. and Izzo P. N. (1994) Central distribution of substance P, calcitonin gene-related peptide and 5-hydroxytryptamine in vagal sensory afferents in the rat dorsal medulla. Neuroscience 59: 195-210.
55. Turner S. A. (1984) A study of catecholamine effects on the baroreceptor reflex pathway in the rabbit. Journal of Physiology 348: 75P.
56. Vayssettes-Courchay C., Bouysset F., Verbeuren T. J. and Laubie M. (1993) Role of the nucleus tractus solitarii and the rostral depressive area in the sympatholytic effect of 8-hydroxy-2-(di-n-propylamino)tetralin in the cat. European Journal of Pharmacology 242: 37-45.
57. Wang W. H. and Lovick T. A. (1992a) Inhibitory serotonergic effects on rostral ventrolateral medullary neurons. Pflügers Archives 422: 93-97.
58. Wang W. H. and Lovick T. A. (1992b) Excitatory 5-HT2-mediated effects on rostral ventrolateral medullary neurones in rats. Neuroscience Letters 141: 89-92.
59. 1A receptor agonists and antagonists on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. British Journal of Pharmacology 116: 2291-2297.
60. 3 receptors mediate an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. British Journal of Pharmacology 118: 1697-1704.
61. 3 receptors mediate an excitatory effect of 5-HT on dorsal vagal preganglionic neurones: an ionophoretic study in rat. British Journal of Pharmacology 120: 38P.
62. Wemer J., Frankhuyzen A. L. and Mulder A. H. (1982) Pharmacological characterization of presynaptic alpha-adrenoceptors in the nucleus tractus solitarii and the cerebral cortex of the rat. Neuropharmacology 21: 499-506.
63. Wilson C. G., Zhang Z. and Bonham A. C. (1996) Non-NMDA receptors transmit cardiopulmonary C fibre input in the nucleus tractus solitarii in rats. Journal of Physiology 496: 773-785.
64. Wolf W. A., Kuhn D. M. and Lovenberg W. (1981) Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. European Journal of Pharmacology 69: 291-299.
65. Yang J., Bao J. and Su D. F. (1992) Effects of serotonin and norepinephrine on neuronal discharges of the nucleus tractus solitarii in medullary slices. Acta Pharmacological Sinica 13: 42-44.
66. Yang R. H., Igarashi Y., Wyss J. M. and Chen Y. F. (1990) Dopamine D2 receptors in the posterior region of the nucleus tractus solitarius mediate the central pressor action of quinpirole (LY171555). Brain Research Bulletin 24: 97-103.
67. Zhang W. and Mifflin S. W. (1995) Excitatory amino acid receptors within the NTS mediate arterial chemoreceptor reflexes in rats. American Journal of Physiology 265: H770-H773.