Mediation by 5-HT3 receptors of an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: An ionophoretic study

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1697-1704

  Wang, Yun ^a   Ramage, Andrew G ^a   Jordan, David ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

5 HT3 receptor; 5 hydroxytryptamine; Dorsal vagal nucleus; Phenylbiguanide

Indexed keywords

CINANSERIN; GRANISETRON; PHENYLBIGUANIDE; SEROTONIN; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; TROPISETRON; BIGUANIDE DERIVATIVE; INDOLE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IONTOPHORESIS; MALE; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; RAT; VAGUS NERVE NUCLEUS; VAGUS NERVE STIMULATION; ANIMAL; CYTOLOGY; DRUG EFFECT; EXTRACELLULAR SPACE; GENERAL ANESTHESIA; METABOLISM; MOTONEURON; NERVE FIBER; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VAGUS NERVE;

ANESTHESIA, GENERAL; ANIMALS; BIGUANIDES; EXTRACELLULAR SPACE; GRANISETRON; INDOLES; IONTOPHORESIS; MALE; MOTOR NEURONS; NERVE FIBERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; VAGUS NERVE;

EID: 0029657969     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15594.x     Document Type: Article

References (43)

1. 2A receptors. Neurosci. Abstr., 21, 443.2.
2. ALBERT, A.P., SPYER, K.M. & BROOKS, P.A. (1995). Effects of selective serotonin receptor agonists on dorsal vagal preganglionic neurones in vitro. Clin. Autonom. Res., 5, 336.
3. 3-like receptors in the rat medial prefrontal cortex: an electrophysiological study. Brain Res., 550, 181-191.
4. 3-like receptor supersensitivity and dopamine receptor supersensitivity in the rat medial prefrontal cortex after the intraventricular administration of the neurotoxin 5,7-Dihydroxytryptamine: microionophoretic study. Neuroscience, 60, 453-462.
5. 1A receptors play a role in the von Bezold-Jarisch reflex in the rat. Br. J. Pharmacol., 100, 757-760.
6. 1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled capsaicin in anaesthetized cats. Br. J. Pharmacol., 117, 724-728.
7. CHITRAVANSHI, V.C. & CALARESU, F.R. (1992). Additive effects of dopamine and 8-OH-DPAT microinjected into the nucleus ambiguus in eliciting vagal bradycardia in rats. J. Autonom. Nerv. Syst., 41, 121-128.
8. 1A receptors on reflex activation of cardiac vagal motoneurones in anaesthetised rabbits and rats. J. Physiol., 479, 110-111P.
9. 3 receptors in the modulation of the response to upper airway stimulation in the anaesthetized rabbit. J. Physiol., 489, 156-157P.
10. 1A binding sites in the brainstem of the cat. Br. J. Pharmacol., 94, 386P.
11. 1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways in anesthetized rabbits with smoke. Brain Res., 629, 349-354.
12. GLAUM, S.R., BROOKS, P.A., SPYER, K.M. & MILLER, R.J. (1992). 5-hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro. Brain Res., 589, 62-68.
13. HAXHIU, M.A., JANSEN, A.S.P., CHERNIACK, N.S. & LOEWY, A.D. (1993). CNS innervation of airway-related parasympathetic preganglionic neurons: a transneuronal labeling study using pseudorabies virus. Brain Res., 616, 115-134.
14. HOYER, D. & FOZARD, J.R. (1991). 5-Hydroxytryptamine receptors. In Receptor Data for Biological Experiments: A Guide to Drug Selectivity. ed. Doods, H.N. & Van Meel, J.C.A. pp. 35-41. New York: Ellis Horwood.
15. IZZO, P.N., DEUCHARS, J. & SPYER, K.M. (1993). Localization of cardiac vagal preganglionic motoneurones in the rat: immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine. J. Comp. Neurol., 327, 572-583.
16. 3 receptor channel. Annu. Rev. Physiol., 57, 447-468.
17. JONES, J.F.X., WANG, Y. & JORDAN, D. (1995). Dorsal medullary neurones activated by stimulation of the cardiac vagal branch of the anaesthetized rat, and their behaviour during the pulmonary chemoreflex. J. Physiol., 483, 89P.
18. KALIA, M. (1981). Brain stem localization of vagal preganglionic neurons. J. Autonom. Nerv. Syst., 3, 451-481.
19. 3 receptors. In 5-Hydroxytryptamine-3 receptor Antagonists. ed. King, F.D., Jones, B.J. & Sanger, G.J. pp. 79-96. Ann Arbor: CRC Press Inc.
20. MANAKER, S. & VERDERAME, H.M. (1990). Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. J. Comp. Neurol., 301, 535-553.
21. 1A receptor agonists. J. Pharmacol. Exp. Ther., 271, 777-781.
22. NOSAKA, S., YAMAMOTO, T. & YASUNAGA, K. (1979). Localization of vagal cardioinhibitory preganglionic neurons within rat brain. J. Comp. Neurol., 186, 79-92.
23. NOSAKA, S., YASUNAGA, K. & TAMAI, S. (1982). Vagal cardiac preganglionic neurones: distribution, cell types and reflex discharges. Am. J. Physiol., 243, R92-R98.
24. PAXINOS, G & WATSON, C. (1986). The Rat Brain in Stereotaxic Coordinates. 2nd Edition. New York: Academic Press.
25. PETERS, J.A., MALONE, H.M. & LAMBERT, J.J. (1992). Recent advances in the electrophysiological characterization of 5-HT3 receptors. Trends Pharmacol. Sci., 13, 391-397.
26. 3 receptors modulate the vagal bradycardia evoked by the von Bezold-Jarisch reflex. Pharmacol. Res., 31 (supplement), P286.
27. 3 receptors in mammalian hindbrain. Trends Pharmacol. Sci., 11, 135-137.
28. 1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. Eur. J. Pharmacol., 138, 179-191.
29. 1A antagonist in anaesthetizd cats. Br. J. Pharmacol., 116, 289P.
30. RICHARDSON, B.P., ENGEL, G., DONATSCH, P & STADLER, P.A. (1985). Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature, 316, 126-131.
31. RUBIN, B., PIALA, J.J., BURKE, L.C. & CRAVER, B.N. (1964). A new potent and specific serotinin inhibitor (SQ 10,643) 2′-(3-dimethylaminopropylthio)cinnamanilide hydrochloride: antiserotonin activity on the uterus and on gastrointestinal, vascular and respiratory systems of animal. Arch. Int. Pharmacodvn., 152, 132-143.
32. 3 receptor antagonism by BRL 43694 (granisetron). Eur. J. Pharmacol., 159, 113-124.
33. SHEPHEARD, S.L., JORDAN, D. & RAMAGE, A.G. (1994). Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetised cat. Br. J. Pharmacol., 111, 616-624.
34. 1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetized rat. Br. J. Pharmacol., 104, 466-470.
35. STEINBUSCH, H.W.M. (1981). Distribution of serotonin-immunoreactivity in the central nervous system of the rat - cell bodies and terminals. Neuroscience, 6, 557-618.
36. 3H]meta-chlorophenylbiguanide. Eur. J. Pharmacol., 243, 13-18.
37. SYKES, R.M., SPYER, K.M. & IZZO, P.N. (1994). Central distribution of substance P, calcitonin gene related peptide and 5-hydroxytryptamine in vagal sensory afferents in the rat dorsal medulla. Neuroscience, 59, 195-210.
38. 1 binding sites in autonomic areas of the rat dorsomedial medulla oblongata. Synapse, 10, 217-227.
39. 3 receptors. FASEB J., 6, A995.
40. 1A receptor antagonists. Br. J. Pharmacol., 114, 160P.
41. 1A receptor agonists and antagonists on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. Br. J. Pharmacol., 116, 2291-2297.
42. 3 receptors mediate an excitatory action of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an in vivo ionophoretic study. Br. J. Pharmacol., 117, 46P.
43. 2 receptors in rats. Am. J. Physiol., 269, R1-R6.