Expression of bcl-2, bax and bcl-X(L) proteins in azoxymethane-induced rat colonic adenocarcinomas

Molecular Carcinogenesis

Volumn 19, Issue 1, 1997, Pages 25-30

  Hirose, Yoshinobu ^a   Yoshimi, Naoki ^a   Suzui, Masumi ^a   Kawabata, Kunihiro ^a   Tanaka, Takuji ^a   Mori, Hideki ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Immunohistochemistry; Sprague Dawley rat; Western blotting

Indexed keywords

AZOXYMETHANE; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COLON CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOCARCINOMA; ANIMALS; AZOXYMETHANE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CARCINOGENS; COLON; COLONIC NEOPLASMS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES;

EID: 0030913740     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199705)19:1<25::AID-MC4>3.0.CO;2-M     Document Type: Article

References (34)

1. Williams GT. Programmed cell death: Apoptosis and oncogenesis. Cell 65:1097-1098, 1991.
2. Vaux DL, Haecker G, Strasser A. An evolutionary perspective on apoptosis. Cell 76:777-779, 1994.
3. Kellett M, Potten CS, Rew DA. A comparison of in vivo cell proliferation measurements in the intestines of mouse and man Epithelial Cell Biol 1:147-155, 1992.
4. Potten CS, Merritt A, Hickman J, Hall P, Faranda A. Characterization of radiation-induced apoptosis in the small intestine and its biological implications. Int J Radiat Biol 65:71-78, 1994.
5. Preston-Martin S, Pike MC, Ross RK, Henderson BE. Epidemiologic evidence for the increased cell proliferation model of carcinogenesis. Environ Health Perspect 101(suppl 5):137-138, 1993.
6. Bedi A, Pasricha PJ, Akhtar AJ, et al. Inhibition of apoptosis during development of colorectal cancer. Cancer Res 55:1811-1816, 1995.
7. Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 80:879-886, 1992.
8. Vaux DS, Cory S, Adams J. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442, 1988.
9. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74:609-619, 1993.
10. Boise LH, Gonzalez-Garcia M, Postema CE, et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608, 1993.
11. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099, 1984.
12. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965, 1991.
13. Merritt AJ, Potten CS, Watson AJM, et al. Differential expression of bcl-2 in intestinal epithelia: Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 108:2261-2271, 1995.
14. Gazzaniga P, Gradilone A, Vercillo R, et al. bcl-2/bax mRNA expression ratio as prognostic factor in low-grade urinary bladder cancer. Int J Cancer 69:100-104, 1996.
15. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC. Immunohistochemical determination of in vivo distribution of bax, a dominant inhibitor of bcl-2. Am J Pathol 145:1323-1336, 1994.
16. Krajewski S, Krajewska M, Shabaik A, et al. Immunohistochemical analysis of in vivo patterns of bcl-x expression. Cancer Res 54:5501-5507, 1994.
17. Hague A, Moorghen M, Hicks D, Chapman M, Paraskeva C. BCL-2 expression in human colorectal adenomas and carcinomas. Oncogene 9:3367-3370, 1994.
18. Bronner MP, Culin C, Reed JC, Furth EE. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 146:20-26, 1995.
19. Öfner D, Riehemann K, Maier H, et al. Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: Correlation with tumour stage and patient survival. Br J Cancer 72:981-985, 1995.
20. Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 56:2422-2427, 1996.
21. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805, 1994.
22. Wang A, Yoshimi N, Suzui M, Yamauchi A, Tarao M, Mori H. Different expression patterns of cyclins A, D1 and E in human colorectal cancer. J Cancer Res Clin Oncol 122:122-126, 1996.
23. Hara A, Iwai T, Niwa M, et al. Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia. Brain Res 711:249-253, 1996.
24. Munakata S, Hendricks JB. Effect of fixation time and microwave oven heating time on retrieval of the Ki-67 antigen from paraffin-embedded tissue. J Histochem Cytochem 41:1241-1246, 1993.
25. Broome HE, Dargan CM, Krajewski S, Reed JC. Expression of bcl-2, bcl-x, and bax after T cell activation and IL-2 withdrawal. J Immunol 155:2311-2317, 1995.
26. Haldar S, Jena N, Croce CM. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92:4507-4511, 1995.
27. Watson AJM, Merritt AJ, Jones LS, et al. Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. Br J Cancer 73:889-895, 1996.
28. Hayashi R, Luk H, Horio D, Dashwood R. Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. Cancer Res 56:4307-4310, 1996.
29. Chao DT, Linette GP, Boise LH, White LS, Thompson CB, Korsmeyer SJ. Bcl-xL and Bcl-2 repress a common pathway of cell death. J Exp Med 182:821-828, 1995.
30. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ. bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 120:301-311, 1994.
31. Motoyama N, Wang F, Roth KA, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510, 1995.
32. Gottschalk AR, Boise LH, Thompson CB, Quintans J. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci USA 91:7350-7354, 1994.
33. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811-813, 1995.
34. Cheng EH-Y, Levine B, Boise LH, Thompson CB, Hardwick JM. Bax-independent inhibition of apoptosis by Bcl-xL. Nature 379:554-556, 1996.