Plasmodium falciparum: An epitope within a highly conserved region of the 47-kDa amino-terminal domain of the serine repeat antigen is a target of parasite-inhibitory antibodies

Experimental Parasitology

Volumn 85, Issue 2, 1997, Pages 121-134

  Fox, Barbara A ^a   Xing Li, Pang ^b   Suzue, Kazutomo ^b   Horii, Toshihiro ^b   Bzik, David J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MALARIA VACCINE; MONOCLONAL ANTIBODY; PARASITE ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALIA; CAPRA HIRCUS; ESCHERICHIA COLI; MURINAE; PLASMODIUM FALCIPARUM; PRIMATES;

EID: 0030913033     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1996.4118     Document Type: Article

References (52)

1. BANIC, D. M., BOSSUS, M., DELPLACE, P., TARTAR, A., GRAS-MASSE, H., CONSEIL, V., MAZINGUE, C., DE TAISNE, C., AND CAMUS, D. 1992. Immunogenicity and antigenicity of the N-term repeat amino acid sequence of the Plasmodium falciparum P126 antigen. Memorial Institute, Oswaldo Cruz, 87(Suppl. III), 159-162.
2. BANIC, D. M., DELPLACE, P., MAZINGUE, C., AND CAMUS, D. 1994. H-2b restriction of the immune response to the p126 Plasmodium falciparum antigen. Clinical and Experimental Immunology 95, 472-478.
3. BANYAL, H. S., AND INSELBURG, J. 1985. Isolation and characterization of parasite-inhibitory Plasmodium falciparum monoclonal antibodies. American Journal of Tropical Hygiene 34, 1055-1064.
4. BARR, P. J., INSELBURG, J., GREEN, J. M., KANSOPON, J., HAHM, B. K., GIBSON, H. L., LEE-NG, C. T., BZIK, D. J., LI, W.-B., AND BATHURST, I. C. 1991. Immunogenicity of recombinant Plasmodium falciparum SERA proteins in rodents. Molecular and Biochemical Parasitology 45, 159-179.
5. BATHURST, I. C., GIBSON, H. L., KANSOPON, J., HAHM, B. K., GREEN, K. M., CHANG, S. P., NUI, G. S. N., SIDDIQUI, W. A., INSELBURG, J., MILLET, P., QUAKYI, I. A., KASLOW, D. C., AND BARR, P. J. 1993. An experimental vaccine cocktail for Plasmodium falciparum malaria. Vaccine 11, 449.
6. BHATIA, A., DELPLACE, P., FORTIER, B., DUBREMETZ, J. F., AND VERNES, A. 1987. Immunochemical analysis of a major antigen of Plasmodium falciparum (P126) among ten geographic isolates. American Journal of Tropical Hygene 36, 15-19.
7. BOUHAROUN-TAYOUN, H., ATTANATH, P., SABCHAREON, A., CHONG-SUPHAJAISIDDHI, T., AND DRUILHE, P. 1990. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. Journal of Experimental Medicine 172, 1633-1641.
8. BOUHAROUN-TAYOUN, H., OEUVRAY, C., LUNEL, F., AND DRUILHE, P. 1995. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. Journal of Experimental Medicine 182, 409-418.
9. BZIK, D. J., LI, W.-B., HORII, T., AND INSELBURG. 1987. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proceedings of the National Academy of Sciences, USA 84, 8360-8364.
10. BZIK, D. J., LI, W.-B., HORII, T., AND INSELBURG, J. 1988. Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA. Molecular and Biochemical Parasitology 30, 279-288.
11. BZIK, D. J., PECK, J. Y., AND Fox, B. A. 1992. Mung bean nuclease exhibits an exon-excision activity upon the Plasmodium falciparum SERA gene. Molecular and Biochemical Parasitology 56, 185-188.
12. BZIK, D. J., FOX, B. A., AND GONYER, K. 1993. Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli. Molecular and Biochemical Parasitology 59, 155-166.
13. CHULAY, J. P., LYON, J. A., HAYNES, J. D., MEIEROVICS, A. I., ATKINSON, C. T., AND AIKAWA, M. 1987. Monoclonal antibody characterization of Plasmodium falciparum antigens in immune complexes formed when schizonts rupture in the presence of immune serum. Journal of Immunology 139, 2768-2774.
14. COPPEL, R. L., CREWTHER, P. E., CULVENOR, J. G., PERRIN, L. H., BROWN, G. V., KEMP, D. J., AND ANDERS, R. F. 1988. Variation in p126, a parasitophorous vacuole antigen of Plasmodium falciparum. Molecular Biology and Medicine 5, 155-166.
15. DEBRABANT, A., AND DELPLACE, P. 1989. Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum. Molecular and Biochemical Parasitology 33, 151-158.
16. DEBRABANT, A., MAES, P., DELPLACE, P., DUBREMETZ, J. F., TARTAR, A., AND CAMUS, D. 1992. Intramolecular mapping of Plasmodium falciparum p126 proteolytic fragments by N-terminal amino acid sequencing. Molecular and Biochemical Parasitology 53, 89-96.
17. DELPLACE, P., DUBREMETZ, J. F., FORTIER, B., AND VERNES, A. 1985. A 50 kilodalton exoantigen specific to the mero-zoite release-reinvasion stage of Plasmodium falciparum. Molecular and Biochemical Parasitology 17, 239-251.
18. DELPLACE, P., FORTIER, B., TRONCHIN, G., DUBREMETZ, J.-F., AND VERNES, A. 1987. Localization, biosynthesis, processing and isolation of a major 126-kDa antigen of the parasitophorous vacuole of Plasmodium falciparum. Molecular and Biochemical Parasitology 23, 193-201.
19. DELPLACE, P., BHATAI, A., CAGNARD, M., CAMUS, D., COLOMBET, G., DEBRABANT, A., DUBREMETZ, J. F., DEUBREUIL, N., PRENSIER, G., FORTIER, B., HAQ, A., WEBER J., AND VERNES, A. 1988. Protein p126: A parasitophorous vacuole antigen associated with the release of Plasmodium falciparum merozoites. Biology and Cell 64, 215-221.
20. EAKTN, A. E., HIGAKI, J. N., MCKERROW, J. H., CRAIK, C. S., MOTTRAM, J. C., COOMBS, G. H., AND NORTH, M. J. 1989. Cysteine or serine proteinase? Nature 342, 132.
21. ENGVALL, E., AND PERLMANN, P. 1972. Enzyme-linked immunosorbent assay. ELISA III. Quantitation of specific antibodies by enzyme-labelled anti-immunoglobulin in antigen-coated tubes. Journal of Immunology 109, 129-135.
22. FANDEUR, T., DUBOIS, P., GYSIN, J., DEDET, J. P., AND PEREIRA L. 1984. In vitro and in vivo studies on protective and inhibitory antibodies against P. falciparum malaria in Saimiri monkeys. Journal of Immunology 132, 432-437.
23. Fox, B. A., AND BZIK, D. J. 1991. The primary structure of Plasmodium falciparum DNA polymerase delta is similar to drug-sensitive delta-like viral DNA polymerases. Molecular and Biochemical Parasitology 49, 289-296.
24. Fox, B. A., LI, W.-B., TANAKA, M., INSELBURG, J., REVICH, G., AND BZIK, D. J. 1993. Molecular characterization of the largest subunit of Plasmodium falciparum RNA polymerase I. Molecular and Biochemical Parasitology 61, 37-48.
25. FOX, B. A., AND BZIK, D. J. 1994. Analysis of stage-specific transcripts of the Plasmodium falciparum serine repeat antigen (SERA) gene and transcription from the SERA locus. Molecular and Biochemical Parasitology 68, 133-144.
26. GEYSEN, H. M., MELOEN, R. H., AND BARTELING, S. J. 1984. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proceedings of the National Academy of Sciences, USA 81, 3998-34002.
27. HIGGINS, D. G., MCCONNELL, D. J., AND SHARP, P. M. 1989. Malarial proteinase? Nature 340, 604.
28. HORII, T., BZIK, D. J., AND INSELBURG, J. 1988. Characterization of antigen-expressing Plasmodium falciparum cDNA clones that are reactive with parasite inhibitory antibodies. Molecular and Biochemical Parasitology 30, 9-18.
29. INSELBURG, J., BZIK, D. J., LI, W-.B., GREEN, K. M., KANSOPON, J., HAHN, B. K., BATHURST, I. C., BARR, P. J., AND ROSSAN, R. N. 1991. Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum. Infection and Immunity 59, 1247-1250.
30. INSELBURG, J., BATHURST, I. C., KANSOPON, J., BARCHFELD, G. L., BARR, P. J., AND ROSSAN, R. N. 1993a. Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: Adjuvant effects on induction of protective immunity. Infection and Immunity 61, 2041-2047.
31. INSELBURG, J., BATHURST, I. C., KANSOPON, J., BARR, P. J., AND ROSSAN, R. 1993b. Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: Further studies using SERA 1 and MF75.2 adjuvant. Infection and Immunity 61, 2048-2052.
32. KNAPP, B., HUNDT, E. NAU, U., AND KUPPER, H.A. 1989. Molecular cloning, gene structure and localization in a blood stage antigen of Plasmodium falciparum characterized by a serine stretch. Molecular and Biochemical Parasitology 32, 73-88.
33. KUMAR, S., YADAVA, A., KEISTER, D. B., TIAN, J. H., OHL, M., PERDUE-GREENFIELD, K. A., MILLER, L. H., AND KASLOW, D. C. 1995. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys. Molecular Medicine 1, 325-332.
34. LAEMMLI, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
35. LI, W.-B., BZIK, D. J., HORII, T., AND INSELBURG, J. 1989. Structure and expression of the Plasmodium falciparum SERA gene. Molecular and Biochemical Parasitology 33, 13-26.
36. LYON, J. A., AND HAYNES, J. D. 1986. Plasmodium falciparum antigens synthesized by schizonts and stabilized at the merozoite surface when schizonts mature in the presence of protease inhibitors. Journal of Immunology 136, 2245-2251.
37. LYON, J. A., HAYNES, J. D., DIGGS, C. L., CHULAY, J. D., AND PRATT-ROSSITER, J.M. 1986. Plasmodium falciparum antigens synthesized by schizonts and stabilized at the merozoite surface by antibodies when schizonts mature in the presence of growth inhibitory immune serum. Journal of Immunology 136, 2252-2258.
38. LYON, J. A., THOMAS, A. W., HALL, T., AND CHULAY, J. D. 1989. Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes. Molecular and Biochemical Parasitology 36, 77-88.
39. MINEO, J. R., KHAN, I. A., AND KASPER, L. H. 1994. Toxoplasma gondii: A monoclonal antibody that inhibits intracellular replication. Experimental Parasitology 79, 351-361.
40. MOTTIAM, J. C., COOMBS, G. H., AND NORTH, M. J. 1989. Cysteine or serine proteinase? Nature (London) 342, 132.
41. OEUVRAY, C., BOUHAROUN-TAYOUN, H., GRAS-MASSE, H., BOTTIUS, E., KAIDOH, T., AIKAWA, M., FILGUEIRA, M.-C., TARTAR, A., AND DRUILHE, P. 1994. MSP-3: a malaria protein inducing antibodies which promote Plasmodium falciparum killing in cooperation with blood monocytes. Blood 84, 1594-1602.
42. PERKINS, M. E., AND ZEIFER, A. 1994. Preferential binding of Plasmodium falciparum SERA and rhoptry proteins to erythrocyte membrane inner leaflet phospholipids. Infection and Immunity 62, 1207-1212.
43. PERRIN, L. H., MERKLI, B., LOCHE, M., CHIZZOLINI, C., SMART, J., AND RICHLE, R. 1984. Antimalarial immunity in saimiri monkeys: Immunization with surface components of blood stages. Journal of Experimental Medicine 160, 441-451.
44. RAGGE, K., ARNOLD, H.-H., TUMMLER, M., KNAPP, B., HUNDT, E., AND LINGELBACH, K. 1990. In vitro biosynthesis and membrane translocation of the serine rich protein of Plasmodium falciparum. Molecular and Biochemical Parasitology 42, 93-100.
45. REESE, R. T., LANGRETH, S. G., AND TRAGER, W. 1979. Isolation of stages in the human parasite Plasmodium falciparum from culture and from animal blood. Bulletin WHO 57 (Suppl. 1), 53-61.
46. ROUSSILHON, C., HUNDT, E., AGRAPART, M., STÜBER, W., KNAPP, B., DUBOIS, P., AND BALLET, J. J. 1990. Responses of T cells from sensitized donors to recombinant and synthetic peptides corresponding to sequences of the Plasmodium falciparum SERP antigen. Immunology Letters 25, 149-154.
47. SAM-YELLOWE, T. Y., AND PERKINS, M. E. 1991. Interaction of the 140/130/110-kDa rhoptry protein complex of Plasmodium falciparum with the erythrocyte membrane and liposomes. Experimental Parasitology 73, 161-171.
48. SAM-YELLOWE, T. Y. 1993. Plasmodium falciparum: Analysis of protein-protein interactions of the 140/130/110-kDa rhoptry protein complex using antibody and mouse erythrocyte binding assays. Experimental Parasitology 77, 179-194.
49. STOWERS, A., PRESCOTT, N., COOPER, J., TAKACS, B., STUEBER, D., KENNEDY, P., AND SAUL, A. 1995. Immunogenicity of recombinant Plasmodium falciparum thoptry associated proteins 1 and 2. Parasite Immunology 17, 631-642.
50. SUGIYAMA, T., SUZUE, K., OKAMOTO, M., INSELBURG, J., TAI, K., AND HORII, T. 1996. Production of recombinant SERA proteins of Plasmodium falciparum in Escherichia coli by using synthetic genes. Vaccine 14, 1069-1076.
51. TOWBIN, H., STAEHELIN, T., AND GORDON, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gel to nitrocellulose sheets: Procedure and some applications. Proceedings of the National Academy of Sciences, USA 76, 4350-4354.
52. WEBER, J. L., LYON, J. A., AND CAMUS, D. 1987. Blood stage antigen genes of Plasmadium falciparum. In "Molecular Strategies of Parasitic Invasion" (N. Agabian, H. Goodman, and N. Noguiera, Eds.), pp. 379-388, A. R. Liss, New York.