Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance

Journal of Cancer Research and Clinical Oncology

Volumn 123, Issue 4, 1997, Pages 201-210

  Hu, Yan Ping ^a   Robert, Jacques ^a  

^a INSTITUT BERGONIÉ   (France)

Author keywords

multidrug resistance; protein kinase C activity; protein kinase C isoforms

Indexed keywords

2,4 BIS(ALLYLAMINO) 6 [4 [[2,2 BIS(4 FLUOROPHENYL)ETHYL]AMINO]PIPERIDINO] 1,3,5 TRIAZINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P; ISOENZYME; PROTEIN KINASE C; QUININE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR CELL LINE;

ANIMALS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; ISOENZYMES; KB CELLS; PROTEIN KINASE C; RATS;

EID: 0030905993     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01240316     Document Type: Article

References (55)

1. Ahmad S, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Glazer RI (1992) Role of protein kinase C in the modulation of multidrug resistance. Expression of the atypical γ-isoform of protein kinase C does not confer increased resistance to doxorubicin. Mol Pharmacol 42:1004-1009
2. Aquino A, Warren BS, Omichinski J, Hartman KD, Glazer RI (1990) Protein kinase C γ is present in Adriamycin-resistant HL-60 leukemia cells. Biochem Biophys Res Commun 166:723-728
3. Bailly JD, Muller C, Jaffrézou JP, Demur C, Cassar G, Bordier C, Laurent G (1995) Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia 9:799-807
4. Basu A (1993) The potential of protein kinase C as a target for anticancer treatment. Pharmacol Ther 59:257-280
5. Bates SE, Lee JS, Dickstein B, Spolyar M, Fojo AT (1993) Differential modulation of P-glycoprotein transport by protein kinase inhibition. Biochemistry 32:9156-9164
6. Blake MS, Johnston KH, Russel-Jones GJ, Gotschlich EC (1984) A rapid sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots. Anal Biochem 136:175-180
7. Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL, Hannun YA (1993) Selective regulation of expression of protein kinase C isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC α. J Biol Chem 268:658-664
8. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
9. Carmichael J, Degraff WG, Gazdar AF, Minna JD, Mitchell JB (1987) Evaluation of a tetrazolium-base semi-automated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47:936-942
10. Chambers TC, Chalikonda I, Eilon G (1990a) Correlation of protein kinase C translocation. P-glycoprotein phosphorylation, and reduced drug accumulation in multidrug-resistant human KB cells. Biochem Biophys Res Commun 169:253-259
11. Chambers TC, McAvoy EM, Jacobs JW, Eilon G (1990b) Protein kinase C phosphorylates P-glycoprotein in mutidrug-resistant human KB carcinoma cells. J Biol Chem 265:7679-7686
12. Chambers TC, Zheng D, Kuo JF (1992) Regulation by phorbol ester and protein kinase C inhibitors and by a protein phosphatase inhibitor (okadaic acid) of P-glycoprotein phosphorylation, and relationship in multidrug-resistant human KB cells. Mol Pharmacol 41:1008-1015
13. Chambers TC, Pohl J, Raynor RL, Kuo JF (1993) Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. J Biol Chem 268:4592-4595
14. Chaudhary PM, Roninson IB (1992) Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res 4:281-290
15. Chen CC (1993) Protein kinase C α, δ, ε, and ζ in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC ζ. FEBS Lett 332:169-173
16. Devine SE, Melera PW (1994) Diversity of multidrug-resistance in mammalian cells. J Biol Chem 269:6133-6139
17. Drew L, Groome N, Hallam TJ, Warr JR, Rumsby MG (1994) Changes in protein kinase C subspecies protein expression and activity in a series of multidrug-resistant human KB carcinoma cell lines. Oncol Res 6:429-438
18. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58:137-171
19. Fine R, Patel J, Chabner BA (1988) Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci USA 85:582-586
20. Ford JM, Hait WN (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42:155-159
21. Georges E, Sharom FJ, Ling V (1990) Multidrug resistance and chemosensitization. Therapeutic implications for cancer chemotherapy. Adv Pharmacol 21:185-220
22. Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM (1996) Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. J Biol Chem 271:1708-1716
23. Goodfellow HR, Sardini A, Reutz S, Callaghan R, Gros P, McNaughton PA, Higgins CF (1996) Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J Biol Chem 271:13668-13674
24. Gottesman MM, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427
25. Gupta S, Kim C, Qin Y, Gollapudi S (1994) Expression of protein kinase C isoenzymes in multidrug-resistant murine leukemia P388/ ADR cells. Int J Oncol 4:311-315
26. Hamada H, Hagiwara KI, Nakajima T, Tsuruo T (1987) Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine and phorbol esters. Cancer Res 47:2860-2865
27. Hannun H, Foglesong RJ, Bell RM (1989) The Adriamycin-iron (III) complex is a potent inhibitor of protein kinase C. J Biol Chem 264:9960-9966
28. Hu YP, Robert J (1995) Azelastine and flezelastine as reversing agents of multidrug resistance: pharmacological and molecular studies. Biochem Pharmacol 50:169-175
29. Huet S, Robert J (1988) The reversal of doxorubicin resistance by verapamil is not due to an effect on calcium channels. Int J Cancer 41:283-286
30. Huet S, Schott B, Robert J (1992) P-glycoprotein expression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines. Br J Cancer 65:538-544
31. Huet S, Chapey C, Robert J (1993) Reversal of multidrug resistance by a new lipophilic cationic molecule S-9788. Comparison with 11 other MDR-modulating agents in a model of doxorubicin-resistant glioblastoma cells. Eur J Cancer 29:1377-1385
32. 4. Nature 227:680-685
33. Lanzi C, Gambetta RA, Banfi P, Franzi A, Guazzoni L, Zunino F (1991) Protein kinase C activation by anthracycline in swiss 3T3 cells. Int J Cancer 47:136-142
34. Lee SA, Karaszkiewicz JW, Anderson WB (1992) Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. Cancer Res 52:3750-3759
35. Ma L, Marquardt P, Takemoto L, Center MS (1991) Analysis of P-glycoprotein phosphorylation in HL-60 cells isolated for resistance to vincristine. J Biol Chem 266:5593-5599
36. Miyamoto KI, Inoko K, Ikeda K, Wakusawa S, Kaijita S, Hasegawa T, Takagi K, Koyama M (1993) Effect of staurosporin derivatives on protein kinase activity and vinblastine accumulation in mouse leukaemia P388/ADR cells. J. Pharm Pharmacol 45:43-47
37. Mon T, Takai Y, Minakuchi R, Binzu Y, Nishizuka U (1980) Inhibitory action of chlorpromazine, dibucaine and other phospholipid-interacting drugs on calcium-activated phospholipid-dependent protein kinase. J Biol Chem 255:8378-8380
38. Muller C, Bailly JD, Goubin F, Laredo J, Jaffrézou JP, Bordier C, Laurent G (1994) Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines. Int J Cancer 56:749-754
39. Nishizuka Y (1992) Intracellulur signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-613
40. O'Brian CA, Fan D, Ward NE, Seid C, Fidler IJ (1989) Level of protein kinase activity correlates directly with resistance to Adriamycin in murine fibrosarcoma cells. FEBS Lett 246:78-82
41. Orr GA, Han EKH, Browne PC, Nieves E, O'Connor BM, Yang CPH, Horwitz SB (1993) Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. J Biol Chem 268:25054-25062
42. Palayoor ST, Stein JM, Hait WN (1987) Inhibition of protein kinase C by antineoplastic agents: implications for drug resistance. Biochem Biophys Res Commun 148:718-725
43. Posada P, Vichi P, Tritton TR (1989) Protein kinase C in Adriamycin action and resistance in mouse sarcoma 180 cells. Cancer Res 49:6634-6639
44. Safa AR (1992) Photoaffinity labeling of P-glycoprotein in multidrug-resistant cells. Cancer Invest 10:295-305
45. Sato W, Yusa K, Natio M, Tsuruo T (1990) Staurosporin a potent inhibitor of kinase enhances drug accumulation in multidrug-resistant cells. Biochem Biophys Res Commun 173:1252-1257
46. Schott B, Londos-Gagliardi D, Ries C, Huet S, Robert J (1993a) Pharmacological and molecular characterization of intrinsic and acquired doxorubicin resistance in murine tumor cell lines. J Cancer Res Clin Oncol 119:527-532
47. Schott B, Bennis S, Pourquier P, Ries C, Londos-Gagliardi D, Robert J (1993b) Differential overexpression of mdr1 genes in multidrug resistant rat glioblastoma cell lines selected with doxorubicin or vincristine. Int J Cancer 55:115-121
48. Schwartz GK, Arkin H, Holland JF, Ohnuma T (1991) Protein kinase C and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate. Cancer Res 51:55-61
49. Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM (1986) Human multidrug resistant cell lines: increased mdr1 expression can precede gene amplification. Science 232:643-645
50. Sparatore B, Patrone M, Salamino F, Passalacqua M, Melloni E, Pontremoli S (1990) A vincristine-resistant murine erythroleukemia cell line secretes a differentiation-enhancing factor. Biochem Biophys Res Commun 173:156-163
51. Stabel S, Parker PJ (1991) Protein kinase C. Pharmacol Ther 51:71-95
52. Twentyman PR (1988) Modifications of cytotoxic drug resistance by non-immunosuppressive cyclosporins. Br J Cancer 57:254-258
53. Ueda K, Cardarelli C, Gottesman MM, Pastan I (1987) Expression of a full-length cDNA for the human MDR1 gene confers resistance to colchicine, doxorubicin and vinblastine. Proc Nat Acad Sci USA 84:3004-3008
54. Ward NE, O'Brian CA (1991) Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in Adriamycin-selected multidrug-resistant and parental murine fibrosarcoma cells. Cancer Lett 58:189-193
55. Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Cowan K, Glazer RI (1991) Transfection with protein kinase C-α confers increased multidrug resistance to MCF-7 cells expression P-glycoprotein. Cancer Commun 3:181-189