메뉴 건너뛰기




Volumn 9, Issue 1, 1996, Pages 21-27

Glutamic acid decarboxylase 65 and 67 isoforms in fetal, neonatal and adult porcine islets: Predominant beta cell co-localization by light and confocal microscopy

Author keywords

Glutamic acid decarboxylase; Immunohistochemistry; Ontogeny; Porcine islets

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE;

EID: 0029940012     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0004     Document Type: Article
Times cited : (8)

References (34)
  • 3
    • 0024489491 scopus 로고
    • Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: Further evidence for non-neural GABA systems
    • Erdo S.L., Joo F., Wolff J.R. 1989. Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: further evidence for non-neural GABA systems. Cell Tissue Res. 255: 431-434
    • (1989) Cell Tissue Res. , vol.255 , pp. 431-434
    • Erdo, S.L.1    Joo, F.2    Wolff, J.R.3
  • 4
    • 0025020409 scopus 로고
    • Gamma-amino butyric acid outside the mammalian brain
    • Erdo S.L., Wolf J.R. 1990. Gamma-amino butyric acid outside the mammalian brain. J. Neurochem. 54: 363-372
    • (1990) J. Neurochem. , vol.54 , pp. 363-372
    • Erdo, S.L.1    Wolf, J.R.2
  • 5
    • 0025895359 scopus 로고
    • Localization of GAD-like immunoreactivity in the pancreas and stomach of the rat and mouse
    • Gilon P., Tappaz M., Remacle C. 1991. Localization of GAD-like immunoreactivity in the pancreas and stomach of the rat and mouse. Histochemistry 96: 355-365
    • (1991) Histochemistry , vol.96 , pp. 355-365
    • Gilon, P.1    Tappaz, M.2    Remacle, C.3
  • 6
    • 0017148989 scopus 로고
    • High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma
    • Okada Y., Taniguchi H., Shimada C. 1976. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. Science 194: 620-622.
    • (1976) Science , vol.194 , pp. 620-622
    • Okada, Y.1    Taniguchi, H.2    Shimada, C.3
  • 7
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesising enzyme glutamic acid decarboxylase
    • Baekkeskov S., Aanstoot H.-J., Christgau S., Reetz A., Solimena M., et al. 1990. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesising enzyme glutamic acid decarboxylase. Nature 347: 151-156
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.-J.2    Christgau, S.3    Reetz, A.4    Solimena, M.5
  • 8
    • 0028020407 scopus 로고
    • Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice
    • De Aizpurua H.J., French M.B., Chosich N., Harrison L.C. 1994. Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice. J. Autoimmun. 7: 643-653
    • (1994) J. Autoimmun. , vol.7 , pp. 643-653
    • De Aizpurua, H.J.1    French, M.B.2    Chosich, N.3    Harrison, L.C.4
  • 10
    • 0026500437 scopus 로고
    • Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin dependent diabetes
    • Atkinson M.A., Kaufmann D., Campbell L., et al. 1992. Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin dependent diabetes. Lancet 339: 458-459
    • (1992) Lancet , vol.339 , pp. 458-459
    • Atkinson, M.A.1    Kaufmann, D.2    Campbell, L.3
  • 11
    • 0027534912 scopus 로고
    • Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes
    • Honeyman M.C., Cram D.S., Harrison L.C. 1993. Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes. J. Exp. Med. 177: 535-540
    • (1993) J. Exp. Med. , vol.177 , pp. 535-540
    • Honeyman, M.C.1    Cram, D.S.2    Harrison, L.C.3
  • 12
    • 0028333066 scopus 로고
    • Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus
    • Lohmann T., Leslie R.D.G., Hawa M., et al. 1994. Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343: 1607-1608
    • (1994) Lancet , vol.343 , pp. 1607-1608
    • Lohmann, T.1    Leslie, R.D.G.2    Hawa, M.3
  • 13
    • 0027294683 scopus 로고
    • Expression of glutamic acid decarboxylase (GAD) in the α, β and δ cells of normal and diabetic pancreas: Implications for the pathogenesis of type 1 diabetes
    • Vives-Pi M., Somoza N., Vargas F., et al. 1993. Expression of glutamic acid decarboxylase (GAD) in the α, β and δ cells of normal and diabetic pancreas: implications for the pathogenesis of type 1 diabetes. Clin. Expt. Immunol. 92: 391-396
    • (1993) Clin. Expt. Immunol. , vol.92 , pp. 391-396
    • Vives-Pi, M.1    Somoza, N.2    Vargas, F.3
  • 14
    • 0021029790 scopus 로고
    • Ontogeny of endocrine cells in porcine gut and pancreas: An immunocytochemical study
    • Alumets J., Hakanson R., Sundler F. 1983. Ontogeny of endocrine cells in porcine gut and pancreas: an immunocytochemical study. Gastroenterology 85: 1359-1372
    • (1983) Gastroenterology , vol.85 , pp. 1359-1372
    • Alumets, J.1    Hakanson, R.2    Sundler, F.3
  • 15
    • 0025812203 scopus 로고
    • Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with pre-clinical and clinical insulin-dependent diabetes
    • Harrison L.C., De Aizpurua H., Loudovaris T., Campbell I.L., Cebon J.S., Tait B.D., Colman P.G. 1991. Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with pre-clinical and clinical insulin-dependent diabetes. Diabetes 40: 1128-1133
    • (1991) Diabetes , vol.40 , pp. 1128-1133
    • Harrison, L.C.1    De Aizpurua, H.2    Loudovaris, T.3    Campbell, I.L.4    Cebon, J.S.5    Tait, B.D.6    Colman, P.G.7
  • 16
    • 0027070567 scopus 로고
    • A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: Coprecipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes
    • De Aizpurua H.J., Honeyman M.C., Harrison L.C. 1992. A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: coprecipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes. J. Autoimmun. 5: 759-770
    • (1992) J. Autoimmun. , vol.5 , pp. 759-770
    • De Aizpurua, H.J.1    Honeyman, M.C.2    Harrison, L.C.3
  • 17
    • 0028842292 scopus 로고
    • Glutamic acid decarboxylase-67 (GAD67): Expression relative to GAD65 in human islets and mapping of autoantibody epitopes
    • Cram D.S., Paulkner-Jones B., Kun J., Harrison L.C. 1995. Glutamic acid decarboxylase-67 (GAD67): expression relative to GAD65 in human islets and mapping of autoantibody epitopes. Endocrinology 136: 1111-1119
    • (1995) Endocrinology , vol.136 , pp. 1111-1119
    • Cram, D.S.1    Paulkner-Jones, B.2    Kun, J.3    Harrison, L.C.4
  • 18
    • 0028855244 scopus 로고
    • Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies
    • Li L., Jiang J., Hagopian W.A., et al. 1995. Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies. J. Histochem. Cytochem. 43: 53-59
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 53-59
    • Li, L.1    Jiang, J.2    Hagopian, W.A.3
  • 19
    • 0026535193 scopus 로고
    • An immunocytochemical study of endocrine cell development in the early fetal guinea pig pancreas
    • Reddy S., Bibby N.J., Elliott R.B. 1992. An immunocytochemical study of endocrine cell development in the early fetal guinea pig pancreas. Gen. Comp. Endocrinol. 86: 275-283
    • (1992) Gen. Comp. Endocrinol. , vol.86 , pp. 275-283
    • Reddy, S.1    Bibby, N.J.2    Elliott, R.B.3
  • 20
    • 0027461045 scopus 로고
    • Differential expression of glutamic acid decarboxylase in rat and human islets
    • Petersen J.S., Russel S., Marshall M.O., et al. 1993. Differential expression of glutamic acid decarboxylase in rat and human islets. Diabetes 42: 484-495
    • (1993) Diabetes , vol.42 , pp. 484-495
    • Petersen, J.S.1    Russel, S.2    Marshall, M.O.3
  • 21
    • 0028070978 scopus 로고
    • Functional state of the β cell affects expression of both forms of glutamic acid decarboxylase
    • Hao W., Li L., Mehta V., Lernmark A., Palmer J.P. 1994. Functional state of the β cell affects expression of both forms of glutamic acid decarboxylase. Pancreas 9: 558-562
    • (1994) Pancreas , vol.9 , pp. 558-562
    • Hao, W.1    Li, L.2    Mehta, V.3    Lernmark, A.4    Palmer, J.P.5
  • 22
    • 0028237147 scopus 로고
    • Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
    • Tuomilehto J., Zimmet P., Mackay I.R., Koskela P., Vidgren G., Toivanen L., et al. 1994. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 343: 1383-1385
    • (1994) Lancet , vol.343 , pp. 1383-1385
    • Tuomilehto, J.1    Zimmet, P.2    Mackay, I.R.3    Koskela, P.4    Vidgren, G.5    Toivanen, L.6
  • 23
    • 0028921580 scopus 로고
    • Sequences of two porcine glutamic acid decarboxylases (65-and 67-kDa GAD)
    • Suzuki R., Asami N., Amann E., Wagatsuma M. 1995. Sequences of two porcine glutamic acid decarboxylases (65-and 67-kDa GAD). Gene 152: 257-260
    • (1995) Gene , vol.152 , pp. 257-260
    • Suzuki, R.1    Asami, N.2    Amann, E.3    Wagatsuma, M.4
  • 24
    • 0022259844 scopus 로고
    • Electron microscopic immunocytochemical localization of glucagon and pancreatic polypeptide in rat pancreas. Characterization of a population of islet cells containing both peptides
    • Kaung H.L.C. 1985. Electron microscopic immunocytochemical localization of glucagon and pancreatic polypeptide in rat pancreas. Characterization of a population of islet cells containing both peptides. Anat. Rec. 212: 292-300
    • (1985) Anat. Rec. , vol.212 , pp. 292-300
    • Kaung, H.L.C.1
  • 25
    • 0025945011 scopus 로고
    • Structural and functional considerations of gaba in islets of Langerhans: β-cells and nerves
    • Sorenson R.L., Garry D.G., Brelje T.C. 1991. Structural and functional considerations of GABA in islets of Langerhans: β-cells and nerves. Diabetes 40: 1365-1374
    • (1991) Diabetes , vol.40 , pp. 1365-1374
    • Sorenson, R.L.1    Garry, D.G.2    Brelje, T.C.3
  • 26
    • 0023029275 scopus 로고
    • Immunohistochemical colocalization of GABA and insulin in B-cells of rat islet
    • Garry D.J., Sorenson R.L., Eide R.P., Maley B.E., Madsen A. 1986. Immunohistochemical colocalization of GABA and insulin in B-cells of rat islet. Diabetes. 35: 1090-1095
    • (1986) Diabetes. , vol.35 , pp. 1090-1095
    • Garry, D.J.1    Sorenson, R.L.2    Eide, R.P.3    Maley, B.E.4    Madsen, A.5
  • 27
    • 0023921130 scopus 로고
    • Cellular and subcellular immunolocalization of L-glutamate decarboxylase in rat pancreatic islets
    • Garry D.J., Appel N.M., Carry M.G., Sorenson R.L. 1988. Cellular and subcellular immunolocalization of L-glutamate decarboxylase in rat pancreatic islets. J. Histochem. Cytochem. 36: 573-580
    • (1988) J. Histochem. Cytochem. , vol.36 , pp. 573-580
    • Garry, D.J.1    Appel, N.M.2    Carry, M.G.3    Sorenson, R.L.4
  • 28
    • 0020660061 scopus 로고
    • Immunohistochemical studies of the GABA system in the pancreas
    • Vincent S.R., Hokfelt T., Wu J.-Y., et al. 1983. Immunohistochemical studies of the GABA system in the pancreas. Neuroendocrinology 36: 197-204
    • (1983) Neuroendocrinology , vol.36 , pp. 197-204
    • Vincent, S.R.1    Hokfelt, T.2    Wu, J.-Y.3
  • 29
    • 0027134795 scopus 로고
    • Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat
    • Faulkner-Jones B.E., Cram D.S., Kun J., Harrison L.C. 1993. Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat. Endocrinology 133: 2962-2972
    • (1993) Endocrinology , vol.133 , pp. 2962-2972
    • Faulkner-Jones, B.E.1    Cram, D.S.2    Kun, J.3    Harrison, L.C.4
  • 31
    • 0028235080 scopus 로고
    • Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets
    • Velloso L.A., Eizirik D.L., Karlsson F.A., Kampe O. 1994. Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets. Clin. Exptl. Immunol. 96: 129-137
    • (1994) Clin. Exptl. Immunol. , vol.96 , pp. 129-137
    • Velloso, L.A.1    Eizirik, D.L.2    Karlsson, F.A.3    Kampe, O.4
  • 32
    • 0026690837 scopus 로고
    • 65 to microvesicles in pancreatic β-cells by palmitoylation in the NH2-terminal domain
    • 65 to microvesicles in pancreatic β-cells by palmitoylation in the NH2-terminal domain. J. Cell Biol. 118: 309-320
    • (1992) J. Cell Biol. , vol.118 , pp. 309-320
    • Christgau, S.1    Aanstoot, H.-J.2    Schierbeck, H.3
  • 33
    • 0342437930 scopus 로고
    • Anatomy and ultrastructural organization of pancreatic islets
    • L.J. DeGroot, G.F. Cahill, W.D. Odell, L. Martini, J.T. Potts, D.H. Nelson, E. Steinberger, and A.I. Winegrad eds. Grune and Stratton, New York.
    • Lacy P.E., Greider M.H. 1979. Anatomy and ultrastructural organization of pancreatic islets. In Endocrinology, volume 2. L.J. DeGroot, G.F. Cahill, W.D. Odell, L. Martini, J.T. Potts, D.H. Nelson, E. Steinberger, and A.I. Winegrad eds. Grune and Stratton, New York. pp. 907-919
    • (1979) Endocrinology , vol.2 , pp. 907-919
    • Lacy, P.E.1    Greider, M.H.2
  • 34
    • 0028140001 scopus 로고
    • Potential autoantigens in IDDM: Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the β-cell surface
    • Aguilar-Diosdado M., Parkinson D., Corbett J.A., et al. 1994. Potential autoantigens in IDDM: expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the β-cell surface. Diabetes 43: 418-425
    • (1994) Diabetes , vol.43 , pp. 418-425
    • Aguilar-Diosdado, M.1    Parkinson, D.2    Corbett, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.