Augmentation of selective serotonin reuptake inhibitor antidepressant efficacy with pindolol and the relevance of 5HT1A autoreceptors

Anxiety

Volumn 2, Issue 3, 1996, Pages 149-153

  Galloway, Matthew P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5HT1a; Autoreceptor; Fluoxetine; Fluvoxamine; Paroxetine; Pindolol; SAARI; Serotonin; Sertraline; SSRI

Indexed keywords

EID: 0005625487     PISSN: 10709797     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1522-7154(1996)2:3<149::aid-anxi7>3.0.co;2-k     Document Type: Article

References (17)

1. Aghajanian GK, Sprouse JS, Rasmussen K (1987) Physiology of midbrain serotonin systems. In Meltzer HY (ed) Psychopharmacology: The Third Generation of Progress, New York: Raven Press, pp 141-149.
2. Blier P, de Montigny C, Chaput Y (1987) Modifications of the serotonin system by antidepressant treatments: Implications for the therapeutic response in major depression. J Clin Psychopharmacol 7:24S-35S.
3. Blier P, de Montigny C (1990) Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: Single cell recording studies. J Clin Psychopharmacol, 1990, 10(suppl 3): 13S-20S.
4. Blier P, Lista A, de Montigny C (1993) Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. J Pharmacol Exp Therap 265:16-23.
5. Clark D, Hjorth S, Carlsson A (1985) Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity. I. Review of the evidence. J Neural Transm 6:1-52.
6. Deakin JFW, Graeff FG, Guimaraes FS (1993) Clinical implication of microdialysis findings. Trends Pharmacol Sci, 14;263.
7. Hjorth S (1993) Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citaloprarn to increase nerve terminal output of 5-HT in vivo - A microdialysis study. J Neurochem 60:776.
8. Howland RH (1995) Biochemical effects of antidepressant augmentation. Arch Gen Psychiatry 52:156.
9. Invernizzi R, Belli S, Samanin R (1992) Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res 584:322.
10. Meller E, Bohmaker K (1994) Differential receptor reserve for 5-HT1A receptor mediated regulation of plasma neuroendocrine hormones. J Pharmacol Exp Ther 271:1246-1252.
11. Meller E, Goldstein M, Bohmaker K (1990) Receptor reserve for 5-HT1A mediated inhibition of serotonin synthesis: Possible relationship to anxiolytic properties of 5-HT1A agonists. Mol Pharmacol 37:231-237.
12. Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V (1994) Novel benzodioxopiperazines acting as antagonists at postsynaptic 5HT1A receptors and as agonists at 5HT1A autoreceptors: A comparative pharmacological characterization with proposed 5HT1A antagonists. J Pharmacol Exp Ther 268:337-352.
13. Riva MA, Creese I (1989) Reevaluation of the regulation of β-adrenergic receptor binding by desipramine treatment. Mol Pharmacol 36:211-218.
14. Routledge C, Gurling J, Wright IK, Dourish J (1993) Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: An in vivo microdialysis study. Eur J Pharmacol 239:195.
15. Stein M (1994/1995) Pharmacology and Clinical Neurobiology. Anxiety 1:244-246.
16. Wolf ME, Roth RH (1990) Autoreceptor regulation of dopamine synthesis. Ann NY Acad Sci 604:323-343.
17. Yocca FD, Iben L, Meller E (1992) Lack of apparent receptor reserve at postsynaptic 5-HT1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Mol Pharmacol 41:1066-1072.