Assessment of insulin sensitivity in glucokinase-deficient subjects

Diabetologia

Volumn 39, Issue 1, 1996, Pages 82-90

  Clement K ^a   Pueyo, M E ^b   Vaxillaire, M ^a   Rakotoambinina, B ^c   Thuillier, F ^d   Passa, Ph ^e   Froguel, Ph ^a   Robert, J J ^c   Velho, G ^b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d INSERM   (France)

^e Ho Pital Necker Enfants Malades   (France)

Author keywords

Glucokinase mutation; Glucose clamp; Insulin resistance; MODY

Indexed keywords

GLUCOKINASE; GLUCOSE; INSULIN;

ADULT; ARTICLE; CHROMOSOME 7; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE OF ONSET; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FAMILY; FEMALE; GLUCOKINASE; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUTATION; POINT MUTATION; REGRESSION ANALYSIS;

EID: 0030070074     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Vionnet N, Stoffel M, Takeda J et al. (1992) Nonsense mutation in the glucokinase gene causes early-onset non insulin dependent diabetes mellitus. Nature 356: 721-722
2. Stoffel M, Froguel Ph, Takeda J et al. (1992) Identification of two missense mutations in glucokinase linked to early-onset non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 89: 7698-7702
3. Froguel Ph, Zouali H, Vionnet N et al. (1993) Familial hyperglycaemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N Engl J Med 328: 697-702
4. Sun F, Knebelmann B, Pueyu ME et al. (1993) Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity onset diabetes of the young. J Clin Invest 92: 1174-1180
5. Hager J, Blanché H, Sun F et al. (1994) Six mutations in the glucokinase gene identified in MODY using a nonradioactive sensitive screening technique. Diabetes 43: 730-733
6. Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39: 647-652
7. Gidh-Jain M, Takeda J, Xu LZ et al. (1993) Glucokinase mutations associated with non insulin dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc Natl Acad Sci USA 90: 1932-1936
8. Takeda J, Gidh-Jain M, Xu LZ et al. (1993) Structure/function studies of human glucokinase: enzymatic properties of sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. J Biol Chem 268: 15200-15204
9. Matschinsky F, Liang Y, Kesavan P et al. (1993) Glucokinase as pancreatic beta-cell glucose sensor and diabetes gene. J Clin Invest 92: 2092-2098
10. Sturis J, Kurland IJ, Byrne MM et al. (1994) Compensation in pancreatic β-cell function in subjects with glucokinase mutations. Diabetes 43: 718-723
11. Velho G, Froguel Ph, Clément K et al. (1992) Primary pancreatic β-cell secretory defect caused by mutations in the glucokinase in kindreds of maturity onset diabetes of the young. Lancet 340: 444-448
12. Byrne MM, Sturis J, Clément K et al. (1994) Insulin secretory abnormalities in subjects with hyperglycaemia due to glucokinase mutations. J Clin Invest 93: 1120-1130
13. Velho G, Hwang J-II, Petersen K et al. (1994) Altered hepatic glycogen synthesis in glucokinase deficient subjects. Diabetologia 37[Suppl 1]:A131 (Abstract)
14. DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15: 318-368
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Preacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28:412-419
16. Fajans SS (1990) Scope and heterogeneous nature of MODY. Diabetes Care 13: 49-64
17. Orita M, Suzuki Y, Sekiya T, Hayashi K (1989) Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874-879
18. WHO Study Group on Diabetes Mellitus (1985) Technical Report Series World Health Organisation no 727, Geneva
19. Tchobroutsky G (1991) Blood glucose levels in diabetic and non-diabetic subjects. Diabetologia 34: 67-73
20. Lestradet H, Deschamps I, Tichet J, Lestradet MO (1989) Hyperglycémie chronique non insulinoprive de l'enfant. Arch Fr Pediatr 46: 19-23
21. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 6:E214-E223
22. Bier DM, Arnold KJ, Sherman WR, Holland WH, Holmes WF, Kipnis DM (1977) In vivo measurement of glucose and alanine metabolism with stable isotopic tracer. Diabetes 26: 1005-1015
23. Steele R (1953) Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82: 420-430
24. Argoud GM, Schade DS, Eaton RP (1987) Underestimation of hepatic glucose production by radioactive and stable tracers. Am J Physiol 252(Endocrinol Metab 15):E606-E615
25. 3H]-glucose infusion and labelled or unlabelled glucose infusates. Diahet Med 9: 840-849
26. Hollenbeck C, Reaven GM (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64: 1169-1173
27. Rudenski AS, Matthews DR, Levy JC, Turner RC (1991) Understanding "insulin resistance": both glucose resistance and insulin resistance are required to model human diabetes. Metabolism 40: 908-917
28. Stoffel M, Patel P, Lo Y-MD et al. (1992) Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes. Nature Genetics 2: 153-156
29. Bell GI, Xiang K-S, Newman MV et al. (1991) Gene for non insulin dependent diabetes mellitus (maturity onset diabetes of the young subtype) is linked to DNA polymorphism on chromosome 20q. Proc Natl Acad Sci USA 88: 1484-1488
30. Hattersley AT, Turner RC Permutt MA et al. (1992) Linkage of type 2 diabetes to the glucokinase gene. Lancet 339: 1307-1310
31. Beck-Nielsen H, Nielsen OH, Pedersen O, Bak J, Faber O, Schmitz O (1988) Insulin action and insulin secretion in identical twins with MODY: evidence for defects in both insulin action and insulin secretion. Diabetes 37: 730-735
32. Mohan V, Sharp PS. Aber VR, Mather HM, Kohner EM (1987) Insulin resistance in maturity-onset diabetes of the young. Diabetes Metab 13: 193-197
33. Jialal I, Naidoo C, Rajput M, Joubert SM (1984) Evidence for insulin resistance in Indian patients with non-insulin dependent diabetes in the young. Horm Metab Res 16; 377-378
34. Winter WE, Maclaren NK, Riley WJ, Clarke DW, Kappy MS, Spillar RP (1987) Maturity-onset diabetes of the young in Black Americans. N Engl J Med 316: 285-291
35. Herman WH, Hajans SS, Ortiz FJ et al. (1994) Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes 43: 40-46