Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) α1 containing receptors and increases inferior collicular seizure sensitivity

Brain Research

Volumn 756, Issue 1-2, 1997, Pages 76-83

  Xiao, Xiao ^a,c   McCown, Thomas J ^a,b   Li, Juan ^a,c   Breese, George R ^a,b   Morrow, A Leslie ^a,b   Samulski, R Jude ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Somatix Corporation   (United States)

Author keywords

Aminobutyric acid (GABA); Adeno associated virus; Antisense; Gene therapy; Inferior colliculus; Seizure

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; COMPLEMENTARY DNA; VIRUS VECTOR; ZOLPIDEM;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; GENE TRANSFER; INFERIOR COLLICULUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SEIZURE;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); DEPENDOVIRUS; DISEASE SUSCEPTIBILITY; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; HYPNOTICS AND SEDATIVES; INFERIOR COLLICULUS; ISOMERISM; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES;

EID: 0030902462     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00120-0     Document Type: Article

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