Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8+CD95+, CD8+CD38+, and CD4+CD95+ T cells are markers for HIV-1 infection and clinical status

Journal of Clinical Immunology

Volumn 17, Issue 2, 1997, Pages 185-192

  Jiang, Jian Dong ^a   Schlesinger, Michael ^b   Sacks, Henry ^a   Mildvan, Donna ^c   Roboz, Julia P ^a   Bekesi, J George ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HEBREW UNIVERSITY   (Israel)

^c BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

apoptosis; CD95+ lymphocytes; HIV 1 infection; soluble CD8; soluble CD95 (Fas)

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN;

ADULT; APOPTOSIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTIGENS, CD8; ANTIGENS, CD95; APOPTOSIS; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HIV-1; HUMANS; STATISTICS;

EID: 0030899167     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027386701052     Document Type: Article

References (35)

1. Ameisen J: Programmed cell death and AIDS: From hypothesis to experiment. Immunol Today 13:388-391, 1992
2. Gougeon M-L, Gracia S, Heeney J, Tschopp R, Lecoeur H, Guetard D, Rame V, Dauguet C, Montagnier L: Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retrovirus 8:553-563, 1993
3. Laurent-Crawford AG, Krust B, Riviere Y, Desgranges C, Mullers S, Kieny MP, Dauguet C, Hovanessian AG: Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res Hum Retrovirus 9:761-773, 1993
4. Corbeil J, Richman DD: Productive infection and subsequent interaction of CD4- gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T-cells. J Gen Virol 76:681-690, 1995
5. Groux H, Torpier G, Monte D, Mouton Y, Capron A, Ameisen JC: Activation induced death by apoptosis from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 175: 331-338, 1992
6. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, Miedema F: Programmed death of T cells in HIV-1 infection. Science 257:217-219, 1992
7. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029-2036, 1995
8. Nagata S, Golstein P: The Fas death factor. Science 267:1449-1456, 1995
9. Trauth BC, Klas C, Peters AMJ, Matzku S, Moller P, Falk W, Debatin KM, Krammer PH: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305, 1989
10. Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178, 1993
11. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczack H, Debatin KM, Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497-500, 1995
12. Kobayashi N, Hamammoto Y, Yamammoto N, Ishii A, Yonehara M, Yohehara S: Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus infected cells without augmenting viral replication. Proc Natl Acad Sci USA 87:9620-9624, 1990
13. Estaquier J, Idziorek T, Zou W, Emilie D, Farber C-M, Bourez J-M: T helper type 1/T helper type 2 cytokines and T cell death: Preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. J Exp Med 182:1759-1767, 1995
14. Debatin KM, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, Krammer PH: High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 83:3101-3103, 1994
15. Gehri R, Hahn S, Rothen M, Steuerwald M, Nuesch R, Erb P: The Fas receptor in HIV infection: Expression on peripheral blood lymphocytes and role in the depletion of T cells. AIDS 10:9-16, 1996
16. Silvestris F, Cafforio P, Frassanito MA, Tucci M, Romito A, Nagata S, Dammacco F: Overexpression of Fas antigen on T cells in advanced HIV-1 infection: Differential ligation constantly induces apoptosis. AIDS 10:131-141, 1996
17. McCloskey TW, Oyaizu N, Kaplan M, Pahwa S: Expression of the Fas antigen in patients infected with human immunodeficiency virus. Cytometry 22:111-114, 1995
18. Yagi MJ, Joesten ME, Wallace J, Roboz JP, Bekesi JG: Human immunodeficiency virus type 1 (HIV-1) genomic sequences and distinct changes in CD8+ lymphocytes precede detectable levels of HIV-1 antibodies in high-risk homosexuals. J Infect Dis 164:183-188, 1991
19. Yagi MJ, Chu F-N, Jiang JD, Wallace J, Mason P, Liu Y, Carafa J, Bekesi JG: Increases in soluble CD8 antigen in plasma, and CD8+ and CD8+CD38+ cells in human immunodeficiency virus type-1 infection. Clin Immunol Immunopathol 63:126-134, 1992
20. Schlesinger M, Chu FN, Badamchian M, Jiang JD, Roboz JP, Goldstein AL, Bekesi JG: A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals. Clin Immunol Immunopathol 73:252-260, 1994
21. Schlesinger M, Peters V, Jiang JD, Roboz JP, Bekesi JG: Increased expression of activation markers on CD8 lymphocytes in children with human immunodeficiency virus-1 infection. Pediatr Res 38:390-396, 1995
22. Prince HE, Jensen ER: Three-color cytofluorometric analysis of CD8 cell subsets in HIV infection. J Acquir Immune Defic Syndr 4:1227-1232, 1991
23. Nishanian P, Hofmann B, Wang Y, Jackson AL, Detels R, Fahey JL: Serum soluble CD8 molecule is a marker of CD8 T-cell activation in HIV-1 disease. AIDS 5:805-812, 1991
24. Agostini C, Pizzolo G, Zambello R, Trentin L, Siviero F, Vinante F, Morosato L, Francavilla E, Cadrobbi P, Semenzato G: Shedding of the soluble form of the CD8 complex by CD8+/HLA-DR+ cells in HIV-1-infected patients. AIDS 5:813-819, 1991
25. Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, Kiefer MC, Barr PJ, Mountz JD: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759-1762, 1995
26. Knipping E, Debatin KM, Stricker K, Heilig B, Eder A, Krammer PH: Identification of soluble APO-1 in supernatants of human B-and T-cell lines and increased serum levels in B- and T-cell leukemias. Blood 85:1562-1569, 1995
27. Yagi MJ, Carrabis S, Bekesi JG: Determination of soluble CD8 T-cell antigen (sCD8) by enzyme-linked immunosorbent assay. In Manual of Clinical Immunology, NR Rose, EC DeMarco, JL Fahey, GM Penn (eds). Washington, DC, ASM, 1992, pp 261-268
28. Myawaki T, Uehara T, Nibu R, Tsui T, Yachie A, Yonehara S, Taniguchi N: Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 149:3753-3758, 1992
29. Bettens F, Frei E, Frutig K, Mauri D, Pichler WJ, Wyss-Coray T: Noncytotoxic human CD4+ T-cell clones presenting and simultaneously responding to an antigen die of apoptosis. Cell Immunol 161:72-76, 1995
30. Oyaizu N, McCloskey TW, Than S, Hu R, Kalyanaraman VS, Pahwa S: Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis alpha secretion. Blood 84:2622-2631, 1994
31. Watanabe-Fukunaga K, Brannan CI, Itoh N, Yonehara S, Copeland NG, Jenkins NA, Nagata S: The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen. J Immunol 148:1274-1279, 1992
32. HO HN, Hultin LE, Mitsuyasu RT, Matud JL, Hausner MA, Bockstoce D, Chou CC, O'Rourke S, Taylor JM, Giorgi JV: Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 150:3070-3079, 1993
33. Levy JA: Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 57:183-289, 1993
34. Giorgi JV, Ho HN, Hirji K, Chou CC, Hultin LE, O'Rourke S, Park L, Margolick JB, Ferbas J, Phair JP: CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLA-DR+ CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels. J Infect Dis 170:775-781, 1994
35. Frabas J, Kaplan AH, Hausner MA, Hultin LE, Matud JL, Liu Z, Panicalli DL, Nerng-Ho H, Detels R, Giorgi JV: Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity. J Infect Dis 172:329-339, 1995