Intracellular [Mg++] determines specificity of K+ channel block by a class III antiarrhythmic drug

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 3, 1996, Pages 951-957

  Sudo, Gisele Zapata ^a,b   Sanguinetti, Michael C ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ANTIARRHYTHMIC AGENT; MAGNESIUM; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL; PYRIDINE DERIVATIVE;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; FEMALE; GUINEA PIG; HEART; MALE; PATCH CLAMP;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HEART; MAGNESIUM; MALE; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNELS; PYRIDINES;

EID: 0030098795     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. AGUS, Z. S. AND MORAD, M.: Modulation of cardiac ion channels by magnesium. Annu. Rev. Physiol. 53: 299-307, 1991.
2. + current in cardiac myocytes by dofetilide. J. Pharmacol. Exp. Ther. 262: 809-817, 1992.
3. COHEN, P.: The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 453-508, 1989.
4. DELMAR, M., IBARRA, J., LORENTE, P. AND JALIFE, J.: Dynamics of the background outward current of single guinea pig ventricular myocytes. Circ. Res. 69: 1316-1326, 1991.
5. DUCHATELLE-GOURDON, I., HARTZELL, H. AND LAGRUTTA, A. A : Modulation of the delayed rectifier potassium current in frog cardiomyocytes by b-adrenergic agonists and magnesium. J. Physiol. (Lond.) 415: 251-274, 1989.
6. 2+ on basal and b-adrenergic-stimulated delayed rectifier potassium current in frog atrial myocytes. J. Physiol. (Lond.) 435: 333-347, 1991.
7. FABIATO, A. AND FABIATO, F.: Calculator programs for computing the compositions of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J. Physiol. (Paris) 75: 463-505, 1979.
8. + channels is caused by intracellular spermine. Cell 80: 149-154, 1995.
9. + channels. Science 266: 1068-1072, 1994.
10. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. AND SIGWORTH, F. J.: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free mabrane patches. Pflügers Arch 391: 85-100, 1981.
11. INGEBRITSEN, T. S., STEWART, A. A. AND COHEN, P.: The protein phosphatases involved in cellular regulation. 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues: An assessment of their physiological roles. Eur. J. Biochem. 132: 297-307, 1983.
12. + current in guineapig cardiac myocytes. J. Physiol. (Lond.) 419: 297-320, 1989.
13. + current by dofetilide. Circ. Res. 72: 75-83, 1993.
14. KAMP, T. J., SANGUINETTI, M. C. AND MILLER, R. J.: Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circ. Res. 64: 338-351, 1989.
15. KEREN, A. AND TZIVONI, D.: Torsades de pointes: Prevention and therapy. Cardiovasc. Drugs Ther. 5: 509-514, 1991
16. MATSUDA, H.: Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. J. Physiol. (Lond.) 397: 237-258, 1988.
17. + channel Annu. Rev. Physiol. 53: 289-298, 1991.
18. 2+. Nature 325: 156-159, 1987.
19. Kl channels. J. Membr. Biol. 116: 41-45, 1990.
20. MAZZANTI, M. AND DIFRANCESCO, D.: Intracellular Ca modulates K-inward rectification in cardiac myocytes. Pflugers Arch. 413: 322-324, 1989.
21. MURPHY, B., STEENBERGEN, C., LEVY, L. A., RAJU, B. AND LONDON, R. E.: Cytosolic free magnesium levels in ischemic rat heart. J. Biol. Chem. 264: 5622-5627, 1989.
22. NOBLE, D. AND TSIEN, R W.: Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J. Physiol. 200: 205-231, 1969.
23. RODEN, D.: Arrhythmic potential of class III antiarrhythmic agents: Comparison with class I agents. In Control of Cardiac Arrrhythmias by Lengthening Repolarization, ed. by B. N. Singh, pp. 559-576, Futura Publishing Co., Mount Kisco, NY, 1988.
24. + current: Differential sensitivity to block by Class III antiarrhythmic agents. J. Gen. Physiol. 96: 195-215, 1990a.
25. K and screens membrane surface charge in cardiac cells. Am. J. Physiol. 259: H1881-H1889, 1990b.
26. + currents. Pflügers Arch. 420: 180-186, 1992.
27. SANGUINETTI, M. C., JURKIEWICZ, N. K., SCOTT, A. AND SIEGL, P. K. S.: Isoproterenol antagonizes prolongation of refractory period by the Class III antiarrhythmic agent, E-4031 in guinea pig myocytes: Mechanism of action. Circ. Res. 68: 77-84, 1991.
28. SHIBASAKI, T.: Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol. 387: 227-250, 1987
29. K in single frog atrial cells. Am. J. Physiol. 257: H1663-H1669, 1989.
30. VANDENBERG, C A : Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc. Natl. Acad. Sci. U.S.A. 84: 2560-2564, 1987.
31. VELDKAMP, M. W., VAN GINNEKEN, A. C. G. AND BOUMAN, L. N. Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circ. Res. 72: 865-878, 1993.